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| 1 | 复方草药制剂减轻高草酸尿导致的氧化应激及预防草酸钙沉积和大鼠肾细胞损伤(英文)显示文摘INTRODUCTION:Cystone is an approved Ayurvedic polyherbal proprietary medicine used in India for various urinary disorders,including urolithiasis.AIM:To evaluate the protective effect of Cystone against hyperoxaluria-induced oxidative stress and calcium oxalate crystal deposition in urolithiasis.METHODS:Ethylene glycol(EG)(0.75%,V/V)in drinking water was given to rats for 28 days to induce urolithiasis with simultaneous treatment of Cystone(500 and 750 mg/kg body weight),and various urinary risk factors of urolithiasis and antioxidant markers were assessed.RESULTS:EG treatment lead to increased urine volume and lowered urinary pH,along with increased urinary excretion of oxalate,calcium and phosphate in untreated animals.These changes caused extensive calcium oxalate crystal deposition,increased lipid peroxidation and decreased activity of antioxidant enzymes(SOD,catalase and GPx)in the kidney of untreated rats.Cystone prevented these hyperoxaluric manifestations and inhibited calcium oxalate crystal deposition in treated rats at both doses.CONCLUSIONS:Cystone therapy provides protection against hyperoxaluria-induced oxidative stress and calcium oxalate crystal deposition by improving renal tissue antioxidant status and diuresis. | Kiran S. Bodakhe Kamta P Namdeo Kartik C.Patra Lalit Machwal Surendra K. Pareta | 2013 | 中国天然药物2013，11，5： | 2 |
| 2 | 多西他赛治疗乳腺癌患者的护理显示文摘目的:研究乳腺癌患者应用多西他赛治疗后的临床护理方法。方法:针对以多西他赛为主治疗的乳腺癌患者52例,根据其不同临床表现采取相对应的临床护理方法。结果:52例患者完成治疗。多西他赛主要毒性是导致骨髓抑制和外周神经的病变,多名患者出现低血压、心动过缓、肌肉关节痛及胃肠道反应等,部分病例出现过敏反应。针对这些临床表现采取相对应的临床护理措施可减轻或消除此类不良反应的发生。结论:多西他赛治疗乳腺癌时根据其药理作用、不良反应,进行提前预防,重点观察及护理,减轻或避免不良反应的发生。 | 刘洁 张淑玲 | 2013 | 中国社区医师(医学专业)2013，15，1： | 1 |
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