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| 1 | 1α,25-dihydroxyvitamin D_(3) prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital显示文摘AIM:To investigate the chemopreventive iffects of 1α,25-dihydroxyvitamin D3 in diethylnitrosamine induced,phenobarbital promoted rat hepatocarcinogenesis.METHODS:The rats were randomly divided into 6 different groups(A-F).Group A,C and E rats received a single intraperitoneal (i.p) injection of diethylnitrosamine (DEN) at a dose of 200 mg/kg body mass in 9 g/L NaCl solution at 4 wk of age ,while group B served as normal vehicle control received normal saline once.After a brief recovery of 2 WK, all the DEN treated rats were given phenobarbital (PB) at 0.5g/L daily in the basal diet till WK 20.Group C was started 4 wk prior to DEN injection and continued thereafter till wk 20 at a dose (os) twice a week.Group E received the treatment of 1α,25-(OH)2D3 at the same dose mentioned as above for 15 wk.The rats in group D and F received 1α,25-(OH)2D3 alone as in group C without DEN injection.RESULTS:The comet assay showed statistically higher mean values for length to width ratios (L:W) of DNA mass and tailed cells (p<0.01;p<0.01 respectively) in DEN treated rats as compared to their normal controls.Continuous supplementation of 1α,25-dihydroxyvitaminD3 showed a significant (p<0.01) decrease in L:W ratio of DNA mass tailed cells.Furthermore,1α,25-(OH)2D3 supplementations elevated the super oxide dismutase (SOD) activety,hepatic malondialdehyde(MDA) levle,reduced glutathione (GSH) and glutathione S-transferase (GST) activety (p<0.01,p<0.01,p<0.05 and p<0.05 respectively).As an endpoint marker histological changes were observed to establish the chemopreventive effects of 1α,25-dihydroxyvitaminD3.CONCLUSION:Supplementations of 1α,25-(OH)2D3 has a marked protection against hepatic nodelogenesis,antioxidant enzymes and DNA damages in DEN induced rat hepatocarcinogenesis promoted by phenobarbital. | Mahendrakumar Chandrasekharappa Banakar Suresh Kanna Paramasivan Mitali Basu Chattopadhyay Subrata Datta Prabir Chakraborty Malay Chatterjee Kalaiselvi Kannan Elayaraja Thygarajan | 2004 | World Journal of Gastroenterology2004，10，9： | 5 |
| 2 | Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation显示文摘导致消炎痛的胃的溃疡在试验性的老鼠模型由 ellagic 酸(EA ) 愈合的机制在我们的学习被描述。溃疡索引(UI ) 和 myeloperoxidase (军邮局) 胃纸巾的活动在消炎痛以后在第三天显示出最大的溃疡(18 mg/kg,单个剂量) 管理。UI 和军邮局活动的初步的观察建议 EA 拥有愈合溃疡的活动。另外的反溃疡参数象前列腺素 E2 的层次那样, cyclooxygenase (艇长) 1 和 2 酶,反煽动性的 cytokines [ interleukin ( IL ) -4 和-5], pro-angiogenic 因素例如脉管的 endothelial 生长因素, hepatocyte 生长因素( HGF ),并且 endothelial 生长因素( EGF )由消炎痛是下面调整的。为 3 天的处理转移了的 EA (7 mg/kg/day ) 导致消炎痛的支持 inflammatory 愈合的生物化学的参数站在一起。这些活动与 EA 的能力被相关改变愈合的 COX-2-dependent 小径。然而, EA 的愈合溃疡的活动被特定的 COX-2 禁止者, celecoxib,和 NS-398 的管理前损害。一起拿,这些结果建议 EA 处理加速溃疡由导致 IL-4 愈合, EGF/HGF 铺平并且提高 COX-2 表示。 | Ananya Chatterjee Sirshendu Chatterjee Smita Das Arpita Saha Subrata Chattopadhyay Sandip K.Bandyopadhyay | 2012 | Acta Biochimica et Biophysica Sinica2012，44，7： | 3 |
| 3 | Acanthus ilicifolius plant extract prevents DNA alterations in a transplantable Ehrlich ascites carcinoma-bearing murine model显示文摘AIM: To investigate the chemopreventive efficacy of the Indian medicinal plant Acanthus ilicifolius L Acanthaceae in a transplantable Ehrlich ascites carcinoma (EAC)- bearing murine model. METHODS: Male Swiss albino mice were divided into four groups: Group A was the untreated normal control; Group B was the EAC control mice group that received serial, intraperitoneal (ip) inoculations of rapidly proliferating 2 x 105 viable EAC cells in 0.2 mL of sterile phosphate buffered saline; Group C was the plant extract-treated group that received the aqueous leaf extract (ALE) of the plant at a dose of 2.5 mg/kg body weight by single ip injections, once daily for 10, 20 and 30 consecutive days following tumour inoculation (ALE control); and Group D was the EAC + ALE- treatment group. The chemopreventive potential of the ALE was evaluated in a murine model by studying various biological parameters and genotoxic markers, such as tumour cell count, mean survival of the animals, haematological indices, hepatocellular histology, immunohistochemical expression of liver metallothionein (MT) protein, sister-chromatid exchanges (SCEs), and DNA alterations.RESULTS: Treatment of the EAC-bearing mice with the ALE significantly (P < 0.001) reduced viable tumour cell count by 68.34% (228.7 x 106 ± 0.53) when compared to EAC control mice (72.4 x 106 ± 0.49), and restored body and organ weights almost to the normal values. ALE administration also increased (P < 0.001) mean survival of the hosts from 35 ± 3.46 d in EAC control mice to 83 ± 2.69 d in EAC + ALE-treated mice. Haematological indices also showed marked improvement with administration of ALE in EAC-bearing animals. There was a significant increase in RBC count (P < 0.001), hemoglobin percent (P < 0.001), and haematocrit value (P < 0.001) from 4.3 ± 0.12, 6.4 ± 0.93, and 17.63 ± 0.72 respectively in EAC control mice to 7.1 ± 0.13, 12.1 ± 0.77, and 30.23 ± 0.57 respectively in EAC + ALE-treated group, along with concurrent decrement (P < 0.001) in WBC count from 18.8 ± 0.54 in EAC control to 8.4 ± 0.71 in EAC + ALE. Furthermore, treatment with ALE substantially improved hepatocellular architecture and no noticeable neoplastic lesions or foci of cellular alteration were observed. Daily administration of the ALE was found to limit liver MT expression, an important marker of cell proliferation with concomitant reduction in MT immunoreactivity (62.25 ± 2.58 vs 86.24 ± 5.69, P < 0.01). ALE was also potentially effective in reducing (P < 0.001) the frequency of SCEs from 14.94 ± 2.14 in EAC control to 5.12 ± 1.16 in EAC + ALE-treated group. Finally, in comparison to the EAC control, ALE was able to suppress in vivo DNA damage by abating the generations of ‘tailed’ DNA by 53.59% (98.65 ± 2.31 vs 45.06 ± 1.14, P < 0.001), and DNA single-strand breaks (SSBs) by 38.53% (3.14 ± 0.31 vs 1.93 ± 0.23, P < 0.01) in EAC-bearing murine liver. CONCLUSION: Our data indicate that, ALE is beneficial in restoring haematological and hepatic histological profiles and in lengthening the survival of the animals against the proliferation of ascites tumour in vivo. Finally, the chemopreventive efficacy of the ALE is manifested in limiting MT expression and in preventing DNA alterations in murine liver. The promising results of this study suggest further investigation into the chemopreventive mechanisms of the medicinal plant A. ilicifolius in vivo and in vitro. | Tridib Chakraborty Dipak Bhuniya Mary Chatterjee Mosiur Rahaman Dipak Singha Baidya Nath Chatterjee Subrata Datta Ajay Rana Kartick Samanta Sunil Srivastawa Sankar K Maitra Malay Chatterjee | 2007 | World Journal of Gastroenterology2007，13，48： | 2 |
| 4 | Ageing behavior of a Cu-bearing ultra high strength steel 显示文摘 | Arindam Ghosh Samar das Subrata Chatterjee | 2008 | Materials Science and Engineering: A2008，486，12： | 1 |
| 5 | 不锈钢/有色金属异质接头的性能优化(英文)显示文摘不锈钢/有色金属异质接头对于先进机械和传统体系设计的前沿研究具有十分重要的意义。本文作者对钛基和铁基两种异质合金进行焊接以提高异质接头的力学性能。在粘接压力范围为1~9 MPa(步长为2 MPa)、750°C和60 min条件下进行焊接获得异质接头。同时比较了采用不同机制和方法得到的钛基和铁基异质接头的力学性能。结果表明,扩散焊接钛、铁基异质金属接头的力学性能得到明显改善。异质金属接头优异的力学性能主要是由于在扩散区产生了能避免脆性Fe-Ti基金属间化合物形成的厚度约为200μm的Ni金属第三相。所得异质接头的最大抗拉强度为560 MPa,伸长率约为11.9%,这是至今为止文献所报道的最佳值。当焊接压力不低于5 MPa时,异质接头显示出加工硬化效应。异质接头中钛基有色金属的膨胀率远高于黑色金属(不锈钢)的膨胀率。采用SEM技术研究反应区的详细情况,并用XRD验证SEM的结果。分析异质接头的力学、物理和断裂性能随焊接参数变化的原因。 | Gopinath THIRUNAVUKARASU Subrata CHATTERJEE Sukumar KUNDU | 2017 | Transactions of Nonferrous Metals Society of China2017，27，7： | 1 |
| 6 | Ageing behavior of a Cu-bearing ultrahigh strength steel显示文摘 | Arindam Ghosh Samar das Subrata Chatterjee | 2008 | Materials Science and Engineering: A2008，486，12： | 1 |
| 7 | Ageing behavior of a Cu-bearing ultrahigh strength steel显示文摘 | Arindam Ghosh Samar das Subrata Chatterjee | 2007 | Materials Science & Engineering A2007，，1： | 1 |
| 8 | Ageing Behavior of a Cu-Bearing Ultrahigh Strength Steel显示文摘 | Arindam Ghosh Samar Das Subrata Chatterjee | 2008 | Materials Science and Engineering2008，486，： | 1 |
| 9 | Leveraging information in multi-echelon inventory systems显示文摘 | Chatterjee A K | 2004 | European Journal of Operational Research2004，152，： | 1 |
| 10 | Electrochemical Study of Diffusion Bonded Joints between Micro-duplex Stainless Steel and Ti6A14V Alloy显示文摘In the present study,corrosion behavior of diffusion bonded joints formed between micro-duplex stainless steel(MDSS) and Ti6AI4V alloy(TiA)(at 900 ℃ for 60 min under 4 MPa uniaxial pressure in vacuum) was investigated in 1 mol/L HCI and 1 mol/L NaOH solutions using various electrochemical measurements such as open circuit potential(OCP),electrochemical impedance spectroscopy(EIS) and potentiodynamic polarization(PD).For comparison,corrosion behavior of base metals(MDSS and TiA) was also evaluated.Bonded joint was characterized by light optical microscopy and scanning electron microscopy using backscattered electron mode.The layer wise σ phase and λ + FeTi phase mixture has been observed at the bond interface and the bond tensile strength and shear strength were ~556.4 MPa and ~420.2 MPa,respectively. | Shaily M.Bhola Sukumar Kundu Rahul Bhola Brajendra Mishra Subrata Chatterjee | 2014 | Journal of Materials Science & Technology2014，30，2： | 1 |
| 11 | Basic Study Hepatitis B virus detected in paper currencies in a densely populated city of India: A plausible source of horizontal transmission?显示文摘BACKGROUND The recent rise in the incidence of hepatitis B virus(HBV)infections in a densely populated city of eastern India(“mixing vessel”of people of varied socioeconomic and immune status)prompted this study.Applying saliva on fingers for enumerating bank notes is a common practice in the Indian subcontinent.Paper notes may be a potential source of“horizontal”transmission of this virus,especially if there are cuts/bruises on the oral mucous membrane or skin.AIM To investigate whether paper currencies could be a plausible mode of horizontal transmission of HBV infection.METHODS Polymerase chain reactions(PCR)followed by nucleotide sequencing was done for the detection of HBV.Hepatitis B virus surface antigen enzyme-linked immunosorbent assay(HBsAg ELISA)was performed on all HBV deoxyribonucleic acid-positive samples to check the detectability of the virus.Atomic force microscopy(AFM)was carried out for visual confirmation of HBV particles in ultracentrifuged/immunoprecipitated samples from currency paper washings.RESULTS HBV-specific PCRs on pellets obtained after ultracentrifugation/immunoprecipitation of the currency paper washings detected potentially intact/viable HBV(genotype D2)in 7.14%of samples(n=70).AFM gave the visual confirmation of HBV particles in ultracentrifuged/immunoprecipitated samples from currency paper washings.However,HBV isolates from the currency notes could not be detected by HBsAg ELISA.CONCLUSION It is a common practice in the Indian subcontinent to count paper currencies by applying saliva on fingertips.Paper notes may be a potential source of“horizontal”transmission of this virus,especially if there are cuts/bruises on the oral mucous membrane or skin,but it was practically not possible to demonstrate experimentally such transmission.Detection of potentially intact/viable and“occult”HBV from currency poses potential risk of silent transmission of this virus among the general population. | Palashpriya Das Ruchi Supekar Ritika Chatterjee Subrata Roy Anisa Ghosh Subhajit Biswas | 2020 | World Journal of Hepatology2020，12，10： | 0 |
| 12 | Author affiliation addition:“Hepatitis B virus detected in paper currencies in a densely populated city of India:A plausible source of horizontal transmission?”显示文摘Addition of authors’affiliation to'Hepatitis B virus detected in paper currencies in a densely populated city of India:A plausible source of horizontal transmission?'World J Hepatol 2020 Oct 27;12(10):775-791.In this article,one of the affiliations of two authors was not mentioned.Ruchi Supekar,a joint first author and Subhajit Biswas,the corresponding author are affiliated to Academy of Scientific and Innovative Research(AcSIR)Ghaziabad-201002,India. | Palashpriya Das Ruchi Supekar Ritika Chatterjee Subrata Roy Anisa Ghosh Subhajit Biswas | 2022 | World Journal of Hepatology2022，14，8： | 0 |
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