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| 1 | Outline of the Report on Cardiovascular Disease in China,2010显示文摘Major and profound changes have taken place in China over the past 30 years.Rapid socioeconomic progress has exerted a great impact on lifestyle,ranging from food,clothing,working and living conditions,and means of transportation to leisure activities and entertainment.At the same time,new health problems have emerged,and health services are facing new challenges.Presently,cardiovascular diseases (CVD) are among the top health problems of the Chinese people,and pose a serious challenge to all engaged in the prevention and control of these diseases.An epidemic of CVD in China is emerging as a result of lifestyle changes,urbanization and longevity.Both national policy decision-making and medical practice urgently need an authoritative report which comprehensively reflects the trends in the epidemic of CVD and current preventive measures.Since 2005,guided by the Bureau of Disease Prevention of the Ministry of Health of the People's Republic of China and the National Center for Cardiovascular Diseases of China,nationwide experts in the fields of epidemiology,clinical medicine and health economics in the realms of CVD,cerebrovascular disease,diabetes and chronic kidney disease,completed the Report on Cardiovascular Diseases in China every year.The report aims to provide a timely review of the trend of the epidemic and to assess the progress of prevention and control of CVD.In addition,as the report is authoritative,representative and readable,it will become an information platform in the CVD field and an important reference book for government,academic institutes,medical organizations and clinical physicians.This publication is expected to play a positive role in the prevention and control of CVD in China.We present an abstract from the Report on Cardiovascular Diseases in China (2010),including trends in CVD,morbidity and mortality of major CVDs,up-to-date assessment of risk factors,as well as health resources for CVD,and a profile of medical expenditure,with the aim of providing evidence for decision-making in CVD prevention and control programs in China,and of delivering the most authoritative information on CVD prevention and control for all citizens. | HUSheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Wen WANG Yong Jun WU Zhao Su CHEN Wei Wei LIU Ming Bo For the editorial board | 2012 | Biomedical and Environmental Sciences2012，25，3： | 93 |
| 2 | Salvia miltiorrhiza: Traditional medicinal uses, chemistry, and pharmacology显示文摘Salvia miltiorrhiza Bunge(SM) is a very popular medicinal plant that has been extensively applied for many years to treat various diseases, especially coronary heart diseases and cerebrovascular diseases, either alone or in combination with other Chinese plant-based medicines. Although a large number of studies on SM have been performed, they are scattered across a variety of publications. The present review is an up-to-date summary of the published scientific information about the traditional uses, chemical constituents, pharmacological effects, side effects, and drug interactions with SM, in order to lay the foundation for further investigations and better utilization of SM. SM contains diverse chemical components including diterpenoid quinones, hydrophilic phenolic acids, and essential oils. Many pharmacological studies have been done on SM during the last 30 years, focusing on the cardiovascular and cerebrovascular effects, and the antioxidative, neuroprotective, antifibrotic, anti-inflammatory, and antineoplastic activities. The research results strongly support the notion that SM has beneficial therapeutic properties and has a potential of being an effective adaptogenic remedy. | SU Chun-Yan MING Qian-Liang RAHMAN Khalid HAN Ting QIN Lu-Ping | 2015 | Chinese Journal of Natural Medicines2015，13，3： | 74 |
| 3 | ECharts: A declarative framework for rapid construction of web-based visualization显示文摘While there have been a dozen of authoring systems and programming toolkits for visual design and development,users who do not have programming skills,such as data analysts or interface designers,still may feel cumbersome to efficiently implement a web-based visualization.In this paper,we present ECharts,an open-sourced,web-based,cross-platform framework that supports the rapid construction of interactive visualization.The motivation is driven by three goals:easy-touse,rich built-in interactions,and high performance.The kernel of ECharts is a suite of declarative visual design language that customizes built-in chart types.The underlying streaming architecture,together with a high-performance graphics renderer based on HTML5 canvas,enables the high expandability and performance of ECharts.We report the design,implementation,and applications of ECharts with a diverse variety of examples.We compare the utility and performance of ECharts with C3.js,HighCharts,and Chart.js.Results of the experiments demonstrate the efficiency and scalability of our framework.Since the first release in June 2013,ECharts has iterated 63 versions,and attracted over 22,000 star counts and over 1700 related projects in the GitHub.ECharts is regarded as a leading visualization development tool in the world,and ranks the third in the GitHub visualization tab. | Deqing Li Honghui Mei Yi Shen Shuang Su Wenli Zhang Junting Wang Ming Zu Wei Chen | 2018 | Visual Informatics2018，2，2： | 69 |
| 4 | A randomized controlled clinical trial on the treatment of Thymosin-a1 versus interferon-α in patients with hepatitis B显示文摘INTRODUCTIONChronic hepatitis B virus (HBV) infection is a serious problem because of its world wide distribution and possible adverse sequelae ,such as cirrhosis and hepatocellular carcinoma .The World Health Organization estimates that HBV has infected mord than 350 million people worldwide ,and up to 20% of them will become chromic carricrs and will be at significant risk for cirrhosis and HCC .The ultimate goal of the therapy for chronic hepatitis B is to prevent progression to cirrhosis and to prevent development of HCC. | Jing You Lin Zhuang Bao Zhang Tang Wei Bo Yang Su Ying Ding Wu Li Rong Xue Wu Hong Li Zhang Yan Mei Zhang Shao Ming Yan Lu Zhang ~1Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China ~2Departrnent of Hepatology,Kunming Third Municipal People’s Hospital,Kunming 650041,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 48 |
| 5 | Summary of Report on Cardiovascular Diseases in China,2012显示文摘The prevalence of cardiovascular diseases(CVDs)is associated with the socioeconomic prosperity,lifestyle changes,accelerated process of ageing and urbanization.The prevalence of CVDs is continuously increasing in China and will remain an upward trend in the next 10 years.CVDs are the leading cause of death for Chinese in both urban area and rural area. | WANG Wen HU Sheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Yong Jun WU Zhao Su CHEN Wei Wei YANG Jin Gang MALi Yuan LIU Ming Bo For the editorial board | 2014 | Biomedical and Environmental Sciences2014，27，7： | 31 |
| 6 | Recent advances in friction and lubrication of graphene and other 2D materials:Mechanisms and applications显示文摘Two-dimensional materials having a layered structure comprise a monolayer or multilayers of atomic thickness and ultra-low shear strength.Their high specific surface area,in-plane strength,weak layer-layer interaction,and surface chemical stability result in remarkably low friction and wear-resisting properties.Thus,2D materials have attracted considerable attention.In recent years,great advances have been made in the scientific research and industrial applications of anti-friction,anti-wear,and lubrication of 2D materials.In this article,the basic nanoscale friction mechanisms of 2D materials including interfacial friction and surface friction mechanisms are summarized.This paper also includes a review of reports on lubrication mechanisms based on the film-formation,self-healing,and ball bearing mechanisms and applications based on lubricant additives,nanoscale lubricating films,and space lubrication materials of 2D materials in detail.Finally,the challenges and potential applications of 2D materials in the field of lubrication were also presented. | Lincong LIU Ming ZHOU Long JIN Liangchuan LI Youtang MO Guoshi SU Xiao LI Hongwei ZHU Yu TIAN | 2019 | Friction2019，7，3： | 29 |
| 7 | Relationship between Cognition Function and Hippocampus Structure after Long-term Microwave Exposure显示文摘Objective To analyze the effects of long-term microwave exposure on hippocampal structure and function in the rat.Methods Experiments were performed on 184 male Wistar rats(three exposure groups and a sham group).Microwaves were applied daily for 6 min over 1 month at average power densities of 2.5,5,and 10 mW/cm2.Learning and memory abilities were assessed by Morris water maze.High performance liquid chromatography was used to detect neurotransmitter concentrations in the hippocampus.Hippocampal structures were observed by histopathological analysis.Results Following long-term microwave exposure there was a significant decrease in learning and memory activity in the 7 d,14 d,and 1 m in all three microwave exposure groups.Neurotransmitter concentrations of four amino acids(glutamate,aspartic acid,glycine,and gamma-aminobutyric acid) in hippocampus were increased in the 2.5 and 5 mW/cm2 groups and decreased in the 10 mW/cm2 group.There was evidence of neuronal degeneration and enlarged perivascular spaces in the hippocampus in the microwave exposure groups.Further,mitochondria became swollen and cristae were disordered.The rough endoplasmic reticulum exhibited sacculated distension and there was a decrease in the quantity of synaptic vesicles.Conclusion These data suggest that the hippocampus can be injured by long-term microwave exposure,which might result in impairment of cognitive function due to neurotransmitter disruption. | ZHAO Li PENG Rui Yun WANG Shui Ming WANG Li Feng GAO Ya Bing DONG Ji LI Xiang SU Zhen Tao | 2012 | Biomedical and Environmental Sciences2012，25，2： | 27 |
| 8 | Closed reduction and internal fixation versus total hip arthroplasty for displaced femoral neck fracture显示文摘ObjectiveTo 为代替的大腿骨的颈 fracture.MethodsIn 比较在关上的减小和内部固定和全部的新潮的关节造形术(THA )(CRIF ) 之间的临床的效果这未来的使随机化的研究,与新潮的破裂(花园 III 或 IV ) 在 65 年上面变老的 285 个病人从 2001 年 1 月被包括到 2005 年 12 月。盒子随机被分配到 CRIF 组或 THA 组。有病理学的破裂(骨头肿瘤或新陈代谢的骨头疾病)的病人,大腿骨的头的外科手术前的 avascular 坏死,骨关节炎,风湿性关节炎,半身麻痹,长期的病床休息和影响新潮的功能的复杂并发症是 excluded.ResultsDuring 5年的后续,有的 CRIF 组更高显著地在新潮的关节复杂并发症评价,一般复杂并发症和操作比 THA 组织(38.3%对12.7%, P ;< ; 0.01 ;45.3% 对 21.7% , P < 0.01;33.6% 对 10.2% , P < 0.05 分别地) 。在在二个组之间的死亡没有差别。在与更高级的哈里斯 scores.ConclusionFor 有利地恢复的 THA 组的新潮的关节的手术后的功能在老病人,代替了大腿骨的颈的破裂 THA 能完成复杂并发症和操作的更低的率,以及新潮的联合功能的更好手术后的恢复与 CRIF 相比。 | Cao Liehu Wang Bin Li Ming Song Shaojun Weng Weizong Li Haihang Su Jiacan | 2014 | Chinese Journal of Traumatology2014，17，2： | 21 |
| 9 | Local Officials' Incentives and China's Economic Growth:Tournament Thesis Reexamined and Alternative Explanatory Framework显示文摘解释中国的戏剧的经济生长,研究人员们建议了一篇比赛论文。根据这篇论文,自从政治提升大部分基于本地经济生长,中央政府设置生长目标的能力在生长起了一个关键作用。我们使用省的官员的事业活动性数据测试这篇论文。为两个时间时期(19791995 和 19792002 ) ,经济性能,在年度、平均、相对的学期测量了,没影响这些官员的事业前进。我们然后勾略一个其他的分析框架为 developmentalism 解释中国本地官员的强壮的冲动并且最后,从这个解释框架拉政策含意。 | Fubing Su Ran Tao Lu Xi Ming Li | 2012 | China & World Economy2012，20，4： | 21 |
| 10 | Controlling factors on the submarine canyon system: A case study of the Central Canyon System in the Qiongdongnan Basin, northern South China Sea显示文摘Based on an integrated analysis of high-resolution 2D/3D seismic data and drilling results, this study analyzes the tectonicsedimentary evolution of the Qiongdongnan Basin(QDNB) since the late Miocene, and discusses the controlling factors on the formation and development of the Central Canyon System(CCS). The sediment failures caused by the relative sea level falling might have discharged deposits from the slope to the canyon. The two suits of the infillings, i.e., turbidites and mass transport complex(MTC), were derived from the northwestern source and northern source, respectively. The sediment supplies, which differ significantly among different areas, might have led to the variations observed in the internal architectures. Tectonic transformation around 11.6 Ma had provided the tectonic setting for the CCS and formed an axial sub-basin in the central part of the Changchang Depression, which could be called the rudiment of the CCS. The tectonic activity of the Red River Fault(RRF) at about 5.7 Ma might have strengthened the hydrodynamics of the deposits at the junction of the Yinggehai Basin(YGHB) and the QDNB to trigger a high-energy turbidity current. The MTC from the northern continental slope system might have been constrained by the Southern Uplift, functioning as a barrier for the infillings of the CCS. Thanks to a sufficient sediment supply during the Holocene period and the paleo-seafloor morphology, the relief of modern central canyon with the starving landform in the eastern Changchang Depression might have been accentuated by deposition of sediments and vertical growth along the canyon flanks, where collapse deposits were widely developed. Corresponding to the segmentation of the CCS, the forming mechanisms of the canyon between the three segments would be different. The turbidite channel in the head area had likely been triggered by the abundant sediment supply from the northwestern source together with the fault activity at about 5.7 Ma of the RRF. The formation and evolution of the canyon in the western segment were caused by combined effects of the turbidite channel from the northwestern source, the MTC from the northern continental slope, and the paleo-seafloor geomorphology. In the eastern segment, the canyon was constrained by the tectonic transformation occurring at approximately 11.6 Ma and the insufficient sediment supply from the wide-gentle slope. | SU Ming ZHANG Cheng XIE XiNong WANG ZhenFeng JIANG Tao HE YunLong ZHANG CuiMei | 2014 | Science China Earth Sciences2014，57，10： | 21 |
| 11 | Gravity Flow on Slope and Abyssal Systems in the Qiongdongnan Basin,Northern South China Sea显示文摘新地震数据的学习在架并且在 Qiongdongnan 盆(QDNB ) 的深渊的设定上以内部建筑学和分发允许沉积严肃流动的鉴定。六种严肃流动类型被认出:(1 ) 有基础、一致的 truncational 的 turbidite 隧道压垂沿着架边和斜坡的关系,包括旁边地转移、使河床升高得垂直地的隧道建筑群;(2 ) 有塑造汤勺的形态学的滑坡在架裂缝上滑动步并且从变丑产生了糟糕巩固并且高水位线内容沉积;(3 ) 商业萧条在架斜坡上被限制,由一个异常斜坡坡度或由差错活动被触发;(4 ) turbidite 表建筑群(TSC ) 被归功于到盆地板扇子和斜坡扇子起源,偶尔由混浊水流喂深海洋的存款;(5 ) 沉积飘动在更低的斜坡盆地板发生,并且盖住约 400 km2 的一个区域,在越过海床流动的水流下面被产生;并且(6 ) 在深水区域的中央峡谷表示严肃流动的一种例外的类型碎片流动, turbidite 隧道,和 TSC 的一个协会创作了。它介绍平面 multisegment 和垂直多相的特征。在峡谷与好 petrophysical 性质联系的 Turbidite 能在 QDNB 被当作一个潜在的探索目标。 | SU Ming XIE Xinong LI Junliang JIANG Tao ZHANG Cheng HE Yunlong TIAN Shanshan ZHANG Cuimei | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 19 |
| 12 | A fishy odor episode in a north China reservoir: Occurrence, origin, and possible odor causing compounds显示文摘A significant outbreak of fishy odor occurred in a reservoir located in Inner Mongolia, China, in the winter of 2011, and the odor rating, algal density and concentrations of some potential odorous compounds were monitored over a period of two months. The peak odor rating of the fishy odor was 7 according to flavor profile analysis. Among the dominant algal species(two diatom and one chrysophyte species) observed during the survey, the chrysophyte Dinobryon sp. was the most abundant species, with the peak density recorded at 88,520 cells/mL. Seven potential algal metabolites including heptanal, 2,4-heptadienal, 2,4-decadienal, nonanal, 2-octenal, 2,6- nonadienal and hexanal were detected. The principal component analysis result showed that n-hexanal, n-heptanal and 2,4-decadienal, possibly the metabolites of diatoms, and 2,4-heptadienal, possibly the metabolite of Dinobryon sp., might have contributed to the fishy odor episode. This study demonstrated that the fishy odor episode in this reservoir might be caused by the abnormal growth of chrysophytes and diatoms under the ice-cover. | Yunyun Zhao Jianwei Yu Ming Su Wei An Min Yang | 2013 | Journal of Environmental Sciences2013，25，12： | 17 |
| 13 | Micro-source Inverters With Capacitive Equivalent Output Impedance for Improving Micro-grid Voltages显示文摘将分布式电源逆变器等效输出阻抗设计成容性可使其体现对系统无功电压调整过程相逆的电源特性,这种特性使得分布式电源逆变器更容易参与公共连接点处的电压调整。对比等效输出阻抗成感性、阻性和容性的3类逆变器下垂控制特性,对容性等效输出阻抗逆变器电压电流控制环进行数学建模;针对容性等效输出阻抗逆变器设计具备下垂调节和克服电压偏离功能的鲁棒功率外环控制器。对比仿真和实验证明,容性输出阻抗分布式电源逆变器控制器能够快速抑制系统功率变化带来的电压波动,能有效地参与系统电压调整。 | LU Zhipeng LIU Haitao SU Jian ZHOU Cheng WU Ming | 2013 | 中国电机工程学报2013，33，9： | 17 |
| 14 | Fine mapping and marker-assisted selection (MAS) of a low glutelin content gene in rice显示文摘Rice with low glutelin content is suitable as functional food for patients affected with diabetes and kidney failure. The fine mapping of the gene(s) responsible for low glutelin content will provide information regarding the distribution of glutelin related genes in rice genome and will generate markers for the selection of low glutelin rice varieties. Following an SDS-PAGE screen of rice germplasm from Taihu Valley of China, Japonica selection W3660 is identified to be a novel mutant characterized with low glutelin content. For fine mapping the mutant gene for low glutelin content, F2 and F3 populations were derived from a cross between W3660 and Jingrennuo. SDS-PAGE analysis of the total endosperm protein showed that the low glutelin content trait was controlled by a single dominant nuclear gene. Genetic mapping, using SSRs, located this gene to chromosome 2, in the region between SSR2-001/SSR2-004 and RM1358. The dis- tances of the two markers to the target gene were 1.1 cM and 3.8 cM respectively. By semi-quantitative RT-PCR analysis, the transcripts of GluB4/GluB5 genes located within the region do not change. However, GluB5 gene located proximal to SSR2-001/SSR2-004 was specifically reduced. SSR profiles of seven Japonica varieties were compared with that of W3660 for loci in the relevant genetic region. The markers SSR2-004 and RM1358 were used for marker- assisted selection. The selection efficiencies of SSR2-004 and RM1358 were 96.8% and 92.7% respectively. This provides a standard starting point for the breeding of low glutelin content rice varieties in China. | Yi Hua WANG Shi Jia LIU Su Lan JI Wen Wei ZHANG Chun Ming WANG Ling JIANG Jian Min WAN | 2005 | Cell Research2005，15，8： | 16 |
| 15 | D2 dissection in laparoscopic and open gastrectomy for gastric cancer显示文摘AIM: To evaluate the radicalness and safety of laparoscopic D2 dissection for gastric cancer. METHODS: Clinicopathological data from 209 patients with gastric cancer, who underwent radical gastrectomy with D2 dissection between January 2007 and February 2011, were analyzed retrospectively. Among these patients, 131 patients underwent laparoscopyassisted gastrectomy (LAG) and 78 underwent open gastrectomy (OG). The parameters analyzed included operative time, blood loss, blood transfusion, morbidity, mortality, the number of harvested lymph nodes (HLNs), and pathological stage.RESULTS: There were no significant differences in sex, age, types of radical resection [radical proximal gastrectomy (PG + D2), radical distal gastrectomy (DG + D2) and radical total gastrectomy (TG + D2)], and stages between the LAG and OG groups (P > 0.05). Among the two groups, 127 cases (96.9%) and 76 cases (97.4%) had 15 or more HLNs, respectively. The average number of HLNs was 26.1 ± 11.4 in the LAG group and 24.2 ± 9.3 in the OG group (P = 0.233). In the same type of radical resection, there were no signifi cant differences in the number of HLNs between the two groups (PG + D2: 21.7 ± 7.5 vs 22.4 ± 9.3; DG + D2: 25.7 ± 11.0 vs 22.3 ± 7.9; TG + D2: 30.9 ± 13.4 vs 29.3 ± 10.4; P > 0.05 for all comparisons). Tumor free margins were obtained in all cases. Compared with OG group, the LAG group had signifi cantly less blood loss, but a longer operation time (P < 0.001). The morbidity of the LAG group was 9.9%, which was not signifi cantly different from the OG group (7.7%) (P = 0.587). The mortality was zero in both groups. CONCLUSION: Laparoscopic D2 dissection is equivalent to OG in the number of HLNs, regardless of tumor location. Thus, this procedure can achieve the same radicalness as OG. | Ming Cui lia-Di Xing Yi-Yuan Ma Zhen-Dan Yao Nan Zhang Xiang-Qian Su Wei Yang | 2012 | World Journal of Gastroenterology2012，18，8： | 16 |
| 16 | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China显示文摘Importance:Neuroblastoma is the most common extracranial malignant solid tumor in children.Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma.Objective:To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center.Methods:This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed,treated,and followed-up in the Hematology-Oncology Center of Beijing Children’s Hospital from 2007 to 2019.Results:The median age at diagnosis was 34 months;80.8%of the patients were younger than 5 years of age.Notably,243 patients(23.3%)were classified as low-risk,249 patients(23.9%)were classified as intermediate-risk,and 549(52.7%)were classified as high-risk.Furthermore,956 patients underwent surgical resections;986(94.7%)patients received chemotherapy;and 176 patients with high-risk neuroblastoma received hematopoietic stem cell transplantation.The 5-year event-free survival(EFS)rate was 91.3%and 5-year overall survival(OS)rate was 97.5%in low-risk group;in the intermediate-risk group,these rates were 85.1%and 96.7%,respectively,while they were 37.7%and 48.9%in the high-risk group(P<0.001 for both).The 5-year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014(P<0.001).In total,278 patients(26.7%)exhibited tumor relapse or progression;the median interval until relapse or progression was 14 months.Of the 233 patients who died,83%died of relapse or progression of neuroblastoma and 4.3%died of therapy-related complications.Interpretation:The 5-year OS rate was low in high-risk patients,compared with low-and intermediate-risk patients.Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma.Additional treatment strategies should be sought to improve the prognosis of patients with high-risk neuroblastoma. | Yan Su Hong Qin Chenghao Chen Shengcai Wang Shihan Zhang Dawei Zhang Mei Jin Yun Peng Lejian He Xiaoman Wang Suyun Qian Maoquan Qin Ming Ge Fuquan Zhang Qi Zeng Huanmin Wang Xiaoli Ma Xin Ni | 2020 | Pediatric Investigation2020，4，3： | 16 |
| 17 | Types,Characteristics and Significances of Migrating Pathways of Gas-bearing Fluids in the Shenhu Area,Northern Continental Slope of the South China Sea显示文摘The first marine gas hydrate expedition in China has been conducted by Guangzhou Marine Geological Survey in the Shenhu Area, northern continental slope of the South China Sea. Previous study has analyzed the P-T conditions, geophysical anomalies and saturation calculations of these gas hydrates, but has not documented in detail the migration of gas-bearing fluids in the study area. Based on the interpretations of 2D/3D seismic data, this work identified two types of migration pathways for gas-bearing fluids in the Shenhu area, i.e., vertical and lateral pathways. The vertical pathways(largescale faults, gas chimneys and mud diapirs) presented as steep seismic reflection anomalies, which could be traced downward to the Eocene source rocks and may penetrate into the Late Miocene strata. The deeper gases/fluids might be allowed migrating into the shallower strata through these vertical conduits. However, the distributions showed distinct differences between these pathways. Large-scale faults developed only in the north and northeast of the Shenhu area, while in the drilling area gas chimneys were the sole vertical migration pathways. Since the Pliocene, normal faults, detachment faults and favorable sediments have constituted the lateral pathways in the Shenhu gas hydrate drilling area. Although these lateral pathways were connected with gas chimneys, they exerted different effects on hydrate formation and accumulation. Gas-bearing fluids migrated upward along gas chimneys might further migrate laterally because of the normal faults, thereby enlarging the range of the chimneys. Linking gas chimneys with the seafloor, the detachment faults might act as conduits for escaping gases/fluids. Re-deposited sediments developed at the early stage of the Quaternary were located within the gas hydrate stability zone, so hydrates would be enriched in these favorable sediments. Compared with the migration pathways(large-scale faults and mud diapirs) in the LW3-1 deep-sea oil/gas field, the migration efficiency of the vertical pathways(composed of gas chimneys) in the gas hydrate drilling area might be relatively low. Description and qualitative discrimination of migration pathways in the Shenhu gas hydrate drilling area are helpful to further understand the relationship between good-quality deep source rocks and shallow, mainly biogenicallyproduced, hydrates. As the main source rocks of the Baiyun sag, lacustrine mudstones in the Wenchang and Enping Formations may provide thermogenic methane. Gas chimneys with relatively low migration efficiency created the vertical pathways. Caused by the Dongsha tectonic movement, the release of overpressured fluids might reduce the vertical migration rates of the thermogenic methane. The thick bathyal/abyssal fine-grained sediments since the Late Miocene provided migration media with low permeability. These preconditions may cause carbon isotopic fractionation ofthermogenic methane during long-distance vertical migrations. Therefore, although geochemical analyses indicate that the methane forming gas hydrate in the Shenhu area was mainly produced biogenically, or was mixed methane primarily of microbial origin, thermogenic methane still contribute significantly. | SU Ming SHA Zhibin ZHANG Cuimei WANG Hongbin WU Nengyou YANG Rui LIANG Jinqiang QIAO Shaohua CONG Xiaorong LIU Jie | 2017 | Acta Geologica Sinica(English Edition)2017，91，1： | 16 |
| 18 | ABO blood type,diabetes and risk of gastrointestinal cancer in northern China显示文摘AIM:To explore the potential risk factors related to gastrointestinal cancer in northern China.METHODS:A total of 3314 cases of gastrointestinal cancer(esophageal,gastric,pancreatic and biliary) and 2223 controls(including healthy individuals,glioma and thyroid cancer) were analyzed by case-control study.Multivariable logistic regression analysis was applied to evaluate the association between different cancers and hepatitis B surface antigen,sex,age,blood type,diabetes,or family history of cancer.RESULTS:Type 2 diabetes was significantly associated with gastric,biliary and pancreatic cancer with an OR of 2.0-3.0.Blood type B was significantly associated with esophageal cancer [odd ratio(OR) = 1.53,95% confidence interval(CI) = 1.10-2.14] and biliary cancer(OR = 1.49,95% CI = 1.09-2.05).The prevalence of type 2 diabetes was significantly higher in gastric,biliary and pancreatic cancers compared with other groups,with ORs ranging between 2.0 and 3.0.Family history of cancer was strongly associated with gastrointestinal compared with other cancers.CONCLUSION:Blood type B individuals are susceptible to esophageal and biliary cancer.Type 2 diabetes is significantly associated with gastric,biliary and especially pancreatic cancer. | Yan Gong Yun-Sheng Yang Xiao-Mei Zhang Ming Su Jean Wang Jin-Dong Han Ming-Zhou Guo | 2012 | World Journal of Gastroenterology2012，18，6： | 14 |
| 19 | microRNAs and ceRNAs: RNA networks in pathogenesis of cancer显示文摘microRNAs (miRNAs) are a class of endogenous, single-stranded non-coding RNAs of 2023 nucleotides in length, functioning as negative regulators of gene expression at the post-transcriptional level. The dysregulation of miRNAs has been demonstrated to play critical roles in tumorigenesis, either through inhibiting tumor suppressor genes or activating oncogenes inappropriately. Besides their promising clinical applications in cancer diagnosis and treatment, recent studies have uncovered that miRNAs could act as a regulatory language, through which messenger RNAs, transcribed pseudogenes, and long noncoding RNAs crosstalk with each other and form a novel regulatory network. RNA transcripts involved in this network have been termed as competing endogenous RNAs (ceRNAs), since they influence each other's level by competing for the same pool of miRNAs through miRNA response elements (MREs) on their target transcripts. The discovery of miRNA-ceRNA network not only provides the possibility of an additional level of post-transcriptional regulation, but also dictates a reassessment of the existing regulatory pathways involved in cancer initiation and progression. | Xiangqian Su Jiadi Xing Zaozao Wang Lei Chen Ming Cui Beihai Jiang | 2013 | Chinese Journal of Cancer Research2013，25，2： | 13 |
| 20 | A Single-institution Experience with Open Irreversible Electroporation for Locally Advanced Pancreatic Carcinoma显示文摘 | Li Yan Yong-Liang Chen Ming Su Tian Liu Kai Xu Feng Liang Wan-Qing Gu Shi-Chun Lu | 2016 | Chinese Medical Journal2016，，24： | 13 |
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