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| 1 | Mycoplasma infections and different human carcinomas显示文摘AIM To explore relationships between human carcinomas and mycoplasma infection.METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffinembedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis. In other gastric diseases, the mycoplasma infection ratio was 28% (18/49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia. The difference is significant with gastric cancer (X2=12.06, P<0.05). In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/58), but it was 20.9% (10/49) in adenomarous polyp (X2=13.46, P<0.005).Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P< 0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/53), 52.6% (31/ 59), 39.7%(25/63) and 41% (38/91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two. The mechanism involved in oncogenesis by mycoplasma remains unknown. | Su Huang Ji You Li Jan Wu Lin Meng Cheng Chao Shou Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100034. ChinaSu Huang, received B. A from Jiangxi Medical College of China in 1994. Now she is a graduate student pursuing a Ph. D degree at the Peking University School of Oncology. | 2001 | World Journal of Gastroenterology2001，7，2： | 18 |
| 2 | Parathyroid hormone versus bisphosphonate treatment on bone mineral density in osteoporosis therapy: a meta-analysis of randomized controlled trials显示文摘 | Shen L Xie X Su Y et at | 2011 | PLoS One2011，6，26： | 1 |
| 3 | Synthesis of aluminum borate nanorods by a low-heating-temperature solid-state precursor method显示文摘 | ZhouJ SU D G LuoJ M et at | 2009 | Materi Res Bull2009，44，1： | 1 |
| 4 | Toll-like receptor 4-mydoid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice显示文摘 | Li H Su X Yan X et at | | 0，，03： | 1 |
| 5 | Long-term result of management of otitis media with effusion in patients with post- irradiated nasopharyngeal carcinoma显示文摘 | Liang KL Su MC Twu CW et at | 2011 | Eur Arch Otorhinolaryng ol2011，268，2： | 1 |
| 6 | The clinical features of hand-arm vibration syndrome in a warm environment--a review of the literature 显示文摘 | Su AT Darus A Bulgiba A | 2012 | J Occup Health2012，54，5： | 1 |
| 7 | A cross sectional study on hand-arm vibration syndrome among a group of tree fellers in a tropical environment显示文摘 | Su AT Maeda S Fukumoto J | 2014 | Ind Health2014，52，4： | 1 |
| 8 | Hierarchical ensemble of global and local classifiers for face recognition显示文摘 | Su Yu Shan Shiguang Chen Xilin at el | 2009 | IEEE Transactions on Image Processing2009，18，8： | 1 |
| 9 | A comparison of hand-arm vibration syndrome between Malaysian and Japanese workers 显示文摘 | Su AT Fukumoto J Darus A | 2013 | J Occup Heahh2013，55，6： | 1 |
| 10 | miR-126 regulates angio- genic signaling and vascular integrity显示文摘 | Fish JE Santoro MM Morton SU et at | 2008 | Dev Cell2008，15，2： | 1 |
| 11 | Surface phases of TiO2 nanopartieles studied by UV Raman spectroscopy and FT-IR spectroscopy 显示文摘 | Su W G Zhang J Feng Z C et at | 2008 | The Journal of Physical Chemistry C2008，112，20： | 1 |
| 12 | Dose-response relationship between hand-transmitted vibration and hand-arm vibration syndrome in a tropical environment 显示文摘 | Su AT Maeda S Fukumoto J | 2013 | Oceup Environ Med2013，70，7： | 1 |
| 13 | Molecular mechanism of the Re -released electrophoresis of human erythrocytes 显示文摘 | Su Y Shen J Gao L et at | 2012 | Elec- trophoresis2012，33，910： | 1 |
| 14 | Characterization of acid-soluble collagen from the coelomic wall of Sipunculida显示文摘 | SU Xiurong SUN Bei LI Yanyan et at | 2009 | Food Hydrocolloids2009，23，： | 1 |
| 15 | Risk of hepatocelluar carcinoma across a biological gradient of serum hepatitis B virus DNA level 显示文摘 | Chen CJ Yang H I Su J at al | 2006 | JAMA2006，295，： | 1 |
| 16 | Development of a specifically enhanced enzyme-linked immunosorbent assay for the detection of melamine in milk显示文摘 | Lei H Su R Haushey S A Wang Q et at | 2011 | Molecules2011，16，7： | 1 |
| 17 | Newl5 developed strategies for multifunetional mitoehondria-targeted agents in cancer therapy 显示文摘 | Zhang E Zhang C Su Y et at | 2011 | Drug Discovery Today2011，16，3： | 1 |
| 18 | The effect of the disease - causing R266K mutation on the heine and PLP environments of human cystathionine - synthase 显示文摘 | Smith AT Su Y Stevens D J | 2012 | Biochemistry2012，27，： | 1 |
| 19 | Activity of 1 -(2' -2fluoro2' deoxy-β-D-arabinofuranosyl) thymine against herpes simplex virus in cell cultures and rabbit eyes 显示文摘 | Trousdale MD Nesburn AB Su TL et at | 1983 | Antimicrob Agents and Chemother1983，23，6： | 1 |
| 20 | Characterization and immunomodu- lating activities of polysaccharide from Lentinus edodes显示文摘 | Ruan Zheng Su Jiea Dai Hanchuan et at | 2005 | International Immunopharmacology2005，5，5： | 1 |
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