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| 1 | CNS-PNETS分子分类中出现新的脑肿瘤实体类型显示文摘中枢神经系统原始神经外胚层肿瘤(CNS—PNET)是具有高度侵袭性分化差的胚胎性肿瘤,主要好发于幼儿,也可见于青少年和成人。 | Sturm D Orr B A Toprak U H 李晓玲 王行富 | 2016 | 临床与实验病理学杂志2016，32，7： | 16 |
| 2 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 3 | Loss of the tissue- specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma 显示文摘 | Sturm I Stephan C Gillissen B | 2006 | Cell Death Differ2006，13，4： | 1 |
| 4 | Effect of dance on cancer - related fatigue and quality of life 显示文摘 | Sturm I Baak J Storek B | 2014 | Support Care Cancer2014，22，8： | 1 |
| 5 | Sta- ble Water Isotopes in Precipitation: A Regional Circula- tion Modeling Approach 显示文摘 | STURM K HOFFMANN G LANGMANN B | 2005 | Hydrology Process2005，19，： | 1 |
| 6 | Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins显示文摘 | Ho M C Sturm M B Almo S C | 2009 | Proc Natl Acad Sci U S A2009，106，20： | 1 |
| 7 | Reemerging HSN1 influenza viruses in Hong Kong in 2002 are highly pathogenic to ducks 显示文摘 | STURM - RAMIREZ K M ELLIS T BOUSFIELD B | 2004 | J Virol2004，78，9： | 1 |
| 8 | Uric acid as a risk factor forprogression of non - diabetic chronic kidney disease显示文摘 | Sturm G Kollerits B Neyer U | 2013 | The Mildto Moderate Kidney Disease(MMKD)Study Exp2013，1，： | 1 |
| 9 | Prognostic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma显示文摘 | NIEDERGETHMANN M WOSTBROCK B STURM J W | 2004 | Pancreas2004，29，3： | 1 |
| 10 | SrI2 scintillator for gamma ray spectroscopy显示文摘 | CHEREPY N J STURM B W DRURY O B | 2009 | Proc SPIE2009，7449，74： | 1 |
| 11 | In vivo mo- lecular imaging of Barrett' s esophagus with confocal la- ser endomicroscopy显示文摘 | Sturm M B Piraka C Elmunzer B J | 2013 | Gastroenterology2013，145，1： | 1 |
| 12 | Anticancer activity of novel extracts from Cautleya gracilis(Smith)Dandy: apoptosis in human medullary thyroid carcinoma cells显示文摘 | Li Z Sturm S Svejda B | 2008 | Anticancer Res2008，28，5： | 1 |
| 13 | Nitrogen removal and nitrifying and denitrifying bacteria quantification in a storm- water bioretention system显示文摘 | CHEN X L PELTIER E STURM B S M | 2013 | Water Research2013，47，： | 1 |
| 14 | Spatial distribution and radiative effects of soot in the snow and sea ice during the SHEBA experiment显示文摘 | Light B Sturm M | 2002 | Journal of Geophysical Research2002，107，10： | 1 |
| 15 | Fluoroalkory substituted as gastric acid seceretioninhibitors显示文摘 | Kohl B Sturm E Raiser G | 1988 | US 47585791988，7，： | 1 |
| 16 | Interleukin-5 is the predominant cytokine produced by peripheral blood mononuclear cells in alveolar echinococcosis显示文摘 | Sturm D Menzel J Gottstein B | 1995 | Infect Immun1995，63，： | 1 |
| 17 | Weak Polyion Multilayer-assisted in Situ Synthesis as a Route Toward a Plasmonic Ag/Ti O2Photocatalyst显示文摘 | Logar M Jancar B Sturm S | 2010 | Langmuir2010，26，12： | 1 |
| 18 | Dynamic expression profile of p21 WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy显示文摘 | Sturm I Lage H | 2003 | J Clin Oncol2003，21，18： | 1 |
| 19 | Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins 显示文摘 | Hom C Sturm M B Ahno S C | 2009 | Proc Natl A cad Sei USA2009，106，20： | 1 |
| 20 | Photoferrotrophs thrive in an Archean Ocean analogue显示文摘 | Crowe S A Jones C Katsev S Magen C O'Neill A H Sturm A Canfield D E Haffner G D Mucci A Sundby B and Fowle D A | | 0，，： | 1 |
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