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| 1 | Loss of mir-101expression promotes wnt/β-catenin signalling pathway activation and malignancy in colon cancer cells显示文摘 | Strillacci A Valerii MC Sansone P | | 0，，03： | 1 |
| 2 | RNA interference as a key to knockdown overexpressed cyclooxygenase-2 gene in tumour cells 显示文摘 | Strillacci A Griffoni C Spisni E | 2006 | Br J Cancer2006，94，9： | 1 |
| 3 | MiR-101 downreg- ulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells显示文摘 | Strillacci A Griffoni C Sansone P | 2009 | Exp Cell Res2009，315，8： | 1 |
| 4 | MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells显示文摘 | Strillacci A Griffoni C Sansone P | 2009 | Exp Cell Res2009，315，： | 1 |
| 5 | RNA interference as a key to knockdown overexpressed cyclooxygenase-2 gene in tumour cells显示文摘 | Strillacci A Griffoni C Spisni E | 2006 | Br J Cancer2006，94，9： | 1 |
| 6 | MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells显示文摘 | Strillacci A Griffoni C Sansone P | 2009 | Exp Cell Res2009，315，8： | 1 |
| 7 | MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells 显示文摘 | Strillacci A Griffoni C Sansone P | 2009 | Exp Cell Res2009，315，8： | 1 |
| 8 | MiRNA-101 down-regulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells显示文摘 | Strillacci A Griffoni C Sansone P | 2009 | Exp Cell Res2009，315，8： | 1 |
| 9 | RNAi-based strategies for Cyclooxygenase-2 inhibition in cancer显示文摘 | Strillacci A Griffoni C Valerii MC | | 0，，13： | 1 |
| 10 | RNA interference as a key to knockdown overexpressed cyclooxygenase -2 gene in tumour cells 显示文摘 | Strillacci A Griffoni C Spisni E | 2006 | Br J Cancer2006，94，9： | 1 |
| 11 | RNAi-based strat- egies for Cyelooxygenase-2 inhibition in caneer显示文摘 | Strillacci A Griffoni C Valerii MC | 2010 | J Biomed Biotechnol2010，82，13： | 1 |
| 12 | Loss of miR-101 expression promotes wnt/β-catenin signalling pathway activation and malignancy in colon cancer cells 显示文摘 | STRILLACCI A VALERII M C SANSONE P | 2013 | J Pathol2013，229，3： | 1 |
| 13 | Caveolae and caveolae constituents in mechanosensing显示文摘 | Enzo Spisni Mattia Toni Antonio Strillacci Grazia Galleri Spartaco Santi Cristiana Griffoni Vittorio Tomasi | 2006 | Cell Biochemistry and Biophysics2006，，2： | 1 |
| 14 | Loss of mi R-101expression promotes Wnt/β-catenin signalling pathway activation and malignancy in colon cancer cells显示文摘 | Strillacci A Valerii MC Sansone P | 2013 | J Pathol2013，229，3： | 1 |
| 15 | Longitudinal analysis of inflammation and microbiota dynamics in a model of mild chronic dextran sulfate sodium-induced colitis in mice显示文摘AIM:To characterize longitudinally the inflammation and the gut microbiota dynamics in a mouse model of dextran sulfate sodium(DSS)-induced colitis.METHODS:In animal models,the most common method used to trigger colitis is based on the oral administration of the sulfated polysaccharides DSS.The murine DSS colitis model has been widely adopted to induce severe acute,chronic or semi-chronic colitis,and has been validated as an important model for the translation of mice data to human inflammatory bowel disease(IBD).However,it is now clear that models characterized by mild intestinal damage are more accurate for studying the effects of therapeutic agents.For this reason,we have developed a murine model of mild colitis to study longitudinally the inflammation and microbiota dynamics during the intestinal repair processes,and to obtain data suitable to support the recovery of gut microbiota-host homeostasis.RESULTS:All plasma cytokines evaluated,except IL-17,began to increase(P<0.05),after 7 d of DSS administration.IL-17 only began to increase 4 d after DSS withdrawal.IL-1βand IL-17 continue to increase during the recovery phase,even when clinical signs of colitis had disappeared.IL-6,IL-10 and IFN-γreached their maxima 4 d after DSS withdrawal and decreased during the late recovery phase.TNFαreached a peak(a three-fold increase,P<0.05),after which it slightly decreased,only to increase again close to the end of the recovery phase.DSS administration induced profound and rapid changes in the mice gut microbiota.After 3 d of DSS administration,we observed a major reduction in Bacteroidetes/Prevotella and a corresponding increase in Bacillaceae,with respect to control mice.In particular,Bacteroidetes/Prevotella decreased from a relative abundance of 59.42%-33.05%,while Bacillaceae showed a concomitant increase from 2.77%to 10.52%.Gut microbiota rapidly shifted toward a healthy profile during the recovery phase and returned normal 4 d after DSS withdrawal.Cyclooxygenase 2 expression started to increase 4 d after DSS withdrawal(P<0.05),when dysbiosis had recovered,and continued to increase during the recovery phase.Taken together,these data indicated that a chronic phase of intestinal inflammation,characterized by the absence of dysbiosis,could be obtained in mice using a single DSS cycle.CONCLUSION:Dysbiosis contributes to the local and systemic inflammation that occurs in the DSS model of colitis;however,chronic bowel inflammation is maintained even after recovery from dysbiosis. | Luigia De Fazio Elena Cavazza Enzo Spisni Antonio Strillacci Manuela Centanni Marco Candela Chiara Praticò Massimo Campieri Chiara Ricci Maria Chiara Valerii | 2014 | World Journal of Gastroenterology2014，20，8： | 1 |
| 16 | MiR-101 downregula- tion is involved in cyclooxygenase-2 overexpression in human colon cancer cells显示文摘 | Strillacci A Griffoni C Sansone P | 2009 | Journa2009，315，8： | 1 |
| 17 | MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells显示文摘 | Strillacci A Griffoni C Sansone P | 2009 | Exp Cell Res2009，，8： | 1 |
| 18 | MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells显示文摘 | Strillacci A Griffoni C Sansone P | 2009 | Experimental Cell Res2009，315，8： | 1 |
| 19 | Loss of miR-101 expression promotes Wnt-β-catenin signalling pathway activation and malignancy in colon cancer cells显示文摘 | Strillacci A Valerii MC Sansone P | 2013 | J Pathol2013，29，3： | 1 |
| 20 | Loss of mi R-101expression promotes Wnt/beta-catenin signalling pathway activation and malignancy in colon cancer cells显示文摘 | Strillacci A Valerii MC Sansone P | 2013 | J Pathol2013，229，3： | 1 |
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