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7篇 您的检索式：作者名="Steven R.Brant"

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		题名	作者	年代	出处	被引量
	1	Peripheral blood MicroRNAs distinguish active ulcerative colitis and Crohn’s disease显示文摘	FengWu Natalie JiaGuo HongyingTian MichaelMarohn SusanGearhart Theodore M.Bayless Steven R.Brant John H.Kwon	2010	Inflamm Bowel Dis2010，，1：	6
	2	Identification of microRNAs associated with ileal and colonic Crohn’s disease显示文摘	FengWu SiminZhang ThemistoclesDassopoulos Mary L.Harris Theodore M.Bayless Stephen J.Meltzer Steven R.Brant John H.Kwon	2010	Inflamm Bowel Dis2010，，10：	2
	3	Genome‐wide gene expression differences in Crohn’s disease and ulcerative colitis from endoscopic pinch biopsies: Insights into distinctive pathogenesis显示文摘	FengWu ThemistoclesDassopoulos LeslieCope AnirbanMaitra Steven R.Brant Mary L.Harris Theodore M.Bayless GiovanniParmigiani ShuktiChakravarti	2007	Inflamm Bowel Dis2007，，7：	2
	4	Update on the heritability of inflammatory bowel disease: The importance of twin studies显示文摘	Steven R.Brant	2010	Inflamm Bowel Dis2010，，：	1
	5	Identification of microRNAs associated with ileal and colonic Crohn’s disease显示文摘	FengWu SiminZhang ThemistoclesDassopoulos Mary L.Harris Theodore M.Bayless Stephen J.Meltzer Steven R.Brant John H.Kwon	2010	Inflamm Bowel Dis2010，，10：	1
	6	Unique patterns of CpG island methylation in inflammatory bowel disease‐associated colorectal cancers显示文摘	Alexandru V.Olaru YulanCheng RachanaAgarwal JianYang StefanDavid John M.Abraham WayneYu John H.Kwon MarkLazarev Steven R.Brant Michael R.Marohn David F.Hutcheon NoamHarpaz Stephen J.Meltzer YurikoMori	2012	Inflamm Bowel Dis2012，，4：	1
	7	Role of telomere shortening in anticipation of inflammatory bowel disease显示文摘BACKGROUND The existence of genetic anticipation has been long disputed in inflammatory bowel disease(IBD)in the absence of the explanatory mechanism.AIM To determine whether it was predictive of genetic anticipation,we evaluated telomere length in IBD.We hypothesized that multiplex IBD families exhibit a genetic defect impacting telomere maintenance mechanisms.METHODS We studied three IBD families with multiple affected members in three successive generations.We determined telomere length(TL)in lymphocytes and granulocytes from peripheral blood of the affected members using flow cytometry and fluorescence in-situ hybridization(flow FISH).We also performed whole exome sequencing in the blood of all available family members and used PhenoDB to identify potential candidate gene variants with recessive or dominant modes of inheritance.RESULTS Out of twenty-four patients of European descent selected to participate in the study,eleven patients,eight parent-child pairs affected by IBD,were included in the genetic anticipation analysis.Median difference in age at diagnosis between two successive generations was 16.5 years,with earlier age at onset in the younger generations.In most of the affected members,the disease harbored similar gastrointestinal and extraintestinal involvement but was more aggressive among the younger generations.TL was not associated with earlier age at onset or more severe disease in members of successive generations affected by IBD.NOD2 gene mutations were present in the Crohn’s disease patients of one family.However,no gene variants were identified as potential candidates for inheritance.CONCLUSION Telomere shortening appears unlikely to be involved in mechanisms of possible genetic anticipation in IBD.Further studies using a larger sample size are required to confirm or refute our findings.	Brindusa Truta Elizabeth Wohler Nara Sobreira Lisa W.Datta Steven R.Brant	2020	World Journal of Gastrointestinal Pharmacology and Therapeutics2020，11，4：	0

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