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| 1 | Single-cell RNA-seq reveals the immune escape and drug resistance mechanisms of mantle cell lymphoma显示文摘Objective:Mantle cell lymphoma(MCL)is a rare subtype of non-Hodgkin lymphoma(NHL)with high heterogeneity and a high recurrence rate.How heterogenous cell populations contribute to relapse remains to be elucidated.Methods:We performed single cell RNA sequencing(scRNA-seq)on approximately 4,000 bone marrow cells sampled from one patient with multidrug resistant MCL.We identified 10 subpopulations comprising 4 malignant B cell subtypes,3 T cell subtypes,2 dendritic cell subtypes and 1 natural killer(NK)cell subtype.Subsequently,we identified cell markers,including a series of genes associated with immune escape and drug resistance.In addition,we explored the roles of these genes in the mechanism of immune escape and drug resistance,and we verified the expression imbalance and clinical prognostic potential by using GEO datasets including 211 MCL samples.Results:The major immune escape mechanisms of MCL included anti-perforin activity,decreased immunogenicity and direct inhibition of apoptosis and cell killing,as mediated by type I and II B cells.The drug resistance mechanisms of different cell clusters included drug metabolism,DNA damage repair,apoptosis and survival promotion.Type III B cells closely communicate with other cells.The key genes involved in the resistance mechanisms showed dysregulated expression and may have significant clinical prognostic value.Conclusion:This study investigated potential immune escape and drug resistance mechanisms in MCL.The results may guide individualized treatment and promote the development of therapeutic drugs. | Liang Wang Steven Mo Xin Li Yingzhi He Jing Yang | 2020 | Cancer Biology & Medicine2020，17，3： | 5 |
| 2 | Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial显示文摘 | Marcia S Brose Christopher M Nutting Barbara Jarzab Rossella Elisei Salvatore Siena Lars Bastholt Christelle de la Fouchardiere Furio Pacini Ralf Paschke Young Kee Shong Steven I Sherman Johannes W A Smit John Chung Christian Kappeler Carol Pe?a István Mo | 2014 | The Lancet2014，，： | 1 |
| 3 | Bench-to-bedside review:Tolllike receptors and their role in septic shock显示文摘 | Steven MO Christian EH | 2002 | Crit Care2002，6，2： | 1 |
| 4 | The uncertain value of the definition for SIRS显示文摘 | Steven MO | 1998 | Chest1998，113，： | 1 |
| 5 | Introduction to the Margaux Confer- ence on critical illness:The endothelium An underrecognized organ in critical illness显示文摘 | Jean D Edward A Steven MO | 2002 | Crit Care Med2002，30，： | 1 |
| 6 | The density of Viable seed in soils of forest plantation in upland显示文摘 | Hill MO Steven PA | 1981 | Britain Journal of Ecology1981，69，： | 1 |
| 7 | Coagulation in sepsis显示文摘 | Andre A Steven MO Jean LV | 2004 | Intensive Care Med2004，30，6： | 1 |
| 8 | Anti-Inflammatory Cytokines显示文摘 | Steven MO Vera AD | 2000 | Chest2000，117，： | 1 |
| 9 | Late Cretaceous non-avian dinosaurs from the James Ross Basin,Antarctica:description of new material,updated synthesis,biostratigraphy,and paleobiogeography显示文摘Although the fossil record of non-avian dinosaurs from the Cretaceous of Antarctica is the poorest of any continent,fossils representing at least five major taxonomic groups(Ankylosauria,early-diverging Ornithopoda,Hadrosauridae,Titanosauria,and Theropoda)have been recovered.All come from Upper Cretaceous(Coniacian–Maastrichtian)marine and nearshore deposits belonging to the Gustav and Marambio groups of the James Ross Basin at the northern tip of the Antarctic Peninsula.The majority of these finds have come from the Campanian–Maastrichtian Snow Hill Island and López de Bertodano formations of James Ross and Vega islands.Given the rarity of Antarctic Cretaceous non-avian dinosaurs,discoveries of any fossils of these archosaurs,no matter how meager,are of significance.Here we describe fragmentary new ornithischian(ankylosaur and ornithopod)material from the upper Campanian–lower Maastrichtian Cape Lamb Member of the Snow Hill Island Formation and the Maastrichtian Sandwich Bluff Member of the López de Bertodano Formation.One of these specimens is considered to probably pertain to the holotypic individual of the early-diverging ornithopod Morrosaurus antarcticus.We also provide an up-to-date synthesis of the Late Cretaceous non-avian dinosaur record of the James Ross Basin and analyze the biostratigraphic occurrences of the various finds,demonstrating that most(including all named taxa and all reasonably complete skeletons discovered to date)occur within a relatively condensed temporal interval of the late Campanian to early Maastrichtian.Most or all James Ross Basin dinosaurs share close affinities with penecontemporaneous taxa from Patagonia,indicating that at least some continental vertebrates could disperse between southern South America and Antarctica during the final stages of the Mesozoic. | Matthew CLAMANNA Judd ACASE Eric MROBERTS Victoria MARBOUR Ricardo CELY Steven WSALISBURY Julia ACLARKE DEdward MALINZAK Abagael RWEST Patrick MO’CONNOR | 2019 | Advances in Polar Science2019，30，3： | 0 |
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