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| 1 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 8 |
| 2 | Silymarin Ascending Multiple Oral Dosing Phase I Study in Noncirrhotic Patients With Chronic Hepatitis C显示文摘 | Roy L. Hawke Sarah J. Schrieber Tedi A. Soule Zhiming Wen Philip C. Smith Rajender K. Reddy Abdus S. Wahed Steven H. Belle Nezam H. Afdhal Victor J. Navarro Josh Berman Qi-Ying Liu Edward Doo Michael W. Fried | 2010 | Journal of Clinical Pharmacology2010，，4： | 2 |
| 3 | Peginterferon and Ribavirin Treatment in African American and Caucasian American Patients With Hepatitis C Genotype 1显示文摘 | Hari S. Conjeevaram Michael W. Fried Lennox J. Jeffers Norah A. Terrault Thelma E. Wiley–Lucas Nezam Afdhal Robert S. Brown Steven H. Belle Jay H. Hoofnagle David E. Kleiner Charles D. Howell | 2006 | Gastroenterology2006，，2： | 2 |
| 4 | Cancellation of GLONASS signals from radio astronomy da- ta 显示文摘 | ELLINGSON Steven W BUNTON John D BELL Jon F | 2009 | The Smithsonian/NASA Astrophysics Data System2009，4015，： | 1 |
| 5 | Long-term mortality and quality of life after prolonged mechanical ventilation显示文摘 | Lakshmipathi Chelluri Kyung Ah Im Steven H. Belle Richard Schulz Armando J. Rotondi Michael P. Donahoe Carl A. Sirio Aaron B. Mendelsohn Michael R. Pinsky | 2004 | Critical Care Medicine2004，，： | 1 |
| 6 | Analysis of pursuit tracking eye movements in pilots and nonfliers 显示文摘 | ENGELKEN E J STEVENS K W BELL A F | 1994 | Biomedical Sciences Instrumentation1994，30，： | 1 |
| 7 | A critical evaluation of Raman spectroscopy for the analysis of lipids: Fatty acid methyl esters显示文摘 | J. Renwick Beattie Steven E. J. Bell Bruce W. Moss | 2004 | Lipids2004，，5： | 1 |
| 8 | Rapid analysis of ecstasy and related phenthylamines in seized tab- lets by Raman spectroscopy 显示文摘 | Steven E J Bell Thorbum Bums D | 2000 | Analyst2000，125，： | 1 |
| 9 | Regularity of the Bergman projection in weakly pseudoconvex domains显示文摘 | Steven R. Bell Harold P. Boas | 1981 | Mathematische Annalen1981，，1： | 1 |
| 10 | Adenoviral delivery of Smac/DIABLO to ovarian carcinoma cells induces sensitivity of caspase显示文摘 | Bellain A M Steven Bell Tristan Mckay | 2002 | Proc AACR2002，43，12： | 1 |
| 11 | Adenoviral delivery of Smac/DIABLO to ovarian carcinoma cells induces apoptosis via a caspase-9-mediated pathway and enhances sensitivity of caspase显示文摘 | Bellain AM Steven Bell Tristan Mckay | 2002 | Proc AACR2002，43，： | 1 |
| 12 | What Good are All These Links? Rethinking the Academic Library Website 显示文摘 | Bell Steven | 2010 | Library Issues2010，30，2： | 1 |
| 13 | From gatekeepers to gate-openers显示文摘 | Bell Steven | 2009 | American Libraries2009，，89： | 1 |
| 14 | A survey of known resuhs and research areas for N-Queens 显示文摘 | Jordan Bell Brett Stevens | 2009 | Discrete Mathematics2009，309，1： | 1 |
| 15 | Prediction of adipose tissue composition using raman spectroscopy: Average properties and individual fatty acids显示文摘 | J. Renwick Beattie Steven E. J. Bell Claus Borgaard Ann Fearon Bruce W. Moss | 2006 | Lipids2006，，3： | 1 |
| 16 | Cost-effectiveness of Crohn's disease post-operative care显示文摘AIM: To define the cost-effectiveness of strategies, including endoscopy and immunosuppression, to prevent endoscopic recurrence of Crohn's disease following intestinal resection.METHODS: In the 'POCER' study patients undergoing intestinal resection were treated with post-operative drug therapy. Two thirds were randomized to active care(6 mo colonoscopy and drug intensification for endoscopic recurrence) and one third to drug therapy without early endoscopy. Colonoscopy at 18 mo and faecal calprotectin(FC) measurement were used to assess disease recurrence. Administrative data, chart review and patient questionnaires were collected prospectively over 18 mo.RESULTS: Sixty patients(active care n = 43, standardcare n = 17) were included from one health service. Median total health care cost was $6440 per patient. Active care cost $4824 more than standard care over 18 mo. Medication accounted for 78% of total cost, of which 90% was for adalimumab. Median health care cost was higher for those with endoscopic recurrence compared to those inremission [ $ 26347( IQR 25045-27485) vs $2729(IQR 1182-5215), P < 0.001]. FC to select patients for colonoscopy could reduce cost by $1010 per patient over 18 mo. Active care was associated with 18% decreased endoscopic recurrence, costing $861 for each recurrence prevented. CONCLUSION: Post-operative management strategies are associated with high cost, primarily medication related. Calprotectin use reduces costs. The long term cost-benefit of these strategies remains to be evaluated. | Emily K Wright Michael A Kamm Peter Dr Cruz Amy L Hamilton Kathryn J Ritchie Sally J Bell Steven J Brown William R Connell Paul V Desmond Danny Liew | 2016 | World Journal of Gastroenterology2016，22，14： | 1 |
| 17 | Colorimetric immuno-protein phosphatase inhibition assay for specific detection of microcystins and nodularins of cyanobacteria显示文摘 | Metcalf James S Bell Steven G Codd Geoffrey A | 2001 | Applied and Environmental Microbiology2001，67，2： | 1 |
| 18 | Classification of Adipose Tissue Species using Raman Spectroscopy显示文摘 | J. Renwick Beattie Steven E. J. Bell Claus Borggaard Anna M. Fearon Bruce W. Moss | 2007 | Lipids2007，，： | 1 |
| 19 | Preliminary investigation of the application of Raman spectroscopy to the prediction of the sensory quality of beef silverside显示文摘 | Rene J. Beattie Steven J. Bell Linda J. Farmer Bruce.W. Moss Desmond Patterson | 2003 | Meat Science2003，，： | 1 |
| 20 | A survey of known results and research ar-eas for N-Queens显示文摘 | Bell J Stevens B | | 0，，01： | 1 |
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