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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | 不明原因生育能力低下且妊娠预测为中等水平的夫妇在控制性超排卵下的宫内人工受精与期待疗法的疗效比较:一项随机临床试验显示文摘Background: Intrauterine insemination with controlled ovarian hyperstimulation is commonly used as first-line treatment for couples with unexplained subfertility. Since such treatment increases the risk of multiple pregnancy, a couple’s chances of achieving an ongoing pregnancy without it should be considered to identify those most likely to benefit from treatment. We aimed to assess the incremental effectiveness of intrauterine insemination with controlled ovarian hyperstimulation compared with expectant management in couples with unexplained subfertility and an intermediate prognosis of a spontaneous ongoing pregnancy. Methods: 253 couples with unexplained subfertility and a 30- 40% probability of a spontaneous ongoing pregnancy within 12 months were randomly assigned either intrauterine insemination with controlled ovarian hyperstimulation for 6 months or expectant management for 6 months. The primary endpoint of this hospital-based study was ongoing pregnancy within 6 months. Analysis was by intention to treat. This trial is registered with the Dutch Trial Register and as an International Standard Randomised Clinical Trial, number ISRCTN72675518. Findings: Of the 253 couples enrolled, 127 were assigned intrauterine insemination with controlled ovarian hyperstimulation and 126 expectant management. In the intervention group, 42 (33% ) women conceived and 29 (23% ) pregnancies were ongoing. In the expectant management group, 40 (32% ) women conceived and 34 (27% ) pregnancies were ongoing (relative risk 0.85, 95% CI 0.63- 1.1). There was one twin pregnancy in each study group, and one woman in the intervention group conceived triplets. Interpretation: A large beneficial effect of intrauterine insemination with controlled ovarian hyperstimulation in couples with unexplained subfertility and an intermediate prognosis can be excluded. Expectant management for 6 months is therefore justified in these couples. | Steures Mrs van der Steeg J.W. Hompes P.G. 朱磊 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，11： | 3 |
| 3 | Staging of brain pathology related to sporadic Parkinson’s disease显示文摘 | Heiko Braak Kelly Del Tredici Udo Rüb Rob A.I de Vos Ernst N.H Jansen Steur Eva Braak | 2002 | Neurobiology of Aging2002，，2： | 2 |
| 4 | Intrauterine insemination with controlled ovarian hyperstimulation versus expectant management for couples with unexplained infertility:collaborative effort on the clinical evaluation in reproductive medicine显示文摘 | Steures P Steeg JW Hompes PG | 2006 | Lancet2006，3，68： | 1 |
| 5 | Obesity affects spontaneous pregnancy chances in subfertile, ovulatory w 显示文摘 | van der Steeg J W Steures P Eijkemans M J | 2008 | Hum Reprod2008，23，2： | 1 |
| 6 | Intrauterine insemination: how many cycles should we perform? 显示文摘 | Custers I M Steures P Hompes P | 2008 | Hum Reprod2008，23，4： | 1 |
| 7 | Neurogenetic correlates of Parkinson's disease:Apolipoprotein-E and cytochrome P450 2D6 genetic polymorphism显示文摘 | Jansen Steur EN De Vos RA | 1999 | Neurosci Lett1999，266，： | 1 |
| 8 | Inter-industry R&D Spitlover: What Difference do They Make? 显示文摘 | Steurs G | 1995 | International Journal of Industrial Organization1995，13，： | 1 |
| 9 | Determinants of willingness-to-pay for GM rice with health benefits in a high-risk region:Evidence from experimental auctions for folatebiofortified rice in China显示文摘 | DE STEUR H | 2012 | Food Quality and Preference2012，25，2： | 1 |
| 10 | Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific FL T3 mumtions显示文摘 | Mizuki M Sehwable J Steur C | 2003 | Blood2003，19，8： | 1 |
| 11 | Cognitive status correlates with neuropathologic stage in Parkinson disease 显示文摘 | Braak H Rub U Jansen Steur EN | 2005 | Neurology2005，64，8： | 1 |
| 12 | Lymph nodedissection in resectable advanced gastric cancer显示文摘 | DE STEUR WO DIKKEN JL HARTGRINK HH | 2013 | Dig Surg2013，30，2： | 1 |
| 13 | Intrauterine insemi- nation:how many cycles should we perform? 显示文摘 | Custers IM Steures P Hompes P | 2008 | Hum Re- prod2008，23，4： | 1 |
| 14 | Intrauterine insemina- tion: how many cycles should we perform? 显示文摘 | Custers IM Steures P Hompes P | 2008 | Hum Reprod2008，23，4： | 1 |
| 15 | Familial cortical tremor with epilepsy and cerebellar pathological findings 显示文摘 | Van Rootselaar AF Aronica E Jansen Steur EN | 2004 | Mov Disord2004，19，： | 1 |
| 16 | Lymph node dissection in resectable advanced gastric cancer显示文摘 | de Steur WO Dikken JL Hartgrink HH | 2013 | Dig Surg2013，30，2： | 1 |
| 17 | Increase in regulatory T cells in the peripheral blood of cancer patients 显示文摘 | Wolf AM Wolf D Steure rM | 2003 | Clin Cancer Res2003，9，2： | 1 |
| 18 | Intrauterine insemination: how many cycles should we perform? 显示文摘 | Custers IM Steures P Hompes P | 2008 | Hum Reprod2008，23，4： | 1 |
| 19 | Cerebrovascular hypo- perfusion : a risk factor for Alzheimer's disease显示文摘 | De Jong GI De Vos RA Steur EN | 1997 | Ann N Y Acad Sci1997，，826： | 1 |
| 20 | Intrauterine in- semination with controlled ovarian hyperstimulation versus expect- ant management for couples with unexplained subfertility and an in- termediate prognosis: a randomised clinical trial 显示文摘 | Steures P van der Steeg JW Hompes PG | 2006 | Lancet2006，368，9531： | 1 |
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