|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | 2012 (9859)2012，，9859： | 3 |
| 2 | Anti-hypertensive drugs in children and adolescents显示文摘Worldwide the prevalence of essential hypertension inchildren and adolescents continues to increase. Tradi-tionally providers have used 'off-label' drugs to treatpediatric hypertension, meaning that rigorous clinicaltrials of these drugs have not been specifically per-formed in pediatric patient populations. Consequentlyproviders have extrapolated dosing, safety and efficacyfrom trials in adults. This practice is sub-optimal as chil-dren demonstrate unique differences in drug metabo-lism and response. Use of unstudied or understudieddrugs increases risk of adverse events and/or can leadto sub-optimal efficacy. Recognizing these concerns,regulatory agencies have created financial incentivesfor industry to conduct pediatric clinical trials. Theseincentives, coupled with the emerging pediatric hyper-tension epidemic, have spurred over 30 clinical trialsof anti-hypertensive drugs over the past 15 years andhave resulted in labeling of 10 new drugs by the UnitedStates Food and Drug Administration for treatment ofhypertension in children and adolescents. Unfortunatelythe financial incentive structures focus on newer drugsand drug classes. Consequently there is now a relativedearth of trial data for older but sometimes commonlyprescribed pediatric antihypertensive drugs. This article reviews recent pediatric antihypertensive drug trials with a focus on trial design and endpoints, drug dosing, safety, efficacy and specific drug indications. We also review the available data and experience for some of the more commonly prescribed, but less well studied 'older' pediatric antihypertensive drugs. | Patricia Y Chu Michael J Campbell Stephen G Miller Kevin D Hill | 2014 | World Journal of Cardiology2014，6，5： | 2 |
| 3 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet2012，，9859： | 2 |
| 4 | Preoperative CA 19-9 and the Yield of Staging Laparoscopy in Patients with Radiographically Resectable Pancreatic Adenocarcinoma显示文摘 | Shishir K. Maithel MD Stephen Maloney MD Corrine Winston MD Mithat G?nen PhD Michael I. D'Angelica MD Ronald P. DeMatteo MD William R. Jarnagin MD Murray F. Brennan MD Peter J. Allen MD | 2008 | Annals of Surgical Oncology2008，，12： | 2 |
| 5 | Global malaria mortality between 1980 and 2010: a systematic analysis显示文摘 | Christopher JL Murray Lisa C Rosenfeld Stephen S Lim Kathryn G Andrews Kyle J Foreman Diana Haring Nancy Fullman Mohsen Naghavi Rafael Lozano Alan D Lopez | 2012 | The Lancet2012，，9814： | 2 |
| 6 | Substrate specificity of the Eschc- richia coli outer membrane protease OmpT 显示文摘 | McCarter JD Stephens D Shoemaker K Rosenberg S Kitsch JF Georgiou G | 2004 | J Bacteriol2004，186，17： | 1 |
| 7 | Detection of ginkgolides by thin-layer chromatography显示文摘 | Stephen G Tallevi D | 1991 | J Nat Prod1991，54，2： | 1 |
| 8 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet . 2012 (9859)2012，，9859： | 1 |
| 9 | Information Visualization 显示文摘 | Nahum D Gershon Stephen G Eick | 1997 | IEEE Computer Graphics and Applications1997，，78： | 1 |
| 10 | Genome-wide comparative diversity uncovers multiple targets of selection for improvement in hexaploid wheat landraces and cultivars 显示文摘 | Cavanagh CS Chao S Wang BE Huang BE Stephen S Kiani S Forrest K Saintenac C Brown-Guedira GL Akhunova A See D Bai G Pumphrey M Tomar L Wong D Kong S Reynolds M da Silva ML Bockelman H Talbert L Anderson JA Dreisigacker S Baenziger S Carter A Korzun V Morrell PL Dubcovsky J Morell MK Sorrells ME Hayden MJ Akhunov E | 2013 | PNAS2013，110，： | 1 |
| 11 | Analysis ofammonia-oxidizing bacteria of the beta subdivision of theclass Proteobacteria in coastal sand dunes by denaturinggradient gel electrophoresis and sequencing of PCR-ampli-fied 16S ribosomal DNA fragments显示文摘 | Kowalchuk G A Stephen J R Boer W D | 1997 | Appl Environ Mi-crobiol1997，63，： | 1 |
| 12 | Screening of in vitro cytoxicity by the adhesive test显示文摘 | Stephen D G | 1990 | Biomaterial1990，11，3： | 1 |
| 13 | Investigation into the mechanisms of flame retardation on wool显示文摘 | GORDON P G MCMAHON D T W STEPHENS L J | 1977 | Text Res J1977，47，11： | 1 |
| 14 | Use of the Delphi method I resolring complex water resources issues显示文摘 | Jonathan G T Stephen D R | 2003 | Journal of the American Water Resources Association2003，39，1： | 1 |
| 15 | On Static Analysis of Finite Repetitive Structures by Discrete Fourier Transform显示文摘 | Karpov E G Stephen N G Dorofeev D L | | 0，，16： | 1 |
| 16 | The application of automated recognition techniques to side-scan sonar imagery显示文摘 | Stephen G J Michael A D | 1994 | IEEE Journal of Oceanic Engineering1994，19，1： | 1 |
| 17 | Proximal tibial fracture stability with intramedullary nail fixation using oblique interlocking screws显示文摘 | Laflamme G Y Heimlich D Stephen D | | 0，，： | 1 |
| 18 | Global malaria mortality between 1980 and 2010: a systematic analysis显示文摘 | Christopher JL Murray Lisa C Rosenfeld Stephen S Lim Kathryn G Andrews Kyle J Foreman Diana Haring Nancy Fullman Mohsen Naghavi Rafael Lozano Alan D Lopez | 2012 | 2012 (9814)2012，，9814： | 1 |
| 19 | Coded aperture imaging in X-and gamma-ray astronomy显示文摘 | Caroli E Stephen J B Cocco G D | 1987 | Space Science Reviews1987，45，： | 1 |
| 20 | Synthesis of surface initiated diblock copolymer brushes from flat silicon substrates utilizing the RAFY polymerization technique显示文摘 | Misty D Rowe-Konopacki Stephen G Boyes | 2007 | Macromolecules2007，，40： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员