|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Previous hepatitis B viral infection–an underestimated cause of pancreatic cancer显示文摘BACKGROUND The etiology of pancreatic cancer remains unclear. This limits the possibility of prevention and effective treatment. Hepatitis B virus(HBV) is responsible for the development of different types of cancer, but its role in pancreatic cancer is still being discussed.AIM To assess the prevalence of previous HBV infection and to identify viral biomarkers in patients with pancreatic ductal adenocarcinoma(PDAC) to support the role of the virus in etiology of this cancer.METHODS The data of 130 hepatitis B surface antigen-negative subjects were available for the final analysis,including 60 patients with PDAC confirmed by cytology or histology and 70 sex-and age-matched controls. All the participants were tested for HBV biomarkers in blood [antibody to hepatitis B core antigen(anti-HBc), antibody to hepatitis B surface antigen(anti-HBs) and HBV DNA], and for those with PDAC, biomarkers in resected pancreatic tissues were tested(HBV DNA, HBV pregenomic RNA and covalently closed circular DNA). We performed immunohistochemistry staining of pancreatic tissues for hepatitis B virus X antigen and Ki-67 protein. Non-parametric statistics were used for the analysis.RESULTS Anti-HBc was detected in 18/60(30%) patients with PDAC and in 9/70(13%) participants in the control group(P = 0.029). Accordingly, the odds of PDAC in anti-HBc-positive subjects were higher compared to those with no previous HBV infection(odds ratio: 2.905, 95% confidence interval: 1.191-7.084, standard error 0.455). HBV DNA was detected in 8 cases of PDAC and in 6 of them in the pancreatic tumor tissue samples only(all patients were anti-HBc positive). Blood HBV DNA was negative in all subjects of the control group with positive results of the serum anti-HBc test. Among 9 patients with PDAC, 5 revealed signs of replicative competence of the virus(covalently closed circular DNA with or without pregenomic RNA) in the pancreatic tumor tissue samples. Hepatitis B virus X antigen expression and active cell proliferation was revealed by immunohistochemistry in 4 patients with PDAC in the pancreatic tumor tissue samples.CONCLUSION We found significantly higher risks of PDAC in anti-HBc-positive patients. Detection of viral replication and hepatitis B virus X protein expression in the tumor tissue prove involvement of HBV infection in pancreatic cancer development. | Sergey Batskikh Sergey Morozov Alexey Dorofeev Zanna Borunova Dmitry Kostyushev Sergey Brezgin Anastasiya Kostyusheva Vladimir Chulanov | 2022 | World Journal of Gastroenterology2022，28，33： | 2 |
| 2 | Evaluation of safety distances related to unconfinedhydrogen explosions显示文摘 | Dorofeev S B | | 0，，32： | 1 |
| 3 | Deformation-induced dissolution of cementite in the nanocomposite material α-Fe+60%Fe3C显示文摘 | Dorofeev G A Elsukov E P Zagainov A V | 2004 | Fizika Metallovi Metallovedenie2004，98，： | 1 |
| 4 | On Static Analysis of Finite Repetitive Structures by Discrete Fourier Transform显示文摘 | Karpov E G Stephen N G Dorofeev D L | | 0，，16： | 1 |
| 5 | Left ventricular geometry reconstruction in ischemic cardiomyopathy patients with predominantly hypokinetic left ventricle显示文摘 | Gorodkov A Dorofeev AV | 2006 | Eur J Cardiothorac Surg2006，，： | 1 |
| 6 | Accumulation and disappearance of dehydrins and sugars depending on freezing tolerance of winter wheat plants at different developmental phase显示文摘 | Stupnikova I V Borovskii G B Dorofeev N V Peshkova A A Voinikov V K | 2002 | J Ther Biol2002，27，： | 1 |
| 7 | Flame acceleration and transition to detonation in ducts显示文摘 | Ciccarelli G Dorofeev S | 2008 | Progress in Energy and Combustion Science2008，34，4： | 1 |
| 8 | Effect of scale on the onset of detonation 显示文摘 | Dorofeev S B Sidorov V P Kurchatov M S | 2000 | Shock Wave2000，10，2： | 1 |
| 9 | DDT in Methane-Air Mixture 显示文摘 | Kuznetsov M Ciccarelli G Dorofeev | 2002 | Shock Waves2002，12，： | 1 |
| 10 | Effect of scale on the onset of detonation显示文摘 | | 2000 | Shock Wave2000，10，2： | 1 |
| 11 | Flame acceleration and transition to detonation in ducts显示文摘 | CICCARELLI G DOROFEEV S | 2008 | Progress in Energy and Combustion Science2008，34，4： | 1 |
| 12 | Forlax in the treatment of chronic constipation of different origins显示文摘 | Rudenko NN Dorofeev AE Agibalow AN | 2000 | Lik Sprava2000，，34： | 1 |
| 13 | Clinical immunological rationale of interferon therapy in chronic bacterial prosta titis 显示文摘 | Kamalov A A Efremov E A Dorofeev S D | 2010 | Urologiia2010，，1： | 1 |
| 14 | Observation and explanation of the unusual growth kinetics of Arthrobacter globiforms显示文摘 | Dorofeev A G et Glagolev M V Bondarenk T F | 1992 | Microbiology1992，61，： | 1 |
| 15 | Effect of scale on the onset of detonation显示文摘 | Dorofeev S B Sidorov V P KurchatovMS | 2000 | Shock Wave2000，10，2： | 1 |
| 16 | Flame acceleration and transition to detonation in ducts显示文摘 | CICCARELLIA G DOROFEEV S | 2008 | Progress in En- ergy and Combustion Science2008，34，4： | 1 |
| 17 | Left ventrieular geometry reconstruction in ischemic cardiomyopathy patients with predominantly hypokinetic left ventricle 显示文摘 | BOCKERIA L GORODKOV A DOROFEEV A V | 2006 | Eur J Cardiothorac Surg2006，29，1： | 1 |
| 18 | Flame acceleration and transition to detonation in ducts显示文摘 | Ciccarelli G Dorofeev S | 2008 | Progress in Energy and Corn bustion Science2008，34，4： | 1 |
| 19 | Porous ceramic membranes for regeneration of waste sulfate solu- tions显示文摘 | Dorofeev V Y Korchagina M V Naumenko A A | 2002 | Glass and Ceramics2002，59，： | 1 |
| 20 | Fluorescent immunolabeling of cancer cells by quantum dots and antibody scFv fragment显示文摘 | Zdobnova TA Dorofeev SG Tananaev PN | 2009 | J Biomed Opt2009，14，02： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员