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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Comparative pharmacokinetics and bioavailability of oxolinic acid in channel catfish (Ictalurus punctatus) and rainbow trout (Oncorhynchus mykiss)显示文摘 | Kleinow K M Jarboe H H Shoemaker K E | 1994 | Can J Fish Aquac Sci1994，51，： | 1 |
| 3 | Substrate specificity of the Eschc- richia coli outer membrane protease OmpT 显示文摘 | McCarter JD Stephens D Shoemaker K Rosenberg S Kitsch JF Georgiou G | 2004 | J Bacteriol2004，186，17： | 1 |
| 4 | Diet-derived 25-hydroxyvitamin D3 activates vitamin D receptor target gene expression and suppresses EGFR mutant non-small cell lung cancer growth in vitro and in vivo显示文摘 | Verone-Boyle AR Shoemaker S Attwood K | 2016 | Oncotarget2016，7，1： | 1 |
| 5 | Animation rotation with quaternion curves显示文摘 | Shoemake K | 1985 | Computer Graphics1985，19，3： | 1 |
| 6 | Comparative pharmacokinetics and bioavailability of oxolinic acid in channel catfish (Ictalurus punctatus) and rainbow trout (Oncorhynchus mykiss)显示文摘 | Kleinow K M Jarboe H H Shoemaker K E | 1994 | Aquaculture1994，51，： | 1 |
| 7 | The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal eompartments显示文摘 | Offe K Dodson S E Shoemaker J T | 2006 | J Neurosei2006，26，5： | 1 |
| 8 | Animating rotation with quaternion curves显示文摘 | Shoemake K | 1985 | Computer Graphics1985，19，3： | 1 |
| 9 | Molecular cloning, chromosome mapping and characterization of a testis-specific cystatin-like cDNA, cystatin T 显示文摘 | Shoemaker K Holloway JL Whitmore TE | 2000 | Gene2000，245，1： | 1 |
| 10 | Animating rotation with quaternion curves 显示文摘 | Shoemake K | 1985 | SIGGRAPH Computer Graph1985，19，3： | 1 |
| 11 | Isolation and characterization of genomic and cDNA clones of human erythropoietin显示文摘 | Jacobs K Shoemaker C Rudersdorf R | 1985 | Nature1985，313，6005： | 1 |
| 12 | Animating rotation with quaternion curves显示文摘 | Shoemake K | 1985 | ACMSIGGRAPH Computer Graphics1985，19，3： | 1 |
| 13 | Genome duplication in soybean (Glycine soja) 显示文摘 | Shoemaker R C K Polzin J Labate | 1996 | Genetics1996，144，： | 1 |
| 14 | Symptom Man-agement:An Important Part of Cancer Care显示文摘 | Shoemaker L K Estfan B Induru R | 2011 | Clere Clin JMed2011，78，1： | 1 |
| 15 | Displacement Considerations for a Ductile Propagating Fracture in Line Pipe显示文摘 | Shoemaker A K McCartney R F | 1974 | Journal of Engineering Materials and Technology1974，，96： | 1 |
| 16 | Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients 显示文摘 | Shoemaker W C Appel P L Kram H B Waxman K Lee T S | 1988 | Chest1988，94，： | 1 |
| 17 | Alpha5betal -integrin controls eboiavirus entryby regulating endosomal cathepsins 显示文摘 | SCHORNBERG K L SHOEMAKER C J DUBE D | 2009 | Proc NatlAcad Sci USA2009，106，19： | 1 |
| 18 | Clinical trial of survivors'cardiorespiratory patterns as therapeutic goals in critically ill postoperative patients 显示文摘 | Shoemaker WC Appel PL Waxman K | 1982 | Crit Care Med1982，10，6： | 1 |
| 19 | Economical experimentation methods for robust design显示文摘 | Shoemaker A C Tsui K L Wu C F J | 1991 | Technometrics1991，33，4： | 1 |
| 20 | The renin-angioten- sin system :a target of and contributor to dyslipidemias,altered glu- cose homeostasis, and hypertension of the metabolic syndrome 显示文摘 | Putnam K Shoemaker R Yiannikouris F | 2012 | Am J Physio Heart Cir Physiol2012，302，6： | 1 |
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