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| 1 | Management of hepatocellular carcinoma with portal vein tumor thrombosis: Review and update at 2016显示文摘Portal vein tumor thrombosis(PVTT) is a common phenomenon in hepatocellular carcinoma(HCC). Compared to HCC without PVTT, HCC with PVTT is characterized by an aggressive disease course, worse hepatic function, a higher chance of complications related to portal hypertension and poorer tolerance to treatment. Conventionally, HCC with PVTT is grouped together with metastatic HCC during the planning of its management, and most patients are offered palliative treatment with sorafenib or other systemic agents. As a result, most data on the management of HCC with PVTT comes from subgroup analyses or retrospective series. In the past few years, there have been several updates on management of HCC with PVTT. First, it is evident that HCC with PVTT consists of heterogeneous subgroups with different prognoses. Different classifications have been proposed to stage the degree of portal vein invasion/thrombosis, suggesting that different treatment modalities may be individualized to patients with different risks. Second, more studies indicate that more aggressive treatment, including surgical resection or locoregional treatment, may benefit select HCC patients with PVTT. In this review, we aim to discussthe recent conceptual changes and summarize the data on the management of HCC with PVTT. | Stephen L Chan Charing CN Chong Anthony WH Chan Darren MC Poon Kenneth SH Chok | 2016 | World Journal of Gastroenterology2016，22，32： | 44 |
| 2 | Nationwide trends and predictors of inpatient mortality in 83884 transjugular intrahepatic portosystemic shunt显示文摘AIM: To evaluate and validate the national trends and predictors of in-patient mortality of transjugular intrahepatic portosystemic shunt(TIPS) in 15 years.METHODS: Using the National Inpatient Sample which is a part of Health Cost and Utilization Project, we identified a discharge-weighted national estimate of 83884 TIPS procedures performed in the United States from 1998 to 2012 using international classification of diseases-9 procedural code 39.1. The demographic, hospital and co-morbility data were analyzed using a multivariant analysis. Using multi-nominal logistic regression analysis, we determined predictive factors related to increases in-hospital mortality. Comorbidity measures are in accordance to the Comorbidity Software designed by the Agency for Healthcare Research and Quality.RESULTS: Overall, 12.3% of patients died during hospitalization with downward trend in-hospitalmortality with the mean length of stay of 10.8 ± 13.1 d. Notable, African American patients(OR = 1.809 vs Caucasian patients, P < 0.001), transferred patients(OR = 1.347 vs non-transferred, P < 0.001), emergency admissions(OR = 3.032 vs elective cases, P < 0.001), patients in the Northeast region(OR = 1.449 vs West, P < 0.001) had significantly higher odds of inhospital mortality. Number of diagnoses and number of procedures showed positive correlations with in-hospital death(OR = 1.249 per one increase in number of procedures). Patients diagnosed with acute respiratory failure(OR = 8.246), acute kidney failure(OR = 4.359), hepatic encephalopathy(OR = 2.217) and esophageal variceal bleeding(OR = 2.187) were at considerably higher odds of in-hospital death compared with ascites(OR = 0.136, P < 0.001). Comorbidity measures with the highest odds of in-hospital death were fluid and electrolyte disorders(OR = 2.823), coagulopathy(OR = 2.016), and lymphoma(OR = 1.842).CONCLUSION: The overall mortality of the TIPS procedure is steadily decreasing, though the length of stay has remained relatively constant. Specific patient ethnicity, location, transfer status, primary diagnosis and comorbidities correlate with increased odds of TIPS in-hospital death. | Edward Wolfgang Lee Andrew Kuei Sammy Saab Ronald W Busuttil Francisco Durazo Steven-Huy Han Mohamed M El-Kabany Justin P Mc Williams Stephen T Kee | 2016 | World Journal of Gastroenterology2016，22，25： | 7 |
| 3 | Cantfibutions of retinoids to the generation and repair of the pulmonary alveolus显示文摘 | STEPHEN E MC GOWAN | 2002 | Chest2002，121，5： | 1 |
| 4 | Immunoglobulin A, IgA1 and IgA2 antibodies to Candida albicans in whole and parotid saliva in human immunodeficiency virus infection and AIDS显示文摘 | Maeve MC Simont T Stephen JC | 1994 | Infect Immun1994，62，3： | 1 |
| 5 | Development of EMDbased denoising methods inspired by wavelet thresholding显示文摘 | Yannis Kopsinis Stephen Mc Laughlin | 2009 | IEEE Transactions on Signal Processing2009，，4： | 1 |
| 6 | Intraarticular calcaneal fractures:effect of open reduction and internal fixation on the contact characteristics of the subtalar joint显示文摘 | Mulcahy DM Mc Cormack DM Stephens MM | 1998 | Foot Ankle Int1998，19，12： | 1 |
| 7 | Temporal trends in mortality of patients with diabetes mellitus suffering acute myocardial infarction:a comparison of over 3000 patients between 1995 and 2003显示文摘 | Richard MC Stephen BW Peter J | 2007 | Eur Heart J2007，28，3： | 1 |
| 8 | Hypertonic saline improves brain resuscitation in a pediatric model of head injury and hemorrhagic shock显示文摘 | Grant T Stephen MC Dean K | 1996 | J Pediat Surg1996，31，1： | 1 |
| 9 | Population structure of Columbia spotted frogs (Rana luteiventris) is strongly affected by the landscape显示文摘 | Funk WC Blouin MC Cron PS Stephen Maxell BA Pilliod DS Amish S Allendorf FW | 2005 | Molecular Ecology2005，14，： | 1 |
| 10 | A Random- ized controlled trial comparing intranasalmidazolam and chloral hydrate for procedural sedation in children 显示文摘 | Stephen MC Mathew J Varghese AM | 2015 | Otolaryngol Head Neck Surg2015，153，6： | 1 |
| 11 | Aneurysmal and microaneurysmal 'angiogram-negative' subarachnoid hemorrhage显示文摘 | Stephen BT Robert MC Christopher SO | 1995 | Neurosurgery1995，37，： | 1 |
| 12 | Enhanced extracellular matrix accumulation in restenosis of coronary arteries after stent deployment显示文摘 | Ick MC Herman KG Stephen MS | 2002 | J Am Coll Cardiol2002，40，20： | 1 |
| 13 | The significance of cagA and va1cA subtypes of helicobacter pylori in the pathogenesis of inflammation and peptic ulceration显示文摘 | Gunn MC Stephens J C Stewart JA | 1998 | J Clin Pathol1998，51，10： | 1 |
| 14 | Strategic analyses in nursingschools:attracting,educating,and graduating more nursing studentsPart 2-Stakeholder Analysis显示文摘 | Stephen MC Sandra JH Sathiadev M | 2008 | Health Care Manag2008，27，4： | 1 |
| 15 | Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 hours in patients with sepsis显示文摘 | Stephen Trzeciak Jonathan V Mc Coy R Phillip Dellinger | 2008 | Intensive Care Med2008，34，12： | 1 |
| 16 | The variation of cage motor losses with skew显示文摘 | Catherine I Mc Clay Stephen Williamson | 2000 | IEEE Transactions on Industry Applications2000，36，6： | 1 |
| 17 | Cloning and sequence of the gene for the heat shock protein 60 from Chlamydia trachomatis and immunological reactivity of the protein 显示文摘 | Cerrone MC Ma JJ Stephens RS | 1991 | Infect Immun1991，59，1： | 1 |
| 18 | Safety and steroid - sparing experience using infliximab for Crohn disease at a pediatric inflammatory bowel disease center显示文摘 | Stephens MC Shepanski MA Mamula P | 2003 | Am J Gastroenterol2003，98，： | 1 |
| 19 | Attitude stabilization of a VTOL quadrotor aircraft显示文摘 | Abdelhamid Tayebi Stephen Mc Gilvray | 2006 | IEEE Transactions on Conlrol Systems Technology2006，14，3： | 1 |
| 20 | Enhanced extracellular matrix accumulation in restenosis of coronary arteries after stent deployment显示文摘 | Ick MC Herman KG Stephen MS | 2002 | J Am Coll Car Vol2002，40，20： | 1 |
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