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| 1 | MRI-determined fat content of human liver,pancreas and kidney显示文摘AIM:To assess and correlate the lipid content of various organs in obese subjects and in persons with a normal body weight.METHODS:Magnetic resonance spectroscopy and a previously validated gradient echo magnetic resonance imaging method with Dixon's two point technique were used in this study to quantify fat in liver,pancreas as well as kidney.RESULTS:In 36 volunteers with body mass index(BMI) ranging from 20.0 to 42.9 kg/m2,the median fat content of liver,pancreas and kidney was 2.3%(interquartile range:0.2%-7.8%),2.7%(1.0%-6.5%) and 0.7%(0.1%-1.4%),respectively.BMI and subcutaneous fat correlated significantly with liver and pancreas fat content.We show for the first time the significant correlation of liver and pancreas fat content in healthy controls(r = 0.43,P < 0.01).These observations are related to body weight as measured by BMI and the amount of subcutaneous fat.Kidney fat content is very low and correlates with none of the other fat depots.CONCLUSION:Renal lipid accumulation,unlike the coupled accumulations of fat in liver and pancreas,is not observed in obese subjects.Unlike suggestions made in previous studies,renal lipid accumulation appears not to be involved in the pathogenesis of renal disease in humans. | Paul E Sijens Mireille A Edens Stephan JL Bakker Ronald P Stolk | 2010 | World Journal of Gastroenterology2010，16，16： | 14 |
| 2 | Laparoscopic radical nephrectomy for unilateral renal cancer in children显示文摘 | Varlet F Stephan JL Guye E | | 0，，2： | 1 |
| 3 | Treatment of familial hemophagocytic lymphohistiocytosis with antithymocyte globulins,steroids and cyclosporin A显示文摘 | Stephan JL Donadieu J Ledeist F Blanche S Griscelli C Fischer A | 1993 | Blood1993，82，8： | 1 |
| 4 | Macrophge activation syndrome and rheumatic disease in childhood:A report of four new cases显示文摘 | Stephan JL Zeller J Hubert P | 1993 | Clin Exp Rheumatol1993，11，4： | 1 |
| 5 | Efficacy of cyclosporine A in the treatment of macrophage activation syndrome in juvenile arthritis:report of five cases显示文摘 | Mouy R Stephan JL Pillet P | 1996 | J Pediatr1996，129，5： | 1 |
| 6 | Macrophage activation syndrome and rheumatic diseases in childhood: a report of four new cases显示文摘 | Stephan JL Zeller J Hubert P | 1993 | Clin Exp Rheumatol1993，11，4： | 1 |
| 7 | Severe combined immunodeficiency : A retrospective single - center study of clinical presentation and outcome in 117 patients显示文摘 | Stephan JL Vlekova V Le Deist F | 1993 | J Pediatr1993，123，4： | 1 |
| 8 | Nephrotic syndrome and Hodgkin disease in children: A report of 5 cases显示文摘 | Stephan JL Deschenes G Perel Y | 1997 | Eur J Pediatr1997，156，3： | 1 |
| 9 | Reactive haemo- phagocytic syndrome in children with inflammatory disorders : a retrospective study of 24 patients 显示文摘 | Stephan JL Kon6-Paut I Gatambrun C | 2001 | Rheumatology (Oxford)2001，40，11： | 1 |
| 10 | Macrophage activation syndrome and rheumatic diseases in childhood: a report of four new cases显示文摘 | Stephan JL Zeller J Hubert P Herbelin C Dayer JM Prieur AM | 1993 | Clin Exp Rheumatol1993，11，4： | 1 |
| 11 | Partial interferon-γ receptor signaling chain deficiency in a patient with Bacille Calmette-Guerin and Mycobacterium abscessus infection显示文摘 | Doffinger R Jouanguy E Dupuis S Fondaneche MC Stephan JL Emile JF | 2000 | J Infect Dis2000，181，： | 1 |
| 12 | Low Dietary Sodium and Exogenous Angiotensin II Infu- sion Decrease Plasma Adiponectin Concentrations in Healthy Men显示文摘 | A Titia Lely Jan A Krikken Stephan JL Bakker | 2007 | The Journal of Clinical Endocrinology & Metabolism2007，92，5： | 1 |
| 13 | The relationship between thyrptropin and low density lipopretein cholesterol in modified by insulin sensi- tivity in healthy euthyroid subjects 显示文摘 | Stephan JL Bakker Jan C | 2001 | J Clin Endocrinol Metab2001，86，8： | 1 |
| 14 | Macrophage ativation syndrome and rheumatic disease in childhood:a report of four new cases 显示文摘 | Stephan JL Zeller J Hubert P | 1993 | Clin Exp Rheumatol1993，11，4： | 1 |
| 15 | Thyroid function is associated with components of the metabolism syndrom in euthyroid subjects 显示文摘 | Annemieke NR Stephan JL Bakker | 2007 | Clin Endocrinol Metab2007，92，2： | 1 |
| 16 | Treatment of familial hemophagocytic lymphohistiocytosis with antithymocyte globulins,steroids and cyclosporin A显示文摘 | Stephan JL Donadieu J Le Deist F | 1993 | Blood1993，82，： | 1 |
| 17 | Laparoscopic radical nephrectomy for unilateral renal cancer in children显示文摘 | Varlet F Stephan JL Guye E | 2009 | Surg Laparosc Endose Percutan Tech2009，19，2： | 1 |
| 18 | Epstein-Barr virus-associated Kikuehi disease in two children显示文摘 | Stephan JL Jeannoel P Chanoz J | 2001 | J Pediatr Hematol Oncol2001，23，4： | 1 |
| 19 | Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects显示文摘 | Annemieke Roos Stephan JL | 2007 | J Clin Endocrinol Metab2007，92，： | 1 |
| 20 | Reactive haemophagocytic syndrome in children with inflammatory disorders:a retrospective study of 24 patients显示文摘 | Stephan JL Kone-Paut I Galambrun C | 2001 | Rheumatology (Oxford)2001，40，11： | 1 |
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