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| 1 | 急性缺血性与出血性卒中危险因素的对比研究显示文摘目的通过对1个大样本的医院脑卒中注册资料的分析,观察各种危险因素在脑卒中患者中的发生率,并对脑梗死与脑出血的危险因素,特别是心脏和动脉病变的因素进行比较。方法研究资料来自瑞士洛桑卒中注册的卒中患者共3901例,其中脑梗死3525例,脑出血376例,均预先对各项临床和辅助资料进行编码,输入计算机数据库。所有病例均进行系统的临床和辅助检查,心脏病变经心电图和超声心动图证实;颈内动脉和椎基底动脉的病变采用彩色超声多普勒、磁共振血管成像或常规脑血管造影确诊。结果高血压在脑出血和脑梗死患者中的发生率分别为53.7%和46.7%,两者相比差异有统计学意义(P<0.01)。高血压是本组脑卒中最突出的危险因素,其后依次是吸烟、轻度颈内动脉狭窄(≤50%)、高胆固醇血症、短暂性脑缺血发作、糖尿病以及心脏缺血。多因素分析研究发现,本组卒中患者无论是男性还是女性,吸烟、高胆固醇血症、短暂性脑缺血发作、心房纤颤、器质性心脏疾病以及动脉病变是脑梗死而非脑出血密切相关的危险因素。易患脑出血的惟一显著相关的危险因素是高血压(OR=0.64,P<0.01);心脏和动脉病变患者更容易发生脑梗死,但是,器质性心脏病和轻度颈内动脉狭窄在全体卒中患者中均特别常见。结论缺血性卒中和出血性卒中的危险因素并不一致,心脏和动脉病变是脑梗死而非脑出血的重要的危险因素,某些危险因素还存在性别差异。 | 刘新峰 徐格林 Guy van Melle Julien Bogousslavsky | 2005 | 中华神经科杂志2005，38，7： | 42 |
| 2 | 湖南柿竹园矽卡岩-云英岩型W-Sn-Mo-Bi矿床地质和成矿作用显示文摘柿竹园钨多金属矿床由三个阶段不同成矿作用复合叠加而形成。它们分别与似斑状黑云母花岗岩、等粒黑云母花岗岩和花岗斑岩脉有着成因联系。第一阶段矿化包括含矿块状钙质矽卡岩和含矿退化蚀变岩;第二阶段为云英岩矿化,在空间上叠加于块状矽卡岩及外部的大理岩;第三阶段为与锰质矽卡岩相伴生的铅锌银矿化。本文详细地描述了前两阶段矿化的地质和成矿地球化学特征,并探讨了其成矿过程。在此基础上,建立了柿竹园矿床的多阶段成矿模式。 | 毛景文 李红艳 B Guy L Raimbault | 1996 | 矿床地质1996，15，1： | 44 |
| 3 | 山东玲珑—焦家地区形变类型与金矿的关系显示文摘山东玲珑-焦家地区的金矿床根据其地质和剪切带特征可分为含金石英黄铁矿大脉型(玲珑)和蚀变岩型(焦家),它们均产于花岗岩中。郯-庐断裂是区域性的、可能深及上地幔的深大断裂,具有区域剪切的性质。在它的作用下,胶东地区形成了一系列剪切带和断裂带。在破头青韧性剪切带的两侧,尤其是左侧,形成了一系列雁行状排列的脆-韧性剪切带,在其中充填和交代形成了玲珑含金石英脉和网脉状以及蚀变岩型矿床。焦家剪切带、河东-河西剪切带属于脆性剪切带。在这种脆性剪切作用下岩石发生形变变成格子状,当含金的成矿流体进入这种格子状的裂隙时,与围岩发生交代作用,从而形成了焦家蚀变岩矿体。在纯的韧性剪切带中是糜棱岩;在脆-韧性剪切带中为初糜棱岩和角砾岩;而在脆性剪切带中则是碎裂岩。关于矿化在剪切带中的位置,笔者认为,焦家矿床的矿化位于脆性剪切带中,在浅部(上部);玲珑西山的含金石英脉型矿化位于脆-韧性剪切带中,即在中部;而产在韧性剪切带中的矿床(如产在破头青剪切带中的矿体)则是位于深部。 | 卢焕章 Guy Arcambault 李院生 魏家秀 陈娜娜 张国平 袁万春 陈晓枫 龙洪波 | 1999 | 地质学报1999，73，2： | 37 |
| 4 | New Trends in Olefin Production显示文摘Most olefins (e.g., ethylene and propylene) will continue to be produced through steam cracking (SC) ofhydrocarbons in the coming decade. In an uncertain commodity market, the chemical industry is investingvery little in alternative technologies and feedstocks because of their current lack of economic viability,despite decreasing crude oil reserves and the recognition of global warming. In this perspective, some of themost promising alternatives are compared with the conventional SC process, and the major bottlenecks ofeach of the competing processes are highlighted. These technologies emerge especially from the abundanceof cheap propane, ethane, and methane from shale gas and stranded gas. From an economic point of view,methane is an interesting starting material, if chemicals can be produced from it. The huge availability ofcrude oil and the expected substantial decline in the demand for fuels imply that the future for proventechnologies such as Fischer-Tropsch synthesis (FFS) or methanol to gasoline is not bright. The abundance ofcheap ethane and the large availability of crude oil, on the other hand, have caused the SC industry to shiftto these two extremes, making room for the on-purpose production of light olefins, such as by the catalyticdehydrogenation of orooane. | Ismael Amghizar Laurien A. Vandewalle Kevin M. Van Geem Guy B. Matin | 2017 | Engineering2017，3，2： | 33 |
| 5 | 基因工程FGF19类似物aldafermin治疗非酒精性脂肪性肝炎的效果和安全性显示文摘aldafermin是一种成纤维细胞生长因子19的工程类似物,可抑制胆汁酸的合成并调节代谢稳态。该研究报告了一项对非酒精性脂肪性肝炎(NASH)患者进行的一系列肝脏活检的为期24周的2期临床试验结果。 | HARRISON SA NEFF G GUY CD 张瑞华 温晓玉 | 2021 | 临床肝胆病杂志2021，37，3： | 22 |
| 6 | An assessment of coal pillar system stability criteria based on a mechanistic evaluation of the interaction between coal pillars and the overburden显示文摘Coal pillar design has historically assigned a factor of safety(Fo S) or stability factor(SF) according to their estimated strength and the assumed overburden load acting on them. Acceptable Fo S values have been assigned based on past mining experience or a statistical link between Fo S and probability of failure(Po F). Pillar width-to-height(w/h) ratio has long been established as having a material influence on both pillar strength and its potential failure mode. However, there has been significant disagreement on using both factor of safety(Fo S) and w/h as part of pillar system stability criterion, as compared to using Fo S in isolation. This paper will argue that there are valid technical reasons to bring w/h ratio into system stability criteria(other than its influence on pillar strength), as it is related to the post-failure stiffness of the pillar, as measured in situ, and its interaction with overburden stiffness. When overburden stiffness is also brought into pillar system stability considerations, two issues emerge. The first is the width-todepth(W/D) ratio of the panel and whether it is sub-critical or super-critical from a surface subsidence perspective. The second relates to a re-evaluation of pillar Fo S based on whether the pillar is in an elastic or non-elastic(i.e., post-yield) state in its as-designed condition, as this is relevant to maintaining overburden stiffness at the highest possible level. The significance of the model is the potential to maximise both reserve recovery and mining efficiencies without any discernible increase in geotechnical risk, particularly in thick seams and higher depth of cover mining situations. At a time when mining economics are, at best, marginal, removing potentially unnecessary design conservatism is of interest to all mine operators and is an important topic for discussion amongst the geotechnical community. | Reed Guy Mctyer Kent Frith Russell | 2017 | International Journal of Mining Science and Technology2017，27，1： | 21 |
| 7 | 中国农村合作医疗最佳实践分析框架——卫生系统的功能与筹资组织(一)显示文摘一、概述 本报告分为3个部分,本文为第1部分,本部分主要试图以《2000年世界卫生报告》中的卫生系统绩效评价为基础,建立评估中国农村合作医疗绩效的框架。 本文在开始部分解释了卫生系统财务风险共担的背景,随后概述了《2000年世界卫生报告》中提出的卫生系统目标和功能的框架。文章的其余部分强调了卫生系统的一项特有功能:农村合作医疗中的筹资。 | Guy Carrin Philip Davies 江芹 | 2002 | 中国卫生经济2002，21，2： | 17 |
| 8 | Delivery of dsRNA for RNAi in insects: an overview and future directions显示文摘抽象 RNA 干扰(RNAi ) 指外长的双 stranded RNA (dsRNA ) silencing 的过程互补内长的送信人 RNA。RNAi 广泛地在昆虫学的研究被使用了因为主要因为它的高特性,在为基于 RNAi 的害虫控制的许多昆虫和它的潜力的功能的 genomics 逐渐地被强调了。这评论集中于介绍 dsRNA 进昆虫房间或昆虫身体导致有效 RNAi 的途径。三个很普通的交货方法,也就是 microinjection,摄取,并且浸泡,在细节和他们的优点被说明,限制为可行 RNAi 研究的目的被总结。在这评论,我们简短也在昆虫学介绍二可能的 dsRNA 举起机械,另外的 dsRNA 交货方法和 RNAi 的历史。在 RNAi 研究影响象 transfection 试剂, dsRNA 区域的选择,长度,和 dsRNA 的稳定性那样的 RNAi 的特性和效率的因素为进一步的研究被讨论。 | Na yu Olivier Christiaens Jisheng Liu Jinzhi Niu Kaat Cappelle Silvia Caccia Hanneke Huvenne Guy Smagghe | 2013 | Insect Science2013，20，1： | 15 |
| 9 | Multiparametric MRI biomarkers for measuring vascular disrupting effect on cancer显示文摘Solid malignancies have to develop their own blood supply for their aggressive growth and metastasis;a process known as tumor angiogenesis.Angiogenesis is largely involved in tumor survival,progression and spread,which are known to be significantly attributed to treatment failures.Over the past decades,efforts have been made to understand the difference between nor-mal and tumor vessels.It has been demonstrated that tumor vasculature is structurally immature with chaotic and leaky phenotypes,which provides opportunities for developing novel anticancer strategies.Targeting tumor vasculature is not only a unique therapeutic interven-tion to starve neoplastic cells,but also enhances the efficacy of conventional cancer treatments.Vascular dis-rupting agents(VDAs) have been developed to disrupt the already existing neovasculature in actively growing tumors,cause catastrophic vascular shutdown within short time,and induce secondary tumor necrosis.VDAs are cytostatic;they can only inhibit tumor growth,but not eradicate the tumor.This novel drug mechanism has urged us to develop multiparametric imaging biomark-ers to monitor early hemodynamic alterations,cellular dysfunctions and metabolic impairments before tumor dimensional changes can be detected.In this article,we review the characteristics of tumor vessels,tubulin-destabilizing mechanisms of VDAs,and in vivo effects of the VDAs that have been mostly studied in preclinical studies and clinical trials.We also compare the differ-ent tumor models adopted in the preclinical studies on VDAs.Multiparametric imaging biomarkers,mainly diffu-sion-weighted imaging and dynamic contrast-enhanced imaging from magnetic resonance imaging,are evalu-ated for their potential as morphological and functional imaging biomarkers for monitoring therapeutic effects of VDAs. | Guy Marchal | 2011 | World Journal of Radiology2011，3，1： | 14 |
| 10 | Urban spatial development and land use in Beijing: Implications from London's experiences显示文摘Beijing is facing a huge challenge to manage the growth of its built-up area whilst also retaining both productive arable land and land for conservation purposes in order to simultaneously realize the three aims of economic development,protecting arable land and generating environmental improvements. Meanwhile,London,as a world city with more than 200 years of industrialization and urbanization,has accumulated rich theoretical and practical experiences for land use planning in a major urban area,such as the creation of Garden Cities,a designated Green Belt and New Towns. This paper firstly analyzes the main characteristics of the spatial distribution of the built-up area,arable land and conservation land in Beijing. Then,some of the key aspects of urban fringe planning in the London region are examined. Lastly,several implications from the experience of London are provided with respect to land-use planning for Beijing,concentrating on a re-appraisal of land-use functions around Beijing,measures to improve the green belt,the development of small towns to house rural-urban migrants and urban overspill,and effective implementation of land-use planning. | TAN Minghong GUY M. Robinson LI Xiubin | 2011 | Journal of Geographical Sciences2011，21，1： | 13 |
| 11 | "La Vie en Rose": Biosynthesis, Sources, and Applications of Betalain Pigments显示文摘Betalains 是专门在 Caryophyllales 顺序的植物发现的导出酷氨酸的红紫、黄的颜料,它拉了科学、经济的兴趣。不过,对 betalain 化学,生物化学,和功能的研究与象 anthocyanins 和类胡萝卜素那样的植物颜料的另外的主要的班作为比较被限制了。这个颜料班的核心 biosynthetic 小径充分仅仅在过去几年里被阐明了,开创为 betalain 颜料的可能性 ? 在植物和微生物的工程。在这评论,我们在这块地里考虑到最近的进展讨论 betalain 新陈代谢,与参加生合成,分解代谢,和 transcriptional 规定,和是的眼界还有待于发现了的 betalain 的描绘的基因和酶的当前的调查。一个宽广看法当前使用,包括生来的来源或新陈代谢的工程的利用,为 betalains 的潜在的新来源在研究和商业使用和 betalains 的潜在的应用的一篇摘要被提供。 | Guy Polturak Asaph Aharoni | 2018 | Molecular Plant2018，11，1： | 13 |
| 12 | Epstein-Barr病毒相关疾病的IgG/Z抗体检测显示文摘血清中Epstein-Barr病毒(EBV)的IgG/Z抗体对鼻咽癌和传染性单核细胞增多症是较特异的,其阳性率分别为85.7%和84%。50%的伯基特淋巴瘤病人亦有IgG/Z抗体。正常人则没有,但有IgG/VCA等抗体,表明IgG/Z抗体在初次感染后是容易消失的。Z抗原与EBV复制相关,故IgG/Z抗体对鼻咽癌不仅有诊断意义,还可能有预后的意义。 | 曾毅 Jean-claude Nicolas Guy Schwaab Guy de The Bernard Clausse Thomas Tursz Irene Joab | 1992 | 病毒学报1992，8，3： | 11 |
| 13 | Helicobacter pylori infection causes gastric cancer? A review of the epidemiological,meta-analytic, and experimental evidence显示文摘自从象 Campylobacter 一样有机体 Helicobacter pylori (H pylori ) 的发现,超过二十年以前,与胃的癌症的一种关系的可能性被要求了,测试并且据说证明。在全世界有来自许多国家的各种各样的图案的众多的人的研究。几元分析被出版了,更最近,实验动物研究的一个小数字被报导看在 H pylori 感染和胃的癌症之间的协会。多年以来,人的流行病学的研究生产了冲突结果;元分析当一个人将期望生产类似的分享的估计,有;当早实验动物研究要求复制时。H pylori 可能由引起胃的癌症的准确机制仍然在调查和遗体下面被阐明。 | Guy D Eslick | 2006 | World Journal of Gastroenterology2006，12，19： | 10 |
| 14 | 绿肥与施氮量对土壤理化性质的影响显示文摘免耕覆盖直播技术是近年来发展起来的一种新型农业种植技术系统,以传统的绿肥施用为基础。本文主要研究DMC(direct seeding mulch-based cropping systems,免耕覆盖直播)技术系统下绿肥和施氮量对土壤理化性质的影响。绿肥选择紫云英(L1)、黄花苜蓿(L2)、蚕豆(L3)、百脉根(L4)及冬季休闲(L0)作对照的5个种植模式,稻田施氮量设为低(N1)、中(N2)、高(N3)3个水平,共15个处理组合。结果表明种植绿肥能够降低土壤容重,增加土壤有机质,提高土壤碱解氮、速效磷和速效钾含量。其中在L3模式下,土壤容重在覆盖作物季和水稻季分别比L0模式降低8.16%和6.37%,土壤有机碳含量在覆盖作物季和水稻全生育期比L0模式高8.20%~22.45%,差异有逐渐增大的趋势,碱解氮含量在覆盖作物季和水稻全生育期比L0高15.10%~25.82%。L2模式下土壤速效磷含量在水稻播种期最高达到了39.63mg/kg。施氮肥(N2)能显著提高土壤有机质和碱解氮含量,但多增施氮肥(N3)提高并不显著。 | 王健波 张斐斐 周嫱 李银生 邱江平 王秀红 林琪 F.Forest L.Séguy B.Favreau | 2012 | 上海交通大学学报(农业科学版)2012，30，1： | 10 |
| 15 | Transcriptome and Metabolic Profiling Provides Insigh into Betalain Biosynthesis and Evolution in Mirabilis jalapa显示文摘 | Guy Polturak Uwe Heinig Noam Grossman Maor Battat Dena Leshkowitz Sergey Malitsky liana Rogachev~ and Asaph Aharoni | 2018 | Molecular Plant2018，11，1： | 10 |
| 16 | Structural geochemistry of gold mineralization in the Linglong-Jiaojia district, Shandong Province, China显示文摘The Linglong-Jiaojia district is one of the most important regions containing gold deposits in China. These gold deposits can be divided into: a) the pyrite-gold-quartz vein type (Linglong type), which is controlled by brittle-ductile to ductile deformation structures, and b) the alteration-zone type (Jiaojia type), characterized by small veinlets, or the disseminated type recognized in brittle shear zones. Lode gold deposits in the Jiaojia area occur in NE brittle fracture zones, formed in a dominantly simple shear deformation regime, mainly in thrust attitude with a minor sinistral strike slip component. In the Linglong area, the lode gold deposits are located at the intersection of three types of structures: NNE and NE brittle-ductile fault zones and the ENE ductile reverse shear zone in the south of the area. The structural characteristics of these brittle shear zones are consistent with a tectonic NNW-SSE principal stress field orientation. Similar stresses explain the ENE Qixia fold axes, the Potouqing and several other ENE reverse ductile shear zones elsewhere in the region, the Tancheng-Lujiang fault zone and its subsidiaries in the vicinity of the Linglong-Jiaojia district, as well as the southern ENE suture zone north of Qingdao. Therefore these structural systems occurred as part of different major tectonic events under NNW-SSE compression principal stress fields in the area. Gold deposits are hosted in smaller-scale structures within the brittle fault zones and brittle-ductile shear zones. Although ore bodies and, on a smaller scale, quartz ore veins often seem to be randomly oriented, it is possible to explain their distribution and orientation in terms of the simple shear deformation process under which they were developed. The progressive simple shear failure is characterized by various fracture modes (tension and shear) that intervene in sequence. The tension and shear fractures are influenced by the stress level (depth of burial beneath the paleosurface) in their structural behavior, show variable dilatancy (void openings) and extend on all scales. By making use of these characteristics, a progressive failure analysis can be applied to predicting the shape and extent of ore bodies as well as the styles of mineralization at any given location. | Huan-zhang LU Guy Archambault LI Yuansheng WEI Jiaxue | 2007 | Chinese Journal Of Geochemistry2007，26，3： | 10 |
| 17 | Targeting PVR(CD155)and its receptors in anti-tumor therapy显示文摘Poliovirus receptor(PVR,CD155)has recently been gaining scientific interest as a therapeutic target in the field of tumor immunology due to its prominent endogenous and immune functions.In contrast to healthy tissues,PVR is expressed at high levels in several human malignancies and seems to have protumorigenic and therapeutically attractive properties that are currently being investigated in the field of recombinant oncolytic virotherapy.More intriguingly,PVR participates in a considerable number of immunoregulatory functions through its interactions with activating and inhibitory immune cell receptors.These functions are often modified in the tumor microenvironment,contributing to tumor immunosuppression.Indeed,increasing evidence supports the rationale for developing strategies targeting these interactions,either in terms of checkpoint therapy(i.e.,targeting inhibitory receptors)or in adoptive cell therapy,which targets PVR as a tumor marker. | Paola Kučan Brlić Tihana Lenac Roviš Guy Cinamon Pini Tsukerman Ofer Mandelboim Stipan Jonjić | 2019 | Cellular & Molecular Immunology2019，16，1： | 10 |
| 18 | 1995-2015年中国人口迁移的时空变化特征显示文摘本文利用人口普查数据,估算了1995—2015年中国地(市)间人口O-D迁移流和迁移率,结合GIS空间分析和社会网络分析方法,揭示了20年间中国人口迁移的时空变化特征。研究发现:(1)中国人口迁移由相对不活跃、局部地区参与的'低活性时代',逐步走向相对活跃、绝大多数地区参与的'高活性时代'。(2)人口迁移地域类型的时空演化过程呈现出各活跃型地(市)不断扩散,而非活跃型地(市)大幅缩减的特点。(3)人口迁移网络以'胡焕庸线'为界,东、西两侧迁移流'东密西疏'且差异悬殊,这一空间格局具有很强的稳定性和顽健性。(4)在人口省内迁移持续增强,以及跨省迁移中沿海三大城市群吸引力的'此消彼长'和西南地区吸引力不断增强的背景下,东中西部地区的人口迁移流场结构表现为:沿海地区主要城市群内部分化和影响范围减弱,中部地区(除湖北省)未能演化出以省为单元的独立社区,西部地区则是西北相对稳定而西南持续变动。 | 柯文前 朱宇 陈晨 Guy JAbel 林李月 林洁 | 2022 | 地理学报2022，77，2： | 9 |
| 19 | Artificial Intelligence in Steam Cracking Modeling: A Deep Learning Algorithm for Detailed Effluent Prediction显示文摘Chemical processes can bene t tremendously from fast and accurate ef uent composition prediction for plant design, control, and optimization. The Industry 4.0 revolution claims that by introducing machine learning into these elds, substantial economic and environmental gains can be achieved. The bottleneck for high-frequency optimization and process control is often the time necessary to perform the required detailed analyses of, for example, feed and product. To resolve these issues, a framework of four deep learning arti cial neural networks (DL ANNs) has been developed for the largest chemicals production process steam cracking. The proposed methodology allows both a detailed characterization of a naphtha feedstock and a detailed composition of the steam cracker ef uent to be determined, based on a limited number of commercial naphtha indices and rapidly accessible process characteristics. The detailed char- acterization of a naphtha is predicted from three points on the boiling curve and paraf ns, iso-paraf ns, ole ns, naphthenes, and aronatics (PIONA) characterization. If unavailable, the boiling points are also estimated. Even with estimated boiling points, the developed DL ANN outperforms several established methods such as maximization of Shannon entropy and traditional ANNs. For feedstock reconstruction, a mean absolute error (MAE) of 0.3 wt% is achieved on the test set, while the MAE of the ef uent predic- tion is 0.1 wt%. When combining all networks using the output of the previous as input to the next the ef uent MAE increases to 0.19 wt%. In addition to the high accuracy of the networks, a major bene t is the negligible computational cost required to obtain the predictions. On a standard Intel i7 processor, predictions are made in the order of milliseconds. Commercial software such as COILSIM1D performs slightly better in terms of accuracy, but the required central processing unit time per reaction is in the order of seconds. This tremendous speed-up and minimal accuracy loss make the presented framework highly suitable for the continuous monitoring of dif cult-to-access process parameters and for the envi- sioned, high-frequency real-time optimization (RTO) strategy or process control. Nevertheless, the lack of a fundamental basis implies that fundamental understanding is almost completely lost, which is not always well-accepted by the engineering community. In addition, the performance of the developed net- works drops signi cantly for naphthas that are highly dissimilar to those in the training set. | Pieter PPlehiers Steffen HSymoens Ismaël Amghizar Guy B.Marin Christian V.Stevens Kevin M.Van Geem | 2019 | Engineering2019，5，6： | 9 |
| 20 | 底栖生物生产力现场测试系统(BCSPM)的建立及其初步实验结果显示文摘为对生态系统的健康评估及底栖生物资源的开发利用提供技术支撑 ,在胶州湾筏式养殖水域 ,建立了底栖生物生产力现场测试系统 (BCSPM ) ,并在光照和黑暗条件下测定了沉积物海水界面溶解氧随时间的变化、计算了氧通量、估算了底栖总初级生产力和群落呼吸。在光照较强的中午时刻测定的群落总生产力为 2 0 .76mgCm-2 h-1;养殖水域沉积物中的群落呼吸要高于邻近水域。BCSPM整体运转良好 ,初步结果为系统的改进和进一步实验提供了依据。 | 张志南 刘晓收 Guy BOUCHER 邓可 黄勇 袁伟 | 2005 | 中国海洋大学学报(自然科学版)2005，35，2： | 8 |
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