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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | Dynamic magnetic resonance defecography in 10 asymptomatic volunteers显示文摘AIM: Evaluation of the wide range of normal findings in asymptomatic women undergoing dynamic magnetic resonance (MR) defecography. METHODS: MR defecography of 10 healthy female volunteers (median age: 31 years) without previous pregnancies or history of surgery were evaluated. The rectum was filled with 180 mL gadolinium ultrasound gel mixture. MR defecography was performed in the supine position. The pelvic floor was visualized with a dynamic T2-weighted sagittal plane where all relevant pelvic floor organs were acquired during defecation. The volunteers were instructed to relax and then to perform straining maneuvers to empty the rectum. The pubococcygeal line (PCGL) was used as the line of reference. The movement of pelvic floor organs was measured as the vertical distance to this reference line. Data were recorded in the resting position as well as during the defecation process with maximal straining. Examinations were performed and evaluated by two experienced abdominal radiologists without knowledge of patient history. RESULTS: Average position of the anorectal junction was located at -5.3 mm at rest and -29.9 mm during straining. The anorectal angle widened significantly from 93° at rest to 109° during defecation. A rectocele was diagnosed in eight out of 10 volunteers showing an average diameter of 25.9 mm. The bladder base was located at a position of +23 mm at rest and descended to -8.1 mm during defecation in relation to the PCGL. The bladder base moved below the PCGL in six out of 10 volunteers, which was formally defined as a cystocele. The uterocervical junction was located at an average level of +43.1 mm at rest and at +7.9 mm during straining. The uterocervical junction of three volunteers fell below the PCGL; described formally as uterocervical prolapse. CONCLUSION: Based on the range of standard values in asymptomatic volunteers, MR defecography values for pathological changes have to be re-evaluated. | Andreas G Schreyer Christian Paetzel Alois Fürst Lena M Dendl Elisabeth Hutzel René Müller-Wille Philipp Wiggermann Stephan Schleder Christian Stroszczynski Patrick Hoffstetter | 2012 | World Journal of Gastroenterology2012，18，46： | 7 |
| 3 | Osteoclast activity modulates B-cell development in the bone marrow显示文摘B 房间开发开是依赖的在 B 房间先锋和骨头髓 stromal 房间之间的相互作用,而是在这的骨破折(OCL ) 的角色处理未知的遗体。B lymphocytopenia 是 osteopetrosis 的一个特征,建议由 OCL 活动的 B 淋巴细胞增殖的调整。探讨这个问题,我们首先由树枝状的房间转移在 osteopetrotic oc/oc 鼠标救了 OCL 功能,导致骨头显型和 B 房间开发的恢复。为了推进,探索在 OCL 活动和 B 淋巴细胞增殖之间的连接,我们由 zoledronic 酸(ZA ) 的注射在正常老鼠导致了 osteopetrosis,骨头再吞的一个禁止者。B 房间数字在对待 ZA 的老鼠的骨头髓明确地减少了。ZA 直接没影响 B 房间区别,增长和 apoptosis,但是由 stromal 房间在 CXCL12 和 IL-7 的表示导致减少,与减少的 osteoblastic 约会联系了。在 oc/oc 老鼠的相等的低 osteoblastic 约会证实它在造骨细胞上源于减少的 OCL 活动而非从 ZA 的直接效果。骨头微型环境的这些戏剧的改变为 B 淋巴细胞增殖是不利的,导致在他们在导致 ZA 的 osteopetrotic 模型的骨头髓壁龛外面的 B 房间祖先的保留。总的来说,我们的数据表明 OCL 由控制骨头微型环境和造骨细胞的命运在骨头髓调制 B 房间开发。他们由 OCL 活动在他们的壁龛为 B 房间的保留的规定提供新奇基础。 | Anna Mansour | 2011 | Cell Research2011，21，7： | 6 |
| 4 | Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-specific Entry into Hepatocytes显示文摘 | Yi Ni Florian A. Lempp Stefan Mehrle Shirin Nkongolo Christina Kaufman Maria F?lth Jan Stindt Christian K?niger Michael Nassal Ralf Kubitz Holger Sültmann Stephan Urban | 2013 | Gastroenterology2013，，： | 5 |
| 5 | Entry of hepatitis B and C viruses — recent progress and future impact显示文摘 | Thomas F Baumert Luke Meredith Yi Ni Daniel J Felmlee Jane A McKeating Stephan Urban | 2013 | Current Opinion in Virology2013，，： | 3 |
| 6 | Genotype-dependent activation or repression of HBV enhancer Ⅱ by transcription factor COUP-TF1显示文摘AIM: To study the expression of HBV enhancer Ⅱ by transcription factor COUP-TF1. METHODS: In order to study the regulation of HBV variants in the vicinity of the NRRE we cloned luciferase constructs containing the HBV enhancer Ⅱ from variants and from HBV genotypes A and D and cotransfected them together with expression vectors for COUP-TF1 into HepG2 cells. RESULTS: Our fi ndings show that enhancer Ⅱ of HBV genotype A is also repressed by COUP-TF1. In contrast, two different enhancer Ⅱ constructs of HBV genotype D were activated by COUP-TF1. The activation was independent of the NRRE because a natural variant with a deletion of nt 1763-1770 was still activated by COUP- TF1. CONCLUSION: Regulation of transcription of the HBV genome seems to differ among HBV genomes derived from different genotypes. These differences in transcriptional control among HBV genotypes may be the molecular basis for differences in the clinical course among HBV genotypes. | Silke F Fischer Katja Schmidt Nicola Fiedler Dieter Glebe Christian Schüttler Jianguang Sun Wolfram H Gerlich Reinald Repp Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，37： | 2 |
| 7 | Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death显示文摘 | Alexander Seiler Manuela Schneider Heidi F?rster Stephan Roth Eva K. Wirth Carsten Culmsee Nikolaus Plesnila Elisabeth Kremmer Olof R?dmark Wolfgang Wurst Georg W. Bornkamm Ulrich Schweizer Marcus Conrad | 2008 | Cell Metabolism2008，，3： | 2 |
| 8 | Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease 显示文摘 | KATHARINA F STEPHAN G YANG Y F | 2009 | BMC Neurosci2009，10，1： | 1 |
| 9 | Aircraft wake-vortex decay in ground proximity-physical mechanisms and artificial en- hancement显示文摘 | Stephan A Holzapfel F Misaka T | 2013 | Journal of Aircraft2013，50，4： | 1 |
| 10 | 2014 ESC/EACTS guidelines on myocardial revascularization显示文摘 | Stephan W Kolh P Alfonso F | 2015 | Rev Esp Cardiol(Engl Ed)2015，68，2： | 1 |
| 11 | Crustal strain in the Southern Alps,France, 1948-1998显示文摘 | Calais E Gallsson L Stephan J F | 2000 | Tectonophysics2000，319，： | 1 |
| 12 | On a Least Squares Adjustment of a Sampled Frequency Table when the Expected Marginal Totals are Known 显示文摘 | Deming W E Stephan F F | 1940 | The Annals of Mathematical Statistics1940，，11： | 1 |
| 13 | Upregulation of β3-adrenoreptors and altered contractile response to inotropic amines in human failing myocardium显示文摘 | Stephane M Lester K Olivier F | 2001 | Circulation2001，103，： | 1 |
| 14 | Prognostic Value of Systemic Endothelial Dysfunction in Patients With Acute Coronary Syndromes: Further Evidence for the Existence of the 'Vulnerable' Patient显示文摘 | Stephan F Susanne B Andreas M | 2004 | Circulation2004，110，： | 1 |
| 15 | On a least squares adjustment ofa sampled frequency table when the expected marginal totalsare known显示文摘 | Deming W E Stephan F F | 1940 | Ann Math Stat1940，11，4： | 1 |
| 16 | Thrombocytopenia in critically ill surgical patients:a case-control study evaluating attributable mortality and transfusion requirements显示文摘 | Stephan F Montblanc JD Cheffi A | 1999 | Crit Care1999，3，： | 1 |
| 17 | High-flow nasal oxygen vs noninvasive positive airway pressure in hypox- emic patients after cardiothoracic surgery: a randomized clinical Trial显示文摘 | Stephan F Barrucand B Petit P | 2015 | JAMA2015，313，23： | 1 |
| 18 | Reflective and transmissive CR scanhead technology on needle image plates显示文摘 | Jorg F Stephan M Clemens H | 2005 | SPIE2005，5745，： | 1 |
| 19 | Thrombocytopenia in a surgical ICU显示文摘 | Stephan F Hollande J Richard O | 1999 | Chest1999，115，5： | 1 |
| 20 | On a Least Squares Adjustment of a Samples Frequency Table when the Expected Marginal Tables are Known显示文摘 | Deming W E Stephan F F | 1940 | Annals of Mathematical Statistics1940，，11： | 1 |
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