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| 1 | Inflammatory bowel disease in an underdeveloped region of Northeastern Brazil显示文摘AIM: To evaluate the demographic characteristics and clinical phenotypes of inflammatory bowel disease(IBD) in a geographic area in Northeastern Brazil.METHODS: This retrospective study was conducted at the Hospital of the Federal University of Piauí in Northeastern Brazil. Demographic characteristics and clinical phenotypes of IBD were analyzed in relation to the time of diagnostic confirmation, which was defined as the date of disease onset. Data were collected between January 2011 and December 2012 and included all census patients 18 years of age or older during that period for whom there was diagnostic confirmation of Crohn's disease(CD), ulcerative colitis(UC), or unclassified colitis according to the Montreal criteria. We also analyzed the period of time between the onset of clinical manifestations and the diagnosis of IBD(delay in the diagnosis). Statistical analyses included means and standard deviations for numeric variables and the Pearson χ2 adherence test for nominal variables. The annual index occurrence and overall prevalence of IBD at our institution were also calculated, with P values < 0.05 indicating statistical significance. This study was approved by the Institutional Ethics and Research Committee.RESULTS: A total of 252 patients with IBD were included, including 152(60.3%) UC patients and 100(39.7%) CD patients. The clinical and demographic characteristics of all patients with IBD showed a female to male ratio of 1.3:1.0 and a mean age of35.2(SD = 14.5) years. In addition, the majority of patients were miscegenated(171, 67.9%), had received higher education(157, 62.4%), lived in urban areas(217, 86.1%), and were under the age of 40 years(97, 62.5%). For patients with CD, according to the Montreal classification, the predominant features present from the onset of disease were an age between 17 and 40 years(A2); colonic disease location(L2); and nonstricturing, nonfistulizing disease behavior(B1). However, approximately one-quarter of all CD patients demonstrated perineal involvement. We also observed considerable delay in the diagnosis of IBD throughout the entire study period(mean = 35.5 mo). In addition, the annual index occurrence rose from 0.08 to 1.53 cases/105 inhabitants/year during the study period, and the prevalence rate was 12.8 cases/105 inhabitants in 2012. Over the last two decades, there was a noted increase in the frequency of IBD in the study area.CONCLUSION: In this study, there was a predominance of patients with UC, young people under 40 years of age, individuals with racial miscegenation, and low annual incomes. | José Miguel Luz Parente Claudio Saddy Rodrigues Coy Viriato Campelo Mírian Perpétua Palha Dias Parente Leonardo Araújo Costa Renata Mendes da Silva Celso Stephan José Murilo Robilotta Zeitune | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 2 | Extrusion of the Altyn Tagh wedge: A kinematic model for the Altyn Tagh fault and palinspastic recon- struction of northern China显示文摘 | Zhou Da Stephan A G | 1996 | Geology1996，24，5： | 1 |
| 3 | Interleukin 6 activates heat shock protein 90B gene expression 显示文摘 | Stephanou A Amin B Isenberg DA | 1997 | Biochem J1997，，： | 1 |
| 4 | Progressive juvenile- onset punctate cataracts caused by mutation of the gammaD-crystallin gene显示文摘 | Stephan DA Gillanders E Vanderveen D | 1999 | Proc Natl Acad Sci U S A1999，96，： | 1 |
| 5 | Alteration in salivary function in early HIV infection显示文摘 | Lin AL Johnson DA Stephan KT | 2003 | J Dent Res2003，82，9： | 1 |
| 6 | Serum marcrophage inhibitory eytokine - 1 ( MIC - 1 ) levels forthe diagnosis of prostate cancer显示文摘 | Brown DA Stephan C Ward RL | 2006 | Clinical Cancer Res2006，12，： | 1 |
| 7 | A novel role for cyclooxy - genase - 2 in regulating vascular channel formation by human breast- cancer cells 显示文摘 | Basu GD Liang WS Stephan DA | 2006 | Breast Cancer Res2006，8，6： | 1 |
| 8 | Serum MIC-1 levels for thediagnosis of prostate cancer显示文摘 | Brown DA Stephan C Ward RL | 2006 | Clin Cancer Res2006，12，1： | 1 |
| 9 | Progressive ju,enile- onset punctate cataracts cuJscd hv mulation of the gamnrystallin genc显示文摘 | Stephan DA Gillanders E Vandcrv cn D el al | 1999 | Proc Natl Acad Sci I S A1999，96，： | 1 |
| 10 | Gene and protein expression changes in human trabecular meshwork cells treated with transforming growth factor-β显示文摘 | Zhao X Ramsey KE Stephan DA | | 0，，： | 1 |
| 11 | A novel role for cyclooxygenase 2 in regulating vascular channel for- mation by human breast cancer cells显示文摘 | Baseu GD Liang WS Stephan DA | 2006 | Breast Cancer Res2006，8，6： | 1 |
| 12 | Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 ( ARVD2 ) 显示文摘 | Tiso N Stephan DA Nava A | 2001 | Hum Mol Genet2001，10，： | 1 |
| 13 | Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD/C2)显示文摘 | Tiso N Stephan DA Nava A | 2001 | Hum Mol Genet2001，10，： | 1 |
| 14 | Peripheral Delivery of a ROCK Inhibitor Improves Learning and Working Memory显示文摘 | Huentelman M J Stephan DA Talboom J | 2009 | Behav Neurosci2009，123，1： | 1 |
| 15 | A novel role for cy- clooxygenase- 2 in regulating vascular channel formation by hu- man breast cancer cells显示文摘 | Basu GD Liang WS Stephan DA | 2006 | Breast Cancer Res2006，8，6： | 1 |
| 16 | Peripheral delivery of a ROCK inhibitor improves learning and working memory显示文摘 | Huentelman M J Stephan DA Talboom J | 2009 | Behav Neurosci2009，123，1： | 1 |
| 17 | Common kibra alleles are associated with human memory performance显示文摘 | Papassotiropoulos A Stephan DA Huentelman MJ | 2006 | Science2006，314，5798： | 1 |
| 18 | Common KIBRA alleles are associated with human memory performance 显示文摘 | Papassotiropoulos A Stephan DA Huentelman M J | 2006 | Science2006，314，： | 1 |
| 19 | Inflammation as a therapeutic target in heart failure? A scientific statement from the translational research committee of the heart failure association of the European Society of Cardiology显示文摘 | Stephane H Emilio H Stefan DA | 2009 | Eur J Heart Failure2009，11，： | 1 |
| 20 | Signal transducer and activator of transcription-1 and heat shock factor-I interact and activate the transcription of the Hsp-70 and Hsp-90beta gene promoters显示文摘 | Stephanou A Isenberg DA Nakajima K | 1999 | J Biol Chem1999，274，3： | 1 |
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