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| 1 | Evaluation of acoustic radiation force impulse imaging for determination of liver stiffness using transient elastography as a reference显示文摘AIM: To evaluate cut-off values and performance of acoustic radiation force impulse imaging (ARFI) using transient elastography [FibroScan■ (FS)] as a reference. METHODS: Six hundred and six patients were enrolled in this study.All patients underwent liver stiffness measurement with FS (FS-LS) and ARFI (with shear wave velocity quantification; ARFI-SWV) and the performance of ARFI in comparison to FS was determined. Sixtyeight patients underwent liver biopsy. RESULTS: Significantly higher success rates for the determination of liver stiffness were found using ARFI as compared to FS [604/606 (99.7%) vs 482/606 (79.5%); P < 0.001]. ARFI-SWV correlated significantly with FS-LS (r = 0.920, P < 0.001). ARFI-SWV increased significantly with the stage of fibrosis (1.09 ± 0.13 m/s for patients with no significant fibrosis (FS-LS < 7.6 kPa); 1.46 ± 0.27 m/s for patients with significant liver fibrosis (7.6 < FS-LS ≤ 13.0 kPa); and 2.55 ± 0.77 m/s for patients with liver cirrhosis (FS-LS > 13.0 kPa)). ARFI-SWV cut-off values were identified for no significant fibrosis (1.29 m/s; sensitivity 91.4% and specificity 92.6%) and for liver cirrhosis (1.60 m/s; sensitivity 92.3% and specificity 96.5%). The optimal cut-off value for predicting liver fibrosis (F ≥ 2) was 1.32 m/s (sensitivity 87.0% and specificity 80.0%) and for liver cirrhosis (F4) 1.62 m/s (sensitivity 100% and specificity 85.7%), for patients who underwent liver biopsy. An excellent inter-and intraobserver reproducibility was observed for ARFI-SWV determinations. CONCLUSION: An ARFI-SWV cut-off value of 1.29 m/s seems to be optimal for patients with no significant liver fibrosis and 1.60 m/s for patients with liver cirrhosis. | Gerald Kircheis Abdurrahman Sagir Christoph Vogt Stephan vom Dahl Ralf Kubitz Dieter Hussinger | 2012 | World Journal of Gastroenterology2012，18，10： | 30 |
| 2 | Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein显示文摘瞄准:肝炎 B 蛋白质 X (HBx ) 被显示了是弱 oncogenic 在试管内。HBx 的转变活动与肿瘤的功能压制的几的抑制或 p53 被连接了。我们学习了 HBx 是否可以在取决于房间类型的 p53 上有不同效果。方法:我们使用了人的肝细胞瘤房间线 HepG2 和使不朽的鼠科的 hepatocyte 线 AML12 并且稳定地分析了表示了 HBx 的生理的数量的 transfected 克隆。P53 被紫外照耀导致。结果:由紫外照耀的 p53 正式就职由 HBx 的稳定的表示是未受影响的。然而,变得被 p53 激活的 cyclin 激酶禁止者 p21 (waf/cip/sdi ) 的表示在 HBx 被影响转变房间线 AML12-HBx9,然而并非在 HepG2。在 AML-HBx9,房间, p21 (waf/cip/sdi ) 蛋白质表示和 p21 (waf/cip/sdi ) 抄写是 deregulated。而且, apoptosis 的过程在调查的二根房间线以相反的方法被影响。当 HBx 的稳定的表示提高了紫外照耀在 HepG2 房间导致的 apoptosis 时, apoptosis 在 HBx 被减少转变 AML12-HBx9。P53 镇压了从 HBV enhancer 的抄写我,当由紫外照耀从表示向量或在内长的 p53 的正式就职以后表示了时。由内长的 p53 的压抑由在两根房间线的稳定地表示的 HBx 部分是可逆的。结论:HBx 的稳定的表示导致取决于使用的房间线的紫外照耀导致的 apoptosis 的解除管制。而在癌的表示导出 hepatocyte 线 HBx,在一根使不朽的 hepatocyte 线, HBx 扮演了 anti-apoptotic 提高的 apoptosis。 | Nicola Fiedler Ellen Quant Ludger Fink Jianguang Sun Ralph Schuster Wolfram H Gerlich Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，29： | 8 |
| 3 | 氮与自然显示文摘在某种程度上,人类对全球氮循环的改变是很重要的,因为增加的氮极大地改变了许多天然生态系统的组成、生产率和其它性质。增加的氮为什么有这么大的影响力?为什么如此多的天然生态系统都处于缺氮状态?减缓氮相对于其它元素的循环过程,和控制生态系统水平的氮输入输出过程,都使氮供应成为生态系统动态的限制因子。我们讨论了可以减慢氮循环的因子陆地植物和其它有机体之间的化学计量学差异,蛋白质沉淀防御植物的多度,土壤有机质中C-N键状态。对输入来讲,氮固定的能量消耗及其后果,氮以外的养分供应,对固氮者的优先取食,所有这些都能限制生物固氮者的多度和/或活动。这些过程加在一起,推动和维持着许多天然陆地生态系统的氮限制。 | Peter M.Vitousek Stephan Htttenschwiler Lydia Olander Steven Allison 王胜 | 2002 | AMBIO-人类环境杂志2002，31，2： | 7 |
| 4 | Genotype-dependent activation or repression of HBV enhancer Ⅱ by transcription factor COUP-TF1显示文摘AIM: To study the expression of HBV enhancer Ⅱ by transcription factor COUP-TF1. METHODS: In order to study the regulation of HBV variants in the vicinity of the NRRE we cloned luciferase constructs containing the HBV enhancer Ⅱ from variants and from HBV genotypes A and D and cotransfected them together with expression vectors for COUP-TF1 into HepG2 cells. RESULTS: Our fi ndings show that enhancer Ⅱ of HBV genotype A is also repressed by COUP-TF1. In contrast, two different enhancer Ⅱ constructs of HBV genotype D were activated by COUP-TF1. The activation was independent of the NRRE because a natural variant with a deletion of nt 1763-1770 was still activated by COUP- TF1. CONCLUSION: Regulation of transcription of the HBV genome seems to differ among HBV genomes derived from different genotypes. These differences in transcriptional control among HBV genotypes may be the molecular basis for differences in the clinical course among HBV genotypes. | Silke F Fischer Katja Schmidt Nicola Fiedler Dieter Glebe Christian Schüttler Jianguang Sun Wolfram H Gerlich Reinald Repp Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，37： | 2 |
| 5 | Randomized Comparison of Strategies for Type B Aortic Dissection: The INvestigation of STEnt Grafts in Aortic Dissection (INSTEAD) Trial显示文摘 | Christoph A. Nienaber Hervé Rousseau Holger Eggebrecht Stephan Kische Rossella Fattori Tim C. Rehders Günther Kundt Dierk Scheinert Martin Czerny Tilo Kleinfeldt Burkhart Zipfel Louis Labrousse Hüseyin Ince | 2009 | Circulation2009，，25： | 2 |
| 6 | Emission from quantum-dot high-β microcavities: transition from spontaneous emission to lasing and the effects of superradiant emitter coupling显示文摘Measured and calculated results are presented for the emission properties of a new class of emitters operating in the cavity quantum electrodynamics regime.The structures are based on high-finesse GaAs/AlAs micropillar cavities,each with an active medium consisting of a layer of InGaAs quantum dots(QDs)and the distinguishing feature of having a substantial fraction of spontaneous emission channeled into one cavity mode(highβ-factor).This paper demonstrates that the usual criterion for lasing with a conventional(lowβ-factor)cavity,that is,a sharp non-linearity in the input–output curve accompanied by noticeable linewidth narrowing,has to be reinforced by the equal-time second-order photon autocorrelation function to confirm lasing.The paper also shows that the equal-time second-order photon autocorrelation function is useful for recognizing superradiance,a manifestation of the correlations possible in high-βmicrocavities operating with QDs.In terms of consolidating the collected data and identifying the physics underlying laser action,both theory and experiment suggest a sole dependence on intracavity photon number.Evidence for this assertion comes from all our measured and calculated data on emission coherence and fluctuation,for devices ranging from light-emitting diodes(LEDs)and cavity-enhanced LEDs to lasers,lying on the same two curves:one for linewidth narrowing versus intracavity photon number and the other for g(2)(0)versus intracavity photon number. | Sören Kreinberg Weng W Chow Janik Wolters Christian Schneider Christopher Gies Frank Jahnke Sven Höfling Martin Kamp Stephan Reitzenstein 无 | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 7 | Inflammatory mediators in heart failure:an overview显示文摘 | Stefan D Stephan H | 2004 | Heart2004，90，4： | 1 |
| 8 | Salinity-dependent switching of osmolyte strategies in a moderately Halophilic Bacterium: glutamate induces proline biosynthesis in Halobacillus halophilus显示文摘 | Stephan H S Volker M | 2007 | Journal of Bacteriology2007，189，19： | 1 |
| 9 | Inflammatory mediators in heart failure andovervie显示文摘 | Stefan D Stephan H | 2004 | Heart2004，90，4： | 1 |
| 10 | 显示文摘 | Ajayan P M Stephan D Redlich P H | 1993 | Nature1993，361，： | 1 |
| 11 | Influence of Cr,Ni and Zn on the properties of pure clinker phases part l C3 S显示文摘 | Stephan D Maleki H Knofel D | 1999 | Cemnet and Concrete Re- search1999，29，4： | 1 |
| 12 | Biochar amendment techniques for upland rice product in Northern Laos:Soil physical properties,leaf SPAD and grain yield显示文摘 | ASAI H SAMSON B K STEPHAN H M | 2009 | Field crops research2009，111，： | 1 |
| 13 | Three dimensional image correlatlon from k-ray computed tomography of solid foam显示文摘 | Stephane R Francois H Philippe V | 2008 | Composites Part A2008，39，8： | 1 |
| 14 | Multivariate statistics as a tool for modelbased prediction of floodplain vegetation and fanna显示文摘 | ANKE H STEPHAN R | 2003 | Ecological Modelling2003，169，： | 1 |
| 15 | Tight gas sands显示文摘 | Stephan A H | 2006 | SPE Journal2006，，1： | 1 |
| 16 | 显示文摘 | Ajayan P M Stephan D Redlich P H | 1995 | Nature1995，375，： | 1 |
| 17 | Material resistance of flame retarded wood-plastic composites against fire and fungal decay显示文摘 | Naumann A Seefeldt H Stephan I | 2012 | Polymer Degradation and Stability2012，97，9： | 1 |
| 18 | Reflective and transmissive CR scanhead technology on needle image plates显示文摘 | Jorg F Stephan M Clemens H | 2005 | SPIE2005，5745，： | 1 |
| 19 | Light interception and partitioningbetween shoots in apple cultivars influenced by training显示文摘 | Stephan J Sinoquet H Dones N | 2008 | Tree Physiology2008，28，： | 1 |
| 20 | Singularity detection and processing with wavelets显示文摘 | STEPHANE M WEN L H | 1992 | IEEE Transactions on Information Theory1992，38，2： | 1 |
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