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| 1 | Incidence of gallstone disease in Italy:Results from a multicenter,population-based Italian study (the MICOL project)显示文摘AIM:To evaluate gallstone incidence and risk factors in a large population-based study. METHODS: Gallstone incidence and risk factors, were evaluated by structured questionnaire and physical examination, respectively, in 9611 of 11 109 (86.5%) subjects who were gallstone-free at the cross-sectional study. RESULTS: Six centers throughout Italy enrolled 9611 subjects (5477 males, 4134 females, aged 30-79 years), 9517 of whom were included into analysis: 424 subjects (4.4%) had gallstones and 61 (0.6%) had been cholecystectomized yielding a cumulative incidence of 0.67% per year (0.66% in males, 0.81% in females). Increasing age, a high body mass index (BMI), a history of diabetes, peptic ulcer and angina, and low cholesterol and high triglyceride levels were identifi ed as risk factors in men while, in females, the only risk factors were increasing age and a high BMI.Increasing age and pain in the right hypocondrium in men and increasing age in females were identifi ed as predictors of gallstones. Pain in the epigastrium/ right hypocondrium was the only symptom related to gallstones; furthermore, some characteristics of pain (forcing to rest, not relieved by bowel movements) were significantly associated with gallstones. No correlation was found between gallstone characteristics and clinical manifestations, while increasing age in men and increasing age and BMI in females were predictors of pain. CONCLUSION:Increasing age and BMI represent true risk factors for gallstone disease (GD); pain in the right hypocondrium and/or epigastrium is confi rmed as the only symptom related to gallstones. | Davide Festi Ada Dormi Simona Capodicasa Tommaso Staniscia Adolfo F Attili Paola Loria Paolo Pazzi Giuseppe Mazzella Claudia Sama Enrico Roda Antonio Colecchia | 2008 | World Journal of Gastroenterology2008，14，34： | 23 |
| 2 | Diverticular disease of the colon:New perspectives in symptom development and treatment显示文摘Diverticular disease of the colon is a common disease worldwide. Although the disease is asymptomatic in about 70-80 % of patients, it represents, at least in Western countries, one of the most important gastrointestinal diseases in terms of direct and indirect health costs. Pathocenesis of the disease is still unknown. However, it is the result of complex interactions between colonic structure, intestinal motility, diet and genetic factors. Whilst efficacious preventive strategies remain to be identified, fibre supplementation in the diet is recommended. Why symptoms develop is still unclear. Results of recent experimental studies on irritable bowel syndrome speculated that low grade inflammation of colonic mucosa, induced by changes in bacterial microflora,could affect the enteric nervous system, which is crucial for normal gut function, thus favouring symptom development.This hypothesis could be extrapolated also for diverticular disease, since bacterial overgrowth is present, at least in a subgroup of patients. These perspectives on symptom development are reviewed and new therapeutic approaches are hypothesized. | Antonio Colecchia Lorenza Sandri Simona Caoodicasa Amanda Vestito Giuseppe Mazzella Tommaso Staniscia Enrico Roda Davide Festi | 2003 | World Journal of Gastroenterology2003，9，7： | 7 |
| 3 | Addit,on ol teicoplanin or vancomycin for the treatment of documented bacteremia due to gram-positive cocci in neutropenic patients with hematological malignancies: microbiological, clinical and economic evaluation显示文摘 | D'Antonio D Staniscia T Piccolomini R | 2004 | Chemotherapy2004，50，2： | 1 |
| 4 | Addition of teicoplanin or vancomycin for the treatment of documented bacteremia due to grampositive cocci in neutropenic patients with hematological malignancies:microbiological,clinical and economic evaluation显示文摘 | D'Antonio D Staniscia S Piccolomin G | 2004 | Chemotherapy2004，50，2： | 1 |
| 5 | Origin, evolutionand paleoepidemiology of brucellosis 显示文摘 | D'Anastasio R Staniscia T Milia ML | 2011 | Epidemiol Infect2011，139，： | 1 |
| 6 | Oncogenic and tumor suppressive roles of polo-like kinases in human hepatocellular carcinoma 显示文摘 | Pellegrino R Calvisi DF Ladu S Ehemann V Staniscia T Evert M | 2010 | Hepatology2010，51，3： | 1 |
| 7 | MF59-adjuvanted H5N1 vaccine induces immunologic memory and heterotypic antibody responses m non-elderly and elderly adults显示文摘 | Banzhoff A Gasparini R Laghi-Pasini F Staniscia T Durando P Montomoli E Capecchi P L di Giovanni P Sficchi L Gentile C Hilbert A Brauer V Tilman S Podda A | | 0，，02： | 1 |
| 8 | Addition of teicoplanin or vancomycin for the treatment of documented bacteremia due to gram-positive cocci in neutropenic patients with hematological malignancies:microbiological,clinical and economic evaluation显示文摘 | D’Antonio D Staniscia S Piccolomin G | 2004 | Chemotherapy2004，50，2： | 1 |
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