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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease显示文摘 | Gavin PJ Crawford SE Shulman ST | 2003 | Arterioscler Thromb Vasc Bio12003，23，4： | 1 |
| 3 | Restraint of inflammatory signalingby interdependent strata of negative regulatory pathways显示文摘 | Murray PJ Smale ST | 2012 | Nat Immunol2012，13，10： | 1 |
| 4 | Corrective lens use and refractive error among United States Air Force aircrew显示文摘 | Wright ST Ivan DJ Clark PJ | 2010 | Mil Med2010，175，3： | 1 |
| 5 | QIIME allows analysis of high-throughput community sequencing data 显示文摘 | Caporaso JG Kuczynski J Stombaugh J Bittinger K Bushman FD Costello EK Fierer N Pena AG Goodrich JK Gordon JI Huttley GA Kelley ST Knights D Koenig JE Ley RE Lozupone CA Mcdonald D Muegge BD Pirrung M Reeder J Sevinsky JR Tumbaugh PJ Walters WA Widmann J Yatsunenko T Zaneveld J Knight R | 2010 | Nat Methods2010，7，5： | 1 |
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| 7 | Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors显示文摘 | Brightbill HD Libraty DH Krutzik SR Yang RB Belisle JT Bleharski JR Maitland M Norgard MV Plevy SE Smale ST Brennan PJ Bloom BR Godowski PJ Modlin RL | 1999 | Science1999，285，5428： | 1 |
| 8 | Ibuprotan-mediated reduction of hypoxia-inducible factors HIF-1 alpha and HIF-2 alpha in prostate cancer cells 显示文摘 | Palayoor ST Tofilan PJ Coleman CN | 2003 | Clin Cancer Res2003，9，8： | 1 |
| 9 | Hypoechoic lesions of the prestate:Clinical relevance of tumor size, digital rectal examination and prostate specific antigen显示文摘 | Torp-pederson ST Littrup PJ | 1989 | Radiology1989，170，1： | 1 |
| 10 | The innervation of the trapezius muscle: a cervical motor supply 显示文摘 | Stacey RJ O Leary ST Hamlyn PJ | 1995 | J Cramiomax- illofac Surg1995，23，4： | 1 |
| 11 | Use of optical coherence tomography to assess variations in macular retinal thickness in myopia 显示文摘 | Lim MC Hoh ST Foster PJ | 2005 | Invest Ophthalmol Vis Sci2005，46，： | 1 |
| 12 | Function of the intercistronic region of BRLF1 BZLF1 bicistronic mRNA in translating the Zta protein of epstein-Barr virus显示文摘 | Chang PJ Liu ST | 2001 | J Virol2001，75，： | 1 |
| 13 | Role of Rta in the translation of bi cistronic BZLF1 of Epstein-Barr virus 显示文摘 | Chang PJ Chang YS Liu ST | 1998 | J Virol1998，72，： | 1 |
| 14 | Performance of CT in deteetion of bowel injury 显示文摘 | Butela ST Federle MP Chang PJ | 2001 | AIR Am J Roentgeno12001，176，1： | 1 |
| 15 | Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease显示文摘 | Gavin PJ Crawford SE Shulman ST | 2003 | Arterioscler Thromb Vasc Biol2003，23，4： | 1 |
| 16 | Transforming growth factor-beta-dependent events in vascular remodeling following ar- terial injury显示文摘 | Ryan ST Koteliansky VE Gotwals PJ | 2002 | J Vasc Res2002，40，1： | 1 |
| 17 | Performance of CT in detection of bowel injury显示文摘 | Butela ST Federle MP Chang PJ | | 0，，01： | 1 |
| 18 | Liver and kidney preservation by perfusion显示文摘 | St Peter SD Imber CJ Friend PJ | 2002 | Lancet2002，359，9306： | 1 |
| 19 | Use of optical coherence tomography to assess variations in macular retinal thickness in myopia 显示文摘 | Lim MC Hoh ST Foster PJ | 2005 | Invest Ophthalmol Vis Sci2005，46，3： | 1 |
| 20 | Inclusionbody myositis presenting solely as dysphagia显示文摘 | Riminton DS Chambers ST Parkin PJ | 1993 | Neurology1993，43，6： | 1 |
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