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	题名	作者	年代	出处	被引量
1	Histone modifications:Targeting head and neck cancer stem cells显示文摘Head and neck squamous cell carcinoma(HNSCC) is the sixth most common cancer worldwide, and is responsible for a quarter of a million deaths annually. The survival rate for HNSCC patients is poor, showing only minor improvement in the last three decades. Despite new surgical techniques and chemotherapy protocols, tumor resistance to chemotherapy remains a significant challenge for HNSCC patients. Numerous mechanisms underlie chemoresistance, including genetic and epigenetic alterations in cancer cells that may be acquired during treatment and activation of mitogenic signaling pathways, such as nuclear factor kappa-light-chain-enhancer-of activated B cell, that cause reduced apoptosis. In addition to dysfunctional molecular signaling, emerging evidence reveals involvement of cancer stem cells(CSCs) in tumor development and in tumor resistance to chemotherapy and radiotherapy. These observations have sparked interest in understanding the mechanisms involved in the control of CSC function and fate. Post-translational modifications of histones dynamically influence gene expression independent of alterations to the DNA sequence. Recent findings from our group have shown that pharmacological induction of posttranslational modifications of tumor histones dynamically modulates CSC plasticity. These findings suggest that a better understanding of the biology of CSCs in response to epigenetic switches and pharmacological inhibitors of histone function may directly translate to the development of a mechanism-based strategy to disrupt CSCs. In this review, we present and discuss current knowledge on epigenetic modifications of HNSCC and CSC response to DNA methylation and histone modifications. In addition, we discuss chromatin modifications and their role in tumor resistance to therapy.	John M Le Cristiane H Squarize Rogerio M Castilho	2014	World Journal of Stem Cells2014，6，5：	6
2	Immunohisto-chemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system显示文摘	Squarize C H Castilho R M Santos P D Jr	2002	J Oral Pathol Med2002，31，：	1
3	Immunohistochemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system显示文摘	Squarize CH Castilho RM Santos D	2002	J Oral Pathol Med2002，31，7：	1
4	mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging显示文摘	Castilho RM Squarize CH Chodosh LA	2009	Cell Stem Cell2009，5，3：	1
5	mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging显示文摘	Castilho RM Squarize CH Chodosh LA	2009	Cell Stem Cell2009，5，3：	1
6	Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma显示文摘	Squarize CH Castilho RM Sriuranpong V	2006	Neoplasia2006，8，9：	1
7	Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma 显示文摘	SQUARIZE C H CASTILHO R M SRIURANPONG V	2006	Neoplasia2006，8，9：	1
8	Immunohistoehemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system显示文摘	Squarize CH Castilho RM Santos Pinto D Jr	2002	J Oral Pathol Med2002，31，7：	1
9	Immunohistochemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the hishological malignancy grading system显示文摘	Squarize CH Castilho RM Santos Pinto D Jr	2002	Oral Pathol Med2002，31，7：	1
10	Dysregulated molecular networks in head and neck carcinogenesis显示文摘	Squarize CH Molinolo AA Amomphimoltham P		0，，4：	1
11	Osteolipoma: a rare lesion in the oral cavity显示文摘	Castilho RM Squarize CH Nunes FD	2004	Br J Oral Maxillofac Surg2004，42，4：	1
12	Osteolipoma: a rare lesion in the oral cavity 显示文摘	Castilho RM Squarize CH Nunes FD	2004	Br J Oral Maxillofac Surg2004，42，4：	1
13	NFkB mediates cisplatin resistance through histone modifications in head and neck squamous cell carcinoma (HNSCC)显示文摘	Luciana O. Almeida Aline C. Abrahao Luciana K. Rosselli-Murai Fernanda S. Giudice Chiara Zagni Andreia M. Leopoldino Cristiane H. Squarize Rogerio M. Castilho	2013	FEBS Open Bio2013，，：	1
14	Immunohisto- chemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading sys- tem 显示文摘	Squarize CH Castilho RM Samos Pinto D Jr	2002	J Oral Pathol Med2002，31，7：	1
15	PTEN Defi- ciency Contribute Contributes to the Development and Pro- gression of Head and Neck Cancer 显示文摘	Squarize CH Castilho RM Abrahao AC	2013	Neoplasia2013，15，5：	1
16	Immunohistochemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system显示文摘	Squarize CH Castilho RM Santos D	2002	J Oral Pathol Med2002，31，7：	1
17	Exploiting PI3K/ mTOR signaling to accelerate epithelial wound healing显示文摘	Castilho RM Squarize CH Gutkind JS	2013	Oral Dis2013，19，6：	1
18	A role for COX2-derived PGE2 and PGE2-re- ceptor subtypes in head and neck squamous carcinoma cell proliferation 显示文摘	ABRAHAO A C CASTILHO R M SQUARIZE C H	2010	Oral Oncology2010，46，12：	1
19	Accelerated woundhealing by mTOR activation in genetically defined mouse models显示文摘	Squarize CH Castilho RM Bugge TH	2010	PLoS One2010，135，10：	1
20	Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling显示文摘	Leopoldino AM Squarize CH Gareia CB	2012	Mol Cell Biochem2012，363，12：	1

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