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	题名	作者	年代	出处	被引量
1	Induction of apoptosis by arsenic trioxide and hydroxycamptothecin in gastric cancer cells in vitro显示文摘AIM To study the effects of arsenic trioxide andHCPT on different degrees of differentiated gastriccancer cells(SGC-7901,MKN-45,MKN-28)withrespect to both cytotoxicity and induction ofapoptosis in vitro.METHODS The cytotoxicity of As₂O₃ and HCPTon gastric cancer cells was determined by MTTassay.Morphologic changes of apoptosis ofgastric cancer cells were observed by lightmicroscopy and transmission electron microscopy.Apoptosis and cell cycle changes of gastric cancercells induced by HCPT and As₂O₃ were investigatedby TUNEL method and flow cytometry.RESULTS As₂O₃ and HCPT had remarkablecytotoxic effects on different degrees ofdifferentiated gastric cancer cells.The IC₅₀ofAs₂O₃ on well differentiated gastric cancer cellMKN-28,moderately differentiated gastric cancercell SGC-7901,and poorly differentiated gastriccancer cell MKN-28 were 8.91 μmol/L,10.57μmol/L,and 11.65 μmol/L,respectively.The IC₅₀of HCPT on MKN-28,SGC-7901,and MKN-45 were9.35 mg/L,10.21 mg/L,and 12.63 mg/Lrespectively after 48 h treatment.After 12 h ofexposure to both drugs,gastric cancer cellsexhibited morphologic features of apoptosis,including cell shrinkage,nuclear condensation, and formation of apoptotic bodies.A typicalsubdiploid peak before G₀/G₁ phase was observedby flow cytometry.The apoptotic rates of SGC-7901,MKN-45,and MKN-28 were 13.84%,22.52%,and 9.68%,respectively after 48 hexposure to 10 μmol/L As₂O₃.The apoptotic ratesof SGC-7901,MKN-45,and MKN-28 were 21.88%,12.35%,and 30.26%,respectively after 48 hexposure to 10 mg/L HCPT.The apoptotic indicewere 7%-15% as assessed by TUNEL method.The effect of As₂O₃ on SGC-7901 showedremarkable cell cycle specificity,which inducedcell death in G₁ phase,and blocked G₂/M phase.HCPT also showed a remarkable cell cyclespecificity,by inducing cell death and apoptosis inG₁ phase and arrest of proliferation at S phase.CONCLUSION As₂O₃ and HCPT exhibitsignificant cytotoxicity on gastric cancer cells byinduction of apoptosis.As₂O₃ and HCPT mighthave a promising prospect in the treatment ofgastric cancer,which needs to be further studied.	Tu SP Zhong J Tan JH Jiang XH Qiao MM Wu YX Jiang SH	2000	World Journal of Gastroenterology2000，6，4：	43
2	Anterograde transport and trophic actions of BDNF and NT-4/5 in the developing rat visual system显示文摘	Spalding KL Tan MM Hendry IA	2002	Molecular & Cellular Neurosciences2002，19，4：	2
3	Central alphaadrenergic receptors and corticotropin releasing factor mediate hemodynamic responses to acute cold stress显示文摘	Tan Y Gan Q Knuepfer MM	2003	Brain Res2003，968，1：	1
4	Urea transporter expression in aging kidney and brain during dehydration显示文摘	Trinh Trang Tan MM Geelen G Teillet L		Am J Physiol Regul lntegr Comp Physiol0，285，：	1
5	Childbirth and Diagnosis Related Groups (DRGs) :patient classification and hospitalreimbursement in 11 European countries显示文摘	Bellanger MM QuentinW Tan SS	2013	Eur J Obstel Gynecol Reprod Biol2013，168，1：	1
6	Central alpha-adrenergic receptors and corticotropin releasing factor mediate hemodynamic responses to acute cold stress显示文摘	Tan Y Gan Q Knuepfer MM	2003	Brain Res2003，968，1：	1
7	Prospective randomized trial comparing the effects of letrazole LEand clomipbene citrate (CC)on follicular development,endometrial thickness and pregnancy rate in patients undergoing super-ovulation prior to intrauterine insemination (IUI)显示文摘	Sammour A Bilijan MM Tan SL	2001	Fertil Steril2001，76，3：	1
8	Quality of life and migraine disability among female migraine patients in a tertiary hospital in Malaysia 显示文摘	Shaik MM Hassan NB Tan HE	2015	Biomed Res Int2015，，52：	1
9	Prospective random- ized trial comparing the effects of letrazole (LE)and clomi phene citrate (CC) on follicular development, endometrial thickness and pregnancy rate in patients undergoing super-o- vulation prior to intrauterine insemination (IUI)显示文摘	Sammour A Biljan MM&Tan SL	2001	Fertil Steril2001，76，3：	1
10	Central alpha-adrenergie receptors and eortieotropin releasing factor mediate hemodynamic responses to acute cold stress显示文摘	Tan Y Gan Oa Knuepfer MM	2003	Brain Res2003，968，1：	1
11	Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin 显示文摘	Wong WW Tan MM Xia ZL	2001	Clin Cancer Res2001，7，7：	1
12	Letrozole and gonadotropins :what is the ideal patient protocol?显示文摘	Healey S Tan SL Biljan MM	2003	FertilSteril2003，80，6：	1
13	Computer aided evaluation of ankylosing spondylitis using high-resolution CT 显示文摘	Tan S Yao J Ward MM	2008	IEEE Trans Med Imaging2008，27，9：	1
14	Characterization and comparison of leuprolide degradation profiles in water and dimethyl sulfoxide显示文摘	Tan MM Leonard JJ	1999	J Peptide Res1999，53，：	1
15	Overexpression of cold-inducible RNA-binding protein increases interferon-gamma production in Chinese-hamster ovary cells显示文摘	Tan HK Lee MM Yap MG	2008	Biotechnol Appl Biochem2008，49，4：	1
16	Letrozote and gonadotropins: what is the ideal patient protocol显示文摘	Healey S Tan SL Biljan MM	2003	Fertil Steril2003，80，6：	1
17	Primary multifocal extranodal lympho-ma of the kidneys, ovaries and bones: utility of FDG PET/CT显示文摘	Lu SJ Tan MM Osmany S	2012	Intern Emerg Med2012，71，：	1
18	Blocking protein gera nyLgeranylation is essential for Lovastatin-indu-ced apoptosis of human acute myeloid leukemia cells显示文摘	Xia Z Tan MM Wong WW	2001	Leukemia2001，15，4：	1
19	Quality of life and migraine disability among female migraine patients in a tertiary hospital in Malaysia显示文摘	Shaik MM Hassan NB Tan HL	2015	Biomed Res Int2015，2015，52：	1
20	Letrozole and gonadotro-pins : what is the ideal patient protocol ? 显示文摘	Healey S Tan SL Biljan MM	2003	Fertil Steril2003，80，6：	1

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