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| 1 | 澳大利亚一个林地环境下的切沟发展过程和侵蚀趋势研究显示文摘 | Majid Soufi | 2002 | 中国水土保持2002，，7： | 4 |
| 2 | 低剂量白细胞介素-2在11种自身免疫疾病中的免疫学和临床疗效:单中心开放临床试验显示文摘背景调节性T(Tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明Treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活Tregs细胞,因此ld-IL2具有广泛的治疗潜力。目的我们通过一项临床试验观察ld-IL2治疗11种自身免疫性疾病中1种的效果,旨在评估ld-IL2的治疗潜力并选择疾病,以用于进一步的临床开发。方法本研究为前瞻开放性Ⅰ~Ⅱa期临床观察,入选了46例轻中度患者,诊断分别为类风湿关节炎、强直性脊柱炎、系统性红斑狼疮、牛皮癣、白塞病、肉芽肿性多血管炎、大动脉炎、克罗恩病、溃疡性结肠炎、自身免疫性肝炎或硬化性胆管炎。所有患者都接受了ld-IL2(100万IU/天)5天,然后每两周注射一次,维持6个月。所有患者均接受了深入的免疫监测和临床评估。结果在任何疾病类型以及任何合并药物治疗的患者中,ld-IL2都显示出了良好的耐受性。通过经典的免疫表型分析和广泛的免疫表型分析发现所有患者的Tregs细胞均被特异性地扩增激活,而效应T细胞没有被活化,提示ld-IL2具有临床疗效的前景。结论本研究中所采用的IL-2剂量和治疗方案可以选择性地激活和扩增Tregs细胞,并且对于不同的疾病种类以及不同的合并用药都是安全的。这一临床疗效以及初步结果可以为ld-IL2在各种自身免疫和自身炎症性疾病中开展Ⅱ期临床试验观察疗效提供了依据。试验注册号NCT01988506. | Michelle Rosenzwajg Roberta Lorenzon Patrice Cacoub Hang Phuong Pham Fabien Pitoiset Karim El Soufi Claire RIbet Claude Bernard Selim Aractingi Beatrice Banneville Laurent Beaugerie Francis Berenbaum Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Arsfene Mekinian Elodie Regnier David Saadoun Joe-Elie Salem Jeremie Sellam Philippe Seksik Anne Daguenel-Nguyen Valene Doppler Jeremie Mariau Eric Vicaut David Klatzmann 杨新蕾(译) 张卓莉(校) | 2019 | 英国医学杂志中文版2019，22，2： | 2 |
| 3 | Application of the EPT- index for ecological status assessment of the riverine water bodies within the basin of Kamchia River 显示文摘 | MOSKOVA G SOUFI R UZUNOV Y | 2008 | Bioautomation2008，11，1： | 1 |
| 4 | PRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate显示文摘 | Soufi A Jayaraman P S | 2008 | Biochem J2008，412，3： | 1 |
| 5 | Protective Effect of Egyptian Propolis against Rabbit Pasteurellosis显示文摘 | Somia A. Nassar Amira H. Mohamed Hamdy Soufy Soad M. Nasr Stelvio M. Bandiera | 2013 | BioMed Research International2013，，： | 1 |
| 6 | Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaetion显示文摘 | Soufi A Gaston K Jayaraman P S | 2006 | Int J Biol Maeromol2006，39，： | 1 |
| 7 | Unsaturated fatty acids isolated from human lipoproteins activate protein phosphatase type 2C beta and induce apoptosis in endothelial cells显示文摘 | Hufnagel B Dworak M Soufi M | 2005 | Atherosclerosis2005，180，： | 1 |
| 8 | Effect of exercise on diabetes-induced oxidative stress in the rat hippocampus 显示文摘 | Alipour M Salehi I Ghadiri Soufi F | 2012 | Iran Red Crescent Med J2012，14，4： | 1 |
| 9 | Osteoprotegerin gene poly?morphisms in men with coronary artery disease显示文摘 | Soufi M Schoppet M Sattler AM | 2004 | J Clin Endocri?nol Metab2004，89，8： | 1 |
| 10 | Osteoprotegerin gene polymorphisms in men with coronary artery disease 显示文摘 | Soufi M Schoppet M Sattler AM etal | 2004 | ClinEndocrinolMetah2004，89，8： | 1 |
| 11 | Stable isotope labeling by amino acids in cell culture (SILAC) applied to quantitative proteomics of Bacillus subtilis显示文摘 | Soufi B Kumar C Gnad F | 2010 | J Proteome Res2010，9，7： | 1 |
| 12 | Interference in a homogeneous assay for low-density lipoprotein cholesterol by lipoprotein X显示文摘 | Herzum I Giehl C Soufi M Junclas H Wahl H G | 2007 | Clin Chem Lab Med2007，45，： | 1 |
| 13 | Osteopretegerin gene polymorphism in men with coronary artery disease显示文摘 | Soufi M Schoppet M Sattler AM | 2004 | J Clin Endocrinol Metab2004，89，8： | 1 |
| 14 | Mass spectrometry-based bacterial pro- teomics: focus on dermatologic microbial pathogens显示文摘 | Soufi Y Soufi B | 2016 | Fron- tiers in microbiology2016，7，： | 1 |
| 15 | Cardiotoxicity of 5- fluorouracil显示文摘 | ALTER P HERZUM M SOUFI M et ol | 2006 | Cardiovasc Hematol Agents Med Chem2006，4，1： | 1 |
| 16 | Osteoprotegerin gene polymorphisms in men with coronary artery disease显示文摘 | Soufi M Schoppet M Sattler AM | | 0，，08： | 1 |
| 17 | Osteoprotegeringene polymorphisms in men with coronary artery disease显示文摘 | Soufi M Schoppet M Sattler AM | 2004 | J Clin Endocrinol Metab2004，89，8： | 1 |
| 18 | Influence of metabolite ochratoxin A on chicken immune response显示文摘 | Karim E L Arbid S A Soufi M S | 1991 | Egypt J Comp Pathol Clin Pathol1991，4，1： | 1 |
| 19 | Osteoprotegerin genepolymorphisms in men with coronary artery disease 显示文摘 | Soufi M Schoppet M Sattler AM | 2004 | J ClinEndocrinol Metab2004，89，： | 1 |
| 20 | Osteoprotegeringene polymorphisms in men with coronary artelT disease显示文摘 | Soufi M Schoppet M Sattler AM | 2004 | J Ciin Endocrinol Metab2004，89，8： | 1 |
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