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| 1 | Heterotopic pancreas in the stomach:A case report and literature review显示文摘Ectopic pancreas is defined as pancreatic tissue found outside the usual anatomic location of the pancreas. It is often an incidental finding and can be found at different sites in the gastrointestinal tract. It may become clinically evident when complicated by pathologic changes such as inflammation, bleeding, obstruction, and malignant transformation. In this report, a 40 years old woman with epigastric pain due to ectopic pancreatic tissue in the stomach is described. The difficulty of making an ac- curate diagnosis is highlighted. The patient has remained free of symptoms since she underwent wedge resection of the lesion three years ago. Frozen sections may help in deciding the extent of resection intraoperatively. Al- though ectopic pancreas is rare, it should be considered in the differential diagnosis of a submucosal gastric tumour. | Grigorios Christodoulidis Dimitris Zacharoulis Sotiris Barbanis Emmanuel Katsogridakis Konstantine Hatzitheofilou | 2007 | World Journal of Gastroenterology2007，13，45： | 31 |
| 2 | Impact of periampullary diverticula on the outcome and fluoroscopy time in endoscopic retrograde cholangiopancreatography显示文摘BACKGROUND: It is unclear whether the presence of periampullary diverticula (PAD) affects technical success and complication rates during endoscopic retrograde cholangio- pancreatography (ERCP). Moreover, the impact of PAD on fluoroscopy duration is still unknown. The present study aimed to investigate the success rate and difficulty of common bile duct (CBD) cannulation, post-procedure complications and fluoroscopy duration in patients with and without PAD. METHODS: Patients from January 2008 to December 2010 with PAD (group A) and without PAD (group B) and similar indications for therapeutic ERCP were prospectively compared. The comparison included patient characteristics, findings of ERCP, and details of procedure and fluoroscopy time. The influence of papilla's location with respect to the diverticulum on procedure was also investigated. RESULTS: A total of 428 consecutive patients who had undergone therapeutic ERCP for similar indications were divided in two groups according to the presence (group A, 107 patients) or absence (group B, 321 patients) of PAD. The mean age and ASA score of the patients with PAD were significantly higher than those patients without PAD. The main indication was choledocholithiasis. Successful final CBD cannulation was achieved in 97.20% of the patients in group A vs 99.69% in group B (P=0.05). CBD diameter, number of stones and the largest stone size were significantly higher in group A thangroup B (P<0.001). Complete clearance of the CBD after the first attempt was achieved in 85.86% and 94.75% of the patients in groups A and B, respectively (P=0.03). In both groups, the time needed to complete the procedure and fluoroscopy time was significantly longer in patients with PAD (22.87 vs 18.99 minutes, P<0.001; 76.51 vs 47.42 seconds, P<0.001). There was no significant difference between the two groups in the complication rate. The type of papilla's location with respect to the diverticulum did not influence the total cannulation rate and post-procedure complications. CONCLUSION: The presence of a PAD does not affect the success rate and complications of therapeutic ERCP in expert hands; however, the fluoroscopy time is significantly longer in patients with PAD. | Panagiotis Katsinelos Grigoris Chatzimavroudis Kostas Tziomalos Christos Zavos Athanasios Beltsis Georgia Lazaraki Sotiris Terzoudis Jannis Kountouras | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，4： | 15 |
| 3 | Interferon-a plus lamivudine vslamivudine reduces breakthroughs, but does not affect sustained response in HBeAg negative chronic hepatitis B显示文摘AIM: To investigate the efficacy of combination treatment of IFN-α and lamivudine compared to lamivudine monotherapy, after 24 mo of administration in HBeAg-negative hepatitis B patients.METHODS: Fifty consecutive patients were randomly assigned to receive IFN-α-2b (5 MU thrice per week, n = 24) plus lamivudine (100 mg daily) or lamivudine only (n = 26) for 24 mo. Patients were followed up for further 6 mo. The primary outcome was the proportion with sustained virological response (undetectable serum HBV DNA concentrations) and or sustained biochemical response (transaminase levels within normal range) at 30 mo (6 mo after the end of therapy). Secondary end-points were timed from initial virological (biochemical) response to VBR (BBR, respectively) and the emergence of YMDD mutants across the two arms.RESULTS: Five of twenty-four (21%) patients in the combination arm vs 3/26 (12%) in the lamivudine arm had sustained response (i.e., normal serum transaminase levels and undetectable HBV DNA by PCR assay) 6 mo after treatment discontinuation. A reduction in the emergence of YMDD mutants and in the development of virological breakthroughs was observed in patients receiving combination treatment (10% vs46%, P= 0.01 and 14% vs46%, P= 0.03,respectively).Time from initial virologic response to virologic breakthrough (VBR) was greater among initial responders receiving combination treatment compared to those receiving lamivudine (22.9 mo vs 15.9 mo, respectively; P = 0.005).CONCLUSION: Our results demonstrate that IFN-α plus lamivudine combination therapy does not increase the sustained response, compared to lamivudine. However,combination therapy reduces the likelihood of VBR due to YMDD mutants and prolongs the time period until the breakthrough development. | Michalis Economou Spilios Manolakopoulos Thomas A Trikalinos Spyros Filis Sotiris Bethanis Dimitrios Tzourmakliotis Alec Avgerinos Sotiris Raptis Epameinondas V Tsianos | 2005 | World Journal of Gastroenterology2005，11，37： | 6 |
| 4 | Favorable response to subcutaneous administration of infliximab in rats with experimental colitis显示文摘AIM: To investigate the influence of infliximab (Remicade)on experimental colitis produced by 2,4,6,trinitrobenzene sulfonic acid (TNBS) in rats.METHODS: Thirty-six Wistar rats were allocated into four groups (three groups of six animals each and a fourth of 12 animals). Six more healthy animals served as normal controls (Group 5). Group 1:colitis was induced by intracolonic installation of 25 mg of TNBS dissolved in 0.25 mL of 50% ethanol and infliximab was subcutaneously administered at a dose of 5 mg/kg BW; Group 2: colitis was induced and infliximab was subcutaneously administered at a dose of 10 mg/kg BW; Group 3: colitis was induced and infliximab was subcutaneously administered at a dose of 15 mg/kg BW; Group 4: colitis was induced without treatment with infliximab. Infliximab was administered on d 2-6. On the 7th d, all animals were killed. The colon was fixed in 10%buffered formalin and examined by light microscopy for the presence and activity of colitis and the extent of tissue damage. Tumor necrosis factor-alpha (TNF-α) and malondialdehyde (MDA) were also measured.RESULTS: Significant differences concerning the presence of reparable lesions and the extent of bowel mucosa without active inflammation in all groups of animals treated with infliximab compared with controls were found. Significant reduction of the tissue levels of TNF-α in all groups of treated animals as compared withthe untreated ones was found (0.47±0.44, 1.09±0.86,0.43±0.31 vs 18.73±10.53 respectively). Significant reduction in the tissue levels of MDA was noticed in group 1 as compared to group 4, as well as between groups 2 and 4.CONCLUSION: Subcutaneous administration of infliximab reduces the inflammatory activity as well as tissue TNF-α and MDA levels in chemical colitis in rats.Infliximab at a dose of 5 mg/kg BW achieves better histological results and produces higher reduction of the levels of TNF-α than at a dose of 10 mg/kg BW.Infliximab at a dose of 5 mg/kg BW produces higher reduction of tissue MDA levels than at a dose of 15 mg/kg BW. | John K Triantafillidis Apostolos E Papalois Aikaterini Parasi Emmanuel Anagnostakis Stavros Burnazos Aristofanis Gikas Emmanuel G Merikas Emmanuel Douzinas Maria Karagianni Helen Sotiriou | 2005 | World Journal of Gastroenterology2005，11，43： | 5 |
| 5 | Partially covered vs uncovered sphincterotome and postendoscopic sphincterotomy bleeding显示文摘AIM: To prospectively compare partially covered vs uncovered sphincterotome use on post-endoscopic biliary sphincterotomy (ES) hemorrhage and other complications. METHODS: All patients referred for therapeutic endoscopic retrograde cholangiopancreatography (ERCP) were randomly assigned to undergo ES either with a partially covered or an uncovered sphincterotome. Both patient and technical risk factors contributing to the development of post-ES bleeding were recorded and analyzed. The characteristics of bleeding was recorded during and after ES. Other complications were also compared. RESULTS: Three-hundred and eighty-seven patients were recruited in this study; 194 patients underwent ES with a partially covered sphincterotome and 193 with conventional uncovered sphincterotome. No statistical difference was noted in the baseline characteristics and risk factors for post-ES induced hemorrhage between the 2 groups. No significant difference in the incidence and pattern of visible bleeding rates was found between the 2 groups (immediate bleeding in 24 patients with the partially covered sphincterotome vs 19 patients with the uncovered sphincterotome, P = 0.418). Delayed bleeding was observed in 2 patients with a partially covered sphincterotome and in 1 patient with an uncovered sphincterotome (P = 0.62). No statistical difference was noted in the rate of other complications. CONCLUSION: The partially covered sphincterotome was not associated with a lower frequency of bleeding. Also, there was no difference in the incidence of other significant complications between the 2 types of sphincterotome. | Panagiotis Katsinelos George Paroutoglou Jannis Kountouras Grigoris Chatzimavroudis Christos Zavos Sotiris Terzoudis Taxiarchis Katsinelos Kostas Fasoulas George Gelas George Tzovaras Ioannis Pilpilidis | 2010 | World Journal of Gastroenterology2010，16，40： | 5 |
| 6 | A NONLOCAL HYBRID BOUNDARY VALUE PROBLEM OF CAPUTO FRACTIONAL INTEGRO-DIFFERENTIAL EQUATIONS显示文摘In this paper,we discuss the existence of solutions for a nonlocal hybrid boundary value problem of Caputo fractional integro-differential equations.Our main result is based on a hybrid fixed point theorem for a sum of three operators due to Dhage,and is well illustrated with the aid of an example. | Bashir AHMAD Sotiris K.NTOUYAS Jessada TARIBOON | 2016 | Acta Mathematica Scientia2016，36，6： | 3 |
| 7 | Ultrahigh-resolution nonlinear optical imaging of the armchair orientation in 2D transition metal dichalcogenides显示文摘We used nonlinear laser scanning optical microscopy to study atomically thin transition metal dichalcogenides(TMDs)and revealed,with unprecedented resolution,the orientational distribution of armchair directions and their degree of organization in the two-dimensional(2D)crystal lattice.In particular,we carried out polarization-resolved second-harmonic generation(PSHG)imaging for monolayer WS2 and obtained,with high-precision,the orientation of the main crystallographic axis(armchair orientation)for each individual 120×120 nm^(2) pixel of the 2D crystal area.Such nanoscale resolution was realized by fitting the experimental PSHG images,obtained with sub-micron precision,to a new generalized theoretical model that accounts for the nonlinear optical properties of TMDs.This enabled us to distinguish between different crystallographic domains,locate boundaries and reveal fine structure.As a consequence,we can calculate the mean orientational average of armchair angle distributions in specific regions of interest and define the corresponding standard deviation as a figure-of-merit for the 2D crystal quality. | Sotiris Psilodimitrakopoulos Leonidas Mouchliadis Ioannis Paradisanos Andreas Lemonis George Kioseoglou Emmanuel Stratakis | 2018 | Light(Science & Applications)2018，7，1： | 3 |
| 8 | Technical challenges in tackling regulatory concerns for urban atmospheric nanoparticles显示文摘Recent Euro 5 and Euro 6 vehicle emission standards are the first ever initiative to control particles on a number basis at the source. Related standards are also desirable for ambient nanoparticles (taken in this article to be those below 300 nm) to protect against possible adverse effects on public health and the environment. However, there are a number of technical challenges that need to be tackled before developing a regulatory framework for atmospheric nanoparticles. Some of the challenges derive from a lack of standardisation of the key measurement parameters, including sampling, necessary for robust evaluation of particle number concentrations, especially in the context of insufficient knowledge of the physicochemical characteristics of emerging sources (i.e. bio-fuel derived and manufactured nanoparticles). Ideally, ambient concentrations of primary particles could be linked to primary particle emissions by use of nanoparticle dispersion models, and secondary nanoparticles using photochemical modeling tools. The limitations in these areas are discussed. Although there is inadequate information on the exact biological mechanism through which these particles cause harm, it is argued that this should not in itself delay the introduction of regulation. This article reviews the missing links between the existing knowledge of nanoparticle number concentrations and the advances required to tackle the technical challenges implied in developing regulations. | Prashant Kumar Alan Robins Sotiris Vardoulakis Paul Quincey | 2011 | Particuology2011，9，6： | 3 |
| 9 | Endoscopic management of occluded biliary uncovered metal stents:A multicenter experience显示文摘AIM:To compare diverse endoscopic interventions in the management of occluded uncovered self-expanding metal stents(SEMSs) that had been placed for palliative treatment of unresectable malignant biliary obstruction.METHODS:A retrospective review was undertaken in 4 tertiary endoscopic centers to determine optimal management of different types of occluded SEMSs.The technical success of performed treatment in occluded SEMSs,the patency of the stent,the need for re-intervention and the financial costs of each treatment were analyzed.RESULTS:Fifty four patients were included in the analysis;21 received Hanaro,19 Wallstent and 14 Flexus.For the relief of obstruction,a plastic stent was inserted in 24 patients,a second SEMS in 25 and mechanical cleaning was performed in 5 patients.The overall median second patency rates between second SEMSs and plastic stents did not differ(133 d for SEMSs vs 106 d for plastic stents;P = 0.856).Similarly,no difference was found between the overall survival of SEMS and plastic stent groups,and no procedure-related complications occurred.Incremental cost analysis showed that successive plastic stenting was a cost-saving strategy at least in Greece.CONCLUSION:Insertion of uncovered SEMSs or plastic stents is a safe and effective treatment for occluded uncovered SEMSs;insertion of plastic stents appears to be the most cost-effective strategy. | Panagiotis Katsinelos Athanasios Beltsis Grigoris Chatzimavroudis Dimitris Paikos George Paroutoglou Dimitris Kapetanos Sotiris Terzoudis Georgia Lazaraki Ioannis Pilpilidis Kostas Fasoulas Stefanos Atmatzidis Christos Zavos Jannis Kountouras | 2011 | World Journal of Gastroenterology2011，17，1： | 2 |
| 10 | REFILL: A lightweight programmable middleware platform for cost effective RFID application development显示文摘 | Achilleas P Anagnostopoulos John K Soldatos Sotiris G Michalakos | 2009 | Pervasive and Mobile Computing2009，，： | 1 |
| 11 | Correlation between activation of PPARγand resistin downregulation in a mouse adipocyte cell line by a series of thiazolidinediones显示文摘 | Sotiriou A Blaauw RH Meijer C | 2013 | Toxicol In Vitro2013，27，5： | 1 |
| 12 | Low-grade central osteosarcoma of distal femur, resembling fibrous dysplasia显示文摘We report a case of a 32 year-old male, admitted for a lytic lesion of the distal femur. One month after the first X-ray, clinical and imaging deterioration was evident. Open biopsy revealed fibrous dysplasia. Three months later, the lytic lesion had spread to the whole distal third of the femur reaching the articular cartilage. The malignant clinical and imaging features necessitated excision of the lesion and reconstruction with a custom-made total knee arthroplasty. Intraoperatively, no obvious soft tissue infiltration was evident. Nevertheless, an excision of the distal 15.5 cm of the femur including 3.0 cm of the surrounding muscles was finally performed. The histological examination of the excised specimen revealed central low-grade osteosarcoma. Based on the morphological features of the excised tumor, allied to the clinical findings, the diagnosis of low-grade central osteosarcoma was finally made although characters of a fibrous dysplasia were apparent. Central low-grade osteosarcoma is a rare, well-differentiated sub-type of osteosarcoma, with clinical, imaging, and histological features similar to benign tumours. Thus, initial misdiagnosis is usual with the condition commonly mistaken for fibrous dysplasia. Central low-grade osteosarcoma is usually treated with surgery alone, with rare cases of distal metastases. However, regional recurrence is quite frequent after close margin excision. | Haris S Vasiliadis Christina Arnaoutoglou Sotiris Plakoutsis Michalis Doukas Anna Batistatou Theodoros A Xenakis | 2013 | World Journal of Orthopedics2013，4，4： | 1 |
| 13 | Breast cancer classification and prognosis based on gene profiles from a population2based study显示文摘 | Sotiriou C Neo SY McShane LM | 2003 | Proc Natl Acad Sci USA2003，100，10： | 1 |
| 14 | Breast cancer classification and prognosis based on gene expression profiles from a population based study 显示文摘 | Sotiriou C Neo S Y McShane L M | 2003 | Proc Natl Acad Sci USA2003，100，10： | 1 |
| 15 | Eosinophilic responses to stent implantation and the risk of Kounis hypersensitivity associated coronary syndrome显示文摘 | Nicholas G. Kounis Sotiris Giannopoulos Grigorios G. Tsigkas John Goudevenos | 2011 | International Journal of Cardiology2011，，2： | 1 |
| 16 | IL-17A, IL- 22, and IL-23 as Markers of Psoriasis Activity: A Cross-sectional, Hospitalbased study 显示文摘 | Fotiadou C Lazaridou E Sotiriou E | 2015 | J Cutan Med Surg2015，19，6： | 1 |
| 17 | Polydispersity of primary particles in agglomerates made by coagulation and sintering显示文摘 | Martin C H Heine A Sotiris E | 2007 | Aerosol Science2007，38，1： | 1 |
| 18 | lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-lintegrin显示文摘 | Sotiriou SN Orlova VV Al-fakhri N | 2006 | FASEB J2006，20，： | 1 |
| 19 | Gene-expression signatures in breast cancer显示文摘 | Sotiriou C Pusztai L | 2009 | N Engl J Med2009，360，12： | 1 |
| 20 | Lipoprotein(a)in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1integrin显示文摘 | Sotiriou SN Orlova VV Al-Fakhri N | 2006 | FASEB J2006，20，3： | 1 |
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