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| 1 | Favorable response to subcutaneous administration of infliximab in rats with experimental colitis显示文摘AIM: To investigate the influence of infliximab (Remicade)on experimental colitis produced by 2,4,6,trinitrobenzene sulfonic acid (TNBS) in rats.METHODS: Thirty-six Wistar rats were allocated into four groups (three groups of six animals each and a fourth of 12 animals). Six more healthy animals served as normal controls (Group 5). Group 1:colitis was induced by intracolonic installation of 25 mg of TNBS dissolved in 0.25 mL of 50% ethanol and infliximab was subcutaneously administered at a dose of 5 mg/kg BW; Group 2: colitis was induced and infliximab was subcutaneously administered at a dose of 10 mg/kg BW; Group 3: colitis was induced and infliximab was subcutaneously administered at a dose of 15 mg/kg BW; Group 4: colitis was induced without treatment with infliximab. Infliximab was administered on d 2-6. On the 7th d, all animals were killed. The colon was fixed in 10%buffered formalin and examined by light microscopy for the presence and activity of colitis and the extent of tissue damage. Tumor necrosis factor-alpha (TNF-α) and malondialdehyde (MDA) were also measured.RESULTS: Significant differences concerning the presence of reparable lesions and the extent of bowel mucosa without active inflammation in all groups of animals treated with infliximab compared with controls were found. Significant reduction of the tissue levels of TNF-α in all groups of treated animals as compared withthe untreated ones was found (0.47±0.44, 1.09±0.86,0.43±0.31 vs 18.73±10.53 respectively). Significant reduction in the tissue levels of MDA was noticed in group 1 as compared to group 4, as well as between groups 2 and 4.CONCLUSION: Subcutaneous administration of infliximab reduces the inflammatory activity as well as tissue TNF-α and MDA levels in chemical colitis in rats.Infliximab at a dose of 5 mg/kg BW achieves better histological results and produces higher reduction of the levels of TNF-α than at a dose of 10 mg/kg BW.Infliximab at a dose of 5 mg/kg BW produces higher reduction of tissue MDA levels than at a dose of 15 mg/kg BW. | John K Triantafillidis Apostolos E Papalois Aikaterini Parasi Emmanuel Anagnostakis Stavros Burnazos Aristofanis Gikas Emmanuel G Merikas Emmanuel Douzinas Maria Karagianni Helen Sotiriou | 2005 | World Journal of Gastroenterology2005，11，43： | 5 |
| 2 | IL-17A, IL- 22, and IL-23 as Markers of Psoriasis Activity: A Cross-sectional, Hospitalbased study 显示文摘 | Fotiadou C Lazaridou E Sotiriou E | 2015 | J Cutan Med Surg2015，19，6： | 1 |
| 3 | Polydispersity of primary particles in agglomerates made by coagulation and sintering显示文摘 | Martin C H Heine A Sotiris E | 2007 | Aerosol Science2007，38，1： | 1 |
| 4 | Synthesisand Evaluation of Titania Powders for Photodestruetion of Phenol 显示文摘 | Fotou George P Vemury Sfinivas Pratsinis Sotiris E | 1994 | Chemical Engineering Science1994，49，24： | 1 |
| 5 | Selective noradrenergic vulnerability in alpha-synuclein transgenic mice 显示文摘 | Sotiriou E Vassilatis DK Vila M | 2010 | Neurobiol Aging2010，31，12： | 1 |
| 6 | Combined nu- trltional support in patients with chronic obstructive pulmonary disease (COPD), under mechanical ventila- tion (MV) 显示文摘 | Grigorakos L Sotiriou E Markou N | 2009 | Hepatogastmentemlosy2009，56，96： | 1 |
| 7 | Telangiectasia macularis eruptive perstans successfully treated with PUVA therapy显示文摘 | Sotiriou E Apalla Z loannides D | 2010 | Photodermatol Photoimmunol Photomed2010，26，1： | 1 |
| 8 | Relative and population attributable risk of traffic injuries in relation to blood-alcohol levels in a Mediterranean country 显示文摘 | Petridou E Trichopoulos D Sotiriou A | 1998 | Alcohol and Alcoholism1998，33，： | 1 |
| 9 | 查看详情显示文摘 | Sotiriou G A Schneider M Pratsinis S E | | 0，，： | 1 |
| 10 | Topical tacrolimus for recalcitrant vulvar lichen sclerosus显示文摘 | Sotiriou E Apalla Z Patsatsi A | 2009 | Eur J Dermatol2009，19，5： | 1 |
| 11 | Treatment of giant Bowen's disease with sequential use of photodynamic therapy and imiquimod cream显示文摘 | Sotiriou E Lallas A Apalla Z et al | 2011 | Photodermatol Photoimmunol Photomed2011，27，3： | 1 |
| 12 | Modeling air quality in street canyons: a review 显示文摘 | SOTIRIS VARDOULAKIS BERNARD E A FISHER | 2003 | Atmospheric Enviroment2003，37，： | 1 |
| 13 | Down-regulation of Dopamine D, and D2 Receptors in the Basal Ganglia of PTZ Kindling Model of Epilepsy: Effects of Angiotensin IV显示文摘 | Tchekalarova J Sotiriou E Angelatou F | 2004 | Brain Res2004，1024，12： | 1 |
| 14 | Treatment of giant Bowen's disease with sequential use of photodynamic therapy and imiquimod cream 显示文摘 | Sotiriou E Lallas A Apalla Z | 2011 | Photodermatol Photoimmunol Photomed2011，27，3： | 1 |
| 15 | IL- 17A, IL-22, and IL-23 as markers of psoriasis activity: A cross-section- al,hospital-based study 显示文摘 | Fotiadou C Lazaridou E Sotiriou E | 2015 | J Cutan Med Surg2015，19，6： | 1 |
| 16 | Photodynamic therapy for distal and lateral subungual toenail onych- omycosis caused by Trichophyton rubrum: preliminary results of a single centre open trial 显示文摘 | Sotiriou E Koussidou Eremonti T | | Acta Derm ve- nereal0，90，2： | 1 |
| 17 | An open trial of 5- aminolevulinic acid photodynamic therapy for vulvar lichen scle- rosus显示文摘 | Sotiriou E Panagiotidou D Ioannidis D | 2008 | Eur J Obstet Gynecol Reprod Biol2008，141，2： | 1 |
| 18 | Ioannides,5-Aminolevulininic acid photodynamic therapy treatment for tinea cruris caused by Trichophyton rubrum:report of 10 cases显示文摘 | Sotiriou E Panagiotidou D Ioannides D | | 0，，03： | 1 |
| 19 | Linear and non- linear analysis of heart rate variability in master athletes and healthy middle-aged non-athletes显示文摘 | SOTIRIOU P KOUIDI E SAMARAS T | 2013 | Med Eng Phys2013，35，11： | 1 |
| 20 | Photodynamic therapy for distal and lateral subungual toenail onychomycosis caused by Trichophyton rubrum:Preliminary results of a single-centre open trial显示文摘 | Sotiriou E Koussidou-Eremonti T Chaidemenos G | | 0，，02： | 1 |
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