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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | 扁桃体鳞癌中HPV感染与EGFR、VEGF表达的相关性研究显示文摘目的:研究扁桃体鳞癌(squamous cell carcinomas of the tonsil tonsillar,SCCs)中人乳头瘤病毒(human papillomavirus,HPV)感染与血管内皮生长因子(vascular endothelial growth factor,VEGF)和表皮生长因子受体(epidermal growth factor,EGFR)表达的关系,探讨HPV与EGFR和VEGF在扁桃体鳞癌发生中的交互效应。方法:采用多重实时荧光定量聚合酶链反应(multiplex real-time polymerase chain reaction,MT-PCR)检测85例扁桃体鳞癌HPV DNA及型别,通过HPV DNA分析进行HPV感染状况的测定;同时采用半定量免疫组化检测HPV(+)组和HPV(-)组中VEGF、EGFR蛋白表达情况。结果:扁桃体鳞癌中HPV感染率为49.4%(42/85),HPV-16型占所有感染者的比例为90.5%(38/42),明显高于其他型别;HPV(+)组EGFR蛋白表达明显低于HPV(-)组(P值均<0.01);HPV(+)组与HPV(-)组VEGF蛋白表达无明显差异;此外,VEGF表达与EGFR、患者的年龄、性别、TNM分期、组织学分级均无明显相关性。结论:HPV感染与扁桃体鳞癌的发生存在相关性,HPV相关的扁桃体鳞癌中,HPV基因可能通过改变EGFR表达致癌,为HPV致癌机理进一步研究提供一个新的视角,具有重要的理论意义。 | 费继敏 Timothy A Dobbins Deanna Jones C Soon Lee Christine Loo Jonathan Clark Barbara Rose | 2015 | 现代肿瘤医学2015，23，4： | 3 |
| 3 | Flexible OLED encapsulated with gas barrier film and adhesive gasket显示文摘 | A Ra Cho Eun Hye Kim Soo Young Park Lee Soon Park | 2014 | Synthetic Metals2014，，： | 2 |
| 4 | Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib显示文摘Background:Cancer-associated fibroblasts(CAFs)play an important role in the induction of chemo-resistance.This study aimed to clarify the mechanism underlying CAF-mediated resistance to two tyrosine kinase inhibitors(TKIs),sorafenib and lenvatinib,and to identify a novel therapeutic target for overcoming TKI resistance in hepatocellular carcinoma(HCC).Methods:We performed a systematic integrative analysis of publicly available gene expression datasets and whole-transcriptome sequencing data from 9 pairs of CAFs and para-cancer fibroblasts isolated from human HCC and para-tumor tissues,respectively,to identify key molecules that might induce resistance to TKIs.We then performed in vitro and in vivo experiments to validate selected targets and related mechanisms.The associations of plasma secreted phosphoprotein 1(SPP1)expression levels before sorafenib/lenvatinib treatment with progression-free survival(PFS)and overall survival(OS)of 54 patients with advanced HCC were evaluated using Kaplan-Meier and Cox regression analysis.Results:Bioinformatic analysis identified CAF-derived SPP1 as a candidate molecule driving TKI resistance.SPP1 inhibitors reversed CAF-induced TKI resistance in vitro and in vivo.CAF-derived SPP1 activated rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)through the integrin-protein kinase C-alpha(PKCα)signaling pathway and promoted epithelial-to-mesenchymal transition(EMT).A high plasma SPP1 level before TKI treatment was identified as an independent predictor of poor PFS(P=0.026)and OS(P=0.047)in patients with advanced HCC after TKI treatment.Conclusions:CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT promotion.Its inhibition represents a promising therapeutic strategy against TKI resistance inHCC.Moreover,plasma SPP1 level before TKI treatment represents a potential biomarker for treatment response prediction. | JungWoo Eun Jung Hwan Yoon Hye Ri Ahn Seokhwi Kim Young Bae Kim Su Bin Lim Won Park TaeWook Kang Geum Ok Baek Moon Gyeong Yoon Ju A Son Ji HyangWeon Soon Sun Kim Hyo Jung Cho Jae Youn Cheong | 2023 | Cancer Communications2023，43，4： | 2 |
| 5 | The Z-phase in 9-12%Cr ferritic steels:a phase stability analysis 显示文摘 | Kocer C Abe T Soon A | 2009 | Materials Science and Engineering2009，505，12： | 1 |
| 6 | A simple phase unwrapping approach based on filtering by windowed Fourier transform 显示文摘 | Qian K Soon S H Asundi A | 2005 | Optics & Laser Technology2005，37，6： | 1 |
| 7 | A novel cooling system to reduce thermally-induced errors of machine tools显示文摘 | DONMEZ M A HAHN M H SOONS J A | 2007 | CIRP Annals-Manufacturing Technology2007，56，1： | 1 |
| 8 | Environmental effects of increased atmospheric carbon dioxide显示文摘 | Robinson A B Robinson N E Soon W | 2007 | Jour- nal of American Physicians and Surgeons2007，12，3： | 1 |
| 9 | Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases显示文摘 | Soon F F Ng L M Zhou X E West G M Kovach A Tan M H Suino-Powell K M He Y Xu Y Chalmers M J Brunzelle J S Zhang H Yang H Jiang H Li J Yong E L Cutler S Zhu J K Griffin P R Melcher K Xu H E | 2012 | Science2012，335，6064： | 1 |
| 10 | Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases显示文摘 | Soon F F Ng L M Zhou X E West G M Kovach A Tan M H Suino-Powell KM He Y Xu Y Chalmers MJ Brunzelle JS Zhang H Yang H Jiang H Li J Yong EL Cutler S Zhu JK Griffin PR Melcher K Xu HE | 2012 | Science2012，335，6064： | 1 |
| 11 | Characterization of the Effects of Process Parameters on Macro-segregation in a High-pressure Die-casting Magnesium Alloy 显示文摘 | Soon Gi lee G R Patel A M Gokhale | 2005 | Materials characterization2005，55，： | 1 |
| 12 | Comparison of the decomposition and N and P mineralization of canola,pea and wheat residues显示文摘 | Soon Y K Arshad M A | 2002 | Biology Fertility of Soils2002，36，1： | 1 |
| 13 | An analysis of soft tis- sue allograft anterior cruciate ligament reconstruction in a rabbit model:a short-term study of the use ofmesenchymal stem cells to enhance tendon osteointegration显示文摘 | Soon MY Hassan A Hui JH | 2007 | Am J Sports Med2007，35，6： | 1 |
| 14 | Echogenicity of breast cancer:is it of prognostic value显示文摘 | Soon PS Vallentine J Palmer A | 2004 | Breast2004，13，3： | 1 |
| 15 | Effects of cropping systems on nitrogen, phosphorus and potassium forms and soil organic carbon in a Gray Luvisol 显示文摘 | Soon Y K Arshad M A | 1996 | Biology and Fertility of Soils1996，22，12： | 1 |
| 16 | Heterogeneous catalytic treatment of synthetic dyes in aqueous media using fenton and photo-assisted Fenton process显示文摘 | SOON A N HAMEED B H | 2011 | Desalination2011，269，123： | 1 |
| 17 | Microstructural evo- lution and mechanical properties of low alloy ste~l tem- pered by induction heating 显示文摘 | SOON T A DAE S K WON J N | 2005 | Materials processing Technology2005，160，： | 1 |
| 18 | Acrat lentigi- nous melanoma mimicking benign disease: the emory experience 显示文摘 | Soon S L Solomon A R Jr Papadopoulos D | 2003 | J Am Acad Dermatol2003，48，2： | 1 |
| 19 | The Z-phase in 9-12% Cr ferritic steels:A phase stability analysis显示文摘 | Kocer C Abe T Soon A | | 0，，： | 1 |
| 20 | Overexprsssion of WISP-1 down-regulated motility and invasion of lung cancer cells throvlsh inhibition of Rac activation显示文摘 | Soon LL Yie TA Shvarts A | 2003 | J Biol Chem2003，278，11： | 1 |
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