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| 1 | Degradation potential of ofloxacin and its resulting transformation products during Fenton oxidation process显示文摘The degradation of ofloxacin(OFX)in the aqueous solution by Fenton oxidation process was investigated in the present study.The optimum operating conditions for the degradation of OFX in our system was determined.More importantly,the degradation pathways on a basis of the identification of transformation products during the degradation of OFX were proposed,which revealed that the initial degradation step could be associated with the decarboxylation at the quinolone moiety.Moreover,the detachment of the F element during the Fenton oxidation process has also been detected.Since the carboxylic group within OFX has been considered as an important bridge for binding quinolones with the DNA gyrase target,the decarboxylation process would offer insights into the reduction of antibacterial potentials. | Yunqing Pi Jinglan Feng Mengke Song Jianhui Sun | 2014 | Chinese Science Bulletin2014，59，21： | 10 |
| 2 | Analysis of Low-polar Ginsenosides in Steamed Panax Ginseng at High-temperature by HPLC-ESI-MS/MS显示文摘A high performance liquid chromatography coupled with electrospray ionization-tandem mass spectrome try(HPLC-ESI-MS/MS) method was developed for the analysis and identification of ginsenosides in the extracts of raw Panax ginseng(RPG) and steamed Panax ginseng at high temperatures(SPGHT). A total of 25 ginsenosides were extracted include of which 10 low-polar ginsenosides, such as ginsenosides F4, Rk3, Rh4, 20S-Rg3, 20R-Rg3 and so on, were identified according to their HPLC retention time and MS/MS data. The results indicated that the low polar ginsenosides were seldom found in RPG. For the exploration of the transformation pattern of the ginsenosides in steam processing, the standards of ginsenosides Re, Rg1, Rb1, Rc, Rb2, Rb3 and Rd were selected and hydrolyzed at a temperature of 120 oC. The results show that these polar ginsenosides can be converted to low-polar ginsenosides such as Rg2, Rg6, F4, Rk3 and Rg5 by hydrolyzing the sugar chains. | ZHANG Yu-chi1,2, PI Zi-feng1, LIU Chun-ming2, SONG Feng-rui1, LIU Zhi-qiang1 and LIU Shu-ying1 1. Changchun Center of Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China 2. Central Laboratory, Changchun Normal University, Changchun 130032, P. R. China | 2012 | Chemical Research in Chinese Universities2012，28，1： | 9 |
| 3 | The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis显示文摘 | Fang Wang Wei Song Hongmei Zhao Yanni Ma Yuxia Li Di Zhai Jingnan Pi Yanmin Si Jiayue Xu Lei Dong Rui Su Mengmeng Zhang Yong Zhu Xiaoxia Ren Fei Miao Wenjie Liu Feng Li Junwu Zhang Aibin He Ge Shan Jingyi Hui Linfang Wang Jia Yu | 2017 | Cell Research2017，27，3： | 7 |
| 4 | Urinary metabonomics study of Wu-tou-tang and its co-decoction with Pinelliae Rhizoma in adjuvant-induced arthritis rats显示文摘Wu-tou-tang was applied to treat rheumatoid arthritis,rheumatic arthritis,and joint pain for thousands of years.Aconiti Radix Cocta is the primary component of Wu-tou-tang,and Aconiti Radix and Pinelliae Rhizoma is one of the famous combination taboos in traditional Chinese medicine.A urinary metabonomics method based on the ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS) had been established to quantify the changes of the endogenous metabolites in the urine of adjuvant-induced arthritis rats treated by Wutou-tang and Wu-tou-tang and Pinelliae Rhizoma(WP) co-decoctions.There was a clear separation between Wu-tou-tang and WP co-decoction treated groups in the PCA model.16 potential biomarkers had been identified which correlated with how Pinelliae Rhizoma influenced the therapeutic effect made by Wu-tou-tang.Results showed that it could reduce the therapeutic effects or make some side effects when Pinelliae Rhizoma is added in Wu-tou-tang.This is the first time to use metabonomics to investigate the reason of combination taboo. | Yao Qi Zi-Feng Pi Shu Liu Feng-Rui Song Ying Xu Na Lin Zhi-Qiang Liu | 2015 | Chinese Chemical Letters2015，26，3： | 6 |
| 5 | Aquathermolysis of conventional heavy oil with superheated steam显示文摘This paper presents a new aquathermolysis study of conventional heavy oil in superheated steam.A new high temperature autoclave was designed,where volume and pressure could be adjusted. Aquathermolysis was studied on two different conventional heavy oil samples under different reaction times and temperatures.Experimental results show that aquathermolysis does take place for conventional heavy oil.As reaction time increases,the oil viscosity reduces.However,the reaction will reach equilibrium after a certain period of time and won’t be sensitive to any further reaction time any more. Analysis shows that,while resin and asphaltenes decrease,saturated hydrocarbons and the H/C ratio increase after reaction.The main mechanism of aquathermolysis includes hydrogenization,desulfuration reaction of resin and asphaltenes,etc. | Song Guangshou Zhou Tiyao Cheng Linsong Wang Yunxian Tian Guoqing Pi Jian Zhang Zheng | 2009 | Petroleum Science2009，6，3： | 6 |
| 6 | Mechanism of Incompatible Herb Pairs, Panax ginseng and Veratrum nigrum L,: Material Basis and Metabolic Profiles of Ginsenosides in Rat Intestinal Bacteria显示文摘在繁体中文药理论,人参属人参和 Veratrum nigrum L。是重要不兼容的植物对。在老鼠的新陈代谢上的主要部件和影响的内容变化上的研究肠的细菌是有用的理解这的不兼容的机制植物对。在这研究,人参皂甙和他们的 metaboltic 的内容变化在 P 的摘录介绍。P 的人参和相容性。有 V 的人参。nigrum L。(G-V ) 用 electrospray 电离团 spectrometry (ESIMS ) 和 UPLCMS n , 分别地。大多数人参皂甙的相对内容在 G-V 的摘录被减少。而且,人参皂甙 Rb 1, Rb 2, Rc 和 Rd 能在老鼠被使产生代射变化到 Rd, F2 和 C-K 肠的细菌。在在 10:5, 10:7 和 10:10 和人参皂甙 Rb 1, Rb 2 的新陈代谢的率的比率的 G-V 摘录的 Rb 1, Rb 2 和 Rc 和到 Rd 的 Rc 的新陈代谢的速度,到在所有相容性摘录的 F2 的 Rd 在 P 是比那低的。人参摘录。在结论,这研究说明了机制由相对内容的比较和在 P 的相容性以后的人参皂甙的新陈代谢的侧面减少效果。人参和 V。nigrum L。 | Xiudong Yang Xue Li Ying Xu Zifeng Pi Na Lin Zhiqiang Liu Fengrui Song | 2015 | Chinese Journal of Chemistry2015，33，9： | 3 |
| 7 | Preparation and characterization of porous titania-grafted poly(styrene-divinylbenzene)/maleic anhydride nanocomposite microspheres显示文摘Mesoporous titania-grafted poly(styrene-divinylbenzene)/maleic anhydride [P(St-DVB)/MA] nanocomposite microspheres were prepared by an open ring reaction method.The titania nanoparticles were first modified by attachment of amino groups to their surface to prevent particle aggregation,and to allow the nanoparticles to covalently bond the polymer microspheres,the surface of which was modified by attachment of MA functional groups to enable the polymer to retain their porous structures and to react with the amino groups on the surface of the titania particles.The porous nanocomposite microspheres were detected by FTIR,SEM,TEM,XRD and UV-Vis spectrophotometry.The results indicated that the nanocomposite microspheres were composed of nanosized titania uniformly distributed on the surface,and exhibited better UV absorbing property than pure polymer microspheres or unmodified titania.Furthermore,compared with pure porous polymer microspheres,the nanocomposite microspheres showed more efficient UV protection and slow release of Parsol-1789(a photo-reactive and cosmetic agent) held inside the porous network of the microspheres. | Li Sen Wang Kuan Zhang ZhiRen Song ChunLian Cheng Jiang Yang ZhuoRu Wen XiuFang Pi PiHui | 2010 | Science China Chemistry2010，53，3： | 3 |
| 8 | 铜绿假单胞菌中基于CRISPR/Cas9系统的基因组编辑与假单胞菌中胞苷脱氨酶介导的碱基编辑技术显示文摘文章简介假单胞菌在自然界分布广泛,种类繁多,在工业生产、生物医学、生态保护等领域具有重要的应用价值。然而假单胞菌的基因组编辑工作操作复杂、步骤繁琐,严重制约了假单胞菌的开发研究工作。 | 陈未中 Ya Zhang Yifei Zhang Yishuang Pi Tongnian Gu Liqiang Song Yu Wang 季泉江 | 2019 | 科学新闻2019，0，2： | 2 |
| 9 | α-Glucosidase immobilization on functionalized Fe_3O_4 magnetic nanoparticles for screening of enzyme inhibitors显示文摘Magnetic nanoparticles(MNPs) are widely used for the immobilization of enzyme owing to the unique properties such as good biocompatibility and rapid separation. Herein, we used Fe_3O_4 magnetic nanoparticles(Fe_3O_4 MNPs) as the carrier core with(3-aminopropyl)triethoxysilane(APTES)modification by our approach, in which a-glucosidase was stereoscopically immobilized on the surface of Fe_3O_4 MNPs via covalent binding. The result of immobilization was characterized by scanning electron microscope(SEM) and fourier transform-infrared spectroscopy(FT-IR). Then we optimized some key parameters of the immobilization reaction, including the ratio of MNPs to enzyme, GA concentration,crosslinking time and immobilization time. Moreover, under the optimal conditions, pH tolerance,thermo stability and reusability of the immobilized enzyme were investigated and compared with the free one. In order to evaluate the change of the affinity of the enzyme to its specific substrate after immobilization, the Michaelis-Menten constant(K_m) was also studied. Finally, the immobilized α-glucosidase combining with high performance liquid chromatography-tandem mass spectrometry technique(HPLC-MS/MS) was applied to screen and identify eight inhibitors from Polygonum cuspidatum extract. These results indicated that the established method had the broad prospects for biotechnological applications. | Guorong Cheng Junpeng Xing Zifeng Pi Shu Liu Zhiqiang Liu Fengrui Song | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 10 | Degradation of the antibiotic sulfamonomethoxine sodium in aqueous solution by photo-Fenton oxidation显示文摘In this study, photo-Fenton oxidation was applied to degradation of sulfamonomethoxine sodium (SMMS) in aqueous solution. The operation parameters of pH, temperature, and concentrations of H2O2, Fe2+ and SMMS were investigated. The optimum conditions for the photo-Fenton process were determined as follows: [SMMS]=4.53 mg/L, pH 4.0, [H2O2]=0.49 mmol/L, [Fe2+]= 19.51 μmol/L and T=25°C. Under these conditions 98.5% of the SMMS degraded. The kinetics were also studied, and degradation of SMMS by the photo-Fenton process could be described by first-order kinetics. The apparent activation energy was calculated as 23.95 kJ/mol. Mineralization of the process was investigated by measuring the chemical oxygen demand (COD), and the COD decreased by 99% after 120 min. This process could be used as a pretreatment method for wastewater containing sulfamonomethoxine sodium. | SUN JianHui FENG JingLan SHI ShaoHui PI YunQing SONG MengKe SHI Yan | 2012 | Chinese Science Bulletin2012，57，5： | 2 |
| 11 | Identification of subsurface damage of 4H-SiC wafers by combining photo-chemical etching and molten-alkali etching显示文摘In this work,we propose to reveal the subsurface damage(SSD)of 4H-SiC wafers by photo-chemical etching and identify the nature of SSD by molten-alkali etching.Under UV illumination,SSD acts as a photoluminescence-black defect.The selective photo-chemical etching reveals SSD as the ridge-like defect.It is found that the ridge-like SSD is still crystalline 4H-SiC with lattice distortion.The molten-KOH etching of the 4H-SiC wafer with ridge-like SSD transforms the ridge-like SSD into groove lines,which are typical features of scratches.This means that the underlying scratches under mechanical stress give rise to the formation of SSD in 4H-SiC wafers.SSD is incorporated into 4H-SiC wafers during the lapping,rather than the chemical mechanical polishing(CMP). | Wenhao Geng Guang Yang Xuqing Zhang Xi Zhang Yazhe Wang Lihui Song Penglei Chen Yiqiang Zhang Xiaodong Pi Deren Yang Rong Wang | 2022 | Journal of Semiconductors2022，43，10： | 2 |
| 12 | Discrimination of dislocations in 4H-SiC by inclination angles of molten-alkali etched pits显示文摘Discrimination of dislocations is critical to the statistics of dislocation densities in 4H silicon carbide(4H-SiC),which are routinely used to evaluate the quality of 4H-SiC single crystals and homoepitaxial layers.In this work,we show that the inclination angles of the etch pits of molten-alkali etched 4H-SiC can be adopted to discriminate threading screw dislocations(TSDs),threading edge dislocations(TEDs)and basal plane dislocations(BPDs)in 4H-SiC.In n-type 4H-SiC,the inclination angles of the etch pits of TSDs,TEDs and BPDs in molten-alkali etched 4H-SiC are in the ranges of 27°−35°,8°−15°and 2°−4°,respectively.In semi-insulating 4H-SiC,the inclination angles of the etch pits of TSDs and TEDs are in the ranges of 31°−34°and 21°−24°,respectively.The inclination angles of dislocation-related etch pits are independent of the etching duration,which facilitates the discrimination and statistic of dislocations in 4H-SiC.More significantly,the inclination angle of a threading mixed dislocations(TMDs)is found to consist of characteristic angles of both TEDs and TSDs.This enables to distinguish TMDs from TSDs in 4H-SiC. | Guang Yang Hao Luo Jiajun Li Qinqin Shao Yazhe Wang Ruzhong Zhu Xi Zhang Lihui Song Yiqiang Zhang Lingbo Xu Can Cui Xiaodong Pi Deren Yang Rong Wang | 2022 | Journal of Semiconductors2022，43，12： | 2 |
| 13 | Investigation of Aconitine-type Alkaloids from Processed Tuber of Aconitum carmiechaeli by HPLC-ESI-MS/MS^n显示文摘Introduction Aconitine-type alkaloids isolated from the roots of Aconitum carmiechaeli show a potential toxicity and a broad spectrum of bioactivity[1-4].On the basis of the C8-substituent of C19-diterpenoid skeleton,aconitine-type alkaloids can be divided into diester-diterpenoid alkaloids(DDAs),monoester-diterpenoid alkaloids(MDAs),and lipo-alkaloids(Fig.1). | YUE Hao PI Zi-feng ZHAO Yu-feng SONG Feng-rui LIU Zhi-qiang LIU Shu-ying | 2007 | Chemical Research in Chinese Universities2007，23，5： | 2 |
| 14 | Evolution of the rice Xa21 disease resistance gene family显示文摘 | SONG W Y PI L Y WANG G L | 1997 | Plant Cell1997，9，： | 1 |
| 15 | Trace determination and characterization of ginsenosides in rat plasma through magnetic dispersive solid-phase extraction based on core-shell polydopamine-coated magnetic nanoparticles显示文摘Enrichment of trace bioactive constituents and metabolites from complex biological samples is challenging.This study presented a one-pot synthesis of magnetic polydopamine nanoparticles(Fe3O4@-SiO2@PDA NPs)with multiple recognition sites for the magnetic dispersive solid-phase extraction(MDSPE)of ginsenosides from rat plasma treated with white ginseng.The extracted ginsenosides were characterized by combining an ultra-high-performance liquid chromatography coupled to a highresolution mass spectrometry with supplemental UNIFI libraries.Response surface methodology was statistically used to optimize the extraction procedure of the ginsenosides.The reusability of Fe3O4@-SiO2@PDA NPs was also examined and the results showed that the recovery rate exceeded 80%after recycling 6 times.Furthermore,the proposed method showed greater enrichment efficiency and could rapidly determine and characterize 23 ginsenoside prototypes and metabolites from plasma.In comparison,conventional methanol method can only detect 8 ginsenosides from the same plasma samples.The proposed approach can provide methodological reference for the trace determination and characterization of different bioactive ingredients and metabolites of traditional Chinese medicines and food. | Ningning Zhao Shu Liu Junpeng Xing Zifeng Pi Fengrui Song Zhiqiang Liu | 2020 | Journal of Pharmaceutical Analysis2020，10，1： | 1 |
| 16 | Anti-inflammatory Activity of Mollugin on DSS-induced Colitis in Mice显示文摘We aimed to explore the anti-infammatory bactivity of mollugin extracted from Rubia cordifolia L,a traditional Chinese medicine,on dextran sulfate sodium(DSS)-induced ulcerative colitis(UC)in mice.Thirty C57BL/6 mice were divided into a control group(n=6),a model group(n=6),and three experimental groups(40,20,10 mg/kg of mollugin,n=6 each).DSS solution(3%)was given to mice in the model group and experimental groups from day 4 to day 10 to induce the mouse UC model.Mice in the experimental groups were intragastrically administrated mollugin from day 1 to day 10.Animals were orally given distilled water in the control group for the whole experiment time and in the model group from day 1 to day 3.The changes in colon pathology were detected by hematoxylin and eosin(HE)staining.Interleukin-1β(IL-1β)in the serum,and tumor necrosis factor-α(TNF-α)and interferon-γ(IFN)in the tissues were measured by enzyme linked immunosorbent assay.Expression levels of Toll-like receptor 4(TLR4)and myeloid differentiation factor 88 in the colon tissues were detected by immunohistochemistry.Results showed that mollugin could significantly reduce weight loss and the disease activity index in the DSS-induced UC mouse model.HE examinations demonstrated that mollugin treatment effectively improved the histological damage(P<0.05).The overproduction of IL-Iβand TNF-α was remarkably inhibited by mollugin treatment at doses of 20 and 40 mg/kg(P<0.05).Additionally,the levels of TLR4 in colon tissues were significantly reduced in mollugin-treated groups compared with the DSS group.Our findings demonstrated that mollugin ameliorates DSS-induced UC by inhibiting the production of pro-inflammatory chemocytokines. | Juan LI Jin-ling ZHANG Xue-peng GONG Meng XIAO Yuan-yuan SONG Hui-fang PI Guang DU | 2020 | Current Medical Science2020，40，5： | 1 |
| 17 | Phase Evolution of Aluminum-Chromium-Phosphate Binders during HeatTreatmen显示文摘 | Chao Zou Dai Hai Zhang YiLi Wen Jian Wang Kui Cheng Chen Lu Song Gao Ling Zhao Pi Yi Du Ge ShenJian Xun Wang Gao Rong Han | | 0，，： | 1 |
| 18 | Paradoxical cellular Ca^2+ signaling in severe but compensated canine left ventricular hypertrophy显示文摘 | Song LS Pi YQ Kim SJ | 2005 | Circ Res2005，97，5： | 1 |
| 19 | Long term survival afteresoph- agectomy for early esophageal squamous cell carcinoma inLinx- ian,China显示文摘 | Song PI Liang H Fan J H | 2011 | J Snrg Oncol2011，104，： | 1 |
| 20 | The expression of functional LPS receptor proteins CD14 and Toll-like receptor 4 in human corneal cells显示文摘 | Song PI Abraham TA Park Y | 2001 | Invest Ophthalmol Vis Sci2001，42，： | 1 |
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