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| 1 | Recent advances in the diagnostic evaluation of pancreatic cystic lesions显示文摘Pancreatic cystic lesions(PCLs)are becoming more prevalent due to more frequent abdominal imaging and the increasing age of the general population.It has become crucial to identify these PCLs and subsequently risk stratify them to guide management.Given the high morbidity associated with pancreatic surgery,only those PCLs at high risk for malignancy should undergo such treatment.However,current diagnostic testing is suboptimal at accurately diagnosing and risk stratifying PCLs.Therefore,research has focused on developing new techniques for differentiating mucinous from non-mucinous PCLs and identifying high risk lesions for malignancy.Cross sectional imaging radiomics can potentially improve the predictive accuracy of primary risk stratification of PCLs at the time of detection to guide invasive testing.While cyst fluid glucose has reemerged as a potential biomarker,cyst fluid molecular markers have improved accuracy for identifying specific types of PCLs.Endoscopic ultrasound guided approaches such as confocal laser endomicroscopy and through the needle microforceps biopsy have shown a good correlation with histopathological findings and are evolving techniques for identifying and risk stratifying PCLs.While most of these recent diagnostics are only practiced at selective tertiary care centers,they hold a promise that management of PCLs will only get better in the future. | Devarshi R Ardeshna Troy Cao Brandon Rodgers Chidiebere Onongaya Dan Jones Wei Chen Eugene J Koay Somashekar G Krishna | 2022 | World Journal of Gastroenterology2022，28，6： | 3 |
| 2 | Sliding wear behaviour of zircon particles reinforced ZA-27 alloy composite materials 显示文摘 | Sharma S C Girish B M Somashekar D R | 1999 | Wear1999，224，1： | 1 |
| 3 | Partial purification and properties of a novel chitosanase secreted by Rhodotorula gracilis显示文摘 | Somashekar D Joseph R | 1992 | Letters in Applied Microbiology1992，14，1： | 1 |
| 4 | Chitosanases-properties and applications: a review显示文摘 | SOMASHEKAR D JOSEPH R | 1996 | Bioresource Technol1996，55，1： | 1 |
| 5 | Heavy metal contamination in roadside soil and their mobility in relations to pH and organic carbon显示文摘 | H Ramakrishnaiah R K Somashekar | 2002 | Soil and sediment contamination2002，11，5： | 1 |
| 6 | Sliding wear behaviour of Ziron particle reinforced ZA-27 alloy composite materials显示文摘 | Sharma S C Girish B M Somashekar D R | 1999 | Wear1999，，224： | 1 |
| 7 | Sliding wear behavior of zircon particles reinforced ZA27 alloy composite materials显示文摘 | Sharma S C Girish B M Somashekar D R | | 0，，01： | 1 |
| 8 | Mechanical properties and fractography of zircon-particle-reinforced ZA-27 alloy composite materials 显示文摘 | SHARMA S C GIRISH B M SOMASHEKAR D R KAMATH R SATISH B M | 1999 | Composite Science and Technology1999，59，： | 1 |
| 9 | Sliding wear behavior of zircon particles reinforced ZA-27 alloy composite materials 显示文摘 | SHARMA S C GIRISH B M SOMASHEKAR D R SATISH B M KAMATH R | 1999 | Wear1999，224，： | 1 |
| 10 | Chitosanases-properties and applications:a review显示文摘 | SOMASHEKAR D JOSEPH R | 1996 | Bioresource Technology1996，55，1： | 1 |
| 11 | Tree Species Diversity and Com-position in Logged and Unlogged Rainforest of Kudremukh National Park,SouthIndia显示文摘 | Nagaraja B C Somashekar R K Bunty R M | 2005 | Journal of Environmental Biology2005，26，4： | 1 |
| 12 | PCR - restric- tion fragment length analysis of aflR gene for differentiation and detection of Aspergillus flavus and Aspergillus parasitic- us inmaize 显示文摘 | Somashekar D Rati E R Chandrashekar A | 2004 | International Journal of Food Microbiology2004，93，1： | 1 |
| 13 | A Method for Generation of Machining and FixturingFeatures from Design Features显示文摘 | Subrahmanyam Somashekar R | 2002 | Computers in Industry2002，147，3： | 1 |
| 14 | Chemo-enzymatic synthesis of optically pure rivastigmine intermediate using alcohol dehydrogenase from baker's yeast显示文摘 | MADHURESH K S SOMASHEKAR R B ANISH K | 2013 | J Mol Catal B Enzym2013，91，： | 1 |
| 15 | A note on the corrosion characteristic of ZA-27/zircon particulate composites in acidic medium 显示文摘 | SHARMA S C SOMASHEKAR D R SATISH B M | 2001 | Journal of Materials Processing Technology2001，118，： | 1 |
| 16 | High-grade pancreatic intraepithelial lesions: prevalence and implications in pancreatic neoplasia显示文摘BACKGROUND: High-grade pancreatic intraepithelial neoplasia(Pan IN-3), a precursor of pancreatic ductal adenocarcinoma(PDAC), is not universally detected in resected pancreatic neoplasms. We sought to determine the prevalence and prognostic relevance of Pan IN-3 lesions in primary surgical resections of PDACs and intraductal papillary mucinous neoplasms(IPMNs).METHODS: A retrospective review of a tertiary care center pathology database(1/2000-6/2014) was performed. Demographics, imaging, pathology, disease-recurrence, and survival data were reviewed.RESULTS: A total of 458 patients who underwent primary pancreatic resection were included. 'Pan IN-3' lesions were found in 74(16.2%) patients who either had PDAC(n=67) or main duct(MD)-IPMN(n=7). Among IPMN-MDs, Pan IN-3 lesions were exclusively found in those with pathological evidence of chronic pancreatitis. For PDACs, the median overall survival(OS) for pancreata with Pan IN-3 lesions was significantly better than those without(OS 1.12 years, interquartile range [IQR] 0.72, 2.05 years vs OS 0.86 years, IQR 0.64,1.60 years respectively; P=0.04). Multivariate Cox regression analysis demonstrated that the presence of Pan IN-3 lesions was associated with a reduced risk of death(HR=0.43; 95% CI: 0.23-0.82; P=0.01).CONCLUSIONS: Following primary resection of pancreatic adenocarcinoma, the lower survival observed in patients without Pan IN-3 lesions might suggest a state of complete or accelerated transformation. Further investigations are necessary to validate these findings that might impact disease prognosis and management. | Jean R Park Feng Li Veeral M Oza Brett C Sklaw Kevin M Cronley Michael Wellner Benjamin Swanson Somashekar G Krishna | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，2： | 1 |
| 17 | Sliding wear behaviour of Ziron particle reinforced ZA-27 alloy composite materials显示文摘 | S C Sharma B M Girish D R Somashekar | 1999 | Wear1999，，224： | 1 |
| 18 | Tree species diversity and composition in logged and unlogged rainforest of Kudremukh National Park, South India显示文摘 | Nagaraja B C Somashekar R K Bunty R M | 2005 | Journal of Environmental Biology2005，26，4： | 1 |
| 19 | Partial purification and properties of a novel chitosanase secreted by Rhodotorula gracilis显示文摘 | Somashekar D Joseph R | 1992 | Lett Appl Microbiol1992，14，1： | 1 |
| 20 | Structure-property relation in polyvinyl alcohol/starch composites显示文摘 | Siddaramaiah Raj B Somashekar R | 2004 | Journal of Applied Polymer Science2004，91，1： | 1 |
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