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| 1 | Hexadecanoic acid-enriched extract of Halymenia durvillei induces apoptotic and autophagic death of human triple-negative breast cancer cells by upregulating ER stress显示文摘Objective:To investigate the effect of the hexane solvent fraction of Halymenia durvillei(HDHE)on triple-negative breast cancer.Methods:The phytochemical profile of HDHE was investigated by GC-MS.The cytotoxicity of HDHE against MDA-MB-231 cells was determined.The apoptotic and autophagic effects of HDHE were analyzed.The expression of molecular markers controlling apoptosis,autophagy,DNA damage,and endoplasmic reticulum(ER)stress was determined.Results:HDHE contains a mixture of fatty acids,mainly hexadecanoic acid.HDHE at a cytotoxic concentration induced apoptotic death of MDA-MB-231 cells through mitochondrial membrane dysfunction,and induction of apoptosis markers,and increased the expression of proteins related to DNA damage response.HDHE also induced the expression of LC-3,a marker of autophagic cell death at a cytotoxic concentration.Moreover,HDHE modulated the expression of ER stress genes.Conclusions:The hexadecanoic acid-enriched extract of Halymenia durvillei promotes apoptosis and autophagy of human triple-negative breast cancer cells.This extract may be further explored as an anticancer agent for triple-negative breast cancer. | Kant Sangpairoj Rapeewan Settacomkul Tanapan Siangcham Krai Meemon Nakorn Niamnont Nilubon Sornkaew Montakan Tamtin Prasert Sobhon Pornpun Vivithanaporn | 2022 | Asian Pacific Journal of Tropical Biomedicine2022，12，3： | 2 |
| 2 | Increase of glutamate/ N-methyl-d-aspartate receptor immunodensity in the dentate gyrus of rats following pseudoephedrine administration 显示文摘 | Nudmamud-Thanoi S Thanoi S Sobhon P | 2006 | Neurotoxicology2006，27，4： | 1 |
| 3 | Classification of differentiating oocytes during ovarian cycle in the giant freshwater prawn,Macrobrachium rosenbergii de man 显示文摘 | Meeratana P Sobhon P | 2007 | Aquaculture2007，270，1： | 1 |
| 4 | Increase of glutamate/N-methyl-d-aspartate receptor immunodensity in the dentate gyrus of rats following pseudoephedrine administration显示文摘 | Nudmamud-Thanoi S Thanoi S Sobhon P | 2006 | Neurotoxicology2006，27，： | 1 |
| 5 | Increase of glutamate/N-methyl-d-aspartate receptor immunodensity in the dentate gyrus of rats following pseudoephedrine administration显示文摘 | Nudmamud-Thanoi S Thanoi S Sobhon P | 2006 | Neurotoxicology2006，，： | 1 |
| 6 | Fasciola gigantica : The in vitro effects of artesunate as compared to triclabendazole on the 3-weeks-old juvenile显示文摘 | Tawewan Tansatit Somphong Sahaphong Suda Riengrojpitak Vithoon Viyanant Prasert Sobhon | 2012 | Experimental Parasitology2012，，1： | 1 |
| 7 | Fasciola gigantica : Anthelmintic effect of the aqueous extract of Artocarpus lakoocha显示文摘 | Naruwan Saowakon Tawewan Tansatit Chaitip Wanichanon Waraporn Chanakul Vichai Reutrakul Prasert Sobhon | 2009 | Experimental Parasitology2009，，4： | 1 |
| 8 | Molecular cloning and charac- terization of two genes encoding 2-Cys peroxiredoxins from Fasciola gigantica 显示文摘 | Chaithirayanon K Sobhon P | 2010 | Exp Parasitol2010，25，： | 1 |
| 9 | Classification of differentiat- ing oocytes during ovarian cycle in the giant freshwater prawn, Macrobrachium rosenbergii de man显示文摘 | MEERATANA P SOBHON P | 2007 | Aquaculture2007，270，14： | 1 |
| 10 | Classification of differentiating oocytes during ovarian cycle in the giant freshwater prawn, Macrobrachium rosenbergii de man显示文摘 | Meeratana P Sobhon P | 2007 | Aquaculture2007，270，： | 1 |
| 11 | An analysis of the calcium-binding protein 1 of Fasciola gigantica with a comparison to its homologs in the phylum Platyhelminthes 显示文摘 | Vichasri-Grams S Subpipattana P Sobhon P | 2006 | Mol Biochem Parasitol2006，146，1： | 1 |
| 12 | Distribution of dopamine and oct-opamine in the central nervous system and ovary during the ovarianmaturation cycle of the giant freshwater prawn, Macrobrachiumrosenbergii 显示文摘 | Tinikul Y Mercier AJ Sobhon P | 2009 | Tissue Cell2009，41，6： | 1 |
| 13 | Increased plasma soluble thrombo- modulin levels in cardiocmbolic stroke 显示文摘 | Dharmasaroja P Dharmasaroja PA Sobhon P | 2012 | Clin Appl Thromb Hemost2012，18，3： | 1 |
| 14 | An analysis of the calcium-binding protein 1 of Fasciola gigantica with a comparison to its homologs in the phylum Platyhelminthes 显示文摘 | Vichasri-Grams S Subpipattana P Sobhon P | 2006 | Mol Biochem Parasitol2006，146，1： | 1 |
| 15 | Fasciola gigantica : Anthelmintic effect of the aqueous extract of Artocarpus lakoocha显示文摘 | Naruwan Saowakon Tawewan Tansatit Chaitip Wanichanon Waraporn Chanakul Vichai Reutrakul Prasert Sobhon | 2009 | Experimental Parasitology2009，，4： | 1 |
| 16 | Bilateral eyestalk ablation of the blue swimmer crab, Portunus pelagicus , produces hypertrophy of the androgenic gland and an increase of cells producing insulin-like androgenic gland hormone显示文摘 | Morakot Sroyraya Charoonroj Chotwiwatthanakun Michael J. Stewart Nantawan Soonklang Napamanee Kornthong Ittipon Phoungpetchara Peter J. Hanna Prasert Sobhon | 2010 | Tissue and Cell2010，，5： | 1 |
| 17 | Fasciola gigantica : The in vitro effects of artesunate as compared to triclabendazole on the 3-weeks-old juvenile显示文摘 | Tawewan Tansatit Somphong Sahaphong Suda Riengrojpitak Vithoon Viyanant Prasert Sobhon | 2012 | Experimental Parasitology2012，，1： | 1 |
| 18 | Increased plasma soluble thrombomodulin levels in cardioembolic stroke 显示文摘 | Dharmasaroja P Dharmasaroja PA Sobhon P | 2012 | Clin ApplThromb Hemost2012，18，3： | 1 |
| 19 | Fasciola gigantica: Studies of tegument as a basis for the development of immunodiagonosi and vaccine显示文摘 | Sobhon P Anantavara S Dangprasert T | 1998 | Southeas Asial J Trop Med Public Health1998，29，： | 1 |
| 20 | The Potential Alveolar Hazard of Carbon Dioxide Laser-induced Smoke显示文摘 | Kunachak S Sobhon P | 1998 | J Med Assoc Thai1998，81，4： | 1 |
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