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1Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F 2005中国神经肿瘤杂志2005,3,3:53
2美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) 2010中国肺癌杂志2010,13,3:43
3阿司匹林在冠心病二级预防中的应用现况显示文摘目的了解中国多省市冠心病患者阿司匹林应用现况。方法以2781例既往曾确诊患有冠心病的门诊患者为研究对象。2006年在中国内地31个省市自治区选择32家三级医院和32家二级医院,每家医院以研究启动时点起连续选择既往曾确诊冠心病的门诊患者50例。采用访谈形式收集患者信息,填写统一表格。主要分析患者阿司匹林的应用及医生处方情况。结果(1)在2781例门诊冠心病患者中,男性1914例,女性867例,年龄(65±10)岁;(2)门诊冠心病患者阿司匹林的服用率为83.6%,男性(85.1%)高于女性(80.4%,P〈0.01),随着年龄的增加,阿司匹林的服用率呈下降趋势(P〈0.05),不同省市协作医院间阿司匹林的服用率存在差异(P〈0.01),其中贵州省患者阿司匹林的服用率最低(64.2%),浙江省最高(97.8%);(3)门诊冠心病患者阿司匹林的处方率为90.4%,总计93.0%的医生处方剂量符合《阿司匹林在动脉硬化性心血管疾病中临床应用:中国专家共识(2005)》中建议使用的剂量(75~150mg/d),不同省市协作医院医生处方剂量存在差异,个别医院1/3的处方剂量低于75mg/d;(4)女性、高龄、月收入低、既往无经皮冠状动脉介入治疗史及冠心病病程长的门诊冠心病患者,阿司匹林的服用率低。结论我国内地门诊冠心病患者阿司匹林的总服用率为83.6%,但31个省市、64家医院间差异较大;各医院医生阿司匹林处方剂量间也存在很大差异,应在冠心病二级预防中引起足够重视。刘军 赵冬 刘静 孙佳艺 Sidney C Smith Jr 2009中华内科杂志2009,48,10:23
4将卒中纳入心血管风险预测工具美国心脏协会/美国卒中协会对医疗卫生专业人员的声明显示文摘背景和目的目前美国针对心血管事件风险预测以及一级和二级预防的指南声明均使用绝对风险估计值来识别血管事件高危患者以及可从特定干预措施中获益的患者。然而,这些指南并未明确地包括卒中患者。本指南对现有证据和争论进行概述以支持:(1)将卒中(尤其是动脉粥样硬化性卒中)患者纳入心血管病绝对风险增高的患者群体;(2)将卒中纳入血管性疾病风险预测工具的转归预测因素。方法和结果写作组成员由委员会联合主席基于先前在相关领域的研究成果来提名,并得到美国心脏协会(American Heart Association,AHA)卒中委员会科学声明监督委员会以及文稿监督委员会的批准。作者采用系统文献回顾(覆盖1980年1月至2010年3月期间的文献)并参考以往公布的指南、个人资料以及专家观点,以归纳现有证据,提出当前知识的不足,并根据AHA标准对适当的问题制定推荐意见。所有写作组成员均有机会对推荐意见进行评论并批准了最终版本。经广泛的AHA内部同行评议以及卒中委员会领导阶层和科学声明监督委员会的审阅后,最终获得AHA科学咨询和协调委员会的批准。将卒中患者(尤其是动脉粥样硬化性卒中患者)纳入冠状动脉和心血管病绝对高危人群的原因如下。首先,有证据显示,缺血性卒中患者发生致死性和非致死性心肌梗死或猝死的绝对风险增高,10年绝对风险≥20%,这一风险阈值已被一些指南用于定义冠状动脉疾病风险等危症。其次,纳入动脉粥样硬化性卒中的原因与纳入糖尿病、周围血管病、慢性肾脏病以及其他动脉粥样硬化性疾病的原因相同,尽管尚缺乏在所有人群或患者中风险增高的统一证据。再次,缺血性卒中的大动脉粥样硬化性卒中亚型与其他这些疾病的病理生理学机制相同。将卒中纳入高危因素将导致高危人群的数量扩大约10%。然而,由于卒中的异质性,尚不确定其他卒中亚型,包括出血性卒中以及非动脉粥样硬化性卒中亚型,是否应被视为具有相同水平的风险,因此有待进一步研究。鉴于卒中对残疾和死亡的影响、卒中与其他血管性疾病预防措施的相似性以及卒中在某些人群中较冠状动脉疾病更高的重要性,将卒中、心肌梗死和猝死纳入心血管事件风险预测工具的转归预测因素是合适的。美国以外的指南常常将卒中患者纳入心血管高危人群,并将卒中作为心脏终点的一个相关转归事件。结论动脉粥样硬化性卒中患者应被纳入会进一步发生冠状动脉粥样硬化事件的高危患者(10年≥20%)。是否应纳入非动脉粥样硬化卒中亚型尚不确定。对于一级预防,缺血性卒中应被纳入绝对风险评估方案的心血管疾病转归事件。将动脉粥样硬化性卒中作为一个高危因素或者更宽泛地将缺血性卒中视作一种转归事件纳入,可能对心血管病的预防具有重要意义,因为被评定为高危风险的患者数量将大幅增加。Daniel T. Lackland Mitchell S.V. Elkind Ralph D'Agostino Sr Mandip S. Dhamoon David C. Goff Jr Randall T. Higashida Leslie A. McClure Pamela H. Mitchell Ralph L. Sacco Cathy A. Sila Sidney C. Smith Jr David Tanne David L. Tirschwell Emmanuel Touze Lawrence R. Wechsler 4:~ 尤寿江(译) 于海龙(译) 刘慧慧(译) 张霞(译) 刘春风(译) 2012国际脑血管病杂志2012,20,11:13
5中国多省市急性冠状动脉综合征住院患者高胆固醇血症患病现况显示文摘目的了解中国多省市急性冠状动脉综合征(ACS)住院患者高胆固醇血症的患病、知晓及治疗现状。方法以2751例住院诊断的ACS患者为研究对象。2006年在中国31个省市自治区选择32家三级医院和32家二级医院,每家医院以研究启动时点起连续选择50例经住院诊断的ACS患者。为避免研究可能带来的干预影响,采用回顾形式收集已出院患者的病历,填写统一表格,分析患者高胆固醇血症的患病、院前知晓及治疗情况。结果(1)在调查的2751例ACS住院患者中,男性占68.8%(1893例),女性占31.2%(858例),平均年龄(65±11)岁;其中心电图ST段抬高心肌梗死占39.4%,非ST段抬高心肌梗死8.8%,不稳定性心绞痛占51.8%;既往有ACS病史者27.3%。(2)2751例ACS住院患者中19.6%伴有高胆固醇血症,女性(25.5%)高于男性(16.9%,P〈0.01);按地理区域分为7个地区(华北、华东、华南、华中、东北、西北和西南),其中华东地区患者高胆固醇血症患病率最高(24.7%),华中地区最低(10.0%),各地区间的差异具有统计学意义(P〈0.01)。(3)在540例高胆固醇血症患者中,入院前知晓率为12.2%,各地区间知晓率的差异具有统计学意义(P〈0.05);入院前高胆固醇血症的治疗率为8.2%,知晓者的治疗率为66.7%;治疗率最高的是华南地区(83.3%),最低是西南地区(0%)。(4)既往有ACS史的患者中高胆固醇血症的患病率为22.1%,知晓率为18.1%,治疗率为76.7%,上述三率均高于既往无ACS病史者(18.7%、9.7%、58.3%);其中仅有21.2%的患者胆固醇控制达标。结论ACS住院患者中近20%伴有高胆固醇血症;入院前高胆固醇血症知晓率为12.2%;治疗率为66.7%。既往有ACS史的高胆固醇血症患者仅有1/5控制达标,这在冠心病二级预防中应当引起重视。刘军 赵冬 刘群 刘静 孙佳艺 Sidney C Smith Jr 2009中华心血管病杂志2009,37,5:6
6Role of illness perception and self-efficacy in lifestyle modification among non-alcoholic fatty liver disease patients显示文摘AIM To describe the relationships between non-alcoholic fatty-liver disease(NAFLD) patient's disease consequences and treatment perceptions, self-efficacy, and healthy lifestyle maintenance. METHODS A cross-sectional study among 146 ultrasound diagnosed NAFLD patients who visited the fatty liver clinic at the TelAviv Medical Center. Eighty-seven of these individuals, participated in a clinical trial of physical activity and underwent fasting blood tests, analyzed at the same lab. Exclusion criteria included positivity for serum HBsA g or anti-HCV antibodies; fatty liver suspected to be secondary to hepatotoxic drugs; excessive alcohol consumption(≥ 30 g/d in men or ≥ 20 g/d in women) and positive markers of genetic or immune-mediated liver diseases. Patients were asked to complete a selfreport structured questionnaire, assembled by the Israeli Center for Disease Control. Nutrition habits were measured using six yes/no questions(0 = no, 1 = yes) adopted from the national survey questionnaire. Participants in the clinical trial completed a detailed semi-quantitative food frequency questionnaire(FFQ) reporting their habitual nutritional intake during the past year. Self-efficacy was assessed by the Self-Efficacy Scale questionnaire, emotional representation, degree of illness understanding, timeline perception, treatment perception and symptoms were measured by the Brief Illness Perception questionnaire. Illness consequences were measured by the Personal Models of Diabetes Interview questionnaire. A path analysis was performed to describe the interrelationships between the patients' illness perceptions, and assess the extent to which the data fit a prediction of nutritional habits.RESULTS The study sample included 54.1% men, with a mean age of 47.76 ± 11.68 years(range: 20-60) and mean body mass index of 31.56 ± 4.6. The average perceived nutrition habits score was 4.73 ± 1.45 on a scale between 0-6, where 6 represents the healthiest eating habits. Most of the study participants(57.2%) did not feel they fully understood what NAFLD is. Better nutritional habits were positively predicted by the degree of illness understanding(β = 0.26; P = 0.002) and selfefficacy(β = 0.25; P = 0.003). Perceptions of more severe illness consequences were related with higher emotional representation(β = 0.55; P < 0.001), which was related with lower self-efficacy(β =-0.17; P = 0.034). The perception of treatment effectiveness was positively related with self-efficacy(β = 0.32; P < 0.001). In accordance with the correlation between self-efficacy and the perceived nutrition habits score, self-efficacy was also correlated with nutrient intake evaluated by the FFQ; negatively with saturated fat(percent of saturated fat calories from total calories)(r =-0.28, P = 0.010) and positively with fiber(r = 0.22, P = 0.047) and vitamin C intake(r = 0.34, P = 0.002). In a sub analysis of the clinical trial participants, objectively measured compliance to physical activity regimen was positively correlated with the self-efficacy level(r = 0.34, P = 0.046). CONCLUSION Self-efficacy and illness understanding are major determinants of lifestyle-modification among NAFLD patients. This information can assist clinicians in improving compliance with lifestyle changes among these patients.Shira Zelber-Sagi Shiran Bord Gali Dror-Lavi Matthew Lee Smith Samuel D Towne Jr Assaf Buch Muriel Webb Hanny Yeshua Assy Nimer Oren Shibolet 2017World Journal of Gastroenterology2017,23,10:6
7右心室超声心动图指标预测患新生儿持续性肺动脉高压婴儿的不良预后显示文摘患新生儿持续性肺动脉高压(persistent pulmonary hypertension of the newborn,PPHN)的婴儿肺血管阻力增高可导致右心衰竭和死亡。临床医师必须准确判断常规治疗可能无效的、需要进行体外膜肺氧合(extra corporeal membrane oxygenation,ECMO)治疗的婴儿,Malowitz JR Forsha DE Smith PB Cotten CM Barker PC Tatum GH 刘莉 叶鹏 2015中华高血压杂志2015,23,4:3
8Impaired swallowing mechanics of post radiation therapy head and neck cancer patients: A retrospective videofluoroscopic study显示文摘AIM: To determine swallowing outcomes and hyolaryngeal mechanics associated with post radiation therapy head and neck cancer(rt HNC) patients using videofluoroscopic swallow studies. METHODS: In this retrospective cohort study, video-fluoroscopic images of rt HNC patients(n = 21) were compared with age and gender matched controls(n = 21). Penetration-aspiration of the bolus and bolus residue were measured as swallowing outcome variables. Timing and displacement measurements of the anterior and posterior muscular slings elevating the hyolaryngeal complex were acquired. Coordinate data of anatomical landmarks mapping the action of the anterior muscles(suprahyoid muscles) and posterior muscles(long pharyngeal muscles) were used to calculate the distance measurements, and slice numbers were used to calculate time intervals. Canonical variate analysis with post-hoc discriminant function analysis was performed on coordinate data to determine multivariate mechanics of swallowing associated with treatment. Pharyngeal constriction ratio(PCR) was also measured to determine if weak pharyngeal constriction is associated with post radiation therapy.RESULTS: The rt HNC group was characterized by poor swallowing outcomes compared to the control group in regards to: Penetration-aspiration scale(P < 0.0001), normalized residue ratio scale(NRRS) for the valleculae(P = 0.002) and NRRS for the piriform sinuses(P = 0.003). Timing and distance measurements of the anterior muscular sling were not significantly different in the two groups, whereas for the PMS time of displacement was abbreviated(P = 0.002) and distance of excursion was reduced(P = 0.02) in the rt HNC group. A canonical variate analysis shows a significant reduction in pharyngeal mechanics in the rt HNC group(P < 0.0001). The PCR was significantly higher in the test group than the control group(P = 0.0001) indicating reduced efficiency in pharyngeal clearance. CONCLUSION: Using videofluoroscopy, this study shows rt HNC patients have worse swallowing outcomes associated with reduced hyolaryngeal mechanics and pharyngeal constriction compared with controls.William G Pearson Jr Alisa A Davidoff Zachary M Smith Dorothy E Adams Susan E Langmore 2016World Journal of Radiology2016,8,2:2
9遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人,刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM 2017中华高血压杂志2017,25,2:2
10Laparoscopic adrenalectomy: new gold standard显示文摘Smith C D Weber C J Amerson JR 1999World J Surg1999,23,:2
11Laparoscopic adrenalectomy : new gold standard 显示文摘Smith CD Weber C J Amerson JR 1999World J Surg1999,23,4:1
12Painful sensory polyneuropathy associated with impaired glucose tolerance显示文摘Singleton JR Smith AG Bromberg MB 2001Muscle Nerve2001,24,:1
13ACC/AHA/SCA I 2005 Guideline Update for Percutaneous Coionary Intervention A Report of the American College of Cardiobgy/American Heart Association Task Force on Practice Guidelines (ACC/AHA/SCAI Writing Committee to Update the 2001 Guidelines for Percutaneous Coinary Intervention) 显示文摘Smith SC Jr Feldman TE Hirshfeld JW Jr 2006J Am Coll Cardoil2006,47,1:1
14ACC/AHA Guidelines for percutaneous coronary intervention 显示文摘 Smith Jr James T 2001Circulation2001,103,24:1
15Laparoscopic adrenalectomy:new gold standard显示文摘Smith CD Weber CJ Amerson JR 1999World J Surg1999,23,4:1
16Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke:a comprehensive analysis using data from primary care 显示文摘Feary JR Rodrigues LC Smith CJ 2010Thorax2010,65,11:1
17Clinical management of metabolic syndrome: report of the Ameri- can Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management显示文摘Grundy S M Hansen B Smith S C Jr 2004Circulation2004,109,4:1
18Treflorine,trenudine,and N-methyltrewiasine:novel maytansinoid tumor inhibitors containing two fused macrocyclic rings显示文摘Powell RG Weisleder D Smith CR Jr 1982J Am Chem Soc1982,104,18:1
19Accurate computation of the radiation from simple antennas using the finite- difference time- domain method显示文摘Maloney J G Smith G S Scott W R JR 1990IEEE Trans Antennas and Propagat1990,38,7:1
20The effect of opening wedge thoracostomy onthoracic insufficiency syndrome associated with fused ribs and congenital scoliosis显示文摘Campbell RM Jr Smith MD Mayes TC 2004J Bone Joint Surg(Am)2004,86,14:1
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