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| 1 | Stem cells for liver tissue repair:Current knowledge and perspectives显示文摘Stem cells from extra-or intrahepatic sources have been recently characterized and their usefulness for the generation of hepatocyte-like lineages has been demonstrated. Therefore, they are being increasingly considered for future applications in liver cell therapy. In that field, liver cell transplantation is currently regarded as a possible alternative to whole organ transplantation, while stem cells possess theoretical advantages on hepatocytes as they display higher in vitro culture performances and could be used in autologous transplant procedures. However, the current research on the hepatic fate of stem cells is still facing difficulties to demonstrate the acquisition of a full mature hepatocyte phenotype, both in vitro and in vivo. Furthermore, the lack of obvious demonstration of in vivo hepatocyte-like cell functionality remains associated to low repopulation rates obtained after current transplantation procedures. The present review focuses on the current knowledge of the stem cell potential for liver therapy. We discuss the characteristics of the principal cell candidates and the methods to demonstrate their hepatic potential in vitro and in vivo. We finally address the question of the future clinical applications of stem cells for liver tissue repair and the technical aspects that remain to be investigated. | Philippe A Lysy David Campard Fran oise Smets Mustapha Najimi Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，6： | 22 |
| 2 | Liver cell transplantation for Crigler-Najjar syndrome type Ⅰ: Update and perspectives显示文摘Liver cell transplantation is an attractive technique to treat liver-based inborn errors of metabolism. The feasibility and efficacy of the procedure has been demonstrated, leading to medium term partial metabolic control of various diseases. Crigler-Najjar is the paradigm of such diseases in that the host liver is lacking one function with an otherwise normal parenchyma. The patient is at permanent risk for irreversible brain damage. The goal of liver cell transplantation is to reduce serum bilirubin levels within safe limits and to alleviate phototherapy requirements to improve quality of life. Preliminary data on Gunn rats, the rodent model of the disease, were encouraging and have led to successful clinical trials. Herein we report on two additional patients and describe the current limits of the technique in terms of durability of the response as compared to alternative therapeutic procedures. We discuss the future developments of the technique and new emerging perspectives. | Philippe A Lysy Mustapha Najimi Xavier Stéphenne Annick Bourgois Franoise Smets Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，22： | 9 |
| 3 | The Effect of Probiotic Strains on the Microbiota of the Simulator of the Human Intestinal Microbial Ecosystem (SHIME)显示文摘 | ALANDER M DE SMET I NOLLET L VERSTRAETE W | 1999 | International Journal of Food Microbiology1999，46，： | 1 |
| 4 | Earthquakes and crush syndrome casuahies : lessons learned from the Kashmir disaster 显示文摘 | Vanhnlder R Van-der-Tol A De Smet M | 2007 | Kidney Int2007，71，1： | 1 |
| 5 | The multidimensional fatigue inventory(MFI) psychometric qualities of an instrument to assess fatigue显示文摘 | Smets E M Garssen B Bonke B | 1995 | J Psychosom Res1995，39，3： | 1 |
| 6 | Activity of new juvenile hormone analogues on a stored food insect, Tribolium confusum (J, du Val) (Coleoptera: Tenebrionidae) 显示文摘 | Smet H Rans M Loof A De | 1989 | J Stored Prod1989，25，： | 1 |
| 7 | Solitary waves with prescribed speed on infinite lattices 显示文摘 | Smets D Willem M | 1977 | Journal of Functional Analysis1977，149，1： | 1 |
| 8 | Selective decontamination of the oral and digestive tract in surgical versus non-surgical patients in intensive care in a cluster-randomized trial显示文摘 | Melsen W G De Smet A M Kluytmans J A | 2012 | Br J Surg2012，99，2： | 1 |
| 9 | Phrenic and diaphragm function after coronary artery bypass grafting显示文摘 | Estenne M Yernault JC De Smet JM | | 0，，04： | 1 |
| 10 | Non-radial ground states for the Hénon equation显示文摘 | Smets D SU Jiabao Willem M | | 0，，： | 1 |
| 11 | An early decrease in Notch activation is required for human TCR-β lineage differentiation at the expense of TCR-γδ T cells显示文摘 | Van de Walle I De Smet G De Smedt M | 2009 | Blood2009，113，13： | 1 |
| 12 | Effect of multiple doses of losartan on the pharmacokinetics of single doses of digoxin in healthy volunteers 显示文摘 | De Smet M Schoors DF De Meyer G | 1995 | Br J Clin Pharmacol1995，40，6： | 1 |
| 13 | Unexpected urinary Sehistosoma infection in a Belgian travel group returning from Malawi显示文摘 | Oyaert M Lagrange W Smet G | 2013 | Aeta Clin Belg2013，68，3： | 1 |
| 14 | Deeontamination of the digestive tract and oropharynx in ICU patients显示文摘 | De Smet A M G A Klu~tmans J A J W Cooper B S | 2009 | N Engl J Med2009，360，1： | 1 |
| 15 | 查看详情显示文摘 | Van de Vyver S Thomas J Geboers J Keyzer S Smet M Dehaen W Jacobs P A Sels B F | | 0，，09： | 1 |
| 16 | Collaborative entrepreneurship: How communities of networked firms use continuous inno- vation to create economic wealth显示文摘 | Smets M | 2006 | Organization Studies2006，27，6： | 1 |
| 17 | Influence of dietary selenium and vitamin E on quality of veal显示文摘 | Sk iivanova E Marounek M De Smet S | 2007 | Meat Sci2007，76，3： | 1 |
| 18 | On the growth mechanism of a-Si : H 显示文摘 | KESSELSW M M SMETS A H M MARRA D C | 2001 | Thin Solid Films2001，383，15： | 1 |
| 19 | Case report 611: Subperisteal aneurysmal bone cyst of tibia 显示文摘 | Bumstein M I De Smet A A Hafez G R | 1990 | Skeletal Radiol1990，19，： | 1 |
| 20 | An Arabidopsis mutant overproducing cytokinins and expressing in vitro organogenic caparity显示文摘 | CATTEROU M DUBOIS F SMETS R | 2002 | Plant Cell2002，10，： | 1 |
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