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| 1 | Risk of recurrence of primary sclerosing cholangitis after liver transplantation is associated with de novo inflammatory bowel disease显示文摘AIM To evaluate risk factors for primary sclerosing cholangitis(PSC) recurrence(rPSC) after orthotopic liver transplantation(OLT) in patients with well-preserved colons. METHODS We retrospectively evaluated the medical records of all patients transplanted for PSC in our center between July 1994 and May 2015 and selected 47 with followup of at least 60 mo for further analysis based on strict inclusion and exclusion criteria. rPSC was confirmed by magnetic resonance or endoscopic retrograde cholangiopancreatography and liver biopsy. All patients were evaluated by protocolary pre-OLT colonoscopy with randomized mucosal biopsies. Colonoscopy was repeated annually after OLT. Both organ donors and recipients were human leukocyte antigen(HLA) typed by serological and/or DNA methods. All input data were thoroughly analyzed employing relevant statistical methods.RESULTS Altogether, 31 men and 16 women with a median(range) age of 36(15-68) years at the time of OLT and a median follow-up of 122(60-249) mo were included. rPSC was confirmed in 21/47(44.7%) of patients, a median 63(12-180) mo after transplantation. De novo colitis [rPSC in 11/12, P ≤ 0.05, hazard ratio(HR): 4.02, 95% confidence interval(CI): 1.58-10.98] and history of acute cellular rejection(rPSC in 14/25, P ≤ 0.05; HR: 2.66, 95%CI: 1.03-7.86) showed strong positive associations with rPSC. According to the univariate analysis, overlapping features of autoimmune hepatitis(r PSC in 5/5, P ≤ 0.05) and HLA-DRB1*07 in the donor(r PSC in 10/15, P ≤ 0.05) represent other potential risk factors for rPSC, while the HLA-DRB1*04(rPSC in 0/6, P ≤ 0.05), HLA-DQB1*03(rPSC in 1/11, P ≤ 0.05), and HLA-DQB1*07(rPSC in 0/7, P ≤ 0.05) recipient alleles may have protective roles.CONCLUSION De novo colitis and acute cellular rejection are clinical conditions significantly predisposed towards recurrence of PSC after liver transplantation. | Lukas Bajer Antonij Slavcev Peter Macinga Eva Sticova Jan Brezina Matej Roder Radim Janousek Pavel Trunecka Julius Spicak Pavel Drastich | 2018 | World Journal of Gastroenterology2018，24，43： | 4 |
| 2 | Thl/Th2 cytokine gene poly- morphisms in patients with idiopathic pulmonary fibrosis 显示文摘 | Vasakova M Striz I Slavcev A | 2006 | Tissue Antigens2006，67，3： | 1 |
| 3 | Correlation of IL-1 alpha and IL- 4 gene polymorphisms and clinical parameters in idiopathic pulmona- ry fibrosis 显示文摘 | Vasakova M Striz I Slavcev A | 2007 | Seand J immuno12007，65，3： | 1 |
| 4 | Soluble CD30 and HLA anti-bodies as potential risk factors for kidney transplant rejection显示文摘 | Slavcev A Lacha J Housova E | 2005 | Transpl Immunol2005，14，2： | 1 |
| 5 | Clinical relevance of antibodies to HLA antigens undetectable by the standard complement-dependent cytotoxicity test显示文摘 | Slavcev A Lacha J Honsova E | 2003 | Transpl Int2003，16，12： | 1 |
| 6 | Addressing the challenge : current and future diredtions in ovarian cancer therapy 显示文摘 | Kaur T Slavcev RA Wettig SD | 2009 | Curr Gene Ther2009，9，6： | 1 |
| 7 | Th1/Th2 cytokine gene poly morphisms in patients with uterine fibroid显示文摘 | Sosna O Kolesor L slavcev A | 2010 | Folia Biol (Praha)2010，56，5： | 1 |
| 8 | Stationary phase-like properties of the bacteriophage lambda Rex exclusion phenotype 显示文摘 | Slavcev RA Hayes S | 2003 | Mol Genet Genomics2003，269，1： | 1 |
| 9 | Th1/Th2 cytokine gene polymorphisms in patients with idiopathic pulmonary fibrosis 显示文摘 | Vasakova M Striz I Slavcev A | 2006 | Tissue Antigens2006，67，3： | 1 |
| 10 | Antibodies to HLA class H antigens as a risk factor for acute rejection of the allogeneic kindey显示文摘 | Slavcev A Lacha J Sajdlova H | 2004 | Ann Transplant2004，9，3： | 1 |
| 11 | Addressing the challenge:current and future directions in ovarian cancer therapy 显示文摘 | Kaur T Slavcev RA Wettig SD | 2009 | Curr Gene Ther2009，9，6： | 1 |
| 12 | Th1/Th2 cytokine gene polymorphisms in patients with idiopathic pulmona- ry fibrosis显示文摘 | Vasakova M Striz I Slavcev A | 2006 | Tissue Antigens2006，67，3： | 1 |
| 13 | Bacteriophage lambda display systems: developments and applications显示文摘 | Jessica Nicastro Katlyn Sheldon Roderick A. Slavcev | 2014 | Applied Microbiology and Biotechnology2014，，7： | 1 |
| 14 | Addressing the challenge : current and future directions in ovarian cancer therapy 显示文摘 | Kaur T Slavcev RA Wettig SD | 2009 | Curt Gene T- her2009，9，6： | 1 |
| 15 | Cytokine gene polymorphisms in idiopathic pulmonary fibrosis显示文摘AIM: To characterize cytokine gene polymorphisms in patients with idiopathic pulmonary fibrosis(IPF) compared to healthy controls.METHODS: Fifty-six IPF patients were involved in the study. The control population consisted of 144 healthy volunteers without history of lung disease.All of the patients were diagnosed with IPF according to the American Thoracic Society/European Respiratory Society consensus statement. Polymorphisms in the interleukin(IL)-1, IL-1, IL-1R, IL-1RA, IL-2, IL-4, IL-6, IL-10, IL-12, tumour necrosis factor, interferon, transforming growth factor, IL-1, IL-2, IL-4 and IL-4RA genes were characterized by polymerase chain reaction with sequence-specific primers. Statistical analysis was performed using the Med Calc statistical software. A Bonferroni correction of significance at an alpha of 0.05 was used for multiple analyses. A corrected P value less than 0.0023(0.05/22) was considered significant. RESULTS: We found significant differences in the IL-4 promoter region polymorphisms between IPF patients and controls. Namely, polymorphisms of IL-4(-590) [computed tomography(CT) in 32 of 56 patients vs 27 of 144 controls; P < 0.0001] and IL-4(-33)(CT in 25 of 56 patients vs 27 of 144 controls; P = 0.0006) differed between both groups. With regard to haplotypes, we found differences in the frequencies for haplotype 1 of IL-4(-1098)(-590)(-33) between IPF and controls(TCC in 23 of 56, TTC in 10 of 56, and TTT in 21 of 56 patients vs TCC in 112 of 144, TTC in 0 of 144, and TTT in 32 of 144 controls; P < 0.0001). We did not find significant differences in gene polymorphism frequencies of other cytokines in the IPF group vs the controls. CONCLUSION: We hypothesize that IL-4 promoter polymorphisms could be involved in the pathogenesis of IPF, likely via enhancement of the Th2 cytokine milieu with exaggerated fibroproliferative healing. | Martina Vasakova Martina Sterclova Libor Kolesar Antonij Slavcev Jelena Skibova Martina Langova Ilja Striz | 2013 | World Journal of Respirology2013，3，1： | 0 |
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