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| 1 | 极高强度他汀治疗对冠状动脉粥样硬化消退的影响——ASTEROID试验显示文摘背景:以前的血管内超声(intravascular ultrasound,IVUS)试验证实,他汀治疗可减缓或阻止动脉粥样硬化的进展,但是迄今尚无应用动脉粥样斑块体积百分比(percent atheroma volume,PAV)证实粥样硬化消退的确切证据。PAV是最严格的评价病变进展和消退的IVUS测量指标。
目标:评价极高强度他汀治疗是否能逆转IVUS确定的冠状动脉粥样硬化。
设计和地点:于美国、加拿大、欧洲和澳大利亚53个社区和3级保健中心进行前瞻性开标盲法终点试验(A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden,ASTEROID)。应用马达驱动回撤IVUS评价基线和治疗24个月时冠状动脉粥样斑块负荷。每对基线和随访IVUS测量结果均进行盲法分析。
病例:从2002年11月到2003年10月,507例患者有基线IVUS检查结果,并接受至少1个剂量的研究药物。在24个月后,349例患者具有可用于评估的系列IVUS检查结果。
干预:所有患者均接受瑞舒伐他汀40ms/d强化治疗。
主要观测指标:预先设定了两个一级疗效指标:PAV变化和基线最严重病变10min节段动脉粥样斑块体积变化。二级疗效指标为整个动脉标准化总斑块体积的变化。结果:平均(SD)LDL—C水平由基线时的130.4(34.3)ms/dL降至60.8(20.0)ms/扎,平均下降了53.2%(P〈0.001)。平均(SD)HDL-C水平从基线时的43.1(11.1)ms/dL升至49.0(12.6)ms/dL,平均增加了14.7%(P〈0.001)。整个血管PAV平均(SD)变化为-0.98%(3.15%),中位数为-0.79%(97.5%CI,-1.21%~-0.53%)(与基线比较,P〈0.001)。最严重病变10min节段斑块体积平均(SD)变化为-6.1(10.1)mm^3,中位数为-5.6mm^3(97.5%CI,-6.8~-4.0mm^3)(与基线比较,P〈0.001)。总斑块体积变化中位数降低了6.8%,平均减少了-14.7(25.7)mm^3,中位数为-12.5mm^3(95%CI,-15.1~-10.5mm^3)(与基线比较,P〈0.001)。不良事件少见,与其他他汀试验相似。
结论:应用瑞舒伐他汀40ms/d进行极高强度他汀治疗可使LDL-C平均水平达到60.8ms/dL,使HDL—C增加14.7%。这导致所有3个预先设定的IVUS斑块负荷指标均显示动脉粥样硬化消退。因此,将LDL-C降至低于目前指南规定的水平,同时显著提高HDL-C,可以使冠心病患者动脉粥样硬化斑块消退。这些变化对临床预后的影响尚需进一步研究确定。 | Steven E. Nissen Stephen J. Nicholls Ilks Sipahi Peter Libby Joel S. Raichlen Christie M. Ballantyne Jean Davignon Raimund Erbel Jean Charles Fruchart Jean-Claude Tardif Paul Schoenhagen Tim Crowe Valerie Cain Kathy Wolski Marlene Coormastic E. Murat Tuzcu 仝其广(译) 王淑敏(译) 胡大一(校) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 341 |
| 2 | 他汀、高密度脂蛋白胆固醇与冠状动脉粥样硬化消退显示文摘背景:他汀类药物可以降低低密度脂蛋白胆固醇(low—density lipoprotein cholesterol,LDL—C)水平并减缓冠状动脉粥样硬化的进展。然而,对于他汀类药物所致高密度脂蛋白胆固醇(high—density lipoprotein cholesterol,HDL—C)变化与疾病进展的关系,目前仍无相关数据描述。目的:了解LDL—C和HDL—C水平变化与动脉粥样硬化的相互关系。设计、地点及患者:对4项前瞻性随机试验(1999~2005年在美国、北美、欧洲和澳大利亚进行)的原始数据进行事后分析。其中1455例经血管造影证实的冠心病患者在接受他汀治疗(18个月或24个月)时进行了系列血管内超声扫描。所有超声分析均在相同的核心实验室中进行。主要观测指标:脂蛋白水平变化与冠状动脉粥样斑块体积的相互关系。结果:他汀治疗期间,LDL—C平均(SD)水平从124.0(38.3)mg,/dL(3.2[0.99]mmol/L)降至87.5(28.8)mg,/dL(2.3[0.75]mmol/L)(下降23.5%;P〈0.001),HDL—C水平从42.5(11.0)mg/dL(1.1[0.28]mmol/L)升至45.1(11.4)mg/dL(1.2[0.29]mmol/L)(上升7.5%;P〈0.001)。LDL—C与HDL—C比值从平均(SD)3.0(1.1)降至2.1(0.9)(下降26.7%;P〈0.001)。这些变化同时伴随平均(SD)百分粥样斑块体积的增加(从39.7%[9.8%]增至40.1%[9.7%])(增加0.5%[3.9%];P=0.001)以及平均(SD)总粥样斑块体积的减小(2.4[23.6]mm^3;P〈0.001)。在单变量分析中,LDL—C、总胆固醇、非HDL胆固醇、载脂蛋白B以及载脂蛋白B与载脂蛋白A-1比值平均水平和治疗引起的变化与动脉粥样硬化进展速率显著相关,而治疗所致HDL—C变化则与动脉粥样斑块体积负相关。在多变量分析中,平均LDL—C水平(β系数,0.11[95%可信区间,0.07~0.15])以及HDL—C升高(β系数,-0.26[95%可信区间,-0.41--0.10])依然为动脉粥样硬化消退的独立预测因子。动脉硬化显著消退(动脉粥样斑块体积减少≥5%)见于治疗期间LDL—C水平低于均值(87.5mg/dL)和HDL—C升高百分比大于均值(7.5%;P〈0.001)的患者。临床事件的发生未见显著差异。结论:在LDL—C显著降低以及HDL上升〉7.5%时,他汀治疗与冠状动脉粥样硬化消退相关。这些结果提示他汀治疗的获益源自致动脉粥样硬化脂蛋白的降低以及HDL.C的升高。尽管血脂水平的这些变化与动脉粥样硬化消退相关,但是后者是否可以转化为临床事件的显著减少,并改善临床预后仍有待进一步研究确定。 | Stephen J. Nicholls, MBBS, PhD E. Murat Tuzcu, MD IIke Sipahi, MD Adam W. Grasso, MD Paul Schoenhagen, MD Tingfei Hu, MS Kathy Wolski, MPH Tim Crowe, BS Milind Y. Desai, MD Stanley L. Hazen, MD, PhD Samir R. Kapadia, MD Steven E. Nissen, MD 李呈亿(译) | 2007 | 美国医学会杂志(中文版)2007，26，3： | 48 |
| 3 | Titanium dioxide induced inflammation in the small intestine显示文摘AIM:To investigate the effects of titanium dioxide (TiO2) nanoparticles (NPTiO 2 ) and microparticles (MPTiO 2 ) on the inflammatory response in the small intestine of mice. METHODS: Bl 57/6 male mice received distilled water suspensions containing TiO 2 (100 mg/kg body weight) as NPTiO 2 (66 nm), or MPTiO 2 (260 nm) by gavage for 10 d, once a day; the control group received only distilled water. At the end of the treatment the duodenum, jejunum and ileum were extracted for assessment of cytokines, inflammatory cells and titanium content. The cytokines interleukin (IL)-1b, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-17, IL-23, tumor necrosis factor-α (TNF-α), intracellular interferon-γ (IFN-γ) and transforming growth factor-β (TGF-β) were evaluated by enzyme-linked immunosorbent assay in segments of jejunum and ileum (mucosa and underlying muscular tissue). CD4 + and CD8 + T cells, natural killer cells, and dendritic cells were evaluated in duodenum, jejunum and ileum samples fixed in 10% formalin by immuno-histochemistry. The titanium content was determined by inductively coupled plasma atomic emission spectrometry. RESULTS: We found increased levels of T CD4 + cells (cells/mm 2 ) in duodenum:NP 1240 ± 139.4, MP 1070 ± 154.7 vs 458 ± 50.39 (P < 0.01); jejunum:NP 908.4 ± 130.3, MP 813.8 ± 103.8 vs 526.6 ± 61.43 (P < 0.05); and ileum:NP 818.60 ± 123.0, MP 640.1 ± 32.75 vs 466.9 ± 22.4 (P < 0.05). In comparison to the control group, the groups receiving TiO 2 showed a statistically significant increase in the levels of the inflammatory cytokines IL-12, IL-4, IL-23, TNF-α, IFN-γ and TGF-β. The cytokine production was more pronounced in the ileum (mean ± SE):IL-12: NP 33.98 ± 11.76, MP 74.11 ± 25.65 vs 19.06 ± 3.92 (P < 0.05); IL-4: NP 17.36 ± 9.96, MP 22.94 ± 7.47 vs 2.19 ± 0.65 (P < 0.05); IL-23: NP 157.20 ± 75.80, MP 134.50 ± 38.31 vs 22.34 ± 5.81 (P < 0.05); TNFα: NP 3.71 ± 1.33, MP 5.44 ± 1.67 vs 0.99± 019 (P < 0.05); IFNγ: NP 15.85 ± 9.99, MP 34.08 ± 11.44 vs 2.81 ± 0.69 (P < 0.05); and TGF-β: NP 780.70 ± 318.50, MP 1409.00 ± 502.20 vs 205.50 ± 63.93 (P < 0.05). CONCLUSION:Our findings indicate that TiO2 particles induce a Th1-mediated inflammatory response in the small bowel in mice. | Carolina Maciel Nogueira Walter Mendes de Azevedo Maria Lucia Zaidan Dagli Sérgio Hiroshi Toma AndréZonetti de Arruda Leite Maria Laura Lordello Iêda Nishitokukado Carmen Lúcia Ortiz-Agostinho Maria IrmaSeixas Duarte Marcelo Alves Ferreira Aytan Miranda Sipahi | 2012 | World Journal of Gastroenterology2012，18，34： | 8 |
| 4 | Petrogenesis of the late Cretaceous Turnagol intrusion in the eastern Pontides:Implications for magma genesis in the arc setting显示文摘A series of Cretaceous plutons is present in the eastern Pontides of northeastern Turkey.The Turnagl intrusion is the least studied and,thus,the least understood plutons in the orogen.This intrusion consists of hornblende-biotite granodiorites emplaced at 78 Ma based on LA-ICP-MS U-Pb zircon dating.It is of sub- alkaline affinity,belongs to the medium- to high-K calc-alkaline series,and displays features typical of Itype granites.The rocks of the intrusion are enriched in large-ion lithophile elements and light rare earthelements with negative Eu anomalies(Eu/Eu*= 0.69-0.82),but are deficient in high-field-strength elements.They have a small range of (87Sr/86Sr)i(0.7060-0.7063),εNdi(-2.6 to -3.1),and δ18O(+8.1 to +9.1) values.Their Pb isotopic ratios are 206Pb/204Pb = 18.63-18.65,207Pb/204Pb = 15.62-15.63,and 208Pb/204Pb = 38.53-38.55.The fractionation of plagioclase,hornblende,and Fe-Ti oxides had key functions in the evolution of the Tumagl intrusion.The crystallization temperatures of the melts ranged from 758 to 885℃ as determined by zircon and apatite saturation thermometry.All these characteristics,combined with the low values of K2O/Na2O and(Na2O + K2O)/(FeOt+MgO + TiO2),as well as the high values of (CaO + FeOt + MgO + TiO2).suggest an origin by dehydration melting from a metabasaltic lowercrustal source. | Abdullah Kaygusuz Ferkan Sipahi Nurdane Ilbeyli Mehmet Arslan Bin Chen Emre Aydincakir | 2013 | Geoscience Frontiers2013，4，4： | 4 |
| 5 | 他汀类药物、高密度脂蛋白胆固醇和冠状动脉粥样硬化减退显示文摘背景:他汀类药物可降低低密度脂蛋白胆固醇(LDL-C)水平并延缓冠状动脉粥样硬化的进展。但目前尚无资料描述他汀类药物所致高密度脂蛋白胆固醇(HDL-C)变化与疾病进展之间的关系。目的:研究LDL-C及HDL-C水平变化与粥样斑块负荷之间的关系。设计、机构和参与者:对4项前瞻性随机试验(1999-2005年分别在美国、北美、欧洲和澳大利亚进行)的原始资料进行事后分析。这些试验共纳入1455例经血管造影确诊冠心病的患者,患者均在接受他汀类药物治疗18个月或24个月时进行系列血管内超声检查。所有研究的超声分析均在同一个中心实验室进行。 | Nicholls S.J. Tuzcu E.M. Sipahi I. 奚群英 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，3，7： | 4 |
| 6 | Improved multilayered antimicrobial alginate-based edible coating extends the shelf life of fresh-cut watermelon ( Citrullus lanatus )显示文摘 | R.E. Sipahi M.E. Castell-Perez R.G. Moreira C. Gomes A. Castillo | 2013 | LWT - Food Science and Technology2013，，1： | 2 |
| 7 | β-blockers and progression of coronary atherosclerosis:pooled analysis of 4 intravascular ultrasonography trials显示文摘 | Sipahi I Tuzcu EM Wolski KE | 2007 | Ann Intern Med2007，147，1： | 1 |
| 8 | Effect of diabetes on progression of coronary atherosclerosis and arterial remodeling: a pooled analysis of 5 intravascular ultrasound trials显示文摘 | Nicholls S J Tuzcu E M Kalidindi S Wolski K Moon K W Sipahi I | 2008 | J Am Coll Cardiol2008，52，： | 1 |
| 9 | Effects of precementation desensitizing laser treatment and conventional desensitizing Agents on Crown Retention显示文摘 | Cumhur Sipahi D Murat Cehreli Julide Ozen | 2007 | J Prosthodont2007，20，3： | 1 |
| 10 | Angiotensin-receptor blockade and risk of cancer:meta-analysis of randomised controlled trials显示文摘 | Sipahi I Debarme SM Rowland DY | 2010 | Lancet Oncol2010，11，7： | 1 |
| 11 | Compensatory enlargement of human coronary arteries during progression of atherosclerosis is unrelated to atheroma burden: serial intravascular ultrasound observations from the REVERSAL trial显示文摘 | Sipahi I Tuzcu E M Sehoenhagen P | 2006 | Eur Heart J2006，27，14： | 1 |
| 12 | Paradoxical increase in lumen size during progression of coronary atherosclerosis显示文摘 | SIPAHI L TUZCU E M SCHOENHAGEN P | 2006 | Atherosclerosis2006，189，1： | 1 |
| 13 | Effect of very high-intensity statin therapy on regression of coronary atherosclerosis:the ASTEROID trial显示文摘 | Nissen SE Nicholls SJ sipahi I | 2010 | JAMA2010，295，13： | 1 |
| 14 | Effect of antihyper- tensive therapy on incident stroke in cohorts with prehypertensive blood pressure levels: a recta-analysis of randomized controlled trials显示文摘 | Sipahi I Swaminathan A Natesan V | 2012 | Stroke2012，43，2： | 1 |
| 15 | Fosfo-mycin in the treatment of extended spectrum beta-lactamase-producing Escherichia coli-related lower urinary tract infections显示文摘 | PULLUKCU H TASBAKAN M SIPAHI O R | 2007 | Int J Antimicrob Agents2007，29，1： | 1 |
| 16 | Ancient nigella seeds from BoyalIHoyok in north--central Turkey显示文摘 | SALIH B SIPAHI T DONMEZ E O | 2009 | Journal of Ethnopharmacology2009，124，： | 1 |
| 17 | Relationship between atheroma regression and change in lumen size after infusion of apolipoprotein A-I Milano 显示文摘 | Nicholls S J Tuzcu E M Sipahi I | 2006 | J Am Coll Cardiol2006，47，5： | 1 |
| 18 | Tu rk Hava Kuvvetleri ucucu personelinde gorulen barodontalji prevalansy显示文摘 | Sipahi C Kar MS Durmaz C | 2007 | Gu Ihane Typ Dergisi2007，49，： | 1 |
| 19 | Tttrk Hava Kuvvetleri ucucu perso - nelinde gfrUlen barodontalji prevalansy显示文摘 | Sipahi C Kar M S Dunnaz C | 2007 | G''tilhane Typ Dergisi2007，49，15： | 1 |
| 20 | Angiotensin- receptor blockade and risk of cancer: meta-analysis of randomised controlled trials显示文摘 | SIPAHI I DEBANNE S M ROWLAND D Y | 2010 | Lancet Oncol2010，11，7： | 1 |
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