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71篇 您的检索式:作者名="Singer Peter"
    题名 作者 年代 出处 被引量
1动物研究中的伦理学问题显示文摘Peter Singer 鲍贻倩 2004中国医学伦理学2004,17,2:32
2Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis显示文摘AIM: To investigate interleukin-18 (IL-18) in patients with chronic panreatitis (CP). METHODS: We studied 29 patients with CP and 30 healthy controls. Peripheral blood mononuclear cells (PBMC) were isolated and incubated with 50 mmol/L ethanol, lipopolysaccharide (LPS) (doses 25 g/L, 250 g/L, 2500 g/L) and both agents for 24 h. Levels of IL-18 in the supernatants, and levels of IL-18, IL-12, interferon (IFN)-γ and soluble CD14 in the serum were analysed by ELISA technique. Expression of IL-18 in PBMC was investigated by reverse-transcription (RT)-PCR. IL-18 protein levels in CP tissue and in normal pancreas were studied by ELISA technique. IL-18 levels in PBMC and pancreatic tissue were determined by Westernblot. Im-munohistochemistry for pancreatic IL-18 expression was performed. RESULTS: In patients, IL-18 serum levels were signifi-cantly enhanced by 76% (mean: 289.9 ± 167.7 ng/L) compared with controls (mean: 165.2 ± 43.6 ng/L; P < 0.0005). IL-12 levels were enhanced by 25% in patients (18.3 ± 7.3 ng/L) compared with controls (14.7 ± 6.8ng/L, P = 0.0576) although not reaching the statistical significance. IFN-γ and soluble CD14 levels were not in-creased. In vitro, LPS stimulated significantly and dose-dependently IL-18 secretion from PBMC. Incubation with ethanol reduced LPS-stimulated IL-18 secretion by about 50%. The mRNA expression of IL-18 in PBMC and the response of PBMC to ethanol and LPS was similar in CP patients and controls. In PBMC, no significant differences in IL-18 protein levels were detected between patients and controls. IL-18 protein levels were increased in CP tissues compared to normal pancreatic tissues. IL-18 was expressed by pancreatic acinar cells and by infiltrating inflammatory cells within the pancreas. CONCLUSION: IL-18 originates from the chronically inflammed pancreas and appears to be involved in the fibrotic destruction of the organ.Alexander Schneider Stephan L Haas Ralf Hildenbrand Sren Siegmund Iris Reinhard Helmut Nakovics Manfred V Singer Peter Feick 2006World Journal of Gastroenterology2006,12,40:4
3TSV:准备好量产了吗?显示文摘IDM公司,芯片代工厂和封装厂正在致力于研发穿透硅通孔技术,但是目前来看,为了能够进一步控制生产成本还有大量的工作需要完成。Peter Singer 2008集成电路应用2008,25,5:4
4伦理学与SARS:多伦多的教训显示文摘SARS的流行说明传染病在世界范围内流行是件多么容易的事,为了更好地应对下一次流行病,我们不仅要解决医学方面的问题,也同样需要解决伦理学方面的问题。Peter A Singer Solomon R Benatar Mark Bernstein Abdallah S Daar Bernard M Dickens Susan K MacRae Ross E G Upshur Linda Wright Randi Zlotnik Shaul 肖月 2004英国医学杂志中文版2004,7,4:3
5纳米压印技术:32纳米光刻之选?显示文摘设想一下,如果能够一步实现低介电常数绝缘材料的双大马士革结构(包括通孔和金属导线槽),就能减少123步的工艺步骤。这就是纳米压印技术所能够带来的惊人之处。此外,这项技术成本低廉、潜力无限。Peter Singer 2006集成电路应用2006,23,10:3
6世界银行《2014年全球普惠金融调查报告》编译显示文摘全球普惠金融数据库(Global Findex)是衡量世界各国成年人在不同时期使用金融服务的一个可持续比较的、综合性最强的数据集。2015年4月15日,世界银行发布了《2014年全球普惠金融调查报告》,对2011年的全球普惠金融指标数据进行了更新,新增了有关移动支付和国内汇款数据,并进行了详细分析,反映了全球普惠金融的最新发展,为进一步推动全球普惠金融发展指明了方向。笔者对报告的主要内容进行了编译整理,供读者参阅。Asli Demirguc-Kunt Leora Klapper Dorothe Singer Peter Van Oudheusden 曾繁荣 2015金融会计2015,,7:2
7Venous thromboembolism prophylaxis practice and its association with outcomes in Australia and New Zealand burns patients显示文摘Background:Patients with burn injuries are considered to have an increased risk of venous thromboembolism(VTE).While untreated VTEs can be fatal,no studies have examined chemoprophylaxis effectiveness.This study aimed to quantify the variation in prevalence of VTE prophylaxis use in patients in Australian and New Zealand burns units and whether prophylaxis use is associated with in-hospital outcomes following burn injury.Methods:Admission data for adult burns patients(aged≥16 years)admitted between 1 July 2016 and 31 December 2018 were extracted from the Burns Registry of Australia and New Zealand.Mixed effects logistic regression modelling investigated whether VTE prophylaxis usewas associated with the primary outcome of in-hospital mortality.Results:There were 5066 admissions over the study period.Of these patients,81%(n=3799)with a valid response to the VTE prophylaxis data field received some form of VTE prophylaxis.Use of VTE prophylaxis ranged from 48.6%to 94.8%of patients between units.In-hospital death was recorded in<1%of patients(n=33).After adjusting for confounders,receiving VTE prophylaxis was associated with a decrease in the adjusted odds of in-hospital mortality(adjusted odds ratio=0.21;95%CI,0.07–0.63;p=0.006).Conclusions:Variation in the use of VTE prophylaxis was observed between the units,and prophylaxis use was associated with a decrease in the odds of mortality.These findings provide an opportunity to engage with units to further explore differences in prophylaxis use and develop future best practice guidelines.Lincoln M.Tracy Peter A.Cameron Yvonne Singer Arul Earnest Fiona Wood Heather Cleland Belinda J.Gabbe 2021Burns & Trauma2021,9,1:2
8ITRS 2006中的重要变化显示文摘支年12月发布的ITRS 2006修正版,基本未对主要版本ITRS 2005做过多的修改。不过有一个例外就是增加双重图形作为潜在的45nm光刻解决方案(参见本刊《不改变光刻波长实现45nm半节距》一文)。另一个重要的变化出现在前段工艺和工艺集成领域。Peter Singer(编) 2007集成电路应用2007,24,4:2
9Cu/低k对45和32nm节点的挑战显示文摘半导体产业正处于限制等比例缩小的基本物理规则开始挑战铜互连技术可扩展性的非常时期。它们包括表面界面所引起的电迁移,基于电子波长与互连尺寸相对大小的电子散射,以及介质常数、电学特性和机械强度等方面的物理极限。这些是Semiconductor Intemationa]最近主办的webcast所得出的主要结论,Dan Edelstein(IBM)、Rudi Cartuyvels(IMEC)、Sitaram Arkalgud(Sematech).Gurtej Sandhu(Micron)和Jim Ryan(Albany NanoTech)等几位专家参与讨论了互连对未来逻辑和存储器件的挑战。Peter Singer 2007集成电路应用2007,24,1:2
10Vascular endothelial growth factor and basic fibroblast growth factor expression in esophageal adenocarcinoma and Barrett esophagus显示文摘Reginald V.N. Lord Ji Min Park Kumari Wickramasinghe Steven R. DeMeester Stefan Oberg Dennis Salonga Jon Singer Jeffrey H. Peters Kathleen D. Danenberg Tom R. DeMeester Peter V. Danenberg 2003The Journal of Thoracic and Cardiovascular Surgery2003,,2:2
11碳纳米管:诱人的互连替代方案显示文摘碳纳米管(CNT)将在未来的片上互连制造中扮演重要的角色。CNT具有许多独特的性能,包括负载超过109A/cm^2的高密度电流的能力,这比常规导线约高三个数量级;超高的热传导率,电子能够沿着碳纳米管进行弹道式输运;以及非常好的机械强度,而且还不会发生电迁移(EM)。Peter Singer 2007集成电路应用2007,24,7:1
12Sputtering Faces New Challenges for Vias, UMB显示文摘Peter Singer 2002Semiconductor International2002,,:1
13Speciesism,Morality and Biology:A Response to Jeffrey Gray显示文摘Singer Peter 1991Psychologist1991,4,5:1
14Alternative methods for the MnO2 oxidation of codeine methyl ether to thebaine utilizing ionic liquids显示文摘Robert D Singer Peter J Scammells 2001Tetrahedmn Letters2001,42,:1
15Fulminant hepatic failure resulting from lamivudine- resistant hepatitis B virus in a renal transplant recipient:durable response after orthotopic liver transplantation on adefovir dipivoxil and hepatitis B immune globulin显示文摘Peters MG Singer G Howard T 1999Transplantation1999,68,12:1
16CONSENSUS STATEMENT: Subclinical Thyroid Dysfunction: A Joint Statement on Management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and The Endocrine Society显示文摘Hossein Gharib R Michael Tuttle H Jack Baskin Lisa H. Fish Peter A. Singer Michael T. McDermott 2005The Journal of Clinical Endocrinology & Metabolism2005,,1:1
17All animals are equal 显示文摘Peter Singer 1974Philosophic Exchange1974,,1:1
18The remembered self:emotion and memoryin personality显示文摘 Peter Salovey The Free Press0,993,:1
19The occurrence of DOX concentration halogenated acid and trihalometanes in water distribution system 显示文摘SINGER P PETER R J DELEER E W 2001Water Research2001,25,6:1
20Air Gaps:小题大作显示文摘“理论上k的最小值是1,空气就是终极低k材料,这使得airgap(空气隙)成为每个互连研究人员的梦想。但是它们会成为一个美梦还是梦魇,将取决于它们在实际应用中的行为和可靠性。”这是IMEC的Ludo Deferm在2005年三月刊的Semiconductor International上做的评论,他准确地描述了airgap的处境。Peter Singer 2007集成电路应用2007,24,9:1
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