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| 1 | Frailty is independently associated with increased hospitalisation days in patients on the liver transplant waitlist显示文摘AIM To investigate the impact of physical frailty on risk of hospitalisation in cirrhotic patients on the liver transplant waitlist.METHODS Cirrhotics listed for liver transplantation at a single centre underwent frailty assessments using the Fried Frailty Index, consisting of grip strength, gait speed, exhaustion, weight loss, and physical activity. Clinical and biochemical data including MELD score as collected at the time of assessment. The primary outcome was number of hospitalised days per year; secondary outcomes included incidence of infection. Univariable and multivariable analysis was performed using negative binomial regression to associate baseline parameters including frailty with clinical outcomes and estimated incidence rate ratios(IRR). RESULTS Of 587 cirrhotics, 64% were male, median age(interquartile range) was 60(53-64) years and MELD score was 15(12-18). Median Fried Frailty Index was 2(1-3); 31.6% were classified as frail(fried frailty ≥ 3). During 12 mo of follow-up, 43% required at least 1hospitalisation; 38% of which involved major infection.107/184(58%) frail and 142/399(36%) non-frail patients were hospitalised at least once(P < 0.001). In univariable analysis, Fried Frailty Index was associated with total hospitalisation days per year(IRR = 1.51,95%CI: 1.28-1.77; P ≤ 0.001), which remained significant on multivariable analysis after adjustment for MELD, albumin, and gender(IRR for frailty of 1.21,95%CI: 1.02-1.44; P = 0.03). Incidence of infection was not influenced by frailty.CONCLUSION In cirrhotics on the liver transplant waitlist, physical frailty is a significant predictor of hospitalisation and total hospitalised days per year, independent of liver disease severity. | Marie Sinclair Eduard Poltavskiy Jennifer L Dodge Jennifer C Lai | 2017 | World Journal of Gastroenterology2017，23，5： | 11 |
| 2 | Effect of protozoan predation on relative abundance of fast- and slow-growing bacteria 显示文摘 | Sinclair J L Alexander M | 1989 | Can J Microbiol1989，35，5： | 1 |
| 3 | Manipulation of the n-3 PUFA content of muscle and adipose tissue in lambs显示文摘 | Cooper S L Sinclair L A Wilkinson R G | 2004 | J Animal Sci2004，82，： | 1 |
| 4 | Evaluation of an evidence-based education program for pressure ulcer prevention显示文摘 | Sinclair L Berwiczonek H Thurston N | 2004 | J Wound Ostomy Continence Nurs2004，31，： | 1 |
| 5 | Effect of air-pollution control on death rates in Dublin, Ireland: an intervention study显示文摘 | Clancy L Goodman P Sinclair H | 2002 | Lancet2002，360，： | 1 |
| 6 | Ecological interactions in agroforestry systems显示文摘 | ANDERSON L S SINCLAIR F L | 1993 | Agroforestry Abstract1993，6，： | 1 |
| 7 | Dilute turbulent gas-solid flow in risers with particle-particle interactio显示文摘 | Bolio E J Mostorancos E Sinclair J L | 1995 | AIChE J1995，41，6： | 1 |
| 8 | Effect of synchronizing the rate of dietary energy and Nitrogen release on rumen fermentation and microbial protein syn- thesis in sheep显示文摘 | Sinclair L A Garnsworth P C Newbold J R | 1993 | The Journal of Agricultural Science1993，120，02： | 1 |
| 9 | Manipulation of the n-3 polyunsaturated fatty acid content of muscle and adipose tissue in lambs 显示文摘 | Cooper S L Sinclair L A Wilkinson R G | 2004 | Journal of Animal Science2004，82，： | 1 |
| 10 | Treatment of autism in young children:Behavioral intervertion and applied behavior analysis显示文摘 | Sinclair L V | 2002 | Infants & Young Children2002，14，4： | 1 |
| 11 | Tectonic forcing of longitudinal valleys in the Himalaya:morphological analysis of the Ladakh Batholith,North India显示文摘 | Jamiesona S S R Sinclair H D Kirstein L A | 2004 | Geomorphology2004，58，： | 1 |
| 12 | Ecological interactions in agrogorstry systems显示文摘 | ANDERSON L S SINCLAIR F L | 1993 | Agroforestry Abaztracts1993，6，： | 1 |
| 13 | Effect of air-pollution control on death rates in Dublin, Ireland: an intervention study显示文摘 | Clancy L Gooodman P Sinclair H | 2002 | Lanct2002，360，： | 1 |
| 14 | Manipulation of the n-3 polyunsaturated fatty acid content of muscle and adipose tissue in lambs显示文摘 | Cooper S L Sinclair L A Wilkinson R G | 2004 | J Anim Sci2004，82，： | 1 |
| 15 | Future contributions of crop modeling-from heuristics and supporting decision making to understanding genetic regulation and aiding crop improvement显示文摘 | Hammer G L Kropff M J Sinclair T R | 2002 | Eur J Agron2002，18，： | 1 |
| 16 | Trichlomacetic acid as a bio- marker of exposure to disinfection by-products in drinking water: a human exposure trial in Adelaid, Australia 显示文摘 | Froese K L Sinclair M I Hmdey S E | 2002 | Environ Health Perspect2002，110，7： | 1 |
| 17 | Production of iturin A by Bacillus amyloliquefaciens suppressing Rhizoetonia solani 显示文摘 | Yu G Y Sinclair J B Hartman G L | 2002 | Soil Biology & Biochemistry2002，34，： | 1 |
| 18 | Production of iturin A by Bacillus amloliquefaciens suppressing Rhizoctonnia solani 显示文摘 | Yu G Y Sinclair J B Hartman G L | 2002 | Soil Biology and Biochemistry2002，34，7： | 1 |
| 19 | Molecular biolo- gy of aging显示文摘 | Johnson F B Sinclair D A Guarente L | 1999 | Cell1999，96，2： | 1 |
| 20 | The effects of source credibility and message framing on exercise intentions,behavior,and attitudes:An integration of the elaboration likelihood model and prospect theory显示文摘 | Jones L W Sinclair R C Courneya K S | | 0，，： | 1 |
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