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| 1 | Malnutrition in cirrhosis:More food for thought显示文摘Malnutrition is highly prevalent in liver cirrhosis and its presence carries important prognostic implications.The clinical conditions and pathophysiological mechanisms that cause malnutrition in cirrhosis are multiple and interrelated.Anorexia and liver decompensation symptoms lead to poor dietary intake;metabolic changes characterised by elevated energy expenditure,reduced glycogen storage,an accelerated starvation response and protein catabolism result in muscle and fat wasting;and,malabsorption renders the cirrhotic patient unable to fully absorb or utilise food that has been consumed.Malnutrition is therefore a considerable challenge to manage effectively,particularly as liver disease progresses.A high energy,high protein diet is recognised as standard of care,yet patients struggle to follow this recommendation and there is limited evidence to guide malnutrition interventions in cirrhosis and liver transplantation.In this review,we seek to detail the factors which contribute to poor nutritional status in liver disease,and highlight complexities far greater than“poor appetite”or“reduced oral intake”leading to malnutrition.We also discuss management strategies to optimise nutritional status in this patient group,which target the inter-related mechanisms unique to advanced liver disease.Finally,future research requirements are suggested,to develop effective treatments for one of the most common and debilitating complications afflicting cirrhotic patients. | Brooke Chapman Marie Sinclair Paul J Gow Adam G Testro | 2020 | World Journal of Hepatology2020，12，11： | 8 |
| 2 | Metabolic response of sheep skin to a chronic infusion of a variant of insulin-like growth factor Ⅰ显示文摘 | Hocking Edwards J E Khalaf S K Sinclaire B R | 1995 | Biochem J1995，308，2： | 1 |
| 3 | Effect of protozoan predation on relative abundance of fast- and slow-growing bacteria 显示文摘 | Sinclair J L Alexander M | 1989 | Can J Microbiol1989，35，5： | 1 |
| 4 | Human CD4^+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells 显示文摘 | Hartigan-O' Connor D J Poon C Sinclair E | 2007 | J Immunol Methods2007，319，12： | 1 |
| 5 | Surgical management of posterior fossa arteriovenous malformations 显示文摘 | Sinclair J Kelly ME Steinberg GK | 2006 | Neurosurgery2006，58，42： | 1 |
| 6 | Dilute turbulent gas-solid flow in risers with particle-particle interactio显示文摘 | Bolio E J Mostorancos E Sinclair J L | 1995 | AIChE J1995，41，6： | 1 |
| 7 | Human CD4^+ regulatory T cells express lower levels of the IL-7 receptor alpha chain ( CD127 ), allowing consistent identification and sorting of live cells显示文摘 | Hartigan-O'Connor DJ Poon C Sinclair EDennis J | 2007 | J Immunol Methods2007，319，12： | 1 |
| 8 | Frequency and time-domain dielectric measurements of stem water contents in the arborescent palm, Sabal palmetto显示文摘 | Holbrook N M Burns M J Sinclair T R | 1992 | Journal of Experimental Botany1992，43，1： | 1 |
| 9 | Social tuning of the self:consequences for the self-evaluations of stereotype targets显示文摘 | Sinclair S Huntsinger J Skorinko J Hardin C D | | 0，，89： | 1 |
| 10 | Effect of synchronizing the rate of dietary energy and Nitrogen release on rumen fermentation and microbial protein syn- thesis in sheep显示文摘 | Sinclair L A Garnsworth P C Newbold J R | 1993 | The Journal of Agricultural Science1993，120，02： | 1 |
| 11 | Perfluorinated Compounds in Aquatic Organisms at Various Trophic Levels in a Great Lakes Food Chain显示文摘 | Kurunthachalam Kannan Lin Tao Ewan Sinclair Stephanie D Pastva Dave J Jude John P Giesy | 2005 | Archives of Environmental Contamination and Toxicology2005，，4： | 1 |
| 12 | Simulation of foreland basin stratigraphy using a diffusion model of mountain belt uplift and erosion:an example from the central Alps,Switzerland显示文摘 | Sinclair H D Coakley B J Allen P A Watts A B | 1991 | Tectonics1991，10，： | 1 |
| 13 | A fragment consisting of the first 204 amino-terminal amino acids of human arylamine N-acetyltransferase one(NAT1) and the first transacetylation step of catalysis显示文摘 | Sinclair J Sim E | 1997 | Biochem Pharmacol1997，53，1： | 1 |
| 14 | Basic aspects of the co-deformation of bcc/fcc materials显示文摘 | SINCLAIR C W EMBURY J D WEATHERLY G C | 1999 | Materials Science and Engineering1999，272，： | 1 |
| 15 | Toughness-strength relations in the overaged 7449 Al-baseed alloy显示文摘 | KAMP N SINCLAIR I STARINK M J | 2002 | Metall Mater Trans A2002，33，1： | 1 |
| 16 | Acquired right ventricular outflow tract obstruction in the recipient twin in twin- twin transfusion syndrome显示文摘 | Lougheed J Sinclair BG Fung Kee Fung K | 2001 | J Am Coil Cardiol2001，38，5： | 1 |
| 17 | Call to needle times after acute myocardial infarction, in urban and rural areas in northeast Scotland : prospective observational study显示文摘 | Rawles J Sinclair C Jennings K | 1998 | BMJ1998，317，8： | 1 |
| 18 | Risk Perceptions in a Resource Community and Communication Implications: Emotion, Stigma, and Identity显示文摘 | MILLER B SINCLAIR J | 2012 | Risk Analysis2012，32，3： | 1 |
| 19 | The search for units of meaning显示文摘 | Sinclair J | 1996 | Textus Ix1996，，： | 1 |
| 20 | Up-regulation of osteopontin and alphaBeta-crystallin in the normal-appearing white matter ofmultiple sclerosis: an immunohistochemical study utilizing tissue microarrays 显示文摘 | Sinclair C MirakhurM Kirk J | 2005 | Neuropathol Appl Neurobiol2005，31，3： | 1 |
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