|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Frailty is independently associated with increased hospitalisation days in patients on the liver transplant waitlist显示文摘AIM To investigate the impact of physical frailty on risk of hospitalisation in cirrhotic patients on the liver transplant waitlist.METHODS Cirrhotics listed for liver transplantation at a single centre underwent frailty assessments using the Fried Frailty Index, consisting of grip strength, gait speed, exhaustion, weight loss, and physical activity. Clinical and biochemical data including MELD score as collected at the time of assessment. The primary outcome was number of hospitalised days per year; secondary outcomes included incidence of infection. Univariable and multivariable analysis was performed using negative binomial regression to associate baseline parameters including frailty with clinical outcomes and estimated incidence rate ratios(IRR). RESULTS Of 587 cirrhotics, 64% were male, median age(interquartile range) was 60(53-64) years and MELD score was 15(12-18). Median Fried Frailty Index was 2(1-3); 31.6% were classified as frail(fried frailty ≥ 3). During 12 mo of follow-up, 43% required at least 1hospitalisation; 38% of which involved major infection.107/184(58%) frail and 142/399(36%) non-frail patients were hospitalised at least once(P < 0.001). In univariable analysis, Fried Frailty Index was associated with total hospitalisation days per year(IRR = 1.51,95%CI: 1.28-1.77; P ≤ 0.001), which remained significant on multivariable analysis after adjustment for MELD, albumin, and gender(IRR for frailty of 1.21,95%CI: 1.02-1.44; P = 0.03). Incidence of infection was not influenced by frailty.CONCLUSION In cirrhotics on the liver transplant waitlist, physical frailty is a significant predictor of hospitalisation and total hospitalised days per year, independent of liver disease severity. | Marie Sinclair Eduard Poltavskiy Jennifer L Dodge Jennifer C Lai | 2017 | World Journal of Gastroenterology2017，23，5： | 11 |
| 2 | 澳大利亚临床共识指南:儿童卒中的诊断和急性期处理显示文摘卒中是导致儿童死亡的十大原因之一,幸存的致残患儿将面临几十年的残疾生活,给患儿及其家庭带来了巨大负担。由于安全性和有效性的证据有限,以及诊断的延误,目前卒中患儿无法接受再灌注治疗。儿童卒中诊断和急性期处理的澳大利亚临床共识指南,旨在最大限度地减少临床诊疗中的不确定性,并记录与成人卒中不同的危险因素、病因和假性卒中情况的最佳证据。临床问题的阐述来自于对2007年至2017年数据库的系统检索,但仅限于英语和儿科研究。该指南应用SIGN方法和国家健康与医学研究委员会系统对证据进行筛选和分类,通过推荐、评估、发展和评价系统(GRADE系统)对推荐进行强弱分级。该指南提供了60多项基于证据的推荐,以帮助参与院前和急症处理的临床医师快速识别儿童卒中,选择最合适的初步检查方案来确定诊断、明确病因,并选择最恰当的干预措施以挽救脑组织、预防复发。同时,指南也提供了颅内压和先天性心脏病管理方面的推荐。该指南的实施需要将院前和急诊系统重组,包括建立区域性卒中网络,建立儿科卒中疾病编码,快速MRI,以及对能够提供再灌注治疗的初级儿科卒中中心进行认证。该指南能够审核治疗的基准时间线,获得急性期的干预措施及预后判断。它还将促进澳大利亚儿童卒中登记的发展,并与国际登记处建立数据联系,以便准确收集卒中发病率、治疗和结果相关的数据。 | Medley TL Miteff C Andrews I Ware T Cheung M Monagle P Mandelstam S Wray A Pridmore C Troedson C Dale RC Fahey M Sinclair A Walsh P Stojanovski S Macka MT 徐佳丽(译) 吴川杰(译) 肖潇(译) 吕俊萱(译) 张博维(译) 吉训明(译) | 2019 | 中国脑血管病杂志2019，16，4： | 9 |
| 3 | Human CD4^+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells 显示文摘 | Hartigan-O' Connor D J Poon C Sinclair E | 2007 | J Immunol Methods2007，319，12： | 1 |
| 4 | Immunization against somatotropin release inhibiting factor increases milk yield in ewes 显示文摘 | Sinclair S E Wynn P C and McDowell G H | 1990 | Aust J Agric Res1990，41，： | 1 |
| 5 | Human CD4^+ regulatory T cells express lower levels of the IL-7 receptor alpha chain(CD127),allowing consistent identification and sorting of live cells显示文摘 | Hartigan-O'Connor DJ Poon C Sinclair E | 2007 | Immunol Methods2007，319，12： | 1 |
| 6 | DNA methylation,insulin resistance, and blood pressure in offspring determined by mater- nal periconceptional B vitamin and methionine status显示文摘 | SINCLAIR K D ALLEGRUCCI C SINGH R | 2007 | Proc Nail Acad Sci USA2007，104，19： | 1 |
| 7 | Recovery of Undisturbed Highly Fractured Bench Scale (30 cm Diameter) Drilled Samples for Laboratory Investigation 显示文摘 | McDermott C Sinclair B Sauter M | 2003 | Engineering Geology2003，69，： | 1 |
| 8 | Human CD4^+ regulatory T cells express lower levels of the IL-7 receptor alpha chain ( CD127 ), allowing consistent identification and sorting of live cells显示文摘 | Hartigan-O'Connor DJ Poon C Sinclair EDennis J | 2007 | J Immunol Methods2007，319，12： | 1 |
| 9 | Social tuning of the self:consequences for the self-evaluations of stereotype targets显示文摘 | Sinclair S Huntsinger J Skorinko J Hardin C D | | 0，，89： | 1 |
| 10 | Effect of synchronizing the rate of dietary energy and Nitrogen release on rumen fermentation and microbial protein syn- thesis in sheep显示文摘 | Sinclair L A Garnsworth P C Newbold J R | 1993 | The Journal of Agricultural Science1993，120，02： | 1 |
| 11 | Classification of drainage basins according to their physical characteristics:An application for flood frequency analysis in Scotland显示文摘 | Sinclair C D | 1986 | Journal of Hydrology1986，84，： | 1 |
| 12 | Generation of carbenes during methanol conversion over brФnsted acidic aluminosilicates: a computational study 显示文摘 | Sinclair P E Catlow C R | 1997 | J Phys Chem1997，101，3： | 1 |
| 13 | Basic aspects of the co-deformation of bcc/fcc materials显示文摘 | SINCLAIR C W EMBURY J D WEATHERLY G C | 1999 | Materials Science and Engineering1999，272，： | 1 |
| 14 | Call to needle times after acute myocardial infarction, in urban and rural areas in northeast Scotland : prospective observational study显示文摘 | Rawles J Sinclair C Jennings K | 1998 | BMJ1998，317，8： | 1 |
| 15 | Ca Cu3Ti4O12:One-step internal barrier layer capacitor显示文摘 | Sinclair D C Adams T B Morrison F D | 2002 | Applied Physics Letters2002，80，12： | 1 |
| 16 | Mesenchymal stem cells and the lung显示文摘 | Sinclair K Yerkovich S T Chambers D C | 2013 | Respirology2013，18，3： | 1 |
| 17 | Release of Cr( Ⅲ ) from Cr( Ⅲ) picolinate upon metabolic activation显示文摘 | Kareus S A Kelley C Walton H S Sinclair P R | 2001 | Journal of Hzardous Materials2001，84，： | 1 |
| 18 | Up-regulation of osteopontin and alphaBeta-crystallin in the normal-appearing white matter ofmultiple sclerosis: an immunohistochemical study utilizing tissue microarrays 显示文摘 | Sinclair C MirakhurM Kirk J | 2005 | Neuropathol Appl Neurobiol2005，31，3： | 1 |
| 19 | HumanCD4 f regulatory T cells express lowers of the 11,7 receptoralpha chain ( CD127 ), allowing consistent identification andsorting of live cells显示文摘 | Hartigan-O'Connor DJ Poon C Sinclair K | 2007 | J Immunol Methods2007，319，12： | 1 |
| 20 | Predicting survival in patients with advanced disease显示文摘 | Glare P Sinclair C Downing M | | 0，，08： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员