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| 1 | Malnutrition in cirrhosis:More food for thought显示文摘Malnutrition is highly prevalent in liver cirrhosis and its presence carries important prognostic implications.The clinical conditions and pathophysiological mechanisms that cause malnutrition in cirrhosis are multiple and interrelated.Anorexia and liver decompensation symptoms lead to poor dietary intake;metabolic changes characterised by elevated energy expenditure,reduced glycogen storage,an accelerated starvation response and protein catabolism result in muscle and fat wasting;and,malabsorption renders the cirrhotic patient unable to fully absorb or utilise food that has been consumed.Malnutrition is therefore a considerable challenge to manage effectively,particularly as liver disease progresses.A high energy,high protein diet is recognised as standard of care,yet patients struggle to follow this recommendation and there is limited evidence to guide malnutrition interventions in cirrhosis and liver transplantation.In this review,we seek to detail the factors which contribute to poor nutritional status in liver disease,and highlight complexities far greater than“poor appetite”or“reduced oral intake”leading to malnutrition.We also discuss management strategies to optimise nutritional status in this patient group,which target the inter-related mechanisms unique to advanced liver disease.Finally,future research requirements are suggested,to develop effective treatments for one of the most common and debilitating complications afflicting cirrhotic patients. | Brooke Chapman Marie Sinclair Paul J Gow Adam G Testro | 2020 | World Journal of Hepatology2020，12，11： | 8 |
| 2 | Immunization against somatotropin release inhibiting factor increases milk yield in ewes 显示文摘 | Sinclair S E Wynn P C and McDowell G H | 1990 | Aust J Agric Res1990，41，： | 1 |
| 3 | Manipulation of the n-3 PUFA content of muscle and adipose tissue in lambs显示文摘 | Cooper S L Sinclair L A Wilkinson R G | 2004 | J Animal Sci2004，82，： | 1 |
| 4 | Manipulation of the n-3 polyunsaturated fatty acid content of muscle and adipose tissue in lambs 显示文摘 | Cooper S L Sinclair L A Wilkinson R G | 2004 | Journal of Animal Science2004，82，： | 1 |
| 5 | Basic aspects of the co-deformation of bcc/fcc materials显示文摘 | SINCLAIR C W EMBURY J D WEATHERLY G C | 1999 | Materials Science and Engineering1999，272，： | 1 |
| 6 | Fulminant hepatitis显示文摘 | SINCLAIR S WAKEFIELD A LEVY G | 1990 | SpringerSeminlmmunopathol1990，12，1： | 1 |
| 7 | Feeding tuna oil to the sow at different times during pregnancy has different effects on piglet long-chain polyunsaturated fatty acid composition at birth and subsequent growth显示文摘 | Rooke J A Sinclair A G Edwards S A | 2001 | British Journal of Nutrition2001，86，1： | 1 |
| 8 | Manipulation of the n-3 polyunsaturated fatty acid content of muscle and adipose tissue in lambs显示文摘 | Cooper S L Sinclair L A Wilkinson R G | 2004 | J Anim Sci2004，82，： | 1 |
| 9 | Future contributions of crop modeling-from heuristics and supporting decision making to understanding genetic regulation and aiding crop improvement显示文摘 | Hammer G L Kropff M J Sinclair T R | 2002 | Eur J Agron2002，18，： | 1 |
| 10 | Nonextraction orthodontic therapy:posttreatment dental and skeletal stability 显示文摘 | GLENN G SINCLAIR P M ALEXANDER R G | 1987 | Am J orthod dentofacial orthop1987，92，： | 1 |
| 11 | Light-induced colour changes of natural dyes 显示文摘 | DUFF David G SINCLAIR Roy S STIRLING David | 1977 | Stud Conserv1977，22，4： | 1 |
| 12 | Nutritionaleffects on fatal growth 显示文摘 | RobinsonJ J Sinclair K D McEvoy T G | 1999 | Animal Science1999，，68： | 1 |
| 13 | Production of iturin A by Bacillus amyloliquefaciens suppressing Rhizoetonia solani 显示文摘 | Yu G Y Sinclair J B Hartman G L | 2002 | Soil Biology & Biochemistry2002，34，： | 1 |
| 14 | Production of iturin A by Bacillus amloliquefaciens suppressing Rhizoctonnia solani 显示文摘 | Yu G Y Sinclair J B Hartman G L | 2002 | Soil Biology and Biochemistry2002，34，7： | 1 |
| 15 | Human cytomegalovirus latency alters the cellular secretome,inducing cluster of differentiation(CD)4+T-cell migration and suppression of effector function显示文摘 | Mason G M Poole E Sissons J G Wills M R Sinclair J H | 2012 | PNAS2012，109，14： | 1 |
| 16 | Nutritional effectson fetal growth显示文摘 | ROBINSON J J SINCLAIR K D MCEVOY T G | 1999 | J Anim Sci1999，68，： | 1 |
| 17 | Endoscopic laser stricturotomy and balloon dilatation for benign colorectal strictures显示文摘 | Luck A Chapuis P Sinclair G | 2001 | ANZ J Surg2001，71，10： | 1 |
| 18 | Tourism and globalization: Economic Impact in Indonesia显示文摘 | Sugiyarto G Blake A Sinclair M T | 2003 | Annals of Tourism Research2003，30，3： | 1 |
| 19 | Analysis of non-fickian transport in polymers using simplified exponential expressions显示文摘 | Peppas N | 1984 | Journal of Membrane Science1984，17，3： | 1 |
| 20 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
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