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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Attrition,abrasion,corrosion and abfraction revisited:A new perspective on tooth surface lesions显示文摘 | Grippo JO Simring M Schreiner S | 2004 | J Am Dent Assoc2004，135，8： | 1 |
| 3 | Dyspeptic symptom development after discontinuation of a proton pump inhibitor:a double-blind placebo-controlled trial显示文摘 | Niklasson A Lindstr?m L Simrén M | 2010 | Am J Gastroenterol2010，105，7： | 1 |
| 4 | Discontinuation of proton pump inhibitors in patients on longterm therapy:a double-blind,placebo-controlled trial显示文摘 | Bj?rnsson E Abrahamsson H Simrén M | 2006 | Aliment Pharmacol Ther2006，24，6： | 1 |
| 5 | Nutrient-dependent enhancement of rectal sensitivity in irritable bowel syndrome(IBS)显示文摘 | Simrén M Agerforz P Bjrnsson ES | 2007 | Neurogastroenterol Motil2007，19，1： | 1 |
| 6 | Anexaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome显示文摘 | Simrén M Abrahamsson H Bjrnsson ES | 2001 | Gut2001，48，1： | 1 |
| 7 | Food-related gastrointestinal symptoms in the irritable bowel syndrome显示文摘 | Simrén M Mansson A Langkilde AM | 2001 | Digestion2001，63，2： | 1 |
| 8 | Lipid-induced colonic hypersensitivity in the irritable bowel syndrome:the role of bowel habit,sex,and psychologic factors显示文摘 | Simrén M Abrahamsson H Bjrnsson ES | 2007 | Clin Gastroenterol Hepatol2007，5，2： | 1 |
| 9 | Functional dyspepsia:evaluation and treatment显示文摘 | Simrén M Tack J | | 0，，02： | 1 |
| 10 | Impact of dialysis on gastroesophageal reflux, dyspepsia, and proton pump inhibitor treatment in patients with chronic renal failure显示文摘 | Strid H Fjell A Simre n M | 2009 | Eur J Gastroenterol Hepatol2009，21，2： | 1 |
| 11 | Clinical trial:the effects of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome-a randomized,double-blind,controlled study显示文摘 | Simrén M Ohman L Olsson J | | 0，，02： | 1 |
| 12 | New insights into the pathogenesis and pathophysiology of irritable bowel syndrome显示文摘 | Ohman L Simrén M | 2007 | Dig Liver Dis2007，39，3： | 1 |
| 13 | The prevalence of gastrointestinal symptoms in patients with chronic renal failure is increased and associated with impaired psychological general well-being显示文摘 | Strid H Simrén M Johansson A C | | 0，，08： | 1 |
| 14 | Overuse of acid suppressant drugs in patients with chronic renal failure显示文摘 | Strid H Simrén M Bjornsson ES | 2003 | Nephrol Dial Transplant2003，18，3： | 1 |
| 15 | The AST/ALT ratio as an indicator of cirrhosis in patients with PBC显示文摘 | Nyblom H Bj(o)rnsson E Simrén M | 2006 | Liver Int2006，26，7： | 1 |
| 16 | A comparison of a short nurse-based and a long multidisciplinary version of structured patient education in irritable bowel syndrome显示文摘 | RINGSTR(O)M G ST(O)RSRUD S SIMR(E)N M | | 0，，08： | 1 |
| 17 | Pathogenesis of IBS:role of inflammation,immunity and neuroimmune interactions显示文摘 | Ohman L Simrén M | | 0，，： | 1 |
| 18 | The pulpal pocket approach: retrograde periodontitis显示文摘 | Simring M Goldberg M | 1964 | J Periodontal1964，35，1： | 1 |
| 19 | Pathogenesis of IBS:role of inflammation,immunity and neuroimmune interactions显示文摘 | hman L Simrén M | 2010 | Nature Reviews Gastroenterology and Hepatology2010，，7： | 1 |
| 20 | CD4+ CD25+ regulatory T cellsin irritable bowel syndrome patients显示文摘 | Holm6n N Isaksson S Simr^n M | 2007 | Neurogastroenterol Motil2007，19，2： | 1 |
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