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| 1 | 涎腺类乳腺分泌性癌:对25例标准RT-PCR法未能检出ETV6-NTRK3融合基因病例的进一步分子分析:4例存在ETV6-X融合基因显示文摘ETV6基因异常在肿瘤病理学已有完整描述,据文献报道不同的上皮性肿瘤和血液系统恶性肿瘤可检出多种ETV6融合基因伴侣。在涎腺肿瘤病理中,ETV6-NTRK3易位被认为是乳腺分泌性癌的特异性改变,而在其他类型的涎腺肿瘤中均木见报道。 | Skálová A Vanecek T Simpson R H 胡舜 余英豪 | 2016 | 临床与实验病理学杂志2016，32，5： | 21 |
| 2 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 3 | 移动学习的案例研究及内容分析——以mGage项目为例显示文摘文章首先对移动学习在中小学课堂中的应用、移动学习的形式和信息设计进行了文献综述。在此基础上,又对美国圣地亚哥州立大学教育技术系开展的mGage项目进行了案例分析。研究者设计出一套详细的评价工具,从视觉吸引力、认知过程、资源质量等16个维度评估学生的WebQuest作品。结果显示,参加移动学习的实验组的得分明显高于对照组。统计分析表明,使用移动设备进行学习的实验组,除了在工具使用维度上具有明显优势外,在认知过程维度和资源质量维度的得分也胜过对照组。文章最后对研究进行了反思总结并展望了下一阶段的研究工作,以期为移动学习进入中小学课堂提供有意义的借鉴。 | 王敏娟 Toni Barone Scott Simpson Victor Leister | 2011 | 现代教育技术2011，21，8： | 14 |
| 4 | 涎腺类乳腺分泌性癌:采用标准RT-PCR法未能检出25例ETV6-NTRK3融合基因的进一步分子分型(4例存在ETV6-X融合基因)显示文摘ETV6基因异常在肿瘤病理学中已有完整描述。据文献报道,不同的上皮性肿瘤和血液系统恶性肿瘤可检出多种ETV6融合基因伴侣。在涎腺肿瘤病理中,ETV6-NTRK3易位被认为是类乳腺分泌性癌(MASC)的特异性改变,而在其他类型的涎腺肿瘤中均未见报道。 | Skálová A Vanecek T Simpson R H 胡舜 余英豪 | 2016 | 临床与实验病理学杂志2016，32，3： | 13 |
| 5 | 原发性卵巢功能不全与卵巢早衰的病因学研究进展显示文摘目前,卵巢早衰(premature ovarian failure,POF)是被广泛接受和应用的专业术语,通常是指女性40岁之前闭经,伴有高卵泡刺激素(FSH)和低雌激素水平。由于临床治疗很棘手,如何预防和预测POF的发生风险,成为临床医生关注的焦点。尽管在POF发病机制的探讨中,染色体结构或数目异常、自身免疫功能、医源性及环境等相关因素与POF发病的相关性研究已取得很大进展,但仍有部分POF患者的病因不清,称为“特发性POF”。 | 陈子江 秦莹莹 Simpson J.L. | 2008 | 中华妇产科杂志2008，43，12： | 13 |
| 6 | Role of inflammation and infection in the pathogenesis of human acute liver failure: clinical implications for monitoring and therapy显示文摘Acute liver failure is a rare and devastating clinical condition. At present, emergency liver transplantation is the only life-saving therapy in advanced cases, yet the feasibility of transplantation is affected by the presence of systemic inflammation, infection and resultant multiorgan failure. The importance of immune dysregulation and acquisition of infection in the pathogenesis of acute liver failure and its associated complications is now recognised. In this review we discuss current thinking regarding the role of infection and inflammation in the pathogenesis of and outcome in human acute liver failure, the implications for the management of such patients and suggest directions for future research. | Mhairi C Donnelly Peter C Hayes Kenneth J Simpson | 2016 | World Journal of Gastroenterology2016，22，26： | 13 |
| 7 | Demand response:a strategy to address residential air-conditioning peak load in Australia显示文摘Rapid growth in electricity network peak demand is increasing pressure for new investment which may be used for only a few hours a year.Residential airconditioning is widely believed to be the prime cause of the rise in peak demand but,in the absence of detailed residential demand research,there is no bottom-up empirical evidence to support this supposition or to estimate its impact.This paper first examines the developments in network peak demand,at a national,network distribution,and local distribution feeder level to show recent trends in peak demand.Secondly,this paper applies analytics to the half-hourly consumption data of a sample of Ausgrid’s interval metered customers,combined with local weather data,to develop an algorithm which can recognize air-conditioner use and can identify consumption patterns and peak load.This estimate is then compared to system peaks to determine residential airconditioning’s impact on overall demand.Finally,this paper considers the future impacts of air-conditioning load on peak demand as penetration rates reaches saturation levels and new minimum energy performance standards take effect reducing new units peak impacts. | Robert SMITH Ke MENG Zhaoyang DONG Robert SIMPSON | 2013 | Journal of Modern Power Systems and Clean Energy2013，1，3： | 10 |
| 8 | 急性阑尾炎显示文摘截止至 2 0 0 2年 6月 ,有关阑尾炎治疗的临床证据如下 :①辅助性抗生素治疗 :1项RCT和 1项回顾性RCT发现 ,经阑尾切除术的复杂性和单纯性阑尾炎的成人和儿童 ,预防性使用抗生素可显著减少伤口感染和腹腔内脓肿。②辅助性抗生素治疗 (儿童复杂性阑尾炎 ) :1项系统评价的亚组分析发现 ,使用抗生素可显著减少伤口感染。③辅助性抗生素治疗 (儿童单纯性阑尾炎 ) :1项系统评价的亚组分析发现 ,使用抗生素不减少伤口感染。 1项儿童单纯性阑尾炎的回顾性RCT发现 ,预防性使用抗生素不能减少伤口感染 ,但该RCT的样本量太小 ,不能排除有临床差别。④抗生素治疗和手术 :1项成人疑诊阑尾炎的RCT发现 ,与手术治疗比较 ,抗生素保守治疗可减少治疗开始后 12h到 10d的疼痛和吗啡的使用。但采取抗生素保守治疗的患者有 35 %在 1年内再次因急性阑尾炎入院 ,并行阑尾切除术。⑤腹腔镜手术和开腹手术 (成人 ) :1项系统评价发现 ,腹腔镜手术可以减少伤口的感染 ,减轻手术后第 1天的疼痛 ,减少住院时间以及恢复工作的时间 ,但增加手术后腹腔内脓肿的发生。⑥腹腔镜手术和开腹手术 (儿童 ) :1项系统评价发现 ,腹腔镜手术可以减少伤口的感染 ,减少住院时间 ,但不能减轻手术后第 1天的疼痛 ,不能减少恢复的时间和腹腔内脓肿的发? | John Simpson William Speake 王慧 周焱 董碧蓉 | 2004 | 中国循证医学杂志2004，4，5： | 10 |
| 9 | Press-pack IGBTs for HVDC and FACTS显示文摘The popularity of insulated gate bipolar transistors(IGBTs)for use in high-voltage direct current(HVDC)transmission and flexible AC transmission systems(FACTS)is increasing.Unfortunately,for these applications wire-bond IGBT technology has a number of shortcomings,such as insufficient current ratings for the most powerful schemes,and inability to fail to short-circuit.Press-pack IGBT technology,conversely,offers increased current ratings,and an inherent short-circuit failure mode,making it a more attractive choice for HVDC and FACTS.However,the design and manufacture of these devices requires a comprehensive understanding of the unique technical challenges,which differ markedly from those for wirebond modules or traditional pressure contact devices.Specific challenges include providing a high degree of mechanical protection for the IGBT chip against normal operating stresses.Furthermore,it is essential to achieve uniform contact pressure across each chip surface to ensure optimum performance.To achieve this,manufacturers have designed products that use rigid copper electrodes manufactured to tighter tolerances than for other pressure contact devices,such as thyristors,and products that use compliant electrodes,incorporating spring assemblies.Dynex is in the advanced stages of development of press-pack IGBT technology with demonstrated robust solutions for the technical challenges outlined in this paper.Design success has been achieved through the use of state-of-the-art simulations in conjunction with a long history of manufacturing expertise for bipolar and IGBT products.Finally,multiple press-pack IGBT variants are currently undergoing evaluation tests prior to product release. | Robin Simpson Ashley Plumpton Michael Varley Charles Tonner Paul Taylor Xiaoping Dai | 2017 | CSEE Journal of Power and Energy Systems2017，3，3： | 10 |
| 10 | Digital Earth 2020:towards the vision for the next decade显示文摘This position paper is the outcome of a brainstorming workshop organised by the International Society for Digital Earth(ISDE)in Beijing in March 2011.It argues that the vision of Digital Earth(DE)put forward by Vice-President Al Gore 13 years ago needs to be re-evaluated in the light of the many developments in the fields of information technology,data infrastructures and earth observation that have taken place since.The paper identifies the main policy,scientific and societal drivers for the development of DE and illustrates the multi-faceted nature of a new vision of DE grounding it with a few examples of potential applications.Because no single organisation can on its own develop all the aspects of DE,it is essential to develop a series of collaborations at the global level to turn the vision outlined in this paper into reality. | Max Craglia Kees de Bie Davina Jackson Martino Pesaresi Gabor Remetey-Fulopp Changlin Wang Alessandro Annoni Ling Bian Fred Campbell Manfred Ehlers John van Genderen Michael Goodchild Huadong Guo Anthony Lewis Richard Simpson Andrew Skidmore Peter Woodgate | 2012 | International Journal of Digital Earth2012，5，1： | 8 |
| 11 | Photochemical smog in China:scientific challenges and implications for air-quality policies显示文摘INTRODUCTION Severe air-pollution events in many parts of China pose a major threat to health and ecosystems[1].China’s air pollution is concentrated to economically developed areas,such as Beijing–Tianjin–Hebei(BTH)and Pearl–River–Delta(PRD)[2,3].The situation has received considerable attention in | Mattias Hallquist John Munthe Min Hu Tao Wang Chak K Chan Jian Gao Johan Boman Song Guo Asa M Hallquist Johan Mellqvist Jana Moldanova Ravi K Pathak Jan BC Pettersson Hakan Pleijel David Simpson Marie Thynell | 2016 | National Science Review2016，3，4： | 8 |
| 12 | 影响林木种子贮藏的因素(英文)显示文摘为了每年提供造林新需的具有生活力的种子及长期保存种质资源,贮藏种子是必要的手段。种子寿命具有遗传性,且因树种而异。种子的贮藏特性可以分成5类:正常型、亚正常型、温带顽拗型、热带顽拗型和中间型。种子含水量和贮藏温度是影响种子贮藏是否成功的两个最重要因素。但因树种及其贮藏特性不同,种子含水量和贮藏温度的最适值也不同。为了保持正常型和亚正常型种子的生活力,这类种子必须密封贮藏;但对顽拗型种子,因其需要保持种子的代谢活性及要进行有氧呼吸,则需要气体交换。 | Ben S P Wang J Dale Simpson | 2006 | 南京林业大学学报(自然科学版)2006，30，1： | 8 |
| 13 | 乳腺柱状细胞病变显示文摘 | Simpson PT Gale T Reis-Filho JS 魏兵(摘译) 步宏(审校) | 2005 | 临床与实验病理学杂志2005，21，5： | 6 |
| 14 | Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice显示文摘雌激素缺乏调停变老,但是内在的机制尚待充分坚定。我们这里报导 aromatase 的指向的混乱在老鼠引起的雌激素缺乏在 vivo 在肾上腺导致 telomerase 活动的重要抑制。基因表示分析证明当雌激素不在时, telomerase 颠倒 transcriptase (TERT ) 基因表示在肾上腺外皮和肾的萎缩与损害房间增长联合被减少。在 c 工具包积极的干细胞被识别在肾的外皮的实质占据。telomeres 的分析表明那雌激素缺乏比那在肾的外皮导致显著地更短的 telomeres 在野类型(WT ) 控制鼠标。为了推进,建立雌激素的原因的效果,我们在这些雌激素缺乏的动物进行了雌激素代替治疗。为 3 个星期的雌激素的管理在雌激素缺乏的老鼠恢复 TERT 基因表示, telomerase 活动和房间增长。因此,我们第一次,那雌激素缺乏在 vivo 在鼠标的肾上腺引起 TERT 基因表示, telomerase 活动, telomere 维护,和房间增长的抑制的数据表演,建议那 telomerase 抑制并且 telomere 弄短可以调停在肾上腺的房间增长拘捕,因此贡献雌激素在生理的条件下面的导致缺乏的老化。 | Sharyn Bayne Margaret EE Jones He Li Alex R Pinto Evan R Simpson Jun-Ping Liu | 2008 | Cell Research2008，18，11： | 6 |
| 15 | Mapping QTL associated with Verticillium dahliae resistance in the cultivated strawberry(Fragaria×ananassa)显示文摘A biparental cross of octoploid strawberry segregating for resistance to Verticillium dahliae,the causative agent of Verticillium wilt,was screened under field conditions for three seasons.Average wilt scores were significantly associated with multiple QTL,which were mostly significant across all years.Markers significantly associated with the traits were used to screen material with known wilt resistance and susceptibility phenotypes.A clear and statistically significant relationship was observed between resistant,tolerant and susceptible material and the total number of markers present in the different resistance classes.In field situations resistance QTL appear to behave in an additive manner.These markers are abundant in the cultivated strawberry germplasm indicating that,despite the large number of markers,clear genetic gain is possible through marker-assisted breeding. | L Antanaviciute NŠurbanovski N Harrison K J McLeary D W Simpson F Wilson D J Sargent R J Harrison | 2015 | Horticulture Research2015，2，1： | 5 |
| 16 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 17 | HMB-45在普通型子宫平滑肌肉瘤中的表达显示文摘 | Simpson K W Albores-Saavedra J 付长霞(摘译) 张仁亚(审校) | 2007 | 临床与实验病理学杂志2007，23，3： | 5 |
| 18 | 胰腺实性-假乳头状肿瘤透明细胞变异型显示文摘 | Albores-Saavedra J Simpson K W Bilello S J 潘敏鸿(摘译) 饶秋(摘译) 周晓军(审校) | 2006 | 临床与实验病理学杂志2006，22，6： | 5 |
| 19 | Hepatitis E virus in patients with acute severe liver injury显示文摘AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit.METHODS: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain reaction.RESULTS: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient died from sepsis and liver failure precipitated as a result of hepatitis E infection and previously undiagnosed cirrhosis. Histopathology data to date is limited to mainly that seen for endemic HepE. All patients, with the exception of patient 1, demonstrated characteristics of HepE infection, as seen in previously described locally acquired cases.CONCLUSION: In patients with acute severe liver injury, HEV testing should be part of the initial diagnostic investigation algorithm irrespective of suspected initial diagnosis, age or travel history. | Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy Janice Davidson Harry R Dalton Linda Scobie | 2014 | World Journal of Hepatology2014，6，6： | 4 |
| 20 | Expression levels of aminopeptidase-N genes in the lightbrown apple moth, Epiphyas postvittana显示文摘tortricid 蛾 Epiphyas postvittana 的五 aminopeptidase-N 基因(EpAPN1-5 ) 从一副中间的内脏被孤立表示顺序标签(EST ) 图书馆。这些基因的相对 RNA 表示被量的反向的抄写聚合酶链反应作为引用基因用肌动朊测量。大小在第五个中间形态幼虫的各种各样的纸巾上被做,在生命周期并且在不同饮食的条件下面的所有舞台上:不同蛋白质来源和层次,并且在胰岛素和 metalloprotease 禁止者的存在。为所有五基因的基因表示在中间的内脏织物是最大的,但是也在后部的内脏被检测,胖身体并且肾小体小管。EpAPN4 是一致地最高表示了,与 EpAPN3 在大约半那水平;EpAPN5 是表示的最少。高,在幼虫的阶段期间,表示通常在中间形态上正在增加,在象出生不满一月的婴儿或第一中间形态的一座早山峰以后。在另外的生活阶段的表示低得多。男性和女性在蛹、成年的阶段显示出不同表示:女表示在蛹是更高的,这在成年人逆行。基因表示层次和比率两个都随着饮食变化了。一本自然苹果叶食谱压抑层次。有最损害的氨基酸平衡的食谱导致了最大的变化;通常, EpAPN1 由最大的比例增加了。朊酶禁止者的增加也增加了基因表示,并且胰岛素禁止者增加,被显示出到两倍 aminopeptidase 活动,也加倍基因表示的层次,是引人注目的。 | Robert M. Simpson Joanne Poulton Ngaire P. Markwick | 2008 | Insect Science2008，15，6： | 4 |
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