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205篇 您的检索式:作者名="Simons L H"
    题名 作者 年代 出处 被引量
1Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study显示文摘Laurent Beaugerie Nicole Brousse Anne Marie Bouvier Jean Frédéric Colombel Marc Lémann Jacques Cosnes Xavier Hébuterne Antoine Cortot Yoram Bouhnik Jean Pierre Gendre Tabassome Simon Marc Maynadié Olivier Hermine Jean Faivre Fabrice Carrat 2009The Lancet . 2009 (9701)2009,,:4
2Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion显示文摘Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEC). Recent evidence suggests that LSEC coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI.Yuri L Boteon Richard Laing Hynek Mergental Gary M Reynolds Darius F Mirza Simon C Afford Ricky H Bhogal 2017World Journal of Gastroenterology2017,23,48:4
3Quantitative Gas-Chromatographic Determination of Pentaerythritol and its By-Products by Direct Oximation and then Silyation of Aqueous Solutions显示文摘Simon C D Comninos H Cornish L 1993Journal of Chromatographic Science1993,31,6:2
4Impact of machine perfusion of the liver on post-transplant biliary complications: A systematic review显示文摘AIM To review the clinical impact of machine perfusion(MP) of the liver on biliary complications post-transplantation, particularly ischaemic-type biliary lesions(ITBL). METHODS This systematic review was performed in accordance with the Preferred Reporting Systematic Reviews and MetaAnalysis(PRISMA) protocol. The following databases were searched: PubMed, MEDLINE and Scopus. The keyword 'liver transplantation' was used in combination with the free term 'machine perfusion'. Clinical studies reporting results of transplantation of donor human livers following ex situ or in situ MP were analysed. Details relating to donor characteristics, recipients, technique of MP performed and post-operative biliary complications(ITBL, bile leak and anastomotic strictures) were critically analysed.RESULTS Fifteen articles were considered to fit the criteria for this review. Ex situ normothermic MP was used in 6 studies, ex situ hypothermic MP in 5 studies and the other 4 studies investigated in situ normothermic regional perfusion(NRP) and controlled oxygenated rewarming. MP techniques which have per se the potential to alleviate ischaemia-reperfusion injury: Such as hypothermic MP and NRP, have also reported lower rates of ITBL. Other biliary complications, such as biliary leak and anastomotic biliary strictures, are reported with similar incidences with all MP techniques. There is currently less clinical evidence available to support normothermic MP as a mitigator of biliary complications following liver transplantation. On the other hand, restoration of organ to full metabolism during normothermic MP allows assessment of hepatobiliary function before transplantation, although universally accepted criteria have yet to be validated.CONCLUSION MP of the liver has the potential to have a positive impact on post-transplant biliary complications, specifically ITBL, and expand extended criteria donor livers utilisation.Yuri L Boteon Amanda PCS Boteon Joseph Attard Lorraine Wallace Ricky H Bhogal Simon C Afford 2018World Journal of Transplantation2018,8,6:2
5Toxicity of oxysterols to human monocyte-macrophages显示文摘Katharine C Simon J H Keri L H 1995Atherosclerosis1995,118,:1
6Lensed fiber-array assembly with individu- al fiber fine positioning in the submicrometer range 显示文摘Johan H C van Zantvoort Simon G L Plukker Erwin C A Dekkers 2006IEEE Selected Topics in Quantum Electronics2006,12,05:1
7Making use of dif- ference: Diversity, debate, and decision comprehensive-ness in top management teams显示文摘Simons T Pelled L H Smith K A 1999Academy of Man- agement Journal1999,42,6:1
8Polyethylene made with in situ supported ni-diimine/SMAO: replication phenomenon and effect of polymerization conditions on polymer microstructure and morphology 显示文摘Simon L C Patel H Soares J B P 2001Macromol Chem Phys2001,202,17:1
9Spin Sta-bilized Magnetic Levitation显示文摘Simon M D H eflinger L O Ridgway S L 0,,:1
10Perspective on future role of biological markers in clinical therapy trials of Alzheimer's dis- ease : A long-range point of view beyond 2020 显示文摘Harald H Simone L Stefan JT 2014Biochem Pharmacol2014,88,4:1
11Premixed rapid-setting calcium phosphate composites for bone repair显示文摘CAREY L E XU H H K SIMON J C G 2005Biomaterials2005,26,:1
12Erosion Resistance of Nano-filled Silicone Rubber 显示文摘EI-HAG A H SIMON L C JAYARAM S H 2006IEEE Transactions on Dielectrics and Electrical Insulation2006,13,1:1
13Expanding the potentialfor waste polyvinyl alcohol 显示文摘ANDREW J H VITALY L B SIMON W B 2009Green Chemistry2009,11,:1
14A Literature Review of Low Pressure Steam Turbine Exhaust Hood and Diffuser Studies显示文摘Zoe B Grant L I Simon H 2013Journal of Engineering for Gas Turbines and Power2013,135,06:1
15Eosinophils and atopic dermatitis 显示文摘SIMON D BRAATHEN L R SIMON H U 2004Allergy2004,59,6:1
16Joint carrier frequency offset and channel estimation for OFDM systems via the EM algorithm in the presence of very high mobility显示文摘Simon E P Ros L Hijazi H 0,,02:1
17Chemical composition of slime from three species of myxomycetes显示文摘Simon H L Henney H R 1970FEBS Lett1970,7,:1
18Effects of annealing on gelatinization and microstructures of corn starches with different amylose/amylopectin ratios显示文摘Liu H S Yu L Simon G 2009Carbohydrate Polymers2009,77,3:1
19Predicting driver drowsiness using vehicle measures: Recent insights and future challenges显示文摘Charles C L Simon G H Michael G L 2009Journal of Safety Research2009,40,4:1
20The Influence of Inlet A- symmetry on Steam Turbine Exhaust Hood Flows显示文摘Zoe B Simon H Grant L I 2013Journal of Engineering for Gas Turbines and Power2013,136,04:1
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