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| 1 | PP2 and piceatannol inhibit PrP106-126-induced iNOS activation mediated by CD36 in BV2 microglia显示文摘Prion 疾病是人和动物的一组能递送的致命的 neurodegenerative 混乱,包括牛的海绵状的 encephalopathy, scrapie,和 CreutzfeldtJakob 疾病。Microglia,中央神经系统的居民巨噬细胞,对病理学的织物改变精致地敏感,改变他们的形态学和显型采用一个所谓的激活的状态并且执行免疫学的响应 pathophysiological 大脑侮辱工作。尽管最近的调查结果提供了珍贵卓见进角色 microglia,在在 prion 观察的 proinflammatory 事件玩,为这些回答的开始负责的细胞内部的发信号分子尚待被阐明。看起来 microglial 激活包含 PrP106126 绑定和象 CD36 和 integrins 那样的房间表面免疫者和粘附分子的激活与象 Fyn 那样的 Src 家庭酷氨酸 kinases 的随后的招募, Lyn,和 Syk kinases。在现在的学习,我们证明 CD36 涉及导致 PrP106126 的 microglial 激活并且 PP2 和 piceatannol (照片) 能废除毒害神经的 prion 在 microglia 的导致肽的可诱导的氮的氧化物 synthase 激活。这些调查结果作为 Src 家庭 kinase Fyn 和涉及毒害神经的 prion peptidesmicroglia 相互作用的酷氨酸 kinase Syk 禁止者揭开 PP2 和照片的一个以前未被认出的角色,因此提供新卓见进由毒害神经的 prion 肽位于 microglia 的激活下面的机制。 | Siming Zhang Lifeng Yang Mohammed Kouadir Rongrong Tan Yun Lu Jiaxin Chang Binrui Xu Xiaomin Yin Xiangmei Zhou Deming Zhao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 2 |
| 2 | Effect of microwaves on rice quality显示文摘 | Siming Zhao Shanbai Xiong Chengguang Qiu Yongliang Xu | 2007 | Journal of Stored Products Research2007，，4： | 1 |
| 3 | Severe airflow obstruction and eosinophilic lung disease after Stevens-Johnson syndrome显示文摘 | Shah AP Xu H Sime PJ | 2006 | Eur Respir J2006，28，6： | 1 |
| 4 | Diffusion kinetics of sodium chloride in Grass carp muscle and its diffusion anisotropy显示文摘 | Qiuliang Zhang Shanbai Xiong Ru Liu Jin Xu Siming Zhao | 2011 | Journal of Food Engineering2011，，3： | 1 |
| 5 | Hybrid Differential Evolution for Estimation of Kinetic Parameters for Biochemical Systems显示文摘Determination of the optimal model parameters for biochemical systems is a time consuming iterative process. In this study, a novel hybrid differential evolution (DE) algorithm based on the differential evolution technique and a local search strategy is developed for solving kinetic parameter estimation problems. By combining the merits of DE with Gauss-Newton method, the proposed hybrid approach employs a DE algorithm for identifying promising regions of the solution space followed by use of Gauss-Newton method to determine the optimum in the identified regions. Some well-known benchmark estimation problems are utilized to test the efficiency and the robustness of the proposed algorithm compared to other methods in literature. The comparison indicates that the present hybrid algorithm outperforms other estimation techniques in terms of the global searching ability and the convergence speed. Additionally, the estimation of kinetic model parameters for a feed batch fermentor is carried out to test the applicability of the proposed algorithm. The result suggests that the method can be used to estimate suitable values of model parameters for a complex mathematical model. | ZHAO Chao XU Qiaoling LIN Siming LI Xuelai | 2013 | Chinese Journal of Chemical Engineering2013，21，2： | 1 |
| 6 | Yin yang 1 is a novel regu- lator of pulmonary fibrosis 显示文摘 | Lin X Sime PJ Xu H | 2011 | Am J Respir Crit Care Med2011，183，12： | 1 |
| 7 | Temperature‑Gated Light‑Guiding Hydrogel Fiber for Thermoregulation During Optogenetic Neuromodulation显示文摘With the rise of optogenetic manipulation of neurons,the effects of optogenetic heating on temperature-sensitive physi-ological processes,and the damage to surrounding tissues have been neglected.This manuscript reports the fabrication of a highly temperature-sensitive semi-interpenetrating optical hydrogel fiber(TSOHF)using the integrated dynamic wet-spinning technique.TSOHF exhibits a structural tunable diameter,clear core/sheath structure,tunable temperature-sensitivity,excellent light propagation property(0.35 dB cm^(-1),650 nm laser light),and good biocompatibility(including tissue-like Young’s modulus,stable dimensional stability,and low cytotoxicity).Based on these properties,a potential application of optogenetic regulation of neural tissue(hypoglossal nerve),with controllable temperature using TSOHF was designed and performed.Further,this work provides new insight into molecular design and a practical approach to continually manufacture a temperature-sensitive hydrogel optical fiber for applications in intelligent photomedicine. | Guoyin Chen Siming Xu Qiangqiang Zhou Yuejiao Zhang Yuhan Song Jing Mi Yuehua Liu Kai Hou Jie Pan | 2023 | Advanced Fiber Materials2023，5，3： | 0 |
| 8 | Nerve transfer with 3D-printed branch nerve conduits显示文摘Background:Nerve transfer is an important clinical surgical procedure for nerve repair by the coaptation of a healthy donor nerve to an injured nerve.Usually,nerve transfer is performed in an end-to-end manner,which will lead to functional loss of the donor nerve.In this study,we aimed to evaluate the efficacy of 3D-printed branch nerve conduits in nerve transfer.Methods:Customized branch conduits were constructed using gelatine-methacryloyl by 3D print-ing.The nerve conduits were characterized both in vitro and in vivo.The efficacy of 3D-printed branch nerve conduits in nerve transfer was evaluated in rats through electrophysiology testing and histological evaluation.Results:The results obtained showed that a single nerve stump could form a complex nerve network in the 3D-printed multibranch conduit.A two-branch conduit was 3D printed for transferring the tibial nerve to the peroneal nerve in rats.In this process,the two branches were connected to the distal tibial nerve and peroneal nerve.It was found that the two nerves were successfully repaired with functional recovery.Conclusions:It is implied that the two-branch conduit could not only repair the peroneal nerve but also preserve partial function of the donor tibial nerve.This work demonstrated that 3D-printed branch nerve conduits provide a potential method for nerve transfer. | Jing Zhang Jie Tao Hao Cheng Haofan Liu Wenbi Wu Yinchu Dong Xuesong Liu Maling Gou Siming Yang Jianguo Xu | 2022 | Burns & Trauma2022，10，1： | 0 |
| 9 | An Optimized Constraint Decomposition Method in Concurrent Engineering显示文摘In order to facilitate solution, a complex problem is normally decomposed into many small sub-problems during product development process. Teams are formed to resolve each sub-problem. The original problem is resolved from solutions of sub-problems. Ideally, sub-problems are not only mutually independent but also inherent parameters of original problem. Solution of original problem can be directly derived from the collection of solutions from simplified sub-problems. In practice, the degree of interdependency is indeed reduced, sub-problems are neither totally independent nor all inherent parameters of original problem. This paper discusses team coordination under this condition and design solution from each team, which not only satisfies total requirements but also is an optimal one. The suggested optimized constraint decomposition method will insure workable Pareto solution. | 常天庆 Xu Wensheng Xiong Guangleng Xing Siming | 2003 | High Technology Letters2003，9，2： | 0 |
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