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| 1 | How aerosol direct effects influence the source contributions to PM2.5 concentrations over Southern Hebei, China in severe winter haze episodes显示文摘 | Litao Wang Joshua S. Fu Wei Wei Zhe Wei Chenchen Meng Simeng Ma Jiandong Wang | 2018 | Frontiers of Environmental Science & Engineering2018，12，3： | 2 |
| 2 | Epidemiological Characteristics of Influenza A and B in Macao,2010–2018显示文摘Influenza is one of the major respiratory diseases in humans.Macao is a tourist city with high density of population and special population mobility.The study on the epidemiological characteristics of influenza in Macao should bring great value for preventing influenza in tourist cities like Macao in the world.In this study,we collected a total of 104,874 samples with influenza-like illness(ILI)in Macao from 2010 to 2018.Chi-square test and binary multivariable logistic regression were used to investigate the epidemiological characteristics of influenza A and B in Macao.Among these ILI samples,the overall positive rate is 17.17%for influenza A and 6.97%for influenza B.The epidemics of influenza in three years(i.e.,2012,2017 and 2018)differ from the remaining years(i.e.,normal years).In a normal year,influenza A occurs year-round whereas influenza B is seasonal.Our research shows significant differences in influenza infections between different age groups in normal years.Interestingly,our analysis shows no significant difference between locals and tourists in influenza A and B infection in a normal year,whereas the odds of influenza A in tourists were significantly higher than those in locals in July 2017 and the odds of influenza B in tourists were significantly higher than those in locals in January–February 2012 and January–February 2018.This is possibly attributed by the policy of free vaccination to everyone in Macao.These findings should be valuable for preventing influenza in not only Macao but also the world. | HoiMan Ng Teng Zhang Guoliang Wang SiMeng Kan Guoyi Ma Zhe Li Chang Chen Dandan Wang MengIn Wong ChioHang Wong Jinliang Ni Xiaohua Douglas Zhang | 2021 | Virologica Sinica2021，36，5： | 1 |
| 3 | “Three medicines and three formulas”in COVID-19:from bench to bedside显示文摘Chinese guideline has proven effective in the fight against coronavirus disease 2019(COVID-19)during the global spread of the epidemic.Traditional Chinese medicine(TCM)is widely recognized for its effectiveness in alleviating symptoms,inhibiting disease progress,reducing mortality,and improving the cure rate of patients with COVID-19.During the pandemic,“three medicines and three formulas”(TMTFs)stood out from hundreds of others in registered clinical studies,which became highly recommended as TCM for COVID-19 treatment.The TMTFs not only effectively relieve the clinical symptoms of fever,cough,fatigue,and phlegm,but also substantially shorten the time of nucleic acid negative conversion,improve lung computed tomography imaging features and inflammation,ameliorate clinical biochemical indicators,and reduce sequelae.Their potential pharmacological mechanisms are mainly related to the crosstalk between viral toxicity,endothelial damage,cytokine storm,immune response,and microthrombus.In brief,the clinical effects and the potential mechanisms of TMTFs on COVID-19 were systematically analyzed and summarized covering the entirety of disease development,including virus invasion and replication,immune response and cytokine storm,and acute respiratory distress syndrome and multiple organ dysfunction syndrome.This review provides a theoretical basis and reference for the in-depth understanding of the positive role of TMTFs in COVID-19 treatment. | Guangxu Xiao Simeng Wang Ruijiao Wang Li Tan Shibo Ma Shuang He Guanwei Fan Yan Zhu Ming Lyu | 2023 | Acupuncture and Herbal Medicine2023，3，4： | 1 |
| 4 | Stacking monolayers at will:A scalable device optimization strategy for two-dimensional semiconductors显示文摘In comparison to monolayer(1L),multilayer(ML)two-dimensional(2D)semiconducting transition metal dichalcogenides(TMDs)exhibit more application potential for electronic and optoelectronic devices due to their improved current carrying capability,higher mobility,and broader spectral response.However,the investigation of devices based on wafer-scale ML-TMDs is still restricted by the synthesis of uniform and high-quality ML films.In this work,we propose a strategy of stacking MoS_(2) monolayers via a vacuum transfer method,by which one could obtain wafer-scale high-quality MoS_(2) films with the desired number of layers at will.The optical characteristics of these stacked ML-MoS_(2) films(>2L)indicate a weak interlayer coupling.The stacked MLMoS_(2) phototransistors show improved optoelectrical performances and a broader spectral response(approximately 300-1,000 nm)than that of 1L-MoS_(2).Additionally,the dual-gate ML-MoS_(2) transistors enable enhanced electrostatic control over the stacked ML-MoS_(2) channel,and the 3L and 4L thicknesses exhibit the optimal device performances according to the turning point of the current on/off ratio and the subthreshold swing. | Xiaojiao Guo Honglei Chen Jihong Bian Fuyou Liao Jingyi Ma Simeng Zhang Xinzhi Zhang Junqiang Zhu Chen Luo Zijian Zhang Lingyi Zong Yin Xia Chuming Sheng Zihan Xu Saifei Gou Xinyu Wang Peng Gong Liwei Liu Xixi Jiang Zhenghua An Chunxiao Cong Zhijun Qiu Xing Wu Peng Zhou Xinyu Chen Ling Tong Wenzhong Bao | 2022 | Nano Research2022，15，7： | 0 |
| 5 | Identification of natural products as novel ligands for the human 5-HT2c receptor显示文摘 | Yao Peng Simeng Zhao Yiran Wu Haijie Cao Yueming Xu Xiaoyan Liu Wenqing Shui Jianjun Cheng Suwen Zhao Ling Shen Jun Ma Ronald J. Quinn Raymond C. Stevens Guisheng Zhong Zhi-Jie Liu | 2018 | Biophysics Reports2018，4，1： | 0 |
| 6 | Atractylenolide-I covalently binds to CYP11B2,selectively inhibits aldosterone synthesis, and improves hyperaldosteronism显示文摘Hyperaldosteronism is a common disease that is closely related to endocrine hypertension and other cardiovascular diseases. Cytochrome P450 11 B2(CYP11 B2), an important enzyme in aldosterone(ALD) synthesis, is a promising target for the treatment of hyperaldosteronism. However, selective inhibitors targeting CYP11 B2 are still lacking due to the high similarity with CYP11 B1. In this study,atractylenolide-I(AT-I) was found to significantly reduce the production of ALD but had no effect on cortisol synthesis, which is catalyzed by CYP11 B1. Chemical biology studies revealed that due to the presence of Ala320, AT-I is selectively bound to the catalytic pocket of CYP11 B2, and the C8/C9 double bond of AT-I can be epoxidized, which then undergoes nucleophilic addition with the sulfhydryl group of Cys450 in CYP11 B2. The covalent binding of AT-I disrupts the interaction between heme and CYP11 B2 and inactivates CYP11 B2, leading to the suppression of ALD synthesis;AT-I shows a significant therapeutic effect for improving hyperaldosteronism. | Wenjuan Liu Zhenqiang Li Simeng Chu Xiaoyao Ma Xiaoying Wang Min Jiang Gang Bai | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 0 |
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