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| 1 | DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor显示文摘AIM: To determine the DNA binding activity and protein levels of the Ku70/80 heterodimer, the functional mediator of the NHEJ activity, in human colorectal carcinogenesis.METHODS: The Ku70/80 DNA-binding activity was determined by electrophoretic mobility shift assays in 20 colon adenoma and 15 colorectal cancer samples as well as matched normal colonic tissues. Nuclear and cytoplasmic protein expression was determined by immunohistochemistry and Western blot analysis.RESULTS: A statistically significant difference was found in both adenomas and carcinomas as compared to matched normal colonic mucosa (P<0.00). However,changes in binding activity were not homogenous with approximately 50% of the tumors showing a clear increase in the binding activity, 30% displaying a modest increase and 15% showing a decrease of the activity.Tumors, with increased DNA-binding activity, also showed a statistically significant increase in Ku70 and Ku86nuclear expression, as determined by Western blot and immunohistochemical analyses (P<0.001). Cytoplasmic protein expression was found in pathological samples,but not in normal tissues either from tumor patients or from healthy subjects.CONCLUSION: Overall, our DNA-binding activity and protein level are consistent with a substantial activation of the NHEJ pathway in colorectal tumors. Since the NHEJ is an error prone mechanism, its abnormal activation can result in chromosomal instability and ultimately lead to tumorigenesis. | Paola Mazzarelli Paola Parrella Davide Seripa Emanuela Signori Giuseppe Perrone Carla Rabitti Domenico Borzomati Armando Gabbrielli Maria Giovanna Matera Carolina Gravina Marco Caricato Maria Luana Poeta Monica Rinaldi Sergio Valeri Roberto Coppola Vito Michele Fazio | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Feasibility of robotic pancreaticoduodenectomy显示文摘 | U. Boggi S. Signori N. De Lio V. G. Perrone F. Vistoli M. Belluomini C. Cappelli G. Amorese F. Mosca | 2013 | Br J Surg2013，，7： | 3 |
| 3 | Thermal degradation of poly(lactic acid) (PLA) and poly(butylene adipate- co -terephthalate) (PBAT) and their blends upon melt processing显示文摘 | Francesca Signori Maria-Beatrice Coltelli Simona Bronco | 2008 | Polymer Degradation and Stability2008，，1： | 2 |
| 4 | Thermal degradation of poly ( lactic acid ) ( PLA ) and poly ( butylenes adipate-co- terephthalate) (PBAT) and their blends upon melt processing 显示文摘 | Francesca Signori Maria-Beatrice Cohelli Simona Bronco | 2009 | Polymer Degradation and Stability2009，94，： | 1 |
| 5 | Endothelial function in patients with slow coronary flow and normal coronary angiography 显示文摘 | SIGNORI LU QUADROS AS SBRUZZI G | 2012 | Clinics ( Sao Paulo)2012，67，6： | 1 |
| 6 | Methacholine bronchial challenge effects on nasal symptoms and function in paticnts with allergic rhinitis 显示文摘 | Cirillo I Medusei G Signori E | 2013 | Ear Atn Allergy Clin Immunol2013，45，4： | 1 |
| 7 | The price of Prato,or measuring the ID effect显示文摘 | SIGNORI LF | 1994 | Papers in Regional Science1994，，73： | 1 |
| 8 | Outcome of 118 pancreas transplants with retroperitoneal portal-enteric drainage显示文摘 | Boggi U Vistoli F Signori S | 2005 | Transplant Proc2005，37，6： | 1 |
| 9 | Feasibility of robotic pancreati- coduodenectomy显示文摘 | Boggi U Signori S de Lio N | 2013 | Br J Surg2013，100，7： | 1 |
| 10 | Prognostic implications of tumor invasion or adhesion to peripancreatic vessels in resected pancreatic cancer显示文摘 | Ugo Boggi Marco Del Chiaro Chiara Croce Fabio Vistoli Stefano Signori Carlo Moretto Gabriella Amorese Salvatore Mazzeo Carla Cappelli Daniela Campani Franco Mosca | 2009 | Surgery2009，，： | 1 |
| 11 | DNA vaccination strategies for anti-tumour effective gene therapy protocols显示文摘 | Signori E Iurescia S Massi E | 2010 | Cancer Immunol Immunother2010，59，10： | 1 |
| 12 | Miniscrew design and bone characteristics: An experimental study of primary stability 显示文摘 | Migliorati M Benedicenti S Signori A | 2012 | Am J Orthod Dentofacial Orthop2012，142，2： | 1 |
| 13 | Temporary anchorage device stability:an evaluation of thread shape factor显示文摘 | Migliorati M Signori A Silvestrini-Biavati A | 2012 | Eur J Orthod2012，34，5： | 1 |
| 14 | Incidence and distribution of deciduous molar anky- losis, a longitudinal study显示文摘 | Silvestrini Biavati A Signori A Castaldo A | 2011 | Eur J Paediatr Dent2011，12，3： | 1 |
| 15 | A combined analytical approach reveals novel EXT1/2 gene mutations in a large cohort of Italian multiple osteochondromas patients 显示文摘 | Signori E Massi E Matera MG | 2007 | Genes Chromosomes Cancer2007，46，5： | 1 |
| 16 | A somatic mutation in the 5' UTR of BRCA1 gene in sporadic breast cancer causes downmodulation of translation efficiency 显示文摘 | Signori E Bagni C Papa S | 2001 | Oncogene2001，20，33： | 1 |
| 17 | Behavioral/environmental intervention improves learning after cerebral hypoxia-ischemia in rats显示文摘 | I-Ching Chou Tatyana Trakht Carina Signori | 2001 | Stroke2001，32，9： | 1 |
| 18 | Ethical (SRI) funds in Italy:a review显示文摘 | Signori S | 2009 | Busi- ness Ethics : A European Review2009，18，2： | 1 |
| 19 | The Price of Prato, or Measuring the ID Effect 显示文摘 | SIGNORI L F | 1994 | Regional Science1994，73，： | 1 |
| 20 | Thermal degradation of poly ( lactic acid) (PLA) and poly ( butylene adipate-co-terephthalate ) ( PBAT ) and their blends upon melt processing 显示文摘 | SIGNORI F COLTELLI M B BRONCO S | 2009 | Polymer Degradation and Stability2009，94，1： | 1 |
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