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| 1 | Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion显示文摘AIM: Nitrative and oxidative DNA damage such as 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine(8-oxodG) formation has been implicated in initiation and/or promotion of inflammation-mediated carcinogenesis.The aim of this study is to clarify whether these DNA lesions participate in the progression of intrahepatic cholangiocarcinoma.METHODS: We investigated the relation of the formation of 8-nitroguanine and 8-oxodG and the expression of hypoxia-inducible factor-1α (HIF-1α) with tumor invasion in 37 patients with intra-hepatic cholangiocarcinoma.RESULTS: Immunohistochemical analyses revealed that 8-nitroguanine and 8-oxodG formation occurred to a much greater extent in cancerous tissues than in non-cancerous tissues. HIF-1α could be detected in cancerous tissues in all patients, suggesting low oxygen tension in the tumors.HIF-1α expression was correlated with inducible nitric oxide synthase (iNOS) expression (r= 0.369 and P = 0.025)and 8-oxodG formation (r = 0.398 and P = 0.015).Double immunofluorescence study revealed that iNOS and HIF-1α co-localized in cancerous tissues. Notably, the formation of 8-oxodG was correlated significantly with lymphatic invasion (r = 0.386 and P= 0.018). Moreover, 8-nitroguanine and 8-oxodG in non-cancerous tissues were associated significantly with neural invasion (P = 0.042and P = 0.026, respectively). These results suggest that reciprocal activation between HIF-1α and iNOS mediates persistent DNA damage, which induces tumor invasiveness via mutations, resulting in poor prognosis.CONCLUSION: The formation of 8-nitroguanine and 8-oxodG plays an important role in multiple steps of genetic changes leading to tumor progression, including invasiveness. | Somchai Pinlaor Banchob Sripa Ning Ma Yusuke Hiraku Puangrat Yongvanit Sopit Wongkham Chawalit Pairojkul Vajarabhongsa Bhudhisawasdi Shinji Oikawa Mariko Murata Reiji Semba Shosuke Kawanishi | 2005 | World Journal of Gastroenterology2005，11，30： | 9 |
| 2 | Sequence-Specific DNA Damage Induced by UVA Radiation in the Presence of Endogenous and Exogenous Photosensitizers显示文摘 | SHOSUKE KAWANISHI YUSUKE HIRAKU | 2001 | Curr Probl Dermatol2001，29，： | 1 |
| 3 | Behavior of Centrally Loaded Concrete-Filled SteelTube Short Columns显示文摘 | KENJI S HIROYUKI N SHOSUKE M | 2004 | Journal of Structural Engineering2004，130，2： | 1 |
| 4 | Vitamin C: Basic metabolism and its function as an index of oxidative stress 显示文摘 | Shosuke K | 2004 | Current Medicinal Chemistry2004，11，： | 1 |
| 5 | Eumelanin and phaeomelanin contents of human epidermis and cultured melanocytes显示文摘 | Gillan H Sylvia K Shosuke I | 1995 | Pigment Cell Res1995，8，4： | 1 |
| 6 | Interaction of major coat color functions in mice as studied by chemical analysis of eumelanin and pheomelanin显示文摘 | Kazumatsu M L Shosuke I | 2001 | Pigment (''ell Res2001，14，1： | 1 |
| 7 | Behavior of Centrally Loaded Concrete Filled Steel Tube Short Columns显示文摘 | Kenji S Hiroyuki N Shosuke M | 2004 | Structural Engineering2004，13，2： | 1 |
| 8 | Behavior of Centrally Loaded Concrete-Filled Steel-Tube Short Columns显示文摘 | Kenji Sakino Hiroyuki Nakahara Shosuke Morino | 2004 | Joumal of Structural Engineering2004，130，2： | 1 |
| 9 | Diterpenes from Euphorbia helioscopia显示文摘 | Shosuke Y Yoshikazu S Seiji K | 1989 | Phytochemistry1989，28，12： | 1 |
| 10 | Quantitative analysis of eumelanin and pheomelanin in human,mice,and other animals:a comparative review 显示文摘 | Shosuke Ito Kazumasa Wakamatsu | 2003 | Pigment Cell Res2003，16，： | 1 |
| 11 | Human hair mel- anins: what we have learned and have not learned from mouse coat color pigmentation 显示文摘 | Shosuke Ito and Kazumasa Wakamatsu | 2010 | Pigment Cell Melano- ma Res2010，24，： | 1 |
| 12 | RNA interference-mediated knockdown of Smad1 inhibits receptor activator of nuclear factor κB ligand expression induced by BMP-2 in primary osteoblasts显示文摘 | Yoshihiro Yoshikawa Tatsuya Yoshizawa Eisuke Domae Yohki Hieda Akira Takeyama Shuitsu Hirota Akiyo Kawamoto Seiji Goda Isao Tamura Aiko Kamada Yutaka Komasa Shosuke Morita Kazuya Yamagata Takashi Ikeo | 2015 | Archives of Oral Biology2015，，9： | 1 |
| 13 | Behavior of Centrally Loaded Concrete - Filled Steel - Tube Short Columns 显示文摘 | KENJI S HIROYUKI N SHOSUKE M etal | 2004 | Journal of Structural Engineering2004，130，2： | 1 |
| 14 | Interaction of major coat color functions in mice as studied by chemical analysis of eumelanin and pheomelanin显示文摘 | Kazumatsu M L Shosuke I | 2001 | Pigment Cell Res2001，14，1： | 1 |
| 15 | Chemical Analysis of Melanins and its Application to the Study of the Regulation of Melanogenesis显示文摘 | Shosuke Ito Kazumasa Wakamatsu Hiroyuki Ozeki | 2000 | Pig- ment Cell Research2000，13，8： | 1 |
| 16 | The eumelanin and pheomelanin contents in dorsal hairs of female recessive yellow mice are greater than in male显示文摘 | Tomohisa Hirobe Kazumasa Wakamatsu Shosuke Ito | 2007 | Journal of Dermatological Science2007，45，： | 1 |
| 17 | Reversible photoin- duced spectral transition in Eu203 -A1203 composites at room temperature 显示文摘 | Shosuke Mochizuki Hiroyuki Araki | 2003 | Physica B2003，，： | 1 |
| 18 | Behavior of Centrally Loaded Concrete Filled Steel Tube Short Columns 显示文摘 | Kenji Sakino Hiroyuki Nakahara Shosuke Morino | 2004 | Journal of Structural Engineering2004，130，2： | 1 |
| 19 | Chemical analysis of melanins and its application to the study of the regulation of melanogenesis显示文摘 | Shosuke Ito Kazumasa Wakamatsu H iroyuki Ozeki | 2000 | Pigment Cell Res2000，13，18： | 1 |
| 20 | Behavior of centrally loaded concrete filled steel tube short columns 显示文摘 | KENJI S HIROYUKIN SHOSUKE M | 2004 | Journal of Structural Engineering2004，13，2： | 1 |
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