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| 1 | Role of illness perception and self-efficacy in lifestyle modification among non-alcoholic fatty liver disease patients显示文摘AIM To describe the relationships between non-alcoholic fatty-liver disease(NAFLD) patient's disease consequences and treatment perceptions, self-efficacy, and healthy lifestyle maintenance. METHODS A cross-sectional study among 146 ultrasound diagnosed NAFLD patients who visited the fatty liver clinic at the TelAviv Medical Center. Eighty-seven of these individuals, participated in a clinical trial of physical activity and underwent fasting blood tests, analyzed at the same lab. Exclusion criteria included positivity for serum HBsA g or anti-HCV antibodies; fatty liver suspected to be secondary to hepatotoxic drugs; excessive alcohol consumption(≥ 30 g/d in men or ≥ 20 g/d in women) and positive markers of genetic or immune-mediated liver diseases. Patients were asked to complete a selfreport structured questionnaire, assembled by the Israeli Center for Disease Control. Nutrition habits were measured using six yes/no questions(0 = no, 1 = yes) adopted from the national survey questionnaire. Participants in the clinical trial completed a detailed semi-quantitative food frequency questionnaire(FFQ) reporting their habitual nutritional intake during the past year. Self-efficacy was assessed by the Self-Efficacy Scale questionnaire, emotional representation, degree of illness understanding, timeline perception, treatment perception and symptoms were measured by the Brief Illness Perception questionnaire. Illness consequences were measured by the Personal Models of Diabetes Interview questionnaire. A path analysis was performed to describe the interrelationships between the patients' illness perceptions, and assess the extent to which the data fit a prediction of nutritional habits.RESULTS The study sample included 54.1% men, with a mean age of 47.76 ± 11.68 years(range: 20-60) and mean body mass index of 31.56 ± 4.6. The average perceived nutrition habits score was 4.73 ± 1.45 on a scale between 0-6, where 6 represents the healthiest eating habits. Most of the study participants(57.2%) did not feel they fully understood what NAFLD is. Better nutritional habits were positively predicted by the degree of illness understanding(β = 0.26; P = 0.002) and selfefficacy(β = 0.25; P = 0.003). Perceptions of more severe illness consequences were related with higher emotional representation(β = 0.55; P < 0.001), which was related with lower self-efficacy(β =-0.17; P = 0.034). The perception of treatment effectiveness was positively related with self-efficacy(β = 0.32; P < 0.001). In accordance with the correlation between self-efficacy and the perceived nutrition habits score, self-efficacy was also correlated with nutrient intake evaluated by the FFQ; negatively with saturated fat(percent of saturated fat calories from total calories)(r =-0.28, P = 0.010) and positively with fiber(r = 0.22, P = 0.047) and vitamin C intake(r = 0.34, P = 0.002). In a sub analysis of the clinical trial participants, objectively measured compliance to physical activity regimen was positively correlated with the self-efficacy level(r = 0.34, P = 0.046). CONCLUSION Self-efficacy and illness understanding are major determinants of lifestyle-modification among NAFLD patients. This information can assist clinicians in improving compliance with lifestyle changes among these patients. | Shira Zelber-Sagi Shiran Bord Gali Dror-Lavi Matthew Lee Smith Samuel D Towne Jr Assaf Buch Muriel Webb Hanny Yeshua Assy Nimer Oren Shibolet | 2017 | World Journal of Gastroenterology2017，23，10： | 6 |
| 2 | New 14-mm diameter Niti-S biliary uncovered metal stent for unresectable distal biliary malignant obstruction显示文摘AIM To investigate whether an uncovered self-expandable metal stent(UCSEMS) with a large diameter could prevent recurrent biliary obstruction(RBO).METHODS Thirty-eight patients with malignant biliary obstruction underwent treatment with an UCSEMS with a 14-mm diameter(Niti-S 14). Retrospectively, we evaluated technical and functional success rate, RBO rate, time to RBO, survival time, and adverse events in these patients.RESULTS Stent placement success and functional success were achieved in all patients. Two patients(5.3%) had RBO due to tumor ingrowth or overgrowth. The median time to RBO was 190(range, 164-215) d. The median survival time was 120(range, 18-502) d. The 6-mo non-RBO rate was 91%. Other adverse events other than RBO occurred as follows: Acute cholecystitis, post-ERCP pancreatitis, hemobilia, and fever without exacerbation of liver injury, and liver abscess in 4(10.3%), 3(7.9%), 2(5.3%), 1(2.6%), and 1(2.6%), respectively. Migration of the stents was not observed.CONCLUSION Niti-S 14 is considered to be a preferable metal stent because of a low rate of RBO with no migration. | Masataka Kikuyama Naofumi Shirane Shinya Kawaguchi Shuzou Terada Tsuyoshi Mukai Ken Sugimoto | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，1： | 5 |
| 3 | Effects of heat treatment on the intermetallic compounds and mechanical properties of the stainless steel 321–aluminum 1230 explosive-welding interface显示文摘The effects of heat treatment on the microstructure and mechanical properties of intermetallic compounds in the interface of stainless steel 321 explosively bonded to aluminum 1230 were investigated in this study. Experimental investigations were performed by optical microscopy, scanning electron microscopy, and microhardness and shear tensile strength testing. Prior to heat treatment, increasing the stand-off distance between samples from 1 to 2.5 mm caused their interface to become wavy and the thickness of intermetallic layers to increase from 3.5 to 102.3 μm. The microhardness increased from HV 766 in the sample prepared at a stand-off distance of 1 mm to HV 927 in the sample prepared at a stand-off distance of 2.5 mm; in addition, the sample strength increased from 103.2 to 214.5 MPa. Heat treatment at 450°C for 6 h increased the thickness of intermetallic compound layers to 4.4 and 118.5 μm in the samples prepared at stand-off distances of 1 and 2.5 mm, respectively. These results indicated that increasing the duration and temperature of heat treatment decreased the microhardness and strength of the interface of explosively welded stainless steel 321-Al 1230 and increased the thickness of the intermetallic region. | Mohammadreza Khanzadeh Gharah Shiran Gholamreza Khalaj Hesam Pouraliakbar Mohamma dreza Jandaghi Hamid Bakhtiari Masoud Shirazi | 2017 | International Journal of Minerals,Metallurgy and Materials2017，24，11： | 4 |
| 4 | Phosphatidylserine improves axonal transport by inhibition of HDAC and has potential in treatment of neurodegenerative diseases显示文摘Familial dysautonomia(FD) is a rare children neurodegenerative disease caused due to a point mutation in the IKBKAP gene that results in decreased IKK complex-associated protein(IKAP) protein production. The disease affects mostly the dorsal root ganglion(DRG) and the sympathetic ganglion. Recently, we found that the molecular mechanisms underlying neurodegeneration in FD patients are defects in axonal transport of nerve growth factors and microtubule stability in the DRG. Neurons are highly polarized cells with very long axons. In order to survive and maintain proper function, neurons depend on transport of proteins and other cellular components from the neuronal body along the axons. We further demonstrated that IKAP is necessary for axon maintenance and showed that phosphatidylserine acts as an HDAC6 inhibitor to rescue neuronal function in FD cells. In this review, we will highlight our latest research findings. | Shiran Naftelberg Gil Ast Eran Perlson | 2017 | Neural Regeneration Research2017，12，4： | 2 |
| 5 | Ductile deformation and its geological implications for retrograded eclogites from the Hongqiyingzi Complex in Chicheng,northern Hebei,China显示文摘The rheology of rocks at depth remains a key point in earth sciences. Deformation of high-temperature–highpressure rocks from the subduction zone has not been fully studied; in particular, the deformation behavior of eclogites remains poorly understood. This research is focused on the microstructure and fabric of retrograded eclogites from the Hongqiyingzi Complex in Chicheng, north Hebei, China, based on photomicrography, scanning electron microscopy(SEM) and electron backscattered diffraction(EBSD) analysis. The analytical results show that plastic deformation occurred in the garnets during exhumation, but they do not show an obvious lattice preferred orientation(LPO). This can be interpreted as being caused by the simultaneous activation of multiple slip systems in the garnets during deformation by dislocation creep. The plagioclases have a special fabric; the(001) LPO presents a maximum in Z direction which can be correlated with a new [100](001) slip system. The misorientation angle distribution(MAD) of the plagioclases in the deformed retrograded garnet augens shows a special bimodal distribution with peaks in both a low-angle range(<40?) and a high-angle range(>140?). In the retrograded garnet augens(i.e. 'white eye socket' garnets) the maximum peak moves from a high-angle range to a low-angle range when we analyze only those plagioclases surrounding the residual garnet porphyroclast. Deformation behavior is controlled by the crystallographic orientation of the host grain and the grain boundary sliding process. Hornblendes in different layers and the retrograded garnet augens show almost the same strong LPO patterns, which are correlated with the [001](010) slip system; and MAD diagrams show a peak in a low-angle range(<40?). Integrating recent studies on metamorphism and geochronology, we argue that ductile deformation occurred during the exhumation periods together with retrograded metamorphism. | LIU ShiRan ZHANG JinJiang QI GuoWei WANG Meng | 2016 | Science China Earth Sciences2016，59，8： | 2 |
| 6 | Discriminating ability of molecular markers and morphological characterization in the establishment of genetic relationships in cultivated genotypes of almond and related wild species显示文摘A 总数 23 词法特点, 19 AFLP教材联合, 80 份 RAPD 教材和 32 SSR 教材配对被用来比较随机的放大多态的 DNA ( RAPD )的增进知识的海角和效率,在在 29 杏仁栽培变种和三相关的野种之中建立基因关系放大了碎片长度多型性( AFLP )和简单顺序重复( SSR )标记。SSR 与 AFLP 和 RAPD 相比介绍了多型性和更大的信息内容的高水平,由期望的 hetrozygosity 估计了。期望的 hetrozygosity 的最低价值为 AFLP 被获得;然而, AFLP 显示出最高的效率,由于他们揭示每反应的大量乐队的能力,它为差异的索引的各种各样的类型导致了高价值。所有三种技术很有效地区别了杏仁遗传型,除了 SSR 没能在‘ M 之间区别 onagha' 和‘ S efied' 杏仁遗传型之外。类似的关联系数为所有三个标记系统是统计上重要的,但是比为 RAPD 和 AFLP 为 SSR 数据是更低的。为所有标记, dendrogram 拓扑学的高类似被获得,尽管一些差别被观察。所有 dendrograms 包括由所有标记数据的联合使用获得了那,根据他们的地理散开为大多数栽培变种反映关系。AMOVA 检测了更多的变化在之中在每个地理组以内栽培了并且联系杏仁的野种类。自举分析表明使用的标记的数字为基因类似的可靠评价并且为标记类型的有意义的比较是足够的。 | Karim Sorkheh Behrouz Shiran Soghra Kiani Nazanin Amirbakhtiar Sadegh Mousavi Vahid Rouhi Shahram Mohammady-D Thomas M. Gradziel Lyudmyla V. Malysheva-Otto Pedro Martinez-Gomez | 2009 | Journal of Forestry Research2009，20，3： | 2 |
| 7 | A new model of bilateral hemispheric ischemia in the rat-three vessel occlusion model显示文摘 | Kameyama M Suzuki J Shirane K | 1985 | Stroke1985，16，： | 1 |
| 8 | Small cell variant of anaplastic large cell lymphoma with positive ilmnunoreactivity for CD99显示文摘 | Shiran MS Tan GC Sabariah AR | 2008 | Med J Malaysia2008，63，2： | 1 |
| 9 | Tricuspid regurgitation in mitrai valve disease incidence, prognostic implications, mechanism, and management显示文摘 | Shiran A Sagie A | 2009 | J Am Coil Cardiol2009，53，5： | 1 |
| 10 | Tricuspid regurgitation in mitral valve disease : inei- denee, prognostic implieations, mechanism and management 显示文摘 | Shiran A Sagie A | 2009 | Am Coil Cardio12009，53，5： | 1 |
| 11 | Postoperative neu- rological deterioration in pediatric moyamoya disease: watershed-shift and hyperperfusion 显示文摘 | Hayashi T Shirane R Fujimura M | 2010 | J Neurosurg Pediar2010，6，： | 1 |
| 12 | Surgical treatment of a sacral nerve root with intermittent claudication in an 85-year-old patient: case report显示文摘 | Su CC Shirane R Okubo T | 1996 | Surg Neurol1996，45，： | 1 |
| 13 | An F-box protein,FWD1,mediates ubiquitin-dependent proteolysis of beta-catenin显示文摘 | Kitagawa M Hatakeyama S Shirane M | 1999 | EMBO J1999，18，9： | 1 |
| 14 | Postoperative neuro- logical deterioration in pediatric moyamoya disease:watershed- shift and hyperperfusion 显示文摘 | Hayaski T Shirane R Fujimura M | 2010 | J Neurosurg Pediatrics2010，6，： | 1 |
| 15 | JAK2, CALR, and MPL mutation spectrum in Japanese patients with myeloproliferative neoplasms 显示文摘 | Shirane S Araki M Morishita S | 2015 | Haematologica2015，100，2： | 1 |
| 16 | Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors显示文摘 | Ishida N Shirane M | 1996 | Cell1996，85，5： | 1 |
| 17 | Polarization Rotation via a Monoclinic Phase in the Piezoelectric 92% PbZn1/3 Nb2/3 O3-8%-PbTiO3显示文摘 | Noheda B Cox D E Shirane G | 2001 | Phys Rev Lett2001，86，17： | 1 |
| 18 | Prediction of metabolic drug clearance in humans, in vitro-in vivo extrapolation vs allometdc scaling 显示文摘 | Shiran MR Proctor N J Howgate EM Rowland-Yeo K Tucker GT Rostami-Hodjegan A | 2006 | Xenobiotica2006，36，7： | 1 |
| 19 | A newmodel of bilateral hemispheric ischemia in the rat- three vessel occlusion model 显示文摘 | Suzuki J ShiraneR | 1985 | Stroke1985，16，： | 1 |
| 20 | Tricuspid regurgitation in mitral valve disease incidence,prognostic implications,mechanism,and management显示文摘 | Shiran A Sagie A | 2009 | J Am Coll Cardiol2009，53，5： | 1 |
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