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| 1 | Molecular mechanisms regulating NLRP3 inflammasome activation显示文摘Inflammasomes 是表明触发煽动性的 caspases 的激活和 interleukin-1β 的成熟的建筑群的多蛋白质;。在各种各样的 inflammasome 建筑群之中, NLRP3 inflammasome 最好被描绘并且与各种各样的人的 autoinflammatory 和自体免疫的疾病被连接了。因此, NLRP3 inflammasome 可以是为反煽动性的治疗的一个有希望的目标。在这评论,我们总结 NLRP3 inflammasome 被在 cytosol 激活的机制的当前的理解。我们也描述激活或禁止 inflammasome 汇编的 NLRP3 inflammasome 建筑群的有约束力的搭挡。我们调整 NLRP3 inflammasome 发信号的机制的知识并且这些怎么影响煽动性的回答,提供进一步的卓见进潜在的治疗学的策略治疗与 NLRP3 inflammasome 的 dysregulation 联系的煽动性的疾病。 | Eun-Kyeong Jo Jin Kyung Kim Dong-Min Shin Chihiro Sasakawa | 2016 | Cellular & Molecular Immunology2016，13，2： | 202 |
| 2 | Clinicopathologic and molecular features associated with patient age in gastric cancer显示文摘AIM: To compare characteristics and prognosis of gastric cancer based on age.METHODS: A retrospective study was conducted on clinical and molecular data from patients(n =1658) with confirmed cases of gastric cancer in Seoul National University Bundang Hospital(Seoul, South Korea) from 2003 to 2010 after exclusion of patients diagnosed with lymphoma, gastrointestinal stromal tumor, and metastatic cancer in the stomach. DNA was isolated from tumor and adjacent normal tissue,and a set of five markers was amplified by polymerase chain reaction to assess microsatellite instability(MSI). MSI was categorized as high, low, or stable if ≥ 2, 1, or 0 markers, respectively, had changed.Immunohistochemistry was performed on tissue sections to detect levels of expression of p53, human epidermal growth factor receptor(HER)-2, and epidermal growth factor receptor. Statistical analysis of clinical and molecular data was performed to assess prognosis based on the stratification of patients by age(≤ 45 and> 45 years).RESULTS: Among the 1658 gastric cancer patients, the number of patients with an age ≤ 45 years was 202(12.2%; 38.9 ± 0.4 years) and the number of patients> 45 years was 1456(87.8%; 64.1 ± 0.3 years).Analyses revealed that females were predominant inthe younger group(P < 0.001). Gastric cancers in the younger patients exhibited more aggressive features and were at a more advanced stage than those in older patients. Precancerous lesions, such as atrophic gastritis and intestinal metaplasia, were observed less frequently in the older than in the younger group(P < 0.001). Molecular characteristics, including overexpression of p53(P < 0.001), overexpression of HER-2(P = 0.006), and MSI(P = 0.006), were less frequent in gastric cancer of younger patients. Cancer related mortality was higher in younger patients(P= 0.048), but this difference was not significant after adjusting for the stage of cancer.CONCLUSION: Gastric cancer is distinguishable between younger and older patients based on both clinicopathologic and molecular features, but stage is the most important predictor of prognosis. | Ji Yeon Seo Eun Hyo Jin Hyun Jin Jo Hyuk Yoon Cheol Min Shin Young Soo Park Nayoung Kim Hyun Chae Jung Dong Ho Lee | 2015 | World Journal of Gastroenterology2015，21，22： | 7 |
| 3 | Wuweizisu C from Schisandra chinensis decreases membrane potential in C6 glioma cells显示文摘瞄准:为了学习 dibenzocyclooctadiene 的效果, lignans 从五味子 chinensis 孤立,例如 wuweizisu C, gomisin N, gomisin A,和 schisandrin,在在 C6 glioma 房间的膜潜力上。方法:膜潜力被在装载 DiBAC 的 glioma 房间测量荧光变化估计。结果:Wuweizisu C 减少了以一种集中依赖者方式的膜潜力。然而, Gomisin N 和 gomisin A 证明微分调整和没有变化被 schisandrin 或 dimethyl-4,4'-dimethoxy-5,6,5' 导致, 6'-dimethylene dioxybipheny 1-2,2'-dicarboxylate,合成的药源于 dibenzocyclooctadiene lignans。我们没发现 G I/O 蛋白质, phospholipase C,和 wuweizisu 上的细胞外的 Na + 膜潜力的导致 C 的减少。由自己的 Wuweizisu C 没改变细胞内部的 Ca 2+[Ca 2+] i 集中,但是减少 C6 glioma 房间的 ATP-indu-ced Ca 2+ 增加。根本,集中在这研究使用了的 4 lignans 没在房间生存能力上导致任何效果。而且,我们在 PC 12 neuronal 房间由 wuweizisu C 发现膜的类似的减少潜在。结论:我们的结果建议在膜潜力和调整的减少[Ca 2+] 由 wuweizisu C 的 i 集中能是 wuweizisu C 的重要行动机制。 | Young-whan CHOI Kyeok KIM Ji-yeong JO Hyo-lim KIM You-jin LEE Woo-jung SHIN Santosh J SACKET Mijin HAN Dong-soon IM | 2008 | Acta Pharmacologica Sinica2008，29，9： | 5 |
| 4 | A gastrointestinal stromal tumor of the duodenum masquerading as a pancreatic head tumor显示文摘Gastrointestinal stromal tumor (GIST) represents the most common kind of mesenchymal tumor that arises from the alimentary tract. GIST is currently defined as a gastrointestinal tract mesenchymal tumor showing CD117 (c-kit protein) positivity at immunohistochemistry. Throughout the whole length of the gastrointestinal tract, GIST arises most commonly from the stomach followed by the small intestine, the colorectum, and the esophagus. Only 3%-5% of GISTs occur in the duodenum, and especially, if GIST arises from the C loop of the duodenum, it can be difficult to differentiate from the pancreas head mass because of its anatomical proximity. Here, we report a case of duodenal GIST, which was assessed as a pancreatic head tumor preoperatively. | Sung Ho Kwon Hee Jeong Cha Seok Won Jung Byung Chul Kim Jae Serk Park In Du Jeong Jong Hwa Lee Yang Won Nah Sung Jo Bang Jung Woo Shin Neung Hwa Park Do Ha Kim | 2007 | World Journal of Gastroenterology2007，13，24： | 4 |
| 5 | Clinical Outcomes of Two‐Week Sequential and Concomitant Therapies for Helicobacter pylori Eradication: A Randomized Pilot Study显示文摘 | Ji Hyun Lim Dong Ho Lee Chiun Choi Seong Tae Lee Nayoung Kim Sook Hyang Jeong Jin Wook Kim Jin Hyeok Hwang Young Soo Park Sang Hyub Lee Cheol Min Shin Hyun Jin Jo Eun Sun Jang In sung Song Hyun Chae Jung | 2013 | Helicobacter2013，，3： | 4 |
| 6 | Effect of biologically active fraction of Nardostachys jatamansi on cerulein-induced acute pancreatitis显示文摘AIM:To determine if the fraction of Nardostachys jatamansi(NJ) has the potential to ameliorate the severity of acute pancreatitis(AP).METHODS:Mice were administered the biologically active fraction of NJ,i.e.,the 4th fraction(NJ4),intraperitoneally,and then injected with the stable cholecystokinin analogue cerulein hourly for 6 h.Six hours after the last cerulein injection,the pancreas,lung,and blood were harvested for morphological examination,measurement of cytokine expression,and examination of neutrophil infiltration.RESULTS:NJ4 administration attenuated the severity of AP and lung injury associated with AP.It also reduced cytokine production and neutrophil infiltration and resulted in the in vivo up-regulation of heme oxygenase-1(HO-1).Furthermore,NJ4 and its biologically active fraction,NJ4-2 inhibited the cerulein-induced death of acinar cells by inducing HO-1 in isolated pancreatic acinar cells.CONCLUSION:These results suggest that NJ4 may be a candidate fraction offering protection in AP and NJ4 might ameliorate the severity of pancreatitis by inducing HO-1 expression. | Gi-Sang Bae Min-Sun Kim Kyoung-Chel Park Bon Soon Koo Il-Joo Jo Sun Bok Choi Dong-Sung Lee Youn-Chul Kim Tae-Hyeon Kim Sang-Wan Seo Yong Kook Shin Ho-Joon Song Sung-Joo Park | 2012 | World Journal of Gastroenterology2012，18，25： | 4 |
| 7 | Multi-directionally wrinkle-able textile OLEDs for clothing-type displays显示文摘A clothing-type wearable display can be utilized in fashion,bio-healthcare,and safety industries as well as smart textiles for the internet of things(IoTs)and wearable devices.In response to this trend,we demonstrate a textile display that can endure the active movements of a human body.It can be applied to any kind of textile,and is durable against conditions such as rain,sweat,and washing.As a key technology for realizing the multi-directional wrinkle-able textile display,we fabricated a stress-lowering textile platform with an ultrathin planarization layer replicated from the flat surface of glass.An elastomeric strain buffer for reducing mechanical stress is also inserted into the textile platform.Here,organic light-emitting diodes(OLEDs)with red,green and blue color,thin film transistors(TFTs)fabricated at a low temperature below 150℃,and a washable encapsulation layer blocking both gas and liquid were demonstrated on the textile platform. | Seungyeop Choi Woosung Jo Yongmin Jeon Seonil Kwon Jeong Hyun Kwon Young Hyun Son Junmo Kim Jun Hong Park Hyuncheol Kim Ho Seung Lee Minwoo Nam Eun Gyo Jeong Jeong Bin Shin Taek-Soo Kim Kyung Cheol Choi | 2020 | npj Flexible Electronics2020，4，1： | 3 |
| 8 | 水稻RIL群体高密度遗传图谱的构建及苗期耐热性QTL定位显示文摘【目的】随着全球气候变暖,高温严重威胁粮食安全,发掘耐热基因资源是培育耐高温新品种和消除高温危害最直接的绿色生态途径,也是阐明耐热生理生化和分子遗传机理的基础。【方法】构建苗期耐热性鉴定评价方法,以热敏感品种周南稻和强耐热品种赣早籼58号杂交衍生的重组自交系(recombinant inbred lines,RIL)群体为研究材料,利用高通量测序技术对亲本和RIL群体进行全基因组测序;依据171个家系的基因型数据,利用滑动窗口法将SNP信息转换成Bin基因型,预测染色体上的重组断点,构建RIL群体高密度BinMap遗传图谱,结合耐热表型数据,运用QTL IciMapping软件完备复合区间ICIM的作图方法,进行高温胁迫下幼苗存活率和耐热等级QTL分析。【结果】构建了一张包含3321个Bin标记高密度遗传图谱,各染色体Bin标记数为159—400个,标记间平均物理距离为106 kb;利用逐步高温胁迫方式鉴定亲本和RIL家系幼苗耐热表型,高温胁迫下,幼苗存活率和耐热等级存在极显著负相关性,且幼苗存活率与籼型基因频率存在显著正相关性,籼型基因频率越高,耐热性越好,RIL群体表型性状呈现双峰连续分布,苗期耐热性可能受少数几个主效QTL调控;共检测到12个苗期耐热性相关的QTL,其中,调控幼苗存活率和耐热等级的QTL分别有8和4个,幼苗存活率和耐热等级相关QTL存在遗传重叠现象,形成调控耐热性的主效QTL簇qHTS2、qHTS7和qHTS8,三者在调控苗期高温抗逆中具有重要作用,其中,qHTS7为新发现主效QTL,对增强苗期耐热性具有较强的功效。【结论】构建了一张包含3321个Bin标记的高密度分子遗传图谱,解析了耐热品种赣早籼58号苗期耐热基因,鉴定出3个苗期耐热调控关键QTL簇,发掘了一个新主效QTL簇qHTS7,基于高密度遗传图谱高效获取目标区段及候选基因,筛选出8个苗期耐热性调控的关键目标基因。 | 刘进 胡佳晓 马小定 陈武 勒思 Jo Sumin 崔迪 周慧颖 张立娜 Shin Dongjin 黎毛毛 韩龙植 余丽琴 | 2022 | 中国农业科学2022，55，22： | 2 |
| 9 | Highly ordered lead-free double perovskite halides by design显示文摘Lead-free double perovskite halides are emerging optoelectronic materials that are alternatives to leadbased perovskite halides.Recently,single-crystalline double perovskite halides were synthesized,and their intriguing functional properties were demonstrated.Despite such pioneering works,lead-free double perovskite halides with better crystallinity are still in demand for applications to novel optoelectronic devices.Here,we realized highly crystalline Cs2AgBiBr6 single crystals with a well-defined atomic ordering on the microscopic scale.We avoided the formation of Ag vacancies and the subsequent secondary Cs3Bi2Br9 by manipulating the initial chemical environments in hydrothermal synthesis.The suppression of Ag vacancies allows us to reduce the trap density in the as-grown crystals and to enhance the carrier mobility further.Our design strategy is applicable for fabricating other lead-free halide materials with high crystallinity. | Chang Won Ahn Jae Hun Jo Jong Chan Kim Hamid Ullah Sangkyun Ryu Younghun Hwang Jin San Choi Jongmin Lee Sanghan Lee Hyoungjeen Jeen Young-Han Shin Hu Young Jeong Ill Won Kim Tae Heon Kim | 2020 | Journal of Materiomics2020，6，4： | 2 |
| 10 | Sex-based differences in histology,staging,and prognosis among 2983 gastric cancer surgery patients显示文摘BACKGROUND Few studies have been conducted on sex differences in the incidence, pathophysiology, and prognosis of gastric cancer(GC).AIM To analyze the differences in GC characteristics according to sex in patients who underwent surgical treatment for GC.METHODS A total of 2983 patients diagnosed with gastric adenocarcinoma who received surgical treatment at the Seoul National University Bundang Hospital between 2003 and 2017 were included.Baseline clinicopathological characteristics, histologic type of GC, overall and GC-specific survival rates, and associated risk factors were analyzed.RESULTS Among the 2983 patients, 2005(67.2%) and 978(32.8%) were males and females, respectively.The average age of the female group(59.36 years) was significantly younger than that of the male group(61.66 years;P < 0.001).Cancer of the gastric body(P < 0.001) and diffuse-type histology(P < 0.001) were more common in females than in males.This trend was more prominent in females younger than 60 years of age, with a significantly higher proportion of diffuse-type cancer than in the male group.Regardless of sex, diffuse-type GC was more common in younger patients, and the proportion of intestinal-type GC increased with age.The overall survival rate was significantly higher in females(P < 0.001).However, this difference disappeared for GC-specific survival(P = 0.168), except for the poor GC-specific survival rate in advanced-stage cancer(stage Ⅲ or above) in females(P = 0.045).The risk factors for GC-related mortality were older age, upper location of GC, and diffuse-or mixed-type histology.In terms of comorbidities, more males died from diseases other than GC, including other malignancies such as lung cancer, hepatocellular carcinoma, and pancreatic cancer, and respiratory diseases such as interstitial lung disease and chronic obstructive pulmonary disease, while there were relatively more cardiovascular or cerebrovascular deaths in females.CONCLUSION Sex-based differences in GC were observed in clinicopathological features, including age at diagnosis, tumor location, histologic type, survival rate, and comorbidities. | Yonghoon Choi Nayoung Kim Ki Wook Kim Hyeong Ho Jo Jaehyung Park Hyuk Yoon Cheol Min Shin Young Soo Park Dong Ho Lee Hyeon Jeong Oh Hye Seung Lee Young Suk Park Sang-Hoon Ahn Yun-Suhk Suh Do Joong Park Hyung-Ho Kim Ji-Won Kim Jin Won Kim Keun-Wook Lee Won Chang Ji HoonPark Yoon Jin Lee Kyoung Ho Lee Young Hoon Kim | 2022 | World Journal of Gastroenterology2022，28，9： | 2 |
| 11 | Cardiac mucosa at the gastroesophageal junction:An Eastern perspective显示文摘AIM:To investigate the nature and origin of cardiac mucosa(CM).METHODS:Biopsy samples from sixty-one individuals were included in this study. The specimens were taken 'at','just below',or 'just above' the gastroesophageal junction,including the histologic squamocolumnar junction. Clinical data were obtained by reviewing electronic medical records for each patient. Patients with a history of stomach adenoma or carcinoma and esophageal carcinoma were excluded,and cases that were endoscopically suspicious of Barrett's esophagus or a polyp were also ruled out. Histologic and endoscopic reviews were performed blinded to the patient's clinical data. Histologic evaluation wasconducted by two pathologists,and endoscopic review was performed by a endoscopist with wide experience in the field. Histologically,the columnar epithelium of squamocolumnar junction,presence and severity of acute and chronic inflammation,atrophy,intestinal metaplasia,and presence of carditis were evaluated. Endoscopically,reflux esophagitis was evaluated by Los Angeles(LA) classification,hiatal hernias were classified by Hill grade,and gastroesophageal flap valves were assessed. RESULTS:Fifty-nine of the 61(96.7%) patients were Korean; 65.6%(40/61) of the patients underwent endoscopy according to the schedule of the National Health Insurance Program as a screening inspection. Of these,only 20.0%(8/40) of cases had reflux s y m p t o m s. C M w a s p r e s e n t i n 4 1 / 6 1( 6 7. 2 %) individuals,and its presence was associated with older age compared to oxyntocardiac mucosa/oxyntic mucosa(60.59 ± 2.02 years vs 51.55 ± 3.35 years; P = 0.018). The presence of CM was associated with endoscopic diagnosis of esophagitis according to the LA classification(P = 0.022). CM was associated with mononuclear cell infiltration and neutrophilic infiltration,which were statistically significant(P = 0.001,and P = 0.004,respectively). The inflammation of CM,'carditis',showed a statistically significant association with endoscopic diagnosis of reflux esophagitis according to the LA classification(P = 0.008). CONCLUSION:CM at the gastroesophageal junction is a common histologic finding in biopsy specimens,though not always present,and associated with gastroesophageal reflux disease and carditis severity. | Ahrong Kim Won-Young Park Nari Shin Hyun Jung Lee Young Keum Kim So Jeong Lee Cheong-Soo Hwang Do Youn Park Gwang Ha Kim Bong Eun Lee Hong-Jae Jo | 2015 | World Journal of Gastroenterology2015，21，30： | 2 |
| 12 | Increased platelet CD63 and P-selectin expression persist in atheroselerotie isehemie stroke 显示文摘 | Cha JK Jo WS Shin HC | 2004 | Platelets2004，15，1： | 1 |
| 13 | Exposure to Volatile Organic Compounds in Residences Adjacent to Dyeing Industrial Complex显示文摘 | Jo Wan-Kuen Lee Jin-Woo Shin Dong-Chun | 2004 | International Archives of Occupational and Environmental Health2004，77，2： | 1 |
| 14 | Effect of γ-irradiation on pathogens inoculated into ready-to-use vegetables 显示文摘 | Lee N Y Jo C Shin D H | 2006 | Food Microbiology2006，23，64： | 1 |
| 15 | Induction of cell death in human macrophages by a highly virulent Korean isolate of Mycobacterium tuberculosis and the virulent strain H37Rv显示文摘 | Sohn H Lee KS Kim SY Shin DM Shin SJ Jo EK Park JK Kim HJ | 2009 | Scand J Immunol2009，69，1： | 1 |
| 16 | The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes显示文摘 | Jung SB Yang CS Lee JS Shin AR Jung SS Son JW Har- ding CV Kim HJ Park JK Paik TH Song CH Jo EK | 2006 | Infect Immun2006，74，5： | 1 |
| 17 | Ihh and Runx2/Runx3 signaling interact to coordinate early chondrogenesis: a mouse model显示文摘 | Kim EJ Cho SW Shin JO | 2013 | PLoS One2013，8，55： | 1 |
| 18 | Effieaey and safety of puer- aria lobata extraet in gray hair prevention: a randomized, double-blind, placebo-controlled study显示文摘 | S Jin Jo H Shin S Hwan Paik | 2013 | Ann Dermatol2013，25，2： | 1 |
| 19 | Biomimetie materials for tissue engineering显示文摘 | SHIN H JO S MIKOS A G | 2003 | Biomaterials2003，24，24： | 1 |
| 20 | Calcineurin regulates ryanodine receptor/Ca2+ -release channels in rat heart显示文摘 | Bandyopadhyay A Shin DW Ahn JO | 2000 | Biochem J2000，352，1： | 1 |
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