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| 1 | Heme oxygenase-1 and gut ischemia/reperfusion injury: A short review显示文摘Ischemia/reperfusion (I/R) injury of the gut is a significant problem in a variety of clinical settings and is associated with a high morbidity and mortality. Although the mechanisms involved in the pathogenesis of gut I/R injury have not been fully elucidated, it is generally believed that oxidative stress with subsequent inflammatory injury plays an important role. Heme oxygenase (HO) is the rate-limiting enzyme in the catabolism of heme, followed by production of CO, biliverdin, and free iron. The HO system is believed to confer cytoprotection by inhibiting inflammation, oxidation, and apoptosis, and maintaining microcirculation. HO-1, an inducible form of HO, serves a vital metabolic function as the rate-limiting step in the heme degradation pathway, and affords protection in models of intestinal I/R injury. HO-1 system is an important player in intestinal I/R injury condition, and may offer new targets for the management of this condition. | Yu-Feng Liao Wei Zhu Dong-Pei Li Xiao Zhu | 2013 | World Journal of Gastroenterology2013，19，23： | 10 |
| 2 | Antioxidative phytoceuticals to ameliorate pancreatitis in animal models: An answer from nature显示文摘Despite enthusiastic efforts directed at elucidating critical underlying mechanisms towards the identification of novel therapeutic targets for severe acute pancreatitis(SAP), the disease remains without a specific therapy to be executed within the first hours to days after onset of symptoms. Although earlier management for SAP should aim to either treat organ failure or reduce infectious complications, the current standard of care for the general management of AP in the first hours to days after onset of symptoms include intravenous fluid replacement, nutritional changes, and the use of analgesics with a close monitoring of vital signs. Furthermore, repeated evaluation of severity is very important, as the condition is particularly unstable in the early stages. In cases where biliary pancreatitis is accompanied by acute cholangitis or in cases where biliary stasis is suspected,an early endoscopic retrograde cholangiopancreatography is recommended.However,practice guidelines regarding the treatment of pancreatitis are suboptimal.In chronic pancreatitis,conservative management strategies include lifestyle modifications and dietary changes followed by analgesics and pancreatic enzyme supplementation.Recently,attention has been focused on phytoceuticals or antioxidants as agents that could surpass the limitations associated with currently available therapies.Because oxidative stress has been shown to play an important role in the pathogenesis of pancreatitis,antioxidants alone or combined with conventional therapy may improve oxidativestress-induced organ damage.Interest in phytoceuticals stems from their potential use as simple,accurate tools for pancreatitis prognostication that could replace older and more tedious methods.Therefore,the use of antioxidative nutrition or phytoceuticals may represent a new direction for clinical research in pancreatitis.In this review article,recent advances in the understanding of the pathogenesis of pancreatitis are discussed and the paradigm shift underway to develop phytoceuticals and antioxidants to treat it is introduced.Despite the promise of studies evaluating the effects of antioxidants/phytoceuticals in pancreatitis,translation to the clinic has thus far been disappointing.However,it is expected that continued research will provide solid evidence to justify the use of antioxidative phytoceuticals in the treatment of pancreatitis. | Jong-Min Park Sooyeon Lee Mi Kyung Chung Sung-Hun Kwon Eun-Hee Kim Kwang Hyun Ko Chang Il Kwon Ki Baik Hahm | 2014 | World Journal of Gastroenterology2014，20，44： | 5 |
| 3 | 雨蛙素腹腔注射致小鼠慢性胰腺纤维化病理组织学观察显示文摘目的:采用雨蛙素反复腹腔注射诱导小鼠慢性胰腺炎,评估胰腺发生纤维化的程度及病变特点。方法:健康雄性C57BL/6小鼠20只,随机分为两组,模型组反复腹腔注射雨蛙素,对照组腹腔注射与模型组等体积的生理盐水,于第7周第1 d留取胰腺组织,光镜下进行胰腺腺泡细胞萎缩、炎性细胞浸润、间质纤维组织增生评分;另一部分行苦味酸-天狼星红染色,偏振光显微镜下观察胰腺间质胶原增生情况;第三部分行免疫组织化学染色,观察α-SMA表达情况。结果:模型组小鼠胰腺HE染色显示明显腺泡细胞萎缩、炎性细胞浸润及纤维化;苦味酸-天狼星红染色显示显著胰腺间质胶原增生,评分明显升高;免疫组织化学染色显示星状细胞活化标志物α-SMA表达明显增强。结论:雨蛙素反复多次腹腔注射可诱导小鼠产生明显的胰腺纤维化病变,纤维化发生机制可能与胰腺星状细胞活化分泌过多细胞外间质有关。 | 崔立华 张一 白景瑞 李东华 刘洪斌 | 2013 | 中国中西医结合外科杂志2013，19，5： | 1 |
| 4 | 鱼油脂肪乳剂预处理对大鼠肺缺血-再灌注损伤的影响显示文摘目的观察鱼油脂肪乳剂预处理对大鼠肺缺血-再灌注损伤的保护作用及可能机制。方法 32只SD大鼠随机分为四组:预给鱼油脂肪乳剂再灌注组(FOFE组)、预给鱼油脂肪乳剂加锌原卟啉再灌注组(FOFE-Z组)、预给生理盐水再灌注组(Saline组)和假手术组(Sham组)。监测并采集大鼠缺血末和实验末时的HR、BP并计算RPP,检测平衡末、缺血末、实验末经股动脉处采血的动脉血气;测定左肺组织湿干重比(W/D)和肺泡损伤评分IQA;检测左肺组织中IL-6和MPO含量以及NF-κB和HO-1(血红素氧化酶-1heme oxygenase-1)的表达,观察左肺组织形态结构改变。结果与FOFE组比较,缺血末和实验末FOFE-Z组的HR明显减慢,SBP和RPP明显降低,实验末Sham组SBP和RPP明显升高(P<0.05);FOFE-Z组和Saline组PaO2明显降低,IL-6含量、IQA评分和W/D明显升高(P<0.05或P<0.01),FOFE-Z组的BE明显降低(P<0.05);Saline组MPO含量明显升高(P<0.05);FOFE-Z组的NF-κB mRNA表达明显升高,FOFE-Z组和Sham组的HO-1的表达明显降低(P<0.05)。与FOFE-Z组比较,缺血末和实验末Sham组HR明显增快,SBP和RPP明显升高(P<0.05),实验末Saline组HR明显增快(P<0.05)。与Sham组比较,实验末FOFE组、FOFE-Z组和Saline组的pH明显降低,IL-6含量和IQA评分明显升高(P<0.05或P<0.01),FOFE-Z组和Saline组的PaO2明显降低,W/D明显升高(P<0.01),FOFE-Z组的BE明显降低(P<0.05),Saline组MPO含量和NF-κB的mRNA表达明显升高(P<0.05)。结论鱼油脂肪乳剂预处理可减轻大鼠肺缺血-再灌注损伤,其机制可能与增强HO-1的活性和表达有关。 | 朱斌斌 胡霞蔚 南芙蓓 陈哲 王莉 徐旭仲 | 2015 | 临床麻醉学杂志2015，31，1： | 1 |
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