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| 1 | Possible mechanisms underlying treatment of Alzheimer’s disease with Traditional Chinese Medicine: active components, potential targets and synthetic pathways of Bulao Elixir显示文摘OBJECTIVE: To elucidate the mechanisms underlying the treatment of Alzheimer’s disease(AD) with Traditional Chinese Medicine(TCM), by examining the active components, potential targets and synthetic pathways of Bulao Elixir(BLE).METHODS: The Absorption, Distribution, Metabolism, Excretion(ADME)/Toxicology(T) calculation was used to screen the active components of Bulao Elixir. Based on the TCM Systems Pharmacology Analysis Platform(TCMSP database) and a text mining tool(GoPubMed database), we predicted and screened the active components of Bulao Elixir and its therapeutic targets for AD. Using the Database for Annotation, Visualization and Integrated Discovery(DAVID), we obtained the targets for AD. Cytoscape software was used to establish a network map of the active component-target and target-pathway of Bulao Elixir. Gene function, related biological processes and signaling pathways were analyzed using the DAVID database.RESULTS: Twelve active components were selected from 196 components of Bulao Elixir. Among 2209 targets, 102 effective targets were selected, and 30 important targets were identified via matching with the disease targets. After further analysis, 14 core targets were identified. Enrichment analysis revealed that most of these important targets were involved in multiple biological processes, including apoptosis, inflammatory reactions, and cell regulation cycles. The synthetic pathways for AD treatment were identified after analyzing and confirming the relevant pathways, providing potentially useful information for diagnosis and treatment methods for AD.CONCLUSION: The current study elucidated the potential treatment mechanisms of Bulao Elixir in AD using network pharmacology, providing a foundation for further clarification of its treatment targets. | Ren Beida Cheng Fafeng Wang Xueqian Wan Yuxiang Ji Wenting Du Xin Zhang Shuang Liu Shilling Ma Chongyang Xiong Yiliang Hao Gaoting Wang Qingguo | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 4 |
| 2 | Inner ear anomalies in cochlear implantees: importance of radiologic measurements in the classification 显示文摘 | Shim H J Shill J E Chung J W | 2006 | Otol Neurotol2006，27，6： | 1 |
| 3 | Reconstitution of NK cell receptor repertoire following HLA-matched hematopoietic cell transplantation 显示文摘 | Shilling HG McQueen KL Cheng NW | 2003 | Blood2003，101，9： | 1 |
| 4 | Fast fourier transform analysis in cavity ring-down spectroscopy:application to an optical detector for atmospheric NO2显示文摘 | Mazurenka M Wada R Shillings A J L | | 0，，： | 1 |
| 5 | Particle mass yield in secondary organic aerosol formed by the dark ozonolysis ofɑ-pinene显示文摘 | Shilling JE Chen Q King SM | 2008 | Atmospheric Chemistry and Physics2008，8，7： | 1 |
| 6 | Limb-girdle muscular dystrophy in the United States显示文摘 | Moore SA Shilling CJ Westra S | 2006 | Neuropathol Exp Neurol2006，65，10： | 1 |
| 7 | Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors显示文摘 | Valiante NM Uhrberg M Shilling HG | 1997 | Immunity1997，7，3： | 1 |
| 8 | Intercomparison of measurements of NO<sub>2</sub> concentrations in the atmosphere simulation chamber SAPHIR during the NO3Comp campaign显示文摘 | Fuchs H. Ball S. M. Bohn B. Brauers T. Cohen R. C. Dorn H.-P. Dubé W. P. Fry J. L. H?seler R. Heitmann U. Jones R. L. Kleffmann J. Mentel T. F. Müsgen P. Rohrer F. Rollins A. W. Ruth A. A. Kiendler-Scharr A. Schlosser E. Shillings A. J. L. Tillmann R. Var | 2010 | Atmospheric Measurement Techniques2010，，5： | 1 |
| 9 | Diabetes, Hyperglycemia, And infections显示文摘 | Shilling AM Raphael J | 2008 | Best Pract Res Clin Anaesthesiol2008，22，3： | 1 |
| 10 | Induction of estrus in greyhound bitches with prolonged idiopathic anestrus or will suppression of estrus after testosterone administration显示文摘 | Moses DL Shille VM | 1988 | J Am Vet Med Assoc1988，192，： | 1 |
| 11 | Mechanical and chemical control of cogongrass ( l~ata eylindrica ) 显示文摘 | Willard T R Shilling D G Gaffney J F | 1996 | Weed Technol1996，10，： | 1 |
| 12 | Prevalence of myopia in Taiwanese schoolchildren: 1983 to 2000 显示文摘 | Lin LL Shill YF Hsiao CK | 2004 | Ann Acad Med2004，33，1： | 1 |
| 13 | Identification of metalloprotease/disintegrins in Xenopus laevis testis with a potential role in fertilization显示文摘 | Kratzschmar J Cai H | 1997 | Dev Biol1997，186，2： | 1 |
| 14 | Evaluation of epicuticu-lar wax removal from whole leaves with chloroform显示文摘 | Bewick T A Shilling D G Querns R | 1993 | Weed Technology1993，7，3： | 1 |
| 15 | Allelic polymorphism synergizes with variable gene content to individualize human KIR genotype显示文摘 | Shilling HG Guethlein LA Cheng NW | 2002 | J Immunol2002，168，： | 1 |
| 16 | Market timing: better than a buy -and -hold strategy显示文摘 | Shilling Gary A | 1992 | Financial Analysts Journal Mar/Apr1992，48，2： | 1 |
| 17 | Parents' agendas in paediatric clinical trial recruitment are different from researchers'and often remain unvoiced: a qualitative study 显示文摘 | Woolfall K Shilling V Hickey H | 2013 | PLoS One2013，8，67： | 1 |
| 18 | Possible influence of the insertion/ddetion polymorphism in the angiotensin Ⅰ-converting enzyme geneon therapeutic outcome in affective disorders显示文摘 | Baghai TC Shille C Zwanzger P | 2001 | Mol Psychiatry2001，6，： | 1 |
| 19 | Plasma homocysteine concentration,statin therapy,and the risk of first acute coronary events显示文摘 | Ridker PM Shill J Cook TJ | 2002 | Circulation2002，105，15： | 1 |
| 20 | Mechanical and chemical control of cogongrass(Imperata cylindrica)显示文摘 | Willard T R Shilling D G Gaffney J F | 1996 | Weed Technol1996，10，： | 1 |
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